- Michael Shanks - Jimmy
- Anne Marie DeLuise - Rachel
- Meghan Ory - Laura S.
- Colin Cunningham - Gerald
- Michael Benyaer - Assam
- Katharine Isabelle - Sophie
- Leah Cairns - Tatha
- Kavan Smith - Detective Joe Kavanaugh
- Laura Mennell - Caird
- Kandyse McClure - Meg
- Miranda Frigon - Danu
- Peter Outerbridge - Malcolm Dawkins
- Cainan Wiebe - Alexei
- Alex Zahara - Carver
- Peter Shinkoda - Andy Fetz
- Mackenzie Gray - Mr.Jones
- Matthew Walker - Oliver Braithwaite
- Sarah Strange - Dr. Allison Grant
- David Richmond-Peck - Jake Polanski
- Panou - Sylvio Rudd
- Adrien Dorval - Braun
- David Nykl - Strickland
- Alison Araya - Giselle
- Malik McCall - Lawrence Birch
- Diana Pavlovská - Jagna Mitrovna
- Ellie Harvie - Eleanor
- Dana McLoughlin - Hooker / John's victim
- Ian A. Wallace - Fire Creature
- Mihola Terzic - Waitress
- Dan Joffre - Transit Cop
- Dan Shea - Transit Cop
- Ivan De Leon - Med Tech
- Nicholas Podbrey - Man
- Sheri Rabold - Molly
- Darien Provost - Young Will
- Lauren K. Robek - Will's Mom
- R. Nelson Brown - Squid
- Nigel Vonas - Cabal Team
- James Kirk - Aaron Braithwaite
- Jeb Beach - Chemist
- Peter Bryant - Cabal Team Leader
- Gabrielle Rose - Ruth Meyers
- Michael Eisner - Edward Meyers
- Chris Nelson Norris - Glen Meyers
- Sam Laird - Robbie Meyers
- Sean Mathieson - Young Henry
- Byron Lawson - Danny
- Rukiya Bernard - Kayla Bradley
- Emily Tennant - Patricia Heathering
- Daryl Shuttleworth - Mr. Peralta
- Brock Johnson - The Mechanic
- Steven Man - The Surgeon
- Christopher Gaze - Warrior
- Rekha Sharma - Amy Saunders
- Simon Webb - Warrior
- John Tench - Warehouse Worker Garvin
- Jason Benson - Uniform Cop
- David Lyle - Father
- Babs Chula - Cabal scientist / Doctor
- Mark Gibbon - Cabal Agent
- Alex Diakun - Doctor
- Quelemia Sparrow - Miss Kennair
- Maiko Yamamoto - Medusa
- Darren Shahlavi - Jason
- Darren Shahlavi - Ennis Camden
- Doug Abrahams - Security Man
- Stanley Tsang - Dr. Hiromata
- Daren A. Herbert - Cabal Tech
- Lani Gelera - Super Abnormal
- Lynda Boyd - Dana Whitcomb
- Hiro Kanagawa - Ark-Fong Li
- Paul Stanley - Navajo Man
- Brenda McDonald - Navajo Woman
- Christine Chatelain - Clara Griffin
- Jason Schombing - Small flying abnormal
- Shayan Bayat - Thad Freelander
- Michael Adamthwaite - Albert Russo
- Michael Adamthwaite - Trace
- Tim Perez - Constantine
- William 'Big Sleeps' Stewart - Constantine Hench
- Dean Mckenzie - Foreman
- Nicole Muñoz - Jessica Mitchell
- Sean Tyson - Simmons
- Amanda May - Jack
- Erica Cerra - Emma Correia
- Colin Lawrence - Scofield
- John Paul McGlynn - Tosen
- Sandy Robson - Remy
- Michael Challenger - Mercenary
- Richard Zeman - Olaf von Ausburg
- Aleks Paunovic - The Duke
- Jason Bryden - Ellison
- Dean Redman - Goon killed by Duke
- Ryan Kennedy - Darrin Wilson
- Chad Rook - Chad Spencer
- Steve Archer - Thomas Rayburne
- Raf Rogers - Geoff
- Giacomo Baessato - Steve
- Monica Mustelier - Maria the Nurse
- Marcia Moulton - Musa
- Hamza Fouad - Zula Empath
- Michael Hanus - Jax - Lead Goon
- Chris Gauthier - Walter
- Chris Gauthier - Walter 'The Adjustor'
- Tatsuya Ishii - The Bug Carrier
- Suniel Samra - Henchman
- Balinder Johal - Bibi
- Terry Chen - Charles
- Callum Blue - Edward Forsythe
- Nimet Kanji - Henchman
- Nimet Kanji - Pili
- Hamza Adam - Helmsman
- Bal Nagra - Janu
- Bhavkhandan Singh Rakhra - Grand Father
- Paul McGillion - Terrence Wexford
- Matty Finochio - Virgil St. Pierre
- Matty Finochio - Zach Spencer
- Sahar Biniaz - Kali
- Byron Chief-Moon - Spirit Being
- Eric Keenleyside - Detective Michael Bronson
- Peter Flemming - FBI Special Agent Bruce Tanner
- Chasty Ballesteros - Bridget
- Raquel Riskin - Cheryl
- Jason Poulsen - Dave
- Tobias Slezak - Adam
- Gary Jones - George
- Mary Black - Grace
- Robin Mossley - Thomas
- Chuck Campbell - Two Faced Guy
- Chuck Campbell - Two-Faced Guy
- Michael J Rogers - Detective Stanley O'Farrell
- Benita Ha - Shirley Wilkins
- Jorgito Vargas Jr. - Danny Stephano
- Fabrice Grover - Father Nathaniel Jensen
- Tim Fellingham - Brad
- Robert Clarke - Scientist
- Adrian Hough - Liam
- Martin Christopher - False Priest
- Martin Christopher - Father Clark
- Patrick Keating - Joe
- Allison Hossack - Lillian
- Chris Nowland - Orderly
- Brent McLaren - Orderly
- Duncan Fraser - Prime Minister
- Margot Berner - Imogene
- Denton Winn - Angelo
- John Emmet Tracy - British Museum Curator
- Sylvesta Stuart - Seralops Abnormal
- Scott McNeil - Birot
- Luvia Petersen - Narra
- Alexander Kambolis - Linor
- Valin Shinyei - Beza
- Nels Lennarson - Praxis Guardsman
- Nels Lennarson - Commander Toland
- Polly Walker - Ranna Seneschal
- Ron Selmour - Kanaan
- Edward Foy - Horatio Gibbs
- Tinsel Korey - Sioux
- James Pizzinato - Koda
- Pauline Egan - Erika Myers
- Peter DeLuise - Ernie Watts
- Rob Hayter - Mothman
- Aliyah O'Brien - Afina
- Peter Wingfield - Dr. James Watson
- Douglas O'Keeffe - Col. Franz Korba
- Vincent Gale - Nigel Griffin
- Aaron Brooks - Lieutenant Hallman
- Juan Riedinger - German Major
- Richard de Klerk - U.S. Sergeant
- Robert Lawrenson - Declan Macrae
- Shaker Paleja - Dr. Ravi Ganapathiramani
- Colleen Winton - Anna
- Nic Rhind - Lieutenant
- Jordana Largy - Josie
- Barclay Hope - Security force commander
- Marvin Ishmael - Ravi
- Andrew Halliwell - French Man
- Elysia Rotaru - French Woman
- Ian Tracey - Adam Worth
- Pascale Hutton - Abby Corrigan
- Françoise Yip - Dr. Lillian Lee
- Tom McBeath - General Villanova
- Greyston Holt - Lt. Coxswell
- Adam Copeland - Thelo
- Jody Thompson - Fallon
- David Milchard - Garris
- Fraser Aitcheson - Herusan
- Riccardo Cicogna - Bear
- Michael Patric - Alistair
- Mark Oliver - Cabal Agent
- Al Sapienza - Will's Father
- Adam Greydon Reid - Bruno Delacourt
- Caroline Cave - Sheila Delacourt
- Conrad Coates - Yusuf
- Brent Stait - Finn Noland
- Alex Ferris - Young Will
- Karyn Michelle Baltzer - Lacynth
- Lee Wilson - Iguana Creature (voice)
- Brian Markinson - Greg Addison
- Lara Gilchrist - Cassidy Turner
- Mig Macario - Wahid / Crixorum
- Sandrine Holt - Charlotte Benoit
- John Novak - Thug Boss
- Martin Cummins - Brad Sylvester
- Tora Hylands - Nicholls
- Charlie Carrick - Tyler
- Kurt Evans - Agent Gavin Crealy
- Sage Brocklebank - Canadian Press Photographer
- Richard Howland - Galvo
- Carlo Rota - Richard Feliz
- Carlo Rota - Feodor 'Frank' Glazov
- Jenn MacLean-Angus - Dr. Coates
- Kwesi Ameyaw - Colonel Bosh
- Darren Bennett - SCIU Agent
- Zak Santiago - Captured Abnormal
- J.C. Williams - SCIU Agent
- Jodi Balfour - Terry
- Anjali Jay - Jasmine
- Dalias Blake - Abnormal Leader
- Richard Stroh - Orin
- Brenda Campbell - Michelle Moran
- Gil Bellows - Caleb
- Venus Terzo - Capt. Franklin
- Gerard Plunkett - Fordis
- Andrea Gorfolova
- Sam Egan
- Lee Wilson
- Martin Wood
- Amanda Tapping
Eric Keenleyside interpreta a Detective Michael Bronson en la serie.
Robin Dunne hace el papel de Dr. Will Zimmerman.
Christopher Heyerdahl interpreta a John Druitt / Bigfoot en la serie.
Ryan Robbins hace el papel de Henry Foss.
Agam Darshi interpreta a Kate Freelander en la serie.
Jim Byrnes interpreta a Gregory Magnus en la serie.
Jonathon Young interpreta a Nikola Tesla en la serie.
Capítulo disponible en las siguientes plataformas:
