- Nakia Burrise - Kerry Hall
- Timothy Olyphant - Winston Funk
- Natasha Leggero - Woman Customer
- Anthony Anderson - Rafael Grace
- Mark Ballas - Mateo Romero
- Rick Hoffman - Chase Chapman
- Tony Hale - Andy Adams
- Eliza Coupe - Willow
- Teddy Sears - Brad
- Rebecca Wisocky - Lindsey
- Billy Zane - Funk
- Kiele Sanchez - Chloe
- James Tupper - Owen
- Brett Rickaby - AA Leader
- Eddie Cibrian - Kevin
- Beth Littleford - Audrey Rhodes
- Ryan Carnes - Brent
- Cybill Shepherd - Paula Drake
- Mary-Kate Olsen - Natalie
- James Patrick Stuart - Bill Jacobs
- Andre Ware - Mac Fresh
- Jerry O'Connell - Craig
- Joy Osmanski - Tracy
- Stephen Rannazzisi - Seth
- Miranda May - 13-Year-Old Dena
- William Abadie - Rene
- Jelynn Sophia - Angry Woman
- Dan Thiel - Dave
- Adam Jennings - Barista
- Jill Talley - AA Female Leader
- Frank Maharajh - Dr. Kegoshian
- Dana Sorman - Jerri
- Jamison Haase - Vic
- B.J. Clinkscales - Waiter
- Jessica St. Clair - Valerie
- Gerald Downey - Paul
- Curt Cornelius - Trey
- Kara Taitz - Bridesmaid
- Ryan Carlberg - Jason
- Rand Holdren - Ryan
- Sarah Spiegel - Young Woman
- Todd Grinnell - Nathan
- Johanna Braddy - Teenage Samantha
- Jagger Chase - Kid
- Kelsey Lee Smith - Young Samantha
- Marilyn Sue Perry - Cashier
- Arshad Aslam - Barista
- Timon Kyle Durrett - Russ
- Tanya Bond - Girl
- Ossie Mair - Driver
- Jaclyn Kerhulas - Sign Language Interpreter
- Morgan Murphy - Woman Protester
- Jim Rash - Artist
- Jonathan Schmock - Hipster
- Brandon Ford Green - Guy
- Ian Duncan - Cameron
- Soledad Campos - Woman
- Tony Winters - Man
- Melody Butiu - Nurse
- Brian Catalano - Orderly
- Sarah Rafferty - Kayla Kaminski
- Gregory Franklin - Announcer
- Rachel Cannon - Carol
- Phoebe Dorin - Older Woman
- Brian D. Phelan - Cute Guy
- Roxana Ortega - Allison
- Steve Wilson - Foreman
- Carla Greene - Waitress
- Sayeed Shahidi - Little Boy
- Marsh Mokhtari - Mike
- McKinley Freeman - Tony Dane
- Joni Kempner - Cameron
- Cooper Thornton - Instructor
- David Douglas - Barista
- Laurie Okin - Mother
- Stefan Marks - Detective Harp
- Ty Barnett - Mugger
- Karlton Johnson - Policeman
- Tara Ochs - Waitress
- Michael Crider - Roth
- Ken Rudulph - Reporter
- Brent Tarnol - Jason
- John Taylor - Tommy Wylder
- Greg Cipes - Street Musician
- Terryn Westbrook - Female Fan #1
- Kathryn Taylor Smith - Female Fan #2
- Dondré Whitfield - Wes Green
- Robin Gwynne - Wife
- Christine Ebersole - Amy
- Florence Henderson - Loretta
- Nora Dunn - Cheryl
- Adam Devine - Tyler
- Hahn Cho - Doctor
- Terrance Christopher Jones - Teacher
- Abdoulaye NGom - Minister
- Denise Gossett - Homeless Woman
- Indira G. Wilson - Photographer
- Charles C. Stevenson Jr. - Gentleman
- Angie Harmon - Gigi
- Bree Condon - Mickey
- Jackie Johnson - Jackie Johnson
- Shulie Cowen - Dolly
- Greg Callahan - Fake Dad
- Anna Zielinski - Ticket Agent
- Andre M. Johnson - Security Guard
- Christina Applegate
- Alex Reid
- Dawn DeKeyser
- Cecelia Ahern
- Bob Kushell
- Donald Todd
Cybill Shepherd interpreta a Paula Drake en la serie.
Nora Dunn interpreta a Cheryl en la serie.
Billy Zane interpreta a Funk en la serie.
Christine Ebersole interpreta a Amy en la serie.
Jerry O'Connell hace el papel de Craig.
Jennifer Esposito interpreta a Andrea Belladonna en la serie.
Kevin Dunn interpreta a Howard en la serie.
Melissa McCarthy interpreta a Dena en la serie.
Tim Russ hace el papel de Frank.
Barry Watson hace el papel de Todd.
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