- Sabrina Lloyd - Wade Welles
- Sabrina Lloyd - Wade Welles (voice)
- Barry Greene - Deitrich
- Joshua Malina - Egghead Announcer
- Marnie McPhail - Elizabeth Mallory
- Jerry Doyle - Sgt. Vernon Larson
- Shane West - Kirk
- Gregory Paul Martin - Gareth Carr
- David Birney - Cadmus
- Thorsten Kaye - Ralph Hackett
- Chuck McCann - Jack Brim
- Isaac Hayes - The Prime Oracle
- Robert Lewis - Mr. Clarke
- Venus Terzo - June
- Bentley Mitchum - M.I.T. Player
- Jason Gray-Stanford - Bellhop
- Zack Ward - Gerald Thomas
- Kristoffer Tabori - Dr. Whelan
- Constance Forslund - Fiona
- Corey Feldman - Reed Michener
- Eddie Mills - D.E.R.I.C.
- Liz Sheridan - Miss Miller
- Brooke Langton - Daelin Richards
- Jacqueline Obradors - Carol
- Jim Turner - Michael Mallory
- Barry Pepper - Skidd
- Brigitta Dau - Amanda
- Jack Kehler - The Poacher
- Meadow Sisto - Ambrosia
- Jeffrey Dean Morgan - Sid
- Lawrence Hilton-Jacobs - Lawrence Hilton-Jacobs / The People's Proponent
- Brian McNamara - Dr. Dunhill / Inspector Reed
- Gordon Michael Woolvett - Judge
- Hallie Foote - Lady Mary
- Duff McKagan - Harker
- Deborah Kellner - Tami
- Stephanie Niznik - Debra Carbol
- J. August Richards - Damon
- Neil Flynn - Officer Phil
- Michael Manasseri - Bobby Hawkes
- Frank John Hughes - Hal
- Antoinette Picatto - Amy Nichols
- Donnie Jeffcoat - Keegan
- Julie St. Claire - Kyra
- John Kassir - Arnold Potts
- Walter Olkewicz - The Boss
- Meg Foster - Col. Margaret Burke
- Peter Jurasik - Dr. Oberon Geiger
- Gwynyth Walsh - Detective L. Specateli
- Tim Thomerson - MacArthur Mallory
- Francis Guinan - Sean Nuinn
- Brigid Brannagh - Erin
- Apollonia Kotero - Dr. Deera Mubaric
- Sherman Howard - Hendrick
- Alex Datcher - Julianne Murphy
- Sara Botsford - Mayor Anita Ross
- Richard Ian Cox - Richie
- Robert Isaac Lee - FBI Agent Harold Yen
- Lee Weaver - Hilton Brown
- Judson Mills - Davy
- Stuart Fratkin - Instructor
- James Patrick Stuart - Derek Bond
- Robert Englund - Dr. James Aldohn
- Phillip Van Dyke - Young Quinn Mallory
- Brad Loree - Driver
- Julie Benz - Jenny Michener
- Michael Des Barres - Prof. Vincent Cardoza
- Lisa Rieffel - Deanne Bloch
- Ken Pogue - Dr. Darren Morton
- George Touliatos - Dr. Lee Antonovich
- Connor Trinneer - Samson
- Valarie Pettiford - Dr. Grace Venable
- Danso Gordon - Otis
- Eric Pierpoint - President Jefferson Williams
- Tommy Chong - Van Elsinger
- Paris Barclay - Bureaucrat
- Randy Vasquez - Carlos
- Katherine Moffat - Dr. Helena Malone
- Pepe Serna - Roberto
- Susan Haskell - Susanna Morehouse
- Kathleen Barr - Aussie Guard
- Maurice Chasse - Prisoner
- John Novak - Ross J. Kelly / Interrogator
- John Novak - Ross J. Kelly
- Gina Philips - Devin
- Dan Gauthier - George Stellos
- Adam Wylie - Trevor
- Robert Curtis Brown - Danny Eisenbach
- Allison Hossack - Dr. Eileen Stanley
- Kevin Cooney - Ken Neisser
- Shaun Toub - Kheri-Heb
- Arthur Reggie III - Rembrandt Brown Jr.
- Charles Cyphers - Coach Almquist
- Tom Pickett - Maurice Fish
- Josh Coxx - Martin
- Donnelly Rhodes - Ben Greenfeld
- Don Most - Skip Collins
- Jeff Rector - Scarface P.A.U.L.
- Katherine LaNasa - Dr. Olivia Lujan
- Laura Harris - Margo Hall
- Danny Masterson - Renfield
- Will Schaub - Parker Whitmore
- Sandra Hess - Marta
- Robin Riker - First Lady Sela Williams
- Charlie Brill - Barry Lipschitz
- Dawnn Lewis - Dr. Natalie Sylvius
- Jennifer Nash - Diana
- Deanna Milligan - Gillian Mitchell
- Christopher Neame - Dr. Manfred Xang
- Ken Steadman - Cutter
- Jordan Warkol - Caleb
- Sarah Strange - Leah Greenfeld
- George DelHoyo - Judge John Nassau
- Rodney Eastman - Byron
- Fredric Lehne - Phil
- Christopher Mayer - Man in Bar
- Ryan Alosio - Morgan
- Georgia Emelin - Dr. Elaine Morris
- Perrey Reeves - Taryn Miller
- Garry Chalk - Lt. Graves
- Nicholas Lea - Ryan Simms
- Gabrielle Miller - Fling
- Gabrielle Rose - Christina Fox-Arturo
- Hrothgar Mathews - Mr. Gale
- Ron Pitts - Play-by-Play Announcer
- Zoe McLellan - Logan St. Claire
- Tamara LaSeon Bass - Stacy
- Doug Llewelyn - Comrade Llewelyn
- Garwin Sanford - Doc
- Roger Cross - Wilkins
- Frank C. Turner - Crazy Kenny / Senator Candidate
- Sook-Yin Lee - Pat
- Raoul Ganeev - Lt. Karpow the Sentry
- Jay Brazeau - KGB Colonel
- Andrew Kavadas - Hot Dog Vendor
- Yee Jee Tso - Wing
- Marie Stillin - Waitress
- Dean Haglund - Stock Boy
- William MacDonald - Medical Moonsuit
- Robyn Palmer - Nurse Pamela
- Patrick Stevenson - Jimmy
- Norma Jean Wick - News Anchor
- Ben Bode - Prince Harold III of America
- Kathleen Duborg - Rebecca
- Tracey Olson - Dixon Vallely
- Chris Humphreys - Oakland Raider
- Bernie Coulson - Oakland Raider
- David Kaye - Reporter
- Obba Babatundé - Cezanne Brown
- Deborah Lacey - Sharon Brown
- Gerry Nairn - Mace Moon
- Michele Goodger - FBI Agent Copeland
- Richard Leacock - Tremelo
- Joy Coghill - Mrs. Ezra Tweak
- Michael Dobson - Policeman
- Joanna Piros - Newscaster
- Peter Spellos - Jimmy Fountain
- Rick Garcia - Referee
- William B. Davis - Prof. Myman
- Rachel Hayward - Karen the Summoner
- Roman Danylo - Boyer
- Johnny Mah - Victor
- Anthony Harrison - FBI Agent Bob Cannon
- Marc Baur - FBI Agent O'Brian
- Amanda O'Leary - Librarian
- Jill Teed - Serena Braxton
- Douglas Sills - Ed Dunleavy
- Andrew Wheeler - Ken
- Ted Cole - Agent Reid
- Ted Cole - Friendly Man
- Liza Huget - Lois
- Garvin Cross - Alverez
- Garvin Cross - Sick Man
- Peter Kelamis - Glenn
- Gerard Plunkett - Driver
- Gerard Plunkett - Father Jerry
- Janice Kent - Quinn's Lawyer
- Andrew Guy - Trevor Grant
- Andrew Guy - Wilson
- Judith Maxie - Charmange
- Nicholas Harrison - Nick
- Peter Hanlon - Expert Analyzer
- Carlton Watson - Reverend
- Carlton Watson - Sebastian Smith
- Eadie Del Rubio - Eadie Del Rubio
- Sheelah Megill - Mrs. Henry
- Sheelah Megill - Dana Bingham
- Elena Del Rubio - Elena Del Rubio
- Milly Del Rubio - Milly Del Rubio
- Brian Arnold - Barry King
- Brian Arnold - Science Correspondent
- Malcolm Stewart - Regent
- Malcolm Stewart - Adam Fontaine
- Tim Henry - Agent Jones
- Michael Kopsa - Agent Wilson
- Nathan Vanering - Father Fergus
- Walter Marsh - Fatherly Man
- Kristina Matisic - News Anchor
- David Glyn-Jones - Elderly Man
- Alex Bruhanski - Pavel Kurlienko
- Rod Wilson - Sorcerer
- Karin Konoval - Fortune Teller
- Jon Pennell - David
- Debbie Podowski - O'Grady
- Kathryn Anderson - Jane Hills
- Alf Humphreys - Family Man
- Alf Humphreys - Pete
- Ona Grauer - Debra
- Clinton Derricks-Carroll - Rembrandt Brown
- Clinton Derricks-Carroll - Rembrandt, Duke of Hemmingshire
- Clinton Derricks-Carroll - Rembrandt Brown #2
- Kendall Cross - Cara
- D. Neil Mark - Stationary Biker
- Kamilyn Kaneko - Desk Clerk
- Tom Butler - Michael Mallory
- Gillian Barber - Nicole Mitchell
- Greg Rogers - Major Phillips
- Peter Flemming - Traffic Policeman
- Mitchell Kosterman - Muscle Guy
- Rebecca Chambers - Michelle
- Joe Maffei - Dabello Patriarch
- Joe Maffei - Bernie
- Claude Brooks - L.J.
- Jed Dixon - Leo
- Raimund Stamm - Big Jake
- Reese McBeth - Blade
- Maria Herrera - Delores
- Chapelle Jaffe - Gladys
- Gary Jones - Michael Hurley
- Scott Swanson - Hostage
- Rebecca Gayheart - Natalie Nassau
- Ravinder Toor - L.C.
- Lesley Ewen - O'Neill
- Tom Heaton - Rummy
- Jed Rees - Hipster
- Robert Metcalfe - Bartender
- Travis MacDonald - Lowlife
- Brent Sheppard - Wayne Davies
- Deanne Henry - Mrs. Mallory
- Stacy Grant - Miss Vonbaeck
- Don MacKay - Artie Feld
- Tom Picket - Leroy Hopkins
- Roy Dotrice - Archibald Chandler
- Roy Dotrice - Marc LeBeau / The Seer
- Linda Ko - Tanika
- Mike Mitchell - Guard
- Heather Hanson - Nurse Dominique Reynolds
- Hiro Kanagawa - Henry
- Paul McGillion - First Officer
- Gillian Carfra - Young Woman
- Ben Immanuel - Tommy Greenfeld
- Mel Tormé - Mel Tormé
- Will Sasso - Gomez Calhoun
- Jano Frandsen - Joseph Biacchi
- Byron Lucas - John
- Aurelio Dinunzio - Pit Boss
- Doug Cameron - Maitre d'
- Paul Jarrett - Razor Gillette
- Elisabeth Rosen - Melanie White
- Trevor Roberts - Bartender
- Jason Emanuel - Policeman
- Una Damon - Mary
- Stephen Macht - Kromanus
- Stephen Macht - Krislov
- Gerry South - Kromagg
- Jason Gaffney - Conrad Bennish Jr.
- Matthew Flint - Dennis McMillan
- Eli Gabay - La Migra
- Mina E. Mina - Judge Jamon Estavez
- Lori Triolo - La Padrona
- Francisco Trujillo - El Padron
- Gerry Rousseau - Jailer
- James Crescenzo - Head Guard
- Jennifer Hetrick - Claire LeBeau
- Jennifer Hetrick - Caroline Fontaine
- Dee Jay Jackson - Bailiff
- Laurie Fortier - Nicky
- Mari Morrow - Monique
- Karen Austin - Lydia the Secretary
- Karen Austin - Amanda Starr
- Michael Bryan French - Adrian Fayne
- Diana Castle - Mrs. Arturo
- Rob Youngblood - Sheriff Burke
- Rob Youngblood - Keeper James
- Warren Sweeney - Bio Mash Vendor
- Phil Fondacaro - Bounty Hunter
- Phil Fondacaro - Mac
- Michael Krawic - Hobo
- Kris Iyer - Maitre D'
- Gerry Del Sol - Train Passenger
- Bill Bolender - Franklin Michener
- Tim Griffin - Jacob
- Leslie Horan - Heather Hanley
- Marty York - Brady Oak
- Robert Winley - Bull
- John Colton - Priest
- Symba - Officer Weber
- Kenny Johnson - Slain Skater
- Michael Lee Gogin - Master Healer
- Christopher Maleki - Wolf
- Kris Lindquist - Jeremy
- Max Grodénchik - Skuldar
- Michelle Burke - Melinda
- Françoise Robertson - Alesha Avo
- Saxon Trainor - Officer Kelley
- Mansell Rivers-Bland - Chief Druid
- Anthony Tyler Quinn - J.C. Ashton
- Lynn Clark - Diana Sylvius
- Ferdinand Carangelo - Foreman
- Veronica Cartwright - The Flame (voice)
- Collin Bernsen - Lance, Captain of the Guards
- Gabrielle Beimford - Nurse
- Marian Green - Winged Girl's Mother
- Paul Goodman - Guard
- Robert DiTillio - Emcee
- Brett Miller - Prison Guard
- Ed Wasser - Studio Guard
- Jerry Rector - P.A.U.L.
- Ted Detwiler - T.E.D.
- Neil Roberts - Ted Bernsen
- Allen Williams - Don Welles
- Sean Flynn - Jason
- Paul Messinger - Priest
- David Purdham - Dr. Bolivar
- Lester Barrie - Elston Diggs
- Suzanne Mara - Dr. Punch
- Taylor Leigh - Mrs. Taylor
- Derik Van Derbeken - Security
- Carmen Nogales - Young Woman
- Brandon Michael - Boy
- Rocco Vienhage - Dr. Achtbit
- Armando Valdes-Kennedy - Seyn Jebid
- Terry Markwell - Tess Martin
- Steven Meek - R.D.I. Agent
- Justin Gorence - Priest
- Lara Steinick - Laurie Miller
- Kristi McDaniel - Alice
- Jeff Markey - Bud
- Todd Babcock - Michael Levy
- Gordon Jennison Noice - One-Arm Fred
- J. Karen Thomas - Lt. Teri Eastman
- Krzysztof Pieczyński - Dr. Vladimir Jariabek
- Michael Houston King - Dr. Baker
- Steve Larson - Street Person
- Roger Daltrey - Col. Angus Rickman
- Charlie O'Connell - Colin Mallory
- Charlie O'Connell - Kit Richards
- Charlie O'Connell - Officer O'Hara
- Mark Kiely - Dr. Stephen Jensen
- Andy Rolfes - Sergeant
- Lorin McCraley - Fenris
- David Chisum - Paramedic
- Alton Butler - Orderly
- Jay Acovone - Dr. Tassler
- Jay Acovone - Ben Siegel III
- Jay Acovone - Stu
- Ron Melendez - Brock
- Oona Hart - Adra
- Kevin Quigley - Bunt La Croix
- Amy Wheaton - Lucy La Croix
- Franc Ross - Billy T
- Marc Tissot - Don
- Danny Mora - Angel
- Thomas G. Waites - Randy, Airplane Mechanic
- David Correia - Customs Official
- Rainer Grant - Gretchen Chambliss
- Mike Terner - Robert Hinds
- Michael Woolson - Andrews
- Neil Dickson - Col. Angus Rickman
- Leslie Soule - Mina
- Barry Livingston - Eddie Selk
- Ted Rooney - Technician
- Charley Lang - Starke
- Bodhi Elfman - Trevor Blue
- Mongo Brownlee - Quinn's Guard
- Tracie May - Kromagg Aide
- Ted Barba - Kromagg Guard
- Monte Rex Perlin - Forklift Operator
- Buddy Daniels Friedman - Horny Kromagg Guard
- Katy Boyer - Jane
- Tim Quill - Gareth
- Mina Badie - Penny
- Tom Westbrook - Krolak
- William Bookston - Body
- Tom Fitzpatrick - Eyeless Man
- John D'Aquino - Randall Simmons
- Sibel Ergener - Duvall
- Bill French - Technician
- Brett Wagner - Guard
- Conchita Leeflang - Secretary
- Rose Portillo - Sister Celine
- Ivory Ocean - Eldon
- Oren Williams - Perkins
- Ben Jones - Sheriff / Dawson
- Adrienne Barbeau - Mother Morehouse
- Sandra P. Grant - Social Worker
- Sandra P. Grant - Melanie Wallace
- Martin Eric - Farmer
- Van Stewman Jr. - Farmer
- Connie Sawyer - Winifred
- Gonzalo Menendez - Jorge
- James Sutorius - Agent Fletcher Lowell
- David Ursin - Cabbie
- Lance Wilson-White - John Smith
- Elyse Mirto - Holly
- Colton James - Matthew
- Louisa Abernathy - Guest
- Kelly Connell - Thomas Beecham
- Chad Todhunter - Kaldeen / Jules
- Leah Ayres - Darla
- Rende Rae Norman - Janie
- Roger Hewlett - Driver
- Marilyn Randall - Nurse
- George McDaniel - Governor Schick
- Jeremy Roberts - Warden Beck
- Carol Huston - Vanessa
- Chris Elwood - Ralph
- Henry G. Sanders - Harold
- Philip Tan - Asian Man
- James Hornbeck - Doctor
- Kristopher Logan - Assassin
- Kristopher Logan - Tourist
- Jimmy Bridges - Doctor
- Kristen Dalton - Kyra
- Meredith Bishop - Jenny Anderson
- Scott Decker - Kryoptus
- Christian Leffler - Spence
- Laird Macintosh - Kromagg Corporal
- Jennifer McComb - Roxanne Crane
- Alex Jachno - Mobster
- Natalie Radford - Christina Griffin
- Jim Metzler - Jonathan Griffin
- Brian Cousins - Korindos / Kaplan
- Claudette Mink - Brice
- Claudette Mink - Sheilah
- Steve Rankin - Kreeshax
- Akrosia Samson - Townsend
- Brien Perry - Soldier
- Angelo Spizzirri - Guard
- Sandy Martin - Shirley Montana
- Christian Oliver - Rick Montana
- Hayley DuMond - Joanne Capshaw
- Ingo Neuhaus - Guard
- John DeMita - Dr. Steven Jensen
- Robert Jayne - Siskin
- Nicholas Worth - Magistrate
- John J. Flynn Jr. - Villager
- Larry McCormick - Weatherman
- Larry McCormick - TV Anchor
- Patrick Thomas O'Brien - Jake
- Jennifer Badger - Virtual Reality Freya
- Carl Gabriel Yorke - Kromagg Leader
- Carl Gabriel Yorke - Technician
- Reiner Schöne - Kolitar
- Burton Gilliam - Stage Driver
- Bob Morrisey - Bill Pappas
- Paula Trickey - Nurse Lauren Perry
- Malcolm-Jamal Warner - R.J.
- David Flynn - Brad
- David Kallaway - Guard
- Michael Sabatino - Derek Nichols
- Harrison Young - Henry Nichols
- Angela Paton - Mrs. Meadows
- Kurt Knudson - Sheriff Hardy
- David Dukes - Thomas Michael Mallory
- Julie Adams - Old Maggie Beckett
- George Gaynes - Old Quinn Mallory
- Marshall R. Teague - General Kronus
- Marshall R. Teague - Redfield
- Marshall R. Teague - Sheriff Redfield
- Rudolf Martin - Kurtz
- Cazimir Milostan - UN Soldier
- Jerry Hardin - Isaac Clark
- Kristanna Loken - Catherine Clark
- John Walcutt - Michael Mallory
- Joey Stafura - Clerk
- J. Anthony McCarthy - Man
- Scott Klace - Hal the Bartender
- Peter Koch - Ike
- Clay Wilcox - Preacher
- Howard S. Miller - Professor
- Kirk B.R. Woller - Private Bates
- Joel Stoffer - Kromagg Lieutenant
- Eamon Behrens - Keeper Samuel
- Granville Van Dusen - Keeper Abraham
- Marshall Bell - Vortak
- Vicki Davis - Sara
- Austin Nichols - Seth
- Cissy Wellman - Head Matron
- Angela Bettis - Jill Krislov
- Michael Keenan - George
- Maury Ginsberg - 5579-A / Guy
- JD Cullum - Arlo Higgins
- Reno Wilson - James
- Judith McConnell - Sylvia
- Judith McConnell - Clerk
- Richard Fancy - Sector Control
- John Vargas - Chuck Pierson
- Matt McKenzie - Tony Jacobs
- Maggie Egan - Reporter
- Bill A. Jones - Kennedy
- Jennifer Leigh Warren - Angie Morgan
- Dwayne Adway - Dropper Daddy
- Shane Stevens - Harrell
- Ken Jenkins - Robert Clark
- Ken Jenkins - Professor Jack Bigelow
- Michael Warren - Detective Wells
- Paul Richards - Bartender
- Sandahl Bergman - Lead Female Dancer
- Winston Rekert - Lt. General Thomas Beckett
- Rob LaBelle - Mr. Xybo
- Steve O'Connor - The Leader
- Lisa Akey - Sam
- Dylan Haggerty - Evans
- James Colby - Bartender
- Mark Vasconcellos - Checkpoint Guard
- Julie Caitlin Brown - Commander Kesh
- Maria Stanton - Wade Welles
- Paul Sand - Dr. Malcolm White
- Claudette Roche - Dr. Alice Ruskin
- Jonathan Brent - Dr. Sean Carter
- Michael McCraine - Jane White
- Phil Parolisi - Pajama Man
- Todd Waring - Mark Einman
- Kevin West - Fred
- Sean Moran - Monarch Burger Manager
- E.J. Callahan - Clown Burger Manager
- Sam Dolan - Union Soldier
- Bruno Angelico - Pimp
- Lamont Dixon - Security Chief
- Clayton Landey - Captain Thompson
- Robert Cuccioli - Paxton
- Todd Kimsey - Grant Curtis
- Lisa Stahl - Monique Mansfield
- Israel Juarbe - Gomez Calhoun
- Lisa Lackey - Gwen
- Marco Rodríguez - Escobar
- Chi McBride - Mule Packer
- Elizabeth Rossa - Sharon Fletcher
- Josh Adell - Vernon
- Sarah Chapman - Lisa
- Linda Henning - Mrs. Mallory
- Kathleen McClellan - E.R.I.C.A. / Shauna Aldohn
- Mark Sheppard - Jack
- Russell Porter - Kenny Hatcher
- Andre Benjamin - Street Radical (uncredited)
- Silvio Pollio - Guard
- Nicole Parker - Monica
- John Landis
- Robert K. Weiss
- David E. Peckinpah
- Tracy Tormé
Angela Paton hace el papel de Mrs. Meadows.
John Rhys-Davies hace el papel de Maximillian Arturo.
Pepe Serna interpreta a Roberto en la serie.
Roy Dotrice interpreta a Archibald Chandler en la serie.
Philip Tan interpreta a Asian Man en la serie.
Lee Weaver interpreta a Hilton Brown en la serie.
Jack Kehler hace el papel de The Poacher.
Corey Feldman interpreta a Reed Michener en la serie.
Jerry O'Connell interpreta a Quinn Mallory en la serie.
Marshall Bell interpreta a Vortak en la serie.
Capítulo disponible en las siguientes plataformas:
