- Rita Moreno - Anita
- Kermit Murdock - Sen. Strohm
- Cliff Potts - Lee Harper
- Frank Puglia - Ignacio Romero
- Michael Strong - Lt. Herbert Decker
- Geoffrey Horne - Neil Scofield
- Michael Cole - Chico Bornmeier
- Tisha Sterling - Tia
- Marino Masé - Luis Reyes
- Audrey Totter - Dorothy Young
- Cec Linder - Warren Windom
- Bruce Glover - Tweed Murcott
- Will Geer - Judge David P. Andrews
- Stanley Waxman - Jamal Mustafa
- Janice Rule - Alicia Stuyvesant
- Michael Evans - Roger Aldington
- Tippi Hedren - Jessica Braden
- Macdonald Carey - Michael Allen
- Don Brodie - The Court Clerk
- Keith Andes - Martin Shawe
- Telly Savalas - Istvan Zabor
- Jill Haworth - Judy Collins
- Ned Romero - Maj. Miguel Del Rio
- Anne Seymour - Mrs. Fielding
- Kelly Corcoran - Dickie Hannagan
- Susan Strasberg - Gina Milan
- Harry Guardino - Enzo
- Rossano Brazzi - Alex Staphos
- Gerald S. O'Loughlin - Ralph Bronson / Timothy
- Diana Muldaur - Dr. Jean Winters
- Howard Keel - Hardie Rankin
- Gena Rowlands - Charlotte Hyde
- Slim Pickens - Sheriff Hoag
- Victoria Vetri - Carmen
- John Drew Barrymore - Goebels
- Kathryn Hays - Belle Frazer
- Abraham Sofaer - Mr. Singh
- Sally Ann Howes - Rhona
- Brooke Bundy - Sarah Sinclair
- Delphi Lawrence - Ellen Carlson
- Billy Daniels - Eddie
- Alejandro Rey - Mario Cudero
- Tige Andrews - Sam Miller
- Joan Blackman - Janet Ford
- Farley Granger - Charley Herrod
- Charles McGraw - Sam Bailey
- Nancy Malone - Katherine
- Rosemary Murphy - Mary Herrick
- Geraldine Brooks - Alice McKenna
- Suzanne Pleshette - Susan Church
- Aldo Ray - Vince Murdock
- Helmut Dantine - Erich Krieger
- Karen Black - Jennifer Palmer
- Dina Merrill - Caroline Willins
- Leonard Stone - Captain Archer
- Coleen Gray - Sally Holt
- Nico Minardos - Bob
- Pat Hingle - Frederick Huffschmidt
- James Anderson - Roy Potter
- Murray MacLeod - Bud Ellis
- Joe De Santis - Eduardo Alonzo
- Quinn K. Redeker - Dr. Ed Gilray
- Ralph Bellamy - Cal Phillips
- Robert Brown - D.T. Randall
- Judy Carne - Gillan Wilmont
- Austin Willis - Myles Prentice
- Bert Freed - Sheriff Parsons
- Felicia Farr - Alita Greenley
- Peter Donat - Burton Wells
- David Hurst - Heinrich Kleist
- Ina Balin - Lisa Sorrow
- Pat Priest - Susan
- Ian Wolfe - Dr. Stanley Brickow
- R. G. Armstrong - Edward Loomis
- Gia Scala - Marika Takacs
- Henry Silva - Carl Torre
- Zara Cully - Old Woman
- Sal Mineo - Tonio
- Phillip Pine - Paolo Bracci
- Fernando Lamas - Ramon De Vega
- George Voskovec - Colonel Zabian
- Tony Bill - Charlie Carson
- Michael Constantine - Colonel Shoner
- Edy Williams - Watusi Dancer
- Marsha Hunt - Mrs. Southworth
- Joan Hackett - Diana Murrow
- Skip Homeier - Charles Cadell
- K.T. Stevens - Mrs. Phillips
- Murray Hamilton - Dr. Raphael
- Chris Alcaide - 1st Killer
- Lesley Ann Warren - Julie Foster
- Edward Mulhare - Clive Darrell
- Wendell Corey - Dwight Sinclair
- Alf Kjellin - Josep Ristic
- Michael Dunn - George Kowal
- Jack Palance - Julian Hays
- Sheree North - Jeannie Lake
- John Dehner - Eliot Ponas
- Eric Braeden - Eric Horst
- Eric Braeden - Janos Takacs
- Chick Hearn - Self
- Mickey Shaughnessy - Morgan
- Frank Silvera - Esteban
- Richard Bull - Jameson Dudley
- Joanna Moore - Kay Mills
- Anne Helm - Molly Pierce
- Jacqueline Scott - Dorothy Baker
- Malcolm Atterbury - Rudy Fowler
- Jack Kelly - Harry Bevins
- Celia Lovsky - Mrs. Kreiger
- Michele Carey - Margo
- Berry Kroeger - Mr. Klein
- Arthur Hill - Bill Dagen
- Harry Carey, Jr. - Corey Munson
- John Forsythe - Spencer Holt
- Victor Millan - Felipe
- Vera Miles - Rachel Pike
- Ford Rainey - Gen. Andrew Douglas
- James Daly - Jerry Haines
- Albert Dekker - Sir Harry Hiller
- Julie Harris - Lucrece Lawrence
- Bobo Lewis - Aunt Turkey
- Don Stroud - Jim Hammack
- Kurt Kasznar - Inspector Kronig
- Kurt Kasznar - Rudy Brademan
- William Boyett - 2nd Detective
- Anne Baxter - Mona Morrison
- Don Rickles - Willy Hatch
- Don Rickles - Leo Mazinov
- Jeff Corey - Abe Lincoln
- Jeff Corey - Fred Morrissey
- Betty Bronson - Alma Sloan
- James Whitmore - Chief Jim Holland
- Lyle Talbot - Steven Blakely
- Diana Hyland - Diana Hays
- Diana Hyland - Eileen Henderson
- Katharine Ross - Laura Beaumont
- Mary Ann Mobley - Laura Bronson
- Mary Ann Mobley - Clarice Newell
- Lynn Carey - Patsy Hannagan
- Linda Watkins - Mrs. Tenati
- Sharon Farrell - Louise
- Sharon Farrell - Jenny
- Sam Wanamaker - Major Joe Rankin
- Don Diamond - Taxi Driver
- Don Diamond - Esteban
- George Furth - Osborne Parquette III
- George Furth - Arthur Neely
- Martin Milner - Mike Green
- Claudine Longet - Nicole
- Collin Wilcox Paxton - Lisa Rand
- Jacques Bergerac - Louis Manet
- Jacques Bergerac - Alejandro Orsini
- Kim Darby - Tina
- Kim Darby - Carol Sherman
- Bruce Dern - Alex Ryder
- Bernie Hamilton - J.C.
- Bobby Darin - Mark Shepherd
- Roddy McDowall - Gyula Bognar
- William Lundigan - David Phillips
- Jan Sterling - Clara Mallory
- Brock Peters - Lieutenant Wallace
- James B. Sikking - Nugent
- James B. Sikking - Doctor
- Elizabeth Ashley - Dina Fuller
- Albert Paulsen - Emile Marnet
- Ed Asner - Carl Cappi
- Reginald Owen - Sir Hillary Cooper
- Kent McCord - Mike Ramsey
- Paula Winslowe - Miss Glenroy
- Paul Lukas - Dr. Werner
- Sugar Ray Robinson - Duke Smith
- Michael Pataki - Dr. Alex Rothman
- Marlyn Mason - Anna Birrel
- Ernest Borgnine - Harry Martin
- Larry Ward - David Baker
- Richard Anderson - Captain Swain
- Peter Hobbs - Henry Gower
- Harold Gould - Phil Colby
- Burr DeBenning - J.B. Flowers
- Robert Yuro - Tony Cupid
- James Farentino - Frank Frazier
- Carol Lawrence - Kate Pierce
- Carol Lawrence - Rosinha Fielding
- Edward Andrews - Andrew Dawson
- Émile Genest - The Judge
- Émile Genest - Georges Corot
- Peter Brocco - Doctor
- Peter Brocco - Joey Cana
- Mark Lenard - Col. Sebastian Peralta
- Barbara Hershey - Saro-Jane
- Jon Lormer - Judge Wallace Barnes
- Charles Aidman - Hal Andre
- Charles Aidman - Christopher
- Robert Duvall - Richard Fletcher
- Barry Sullivan - Sheriff Trumbell
- Dana Wynter - Louise Brode
- Paul Fix - Joseph Farrell
- Gene Evans - Jim Seaborne
- Burt Mustin - Drunken church-goer
- Vinton Hayworth - Dr. Fraser
- Pepe Hern - Desk Clerk
- Gregory Gaye - Straka
- Jeremy Slate - Pete Gaffney
- Jocelyn Lane - Brigitte Lemaire
- Peter Lawford - Larry Carter
- Don Galloway - Gordon Von Rhine
- Robert Pine - Allan Frazer
- Edward Faulkner - Asst. District Attorney
- Peter Graves - Jim Carlson
- Anthony Eisley - Tom Stone
- Walter Brooke - Ralph Phillips
- Walter Brooke - Richard Phillips
- Walter Brooke - The Examiner
- Jon Cedar - Nat Stevens
- David Lewis - Miller
- David Lewis - The Consul
- Jason Wingreen - Harbormaster
- Cloris Leachman - Deborah Wilson
- Joan Van Ark - Donna Hayward
- Lenore Kingston - Arlene Wilenski
- Carlos Romero - Lt. Ortiz
- Donnelly Rhodes - Harry Blunt
- Donnelly Rhodes - Collier Johnson
- Renzo Cesana - Derek Wolf
- Renzo Cesana - Luigi
- George Murdock - Police Sergeant
- Strother Martin - Holly Amberton
- Jason Evers - Garret Hamilton
- Frank Maxwell - 1st Detective
- Robert Donner - Scully
- Robert Donner - Sheriff Hinkleman
- George Mitchell - Joseph Wagner, DA
- Booth Colman - Prosecutor Coleman
- John van Dreelen - Henrik Verbeck
- John van Dreelen - Jan Vlasek
- Ted Knight - Sam Billings
- Trevor Bardette - Farmer
- Marianna Hill - Marta
- Marianna Hill - Valerie Phillips
- Mike Road - Brad Capo
- Jack Albertson - Harry Krissel
- Jack Albertson - Joe Murray
- Michele Montau - Helene Delmore
- Eve Arden - Mame Huston
- Garry Walberg - Master Sergeant Bill Martin
- Carol Lynley - April Martin
- Louise Sorel - Elizabeth Brentano
- Joan Collins - Gilian Wales
- William Windom - Ralph Wilson
- Dabney Coleman - Fred Palmer
- Susan Clark - Kathryn Aller
- Frank Marth - Assistant District Attorney
- Warren Oates - Deputy LaVern Potter
- Dana Elcar - Dr. George Graham
- Vaughn Taylor - Henry Sloan
- George Chandler - Fred Mackey
- James T. Callahan - Major Ted Fowler
- Larry D. Mann - Dr. Albert Mann
- Andrew Duggan - James Seaborne
- Andrew Duggan - Lieutenant Jim Seaborne
- Robert Osterloh - Frank Nemo
- Henry Beckman - Hank Kellogg
- Henry Beckman - Lt. Flaherty
- Henry Beckman - Tourist
- Lawrence Montaigne - George Woodstock
- John Kerr - Alex Ryder
- Mario Alcalde - Tony Olivera
- Pat Harrington, Jr. - Nick Cooper
- Robyn Millan - Suzie Scholl
- Michael Bell - George Travis
- Tom Skerritt - Lou Patterson
- Gregg Palmer - Deputy Morgan
- Robert Loggia - Gen. Carlos Portaz
- Robert Drivas - Bret
- Edward Binns - Colonel Delaney
- Grace Lee Whitney - Billie
- Grace Lee Whitney - Millie
- Don Kennedy - 1st Homicide Man
- John Ireland - Dr. Mason
- S. John Launer - The Conductor
- Nicholas Colasanto - George Karpantos
- Nicholas Colasanto - The Bartender
- Nicholas Colasanto - Maxie
- Nicholas Colasanto - Benno Capalupo
- Nicholas Colasanto - Jake Wexler
- Joseph Sirola - Vilovic
- Paul Newlan - Dr. Lewis
- Tom Stern - Tony Bell
- Jack Goode - Sidney Cruikshank
- Franchot Tone - Judge Taliaferro Wilson
- Michael Stanwood - Henry Kalb
- Michael Stanwood - Eddie
- Ossie Davis - Sgt. Dave Corbett
- Ossie Davis - Frankie Morton
- Ossie Davis - Dave Corbett
- Carolyn Nelson - Girl at Desk
- Tracy Stratford - Girl Scout
- Don Knight - Bartender
- Don Knight - Freddie
- Don Knight - Tim O'Rourke
- Tom Allen - J. Thomas Bledsoe
- Tom Allen - Frank Tiessen
- Stephen McNally - Mike Allen
- Stephen McNally - Phil Beaumont
- James Oliver - Freddie
- James Oliver - Oregon
- Charles Seel - Rudy Fowler
- Alberto Morin - Sebastian
- Tom Simcox - Johnny Cadell
- John Davis Chandler - Dr. Walker
- Larry Gelman - Reporter
- Larry Gelman - Deputy
- Dan Frazer - Mr. Gillman
- Christopher Riordan - Nightclub Dancer (uncredited)
- Arch Whiting - Embassy Aide
- Arch Whiting - Gregg Durkin
- Arch Whiting - State Trooper
- Dale Van Sickel - State Trouper
- Sandra Smith - Diana Burke
- Joseph Campanella - Ward Cooper
- Cyril Delevanti - Judge Kleiner
- Don Dillaway - The Jury Foreman
- Lew Palter - 1st Trucker
- Brenda Scott - Kathy Sloan
- Russell Thorson - Judge Andy Harris
- Len Wayland - John Hardy
- Len Wayland - Lt. Omar Blix
- Len Wayland - Daniel Fulton
- George Macready - David Courtney (uncredited)
- Harold J. Stone - Angie Zeno
- Linden Chiles - Jay Saunders
- Ray Ballard - Stuffy Reporter
- Roy Huggins
- Paul Freeman
- Gordon Hessler
- Jo Swerling Jr.
Peter Lawford hace el papel de Larry Carter.
Coleen Gray hace el papel de Sally Holt.
Kent McCord interpreta a Mike Ramsey en la serie.
Robert Duvall interpreta a Richard Fletcher en la serie.
Helmut Dantine interpreta a Erich Krieger en la serie.
Mark Lenard interpreta a Col. Sebastian Peralta en la serie.
George Murdock interpreta a Police Sergeant en la serie.
Tom Skerritt interpreta a Lou Patterson en la serie.
Paul Lukas hace el papel de Dr. Werner.
Vaughn Taylor interpreta a Henry Sloan en la serie.
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