- Ben Shenkman - Dr. Jeremiah Sacani
- Julie Benz - Elyse
- Amara Zaragoza - April
- Kyle Howard - Dr. Paul Van Dyke
- Meredith Hagner - Libby
- Judy Del Giudice - Receptionist Nurse
- Gillian Jacobs - Tess Frimoli
- Michael Roark - Todd Stiles
- Stephanie Corneliussen - Sloane Lerner
- Nate Torrence - Josh Dunlap
- Ryan Dinning - Tommy
- Amelia Rose Blaire - Fiona Van Ark
- Jordan Dean - Officier Kern
- Brad Beyer - Don O'Shea
- Kate Jennings Grant - Dr Sylvander
- David Alpay - Santi
- Hoon Lee - Stu
- Azie Tesfai - Aubrey Wolfhouse
- Adriane Lenox - Hospital Administrator
- Willa Fitzgerald - Emma Miller
- Dreama Walker - Melody Everett
- Gameela Wright - Nurse
- Maria Dizzia - Cindy Green
- Julie Lauren - Dr Kathryn Neil
- Amy Sedaris - Nan
- Cory Nichols - Chip
- Kathleen McNenny - Dr Heidi Jaffe
- Kelly Deadmon - Leslie
- Sterling Jerins - Gina
- Sami Gayle - Natalie
- Fatima Ptacek - Olivia
- Emily Tremaine - Becki
- Dale Raoul - Francesca Bragalini
- Christine Ebersole - Ms. Newberg
- Renée Elise Goldsberry - Mrs. Phillips
- Aaron Mayer - Boy
- Eric Stanton Betts - Party Guest
- Rupak Ginn - Rajan Bandyopadhyay
- Timothée Chalamet - Luke
- Tracee Chimo - Lauren
- Kearran Giovanni - Greeter
- Nicole Maines - Anna
- Julie Ann Emery - Susie
- Judy Greer - Ms. Match-Maker
- Aramis Knight - Amir
- Joy Suprano - Caroline Koch
- Ezra Miller - Tucker Bryant
- Grayson Taylor - Sam
- Pauline Chalamet - La danseuse
- Michael Delano - Casino Host
- Zoe McLellan - Kim the Winemaker
- Alex Brightman - Chic Geek
- Teddy Geiger - Lucky
- Mo Rocca - Officiant
- Daisy Tahan - April
- JoAnna Garcia - Dr. Nina Greene
- Jake Lacy - Floyd
- Peter Francis James - Mackintosh
- Ronald Guttman - Auction House Official
- Tom Cavanagh - Jack O'Malley
- Tanner Flood - Simon Fields
- Elizabeth Masucci - Edie
- Michael Mulheren - Jim Harper
- Marnie Schulenburg - Sherrie Tanner
- Jody E. Smith - April's Mom
- Jake Weber - Gabriel Gleason
- Sutton Foster - Julie Sharp
- Spencer Aste - Quince
- Tina Benko - Titania
- Deya Danielle Drake - Hermia
- Jennifer Ferrin - Kate Murray
- Cecilia Foss - Peaseblossom
- Anastasia Griffith - Dr. Emily Peck
- Paola Turbay - Dr. Marisa Casseras
- Eddie Shin - Tony Lee
- Eric William Morris - Craig
- Liz Holtan - Mikell
- Melissa Fumero - Brooke
- Mark Zimmerman - Dr. Tripp
- José Alvarez - MRI Tech (uncredited)
- Trevor Kuhn - Valet (uncredited)
- Kresh Novakovic - Guard (uncredited)
- Collette Wolfe - Greer
- Pascale Hutton - Nikki
- Robert LuPone - Dr. Silver
- Jace Alexander - Male Fashionista
- Athena Currey - Model #1
- Kim Matulova - Model #4
- Dieter Riesle - Boris's Key Servant
- Joseph McKenna - Valet Captain
- René Ifrah - Israeli Bodyguard #1
- Michael Elian - Israeli Bodyguard #2
- John Farrer - Clayton Hale Gardner
- Don Guillory - Dr. Wolf
- Jessie O'Donohue - Isabelle
- Sean Dominic - Ballplayer #2
- Sonnie Brown - Nurse
- Millie Tirelli - Tucker's Maid
- Eric Lindh - Helicopter Crew Chief
- Al Cerullo - Helicopter Pilot
- Larry Sherman - Atmosphere
- Gerard Adimando - Pool Guest (uncredited)
- Danny Boushebel - VIP Pool Guest (uncredited)
- Courtney S. Bunbury - Ball Player (uncredited)
- Stephen Dexter - Hamptons Socialite (uncredited)
- Sydney Harris - Female Fashionista (uncredited)
- Puneet Prasad - Rooftop Disc Jockey (uncredited)
- Samantha Safdie - Party Goer (uncredited)
Paulo Costanzo hace el papel de Evan R. Lawson.
Brooke D'Orsay interpreta a Paige Collins en la serie.
Mark Feuerstein hace el papel de Hank Lawson.
Reshma Shetty hace el papel de Divya Katdare.
Ben Shenkman interpreta a Dr. Jeremiah Sacani en la serie.
Cristián de la Fuente interpreta a Tobias en la serie.
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