- Gavin Lewis - Young Michael
- Tsailii Rogers - Helena
- Olivia Taylor - Jasmine
- Jessica Treska - Young Isobel
- Alaina Warren Zachary - Mara
- Monique Candelaria - Guard
- Gaius Charles - Bronson
- Jason Behr - Tripp Manes
- Dylan Schombing - Young Max
- Ava Wagenman - Young Isobel
- Jamie Clayton - Charlie Cameron
- Cassandra Jean Amell - Louise
- Madison McLaughlin - Iris Sanchez
- Chelsea Edmundson - Lindsey
- Rebekah Patton - Holly
- Mitchell Hoog - Young Jesse
- Preston Oliver - Young Michael
- E.J. Bonilla - Frederico
- Major Dodge Jr. - Walt
- Ryan Begay - Wolf
- Bob Jesser - Lt. Greg Hansen
- Jason Coviello - Harlan Manes
- Stafford Douglas - Dr. Everet
- Claudia Black - Ann Evans
- Diane Villegas - Dr. Yolanda Avila
- Tenaya Torres - Chiana
- Jack Justice - Gary
- Kayla Ewell - Nora Truman
- Kayla Ewell - Young Mara
- Sonya Balmores - Arizona
- Michael Davis - Old Man
- Kenneth Ruthardt - Clerk
- Kiowa Gordon - Flint Manes
- Bruce McIntosh - Clerk
- Matthew Van Wettering - Hank
- Samuel Goergen - 12 year old Heath
- Carl Savering - Older geneticist
- Mikael Ayele - Freddie
- RaShayla Daniels - Wife
- Mimi Fletcher - Hospital adminstrator
- Barney Fuller - Doctor Lockhart
- Mickey Dolan - Carhop
- Christian Antidormi - Forrest
- Rosa Arredondo - Sheriff Michelle Valenti
- Gillian Vigman - Brooke Taylor
- Shiri Appleby - Allie
- Kate Chavez - FBI Agent
- Tanner Novlan - Gregory Manes
- Bennie Taylor - MIB Guy
- Dylan McTee - Wyatt Long
- Carlos Compean - Arturo Ortecho
- Amy Puente - Renata
- Amy Puente - Female Trucker
- Steven Krueger - Heath Tuchman
- Nathaniel Augustson - Agent Smith
- Nicholas Ballas - Sanders
- Peter Diseth - Grant Green
- Sibongile Mlambo - Anatsa
- Samantha Ashley - Vanessa
- Ellen Humphreys - Kira Adams
- Case Matthews - Hank
- Jennifer Field - Dr. Erin Lang
- Sherri Saum - Mimi DeLuca
- Quentin Plair - Dallas
- David DeSantos - Eduardo Ramos
- Riley Voelkel - Jenna Cameron
- Gavin Houston - Theodore
- Brigitte Kali Canales - Tezca
- Zoe Cipres - Bonnie
- Andrew Lees - Clyde
- Rekha Sharma - Shivani
- Alexander Alayon Jr. - Bartender/Local Diner Patron (uncredited)
Capítulo disponible en las siguientes plataformas:
