- Stacy Edwards - Judy Sanders
- Anthony Michael Hall - Detective Willet
- Glenn Stanton - DJ Prince 305
- Christian Navarro - Carlos Gomez
- Patrick Michael Buckley - Chester Bly
- Victoria Vodar - Jen the Masseuse
- Owen Harn - Hanz the Bodyguard
- Nicole Ari Parker - Kat
- Chandra West - Kerry Conforth
- Angelina Assereto - Beth
- Rodney To - Neil
- Scott Michael Morgan - Detective Feldheim
- Emiliano Torres - Manager
- Cerina da Graça - Xiang Wen
- Michael Andrew Baker - Young Father
- Al Coronel - Officer Jacott
- Chance Harlem Jr. - Dante Harrell
- Mackenzie Astin - Dr. Max Cahn
- Adam Lazarre-White - Delroy Ellis
- Chris Bosh - Chris Bosh
- Harrison White - Lot Manager
- Shaan Sharma - Diego
- Keisuke Hoashi - Dr. Wei
- Adrian Pasdar - Dr. Derek Foster
- Merle Dandridge - Charlotte
- H. Richard Greene - Alexis Stavros
- Rayna Tharani - Felicia
- Deborah Rayne - Eva Freydont
- Manuel Eduardo Ramirez - Patrol Officer
- David A. Kimball - David Moran
- Exie Booker - Bouncer
- Derek Phillips - Trevor McCown
- Hope Olaidé Wilson - Tiana Denard
- Khalilah Joi - Regine Denard
- Asante Jones - Detective Vernon
- Nikea Gamby-Turner - Ilene Desouza
- Camille Collard - Isabella
- Michael Irby - Agent Giordano
- Vondie Curtis-Hall - Beaumont Rosewood Sr.
- Con Schell - Peter
- Stacy Hall - Security Officer
- Stella Farentino - Janice
- Ryan W. Garcia - IAD Agent Malcute
- Michelle Bonilla - District Attorney Sandra Drake
- Adam Kulbersh - Defense Attorney Adam Burke
- Christopher Carroll - Judge Walters
- Katherine Kendall - Debra Monroe
- Jeffrey Doornbos - Joel Monroe
- Chris O'Brien - Lester Goree
- Jacob McCafferty - Jeff
- Jordan Pratt-Thatcher - Anton Monroe
- Scott Broderick - Bailiff
- Max Shippee - Coach Walker
- Lisa Vidal - Daisie Villa
- Kurt Fuller - Floyd Butters
- Cole Bernstein - Beatrice Guzman
- Lauren Bowles - Loretta Franks
- Reynaldo Gallegos - Marlan Guzman
- Sarah Domin - Employee
- Emayatzy Corinealdi - Gigi Gaston
- Matthew Risch - Ian Hunter
- Matt Cedeño - Chuy Mendez
- Taye Diggs - Dr. Mike Boyce
- Thomas Silcott - Sam
- Melinda Y. Cohen - Angela York
- Rico Simonini - Dr. Houser
- Sam Gros - Nurse #1
- Barrett Kiick - Nurse #2
- Sam Witwer - Heath Casablanca
- Sprague Grayden - Dina Katz
- Tom Beyer - Dev Fagen
- Kavita Patil - Elaine Haldeman
- Scott Mosenson - Roger Jones
- Matt Borlenghi - Gino Smith
- Felisha Cooper - Skylar
- Christopher B. Duncan - Marcel Crawford
- Alysia Reiner - Lilian Izikoff
- Shakira Barrera - Ananda 'Andi' Singh
- Shaun Duke - Chief Ewing
- Alice Amter - Chitra Singh
- Ismail Bashey - Rishi Singh
- Cate Cohen - Joanne
- Andrew Thacher - CSI Tech
- Alexis DeLaRosa - CSI Tech Nico
- Mel Fair - Reporter #1
- Tia Mowry - Cassie
- John Gabriel - Detective Martinez
- Jeff Adler - Nolan
- Allius Barnes - Oscar Diaz
- Joy Bryant - Dr. Erica Kincaid
- Mark Atteberry - Jason Barrett
- Danielle Rayne - Camille Barrett
- Samantha Hodges - Kira Barrett
- William Charlton - Rob Shuman
- Scott Alan Smith - Dr. Moore
- Matt Kaminsky - Business Man
- Dean Cudworth - Detective Roday
- Christine Devine - TV News Reporter
- Scott Porter - Det. Russ Hame
- Marco Sanchez - Dr. Gus Willing
- Michael Filipowich - Nova
- Sherri Shepherd - Dr. Anita Eubanks
- Phil Abrams - Bob Safran
- Stephen Full - Alan Peters
- Kassandra Kanaar - Hygienist Cindy
- Jessica Morris - Mandy Willing
- Frank Maharajh - Slick Surgeon
- Robin De Lano - Angry Resident
- Nan McNamara - Angrier Resident
- Wayne Alon Scott - Henchman #1
- Azie Tesfai - Lil Kim
- Eric Nenninger - Zachary Wilford III
- Lisa Banes - Esther Wilford
- Michael Trotter - Joe Fuller
- Jeff Ward - Wyatt Montgomery
- Mirela Burke - Holly Keaton
- Ray Santiago - Tony 'Ponce' De Leon
- David Julian Hirsh - Dr. Kipley Reed
- Shannon Lucio - Casey Reed
- Scott Klace - Dr. Melvin Damski
- Brianne Davis - Suzie Q
- Frederick Koehler - Antonius Block
- Henry Czerny - Arthur Izikoff
- Peggy Dunne - Woman (Block's Mom)
- Christian Lyon - EMT
- Doreen Calderon - Maid
- John Nicholas - Older Male Pathologist
- Amanda Leighton - Sophie Hornstock
- Rick Gonzalez - Jay Stottlemyre
- Delaina Mitchell - Mia Barnes
- Nick Steele - Darrin Barber
- Paul Norwood - Phil Barber
- Noah Nevins - Brody
- Juan Pablo Di Pace - Antonio Espada
- Yara Martinez - Julia Delgado
- Ricky Saenz - Jaime Herrera
- Dennis Cockrum - Salesman
- Matt Knudsen - Gabriel Haskell
- Pilar Holland - Maria De La Vina
- Mayra Leal - Latina Woman (Melissa Peña)
- Peter Spruyt - Weird Warren
- Rickey Brown - Lil' Ronnie
- Sam Huntington - Mitchie Mendelson
- Katherine Boecher - Jackie Sloan
- Cara Pifko - Barbara Gaines
- Nahesi Crawford - Runner on Beach
- Brian Balzerini - Bartender
- Antwon Tanner - Sylvester
- Christina Moses - Daphne
- Michael Traynor - Walter
- Drew Lipson - Steve
- Quincy Ndekwe - Billy
- Luke Rampersad - Deon
- Michael Meir Saltzman - Rude Patron
- Anthony Ma - Glenn
- J.R. Ramirez - Frank Escajeda
- Antonio Jaramillo - Vladimir Dominguez
- Bianca Bethune - ATF Tiffany
- Kamal Angelo Bolden - Joo Joo
- Kamal Angelo Bolden - Julius 'Joo Joo' Beeman
- Kamal Angelo Bolden - Julius 'Joo-Joo' Beeman
- Aria Sirvaitis - Kelly Downs
- Charles Dougherty - Older Man in Montage
- Tonya Kay - Dancer in Montage
- Scott Menville - Angry Man
- Sheryl Lee - Brenda Downs
- Salli Richardson-Whitfield - Dr. Aubrey Joseph
- Chris Johnson - Calvin Spitz / Carter Dobbs
- Michael William Freeman - Gene
- James Patrick Stuart - Dr. Saffron Fields
- Jonathan Craig Williams - Bank Manager
- Christopher Boyer - Older Seasoned Farmer
- Lauren Lakis - Clara Reesner
- Bret Grantham - Patient #2
- Wayne Sable - Patient #3
- Matthew Glave - Andre Ward
- Mark Rolston - Harvey
- Chad Lindberg - Louie Van Winkle
- Shi Ne Nielson - Carla Reid
- John Billingsley - Judge West Waters
- Carlos E. Campos - Sammy the Manager
- André Tardieu - Sebastian Le Mercie
- Adam Cabrera - Joe Campos
- Scout Taylor-Compton - Christa
- Yancey Arias - Mayor Ramon Esparza
- Timothy Granaderos - Lane Piven
- Micah Cohen - James Patton
- Danny Jacobs - Saul Bailey
- Alisha Wainwright - Cassie Hanson
- Robert Wisdom - Gerald Kelly
- Robert Wisdom - Gerald
- Jake Nutty - Idiot Frat Brother
- Ashley Jackson - Betsy
- Alex Lombard - Linda Esparza
- Jeff Sumner - Forensic Tech E.G. Attie
- Nishi Munshi - Jenny Williams
- Tate Ellington - Troy Randolph
- Andy Favreau - Danny Williams / Connor Thorne
- Greg Vrotsos - Luke Firth
- Antony Del Rio - Nate Higuera
- Erica Luttrell - Milia Mae
- Josh Fingerhut - Biff
- Amanda Grace Jenkins - Liz the Sexy Waitress
- Gabriel Luna - Eddie Lunez
- Wallace Langham - Duncan Jacott
- Benny Ciaramello - Anthony
- Don Stark - Captain Roy Murillo
- Marque Richardson - Bennie
- Ken Garito - Man #1 / DEA Agent #1
- David Paladino - Man #2 / DEA Agent #2
- Garren Stitt - Oliver Jacott
- Tim Cummings - Principal Neff Garrity
- Robert Catrini - Trainer
- Farley Jackson - Tatted Up Boxer
- Natalie Ceballos - Lucia
- Izzy Martinez - Cameron
- Alain Mesa - Masked Man
- Tiffany Yvonne Cox - Stewardess
- Dawn Richard - Girl Singer
- P.J. Marino - Henchman #1
- Victor Winters-Junco - Henchman #3
- LeToya Luckett - Tawnya
- Tracey Fairaway - Bree Jones
- David Clayton Rogers - Karl Benson
- Carlos Leal - Edgar Moreno
- Josh Zuckerman - Cody Tucker
- Jay Huguley - David B. Jones
- David Atkinson - Billy Blackmar
- Faye Viviana - Selfie Girl
- Trevor David - Producer
- Eric Edwards - Male Patron
- Edwin Garcia II - Another Prisoner
- Eric Winter - Adrian Webb
- Amy Price-Francis - Jillian Russell
- Edwin Hodge - Doug Russell
- Michael Weaver - Hunter
- Joel Stoffer - Nick Holmes
- Adam Zolotin - Malcolm the Messenger
- Eric Satterberg - Joseph Marks
- Nathan Parsons - Nip-Tuck
- Brando Eaton - Star Lord
- Abhi Sinha - Robo Doc
- Bess Rous - Lara
- Amanda Clayton - Jodi Carvel
- Rubén Garfias - Carlos Santiago
- Bonnie Burroughs - Lynn Spencer
- Gabriela Lopez - Elena Santiago
- Chanel Marriott - Misty Spencer
- Justin James Hughes - Vaz Dera
- Sandra Hinojosa - Sadie
- Randolph Thompson - Lab Tech
- Miles Gaston Villanueva - Ken Daltry
- Kim Hawthorne - Ronna Burke
- Nathan Sutton - Andrew Meyers
- Harry Van Gorkum - Dr. Greg Hawking
- Chasty Ballesteros - Carina Radnor
- Leonard Robinson - Handsome Chess Player
- Aaron Leddick - Freddy
- Jack Benza - Schlubby Guy
- Shahaub Roudbari - Photographer
- Carlos Antonio - Assistant Director
- Nicholas Anthony Reid - Michael
- Jully Lee - Jennifer
- Marshall Allman - Ben Kapono
- J. J. Soria - Duane Posada
- Noemi Gonzalez - Leticia Covarrubias
- Scottie Thompson - Simone Kilgore
- Renwick D. Scott II - Ike Cantwell
- Scotty Tovar - Ricky Dawson
- Leah Briese - College Girl #1
- Carla Gallo - Daisy Wick
- Joy Brunson - Michelle Kelly
- James Harvey Ward - Harley
- Daniel Roebuck - Ernie Portnoy
- Roberto 'Sanz' Sanchez - Lorenzo 'Lo Down' Veras
- Jerry Kernion - Barnabas Rudd
- Christopher Rivas - Manny
- Nathaniel Kweku - Lonnie Kelly
- Andy Martinez, Jr. - Gunnar Tiegen
- Sammy Busby - Guard
- Jay Jackson - Reporter #2
- Michael Weston - Owen Panitch
- Dawn Olivieri - Agent Harrows
- Julianna Guill - Astrid
- Daniel Buran - Duke
- Vince Cefalu - Officer Brodhead
- Heath McGough - Walter Panitch
- Rico E. Anderson - Agent Fitzpatrick
- Briana Cap - Barbara Dicasoli
- Cuyle Carvin - Young Agent
- Janel Parrish - Selena Monet
- Philip Anthony-Rodriguez - Jamil Luther
- Francia Raísa - Lena Price
- Allen Maldonado - Victor 'Lil V' Rivera
- Angell Conwell - Keke Fairbanks
- Matt Pascua - Chase Austin
- Juan Pacheco - Jeff 'El Jefe' Rodriguez
- Patrick Hume - Leland Evan Manson
- Steven Allerick - Marcus the Bartender
- Robert Roldan - Damon Knox
- Hardy Awadjie - Music Video Director
- Tamera Kissen - Kitty
- Melissa L. Williams - Woman #1
- Spencer Locke - Danni Wagner
- Kendrick Sampson - Nathan Turner
- Joel Swetow - Zavier Salvas
- Adam Chambers - Kristoff Kade
- Maurice Mejia - Emilio Sanchez
- Jay Pickett - Lukas Nilsson
- Ashley Gallegos - Lily Zhukov
- Paul Thomas Arnold - Mick Furman
- Lawrence Mandley - Dr. James Mitchka
- Katee Shean - Tina
- Brett Edwards - Dealer
- Natalia Abelleyra - Waitress
- Phil Tyler - Head of Security
- Octavio Solorio - Pool Maintenance Guy
- Maura M. Knowles - Woman in the Crowd
- Ashley St. George - Hot Girl
- Katharine Isabelle - Naomi Bauer
- Wilke Itzin - Dmitry
- Patrick Cage - Craig
- Lony'e Perrine - Greta
- Pat Towne - Ian Alexander
- Kevin Sifuentes - Judge Diaz
- Brent Pope - Building Manager
- Emily Berry - Nurse
- Claire Gordon-Harper - Colleen Brady
- Chandler Rylko - John Teller
- Patrick Fischler - Chuck Furwell
- Derek Mio - Rick Wu
- Justin Bruening - Micah Holmes
- Matt Doherty - Alan Rast
- Mario López - Himself
- Rezeta Veliu - Alina
- Matthew Gottlieb - Eduardo Klein
- Casey Ford Alexander - EMPD Tech
- Eric Ladin - Ivan Keller
- Phillip Rhys - Raymond Larsen
- Bruce Nozick - Gavin Eauclaire
- Chen Tang - Bradley Morgan
- Cameron Kelly - Sarah Anders
- Jacqui Calloway - Model #3
- Felisha Terrell - Erin Given
- Aaron Himelstein - Pete Harmon
- Thom Rivera - Mayer Monteverde
- Jean Paul San Pedro - Jude Manifort
- Brian Takahashi - Tech #1
- Brian Takahashi - EMPD Tech
- Andy Milder - Howard Godfrey
- Orson Chaplin - Victor Jones
- Martin Papazian - EMT
- Manny Montana - Marcos Villa
- Matthew Yang King - Jason Hiyashi
- Nicholas Gonzalez - Rodrigo Vargas
- Andrew Borba - Ram Esposito
- Sarah Power - Evie Hower
- Gene Farber - Yuri Cvetko
- TJ Linnard - Vince Hanna
- Angie Patterson - Laura Ann Hill
- Edwin H. Bravo - Airport Worker
- J. Francisco Rodriguez - Migrant Worker #1
- Adam Aseem Tiwari - Physical Therapist
- Ginifer King - Veronica Collins
- Gina Hecht - Paula Benjamin
- Ellen Wroe - Gretchen Benjamin
- Kim Matula - Leanne Forrest
- Lauren Shaw - Ashley Morrison
- Sally Hughes - Diane Bartram
- Arturo del Puerto - Ian Gutierrez
- Blake Shields - Asa Stratton
- Terri Hoyos - Izzy Vermundo
- Pablo Soriano - Older Patron
- Sarah Alami - Waitress
- Dana Ashbrook - Jeff Groves
- Diandra Lyle - Sheriff Amy Potts
- Alexandra Kyle - Sandy Langford
- Scott Michael Campbell - Earl Langford
- Nicole Lynn Evans - Beverly
- Fitz Houston - Townsperson
- Patrick Gallagher - Captain Marino
- Carmela Zumbado - Thanny Torres
- Emily Tosta - Yaselyn
- Al Carabello - Sherman Camp
- Christopher Cho - Medical Examiner
- Cazimir Milostan - Officer
- Chris Candy - Patrolman Magintoter
- Kelly LaMarr - Elderly Officer
- Jay Giannone - Newspaper Guy
- Jonathan Silverman - Bastion Bleiweiss
- Betsy Beutler - Myra Reeves
- Austin Dillon - Wayne Cirito
- Eli Michael Kaplan - Rico Hornstock
- Elizabeth Sandy - Martha Hornstock
- Akrosia Samson - Nkechi
- Erica Vogelvang - Detective True
- Paul Archer - Officer Paul Jackson
- Yaani King Mondschein - Nadine
- Nicholas Ryan Hernandez - Jacob
- Michael Hogan - Skip Rogers
- Ashley Park - College Girl #2
- Laura Julian - Older Female Pathologist
- Ken Teaney
Anthony Michael Hall hace el papel de Detective Willet.
Morris Chestnut interpreta a Dr. Beaumont Rosewood, Jr. en la serie.
Anna Konkle hace el papel de Tara Milly Izikoff (aka TMI).
Lorraine Toussaint interpreta a Donna Rosewood en la serie.
Domenick Lombardozzi interpreta a Captain Ira Hornstock en la serie.
Jaina Lee Ortiz interpreta a Det. Annalise Villa en la serie.
Gabrielle Dennis interpreta a Pippy Rosewood en la serie.
Eddie Cibrian interpreta a Captain Ryan Slade en la serie.
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