- Stacy Edwards - Judy Sanders
- Anthony Michael Hall - Detective Willet
- Glenn Stanton - DJ Prince 305
- Christian Navarro - Carlos Gomez
- Patrick Michael Buckley - Chester Bly
- Victoria Vodar - Jen the Masseuse
- Owen Harn - Hanz the Bodyguard
- Nicole Ari Parker - Kat
- Chandra West - Kerry Conforth
- Angelina Assereto - Beth
- Rodney To - Neil
- Scott Michael Morgan - Detective Feldheim
- Emiliano Torres - Manager
- Cerina da Graça - Xiang Wen
- Michael Andrew Baker - Young Father
- Al Coronel - Officer Jacott
- Chance Harlem Jr. - Dante Harrell
- Mackenzie Astin - Dr. Max Cahn
- Adam Lazarre-White - Delroy Ellis
- Chris Bosh - Chris Bosh
- Harrison White - Lot Manager
- Shaan Sharma - Diego
- Keisuke Hoashi - Dr. Wei
- Adrian Pasdar - Dr. Derek Foster
- Merle Dandridge - Charlotte
- H. Richard Greene - Alexis Stavros
- Rayna Tharani - Felicia
- Deborah Rayne - Eva Freydont
- Manuel Eduardo Ramirez - Patrol Officer
- David A. Kimball - David Moran
- Exie Booker - Bouncer
- Derek Phillips - Trevor McCown
- Hope Olaidé Wilson - Tiana Denard
- Khalilah Joi - Regine Denard
- Asante Jones - Detective Vernon
- Nikea Gamby-Turner - Ilene Desouza
- Camille Collard - Isabella
- Michael Irby - Agent Giordano
- Vondie Curtis-Hall - Beaumont Rosewood Sr.
- Con Schell - Peter
- Stacy Hall - Security Officer
- Stella Farentino - Janice
- Ryan W. Garcia - IAD Agent Malcute
- Michelle Bonilla - District Attorney Sandra Drake
- Adam Kulbersh - Defense Attorney Adam Burke
- Christopher Carroll - Judge Walters
- Katherine Kendall - Debra Monroe
- Jeffrey Doornbos - Joel Monroe
- Chris O'Brien - Lester Goree
- Jacob McCafferty - Jeff
- Jordan Pratt-Thatcher - Anton Monroe
- Scott Broderick - Bailiff
- Max Shippee - Coach Walker
- Lisa Vidal - Daisie Villa
- Kurt Fuller - Floyd Butters
- Cole Bernstein - Beatrice Guzman
- Lauren Bowles - Loretta Franks
- Reynaldo Gallegos - Marlan Guzman
- Sarah Domin - Employee
- Emayatzy Corinealdi - Gigi Gaston
- Matthew Risch - Ian Hunter
- Matt Cedeño - Chuy Mendez
- Taye Diggs - Dr. Mike Boyce
- Thomas Silcott - Sam
- Melinda Y. Cohen - Angela York
- Rico Simonini - Dr. Houser
- Sam Gros - Nurse #1
- Barrett Kiick - Nurse #2
- Sam Witwer - Heath Casablanca
- Sprague Grayden - Dina Katz
- Tom Beyer - Dev Fagen
- Kavita Patil - Elaine Haldeman
- Scott Mosenson - Roger Jones
- Matt Borlenghi - Gino Smith
- Felisha Cooper - Skylar
- Christopher B. Duncan - Marcel Crawford
- Alysia Reiner - Lilian Izikoff
- Shakira Barrera - Ananda 'Andi' Singh
- Shaun Duke - Chief Ewing
- Alice Amter - Chitra Singh
- Ismail Bashey - Rishi Singh
- Cate Cohen - Joanne
- Andrew Thacher - CSI Tech
- Alexis DeLaRosa - CSI Tech Nico
- Mel Fair - Reporter #1
- Tia Mowry - Cassie
- John Gabriel - Detective Martinez
- Jeff Adler - Nolan
- Allius Barnes - Oscar Diaz
- Joy Bryant - Dr. Erica Kincaid
- Mark Atteberry - Jason Barrett
- Danielle Rayne - Camille Barrett
- Samantha Hodges - Kira Barrett
- William Charlton - Rob Shuman
- Scott Alan Smith - Dr. Moore
- Matt Kaminsky - Business Man
- Dean Cudworth - Detective Roday
- Christine Devine - TV News Reporter
- Scott Porter - Det. Russ Hame
- Marco Sanchez - Dr. Gus Willing
- Michael Filipowich - Nova
- Sherri Shepherd - Dr. Anita Eubanks
- Phil Abrams - Bob Safran
- Stephen Full - Alan Peters
- Kassandra Kanaar - Hygienist Cindy
- Jessica Morris - Mandy Willing
- Frank Maharajh - Slick Surgeon
- Robin De Lano - Angry Resident
- Nan McNamara - Angrier Resident
- Wayne Alon Scott - Henchman #1
- Azie Tesfai - Lil Kim
- Eric Nenninger - Zachary Wilford III
- Lisa Banes - Esther Wilford
- Michael Trotter - Joe Fuller
- Jeff Ward - Wyatt Montgomery
- Mirela Burke - Holly Keaton
- Ray Santiago - Tony 'Ponce' De Leon
- David Julian Hirsh - Dr. Kipley Reed
- Shannon Lucio - Casey Reed
- Scott Klace - Dr. Melvin Damski
- Brianne Davis - Suzie Q
- Frederick Koehler - Antonius Block
- Henry Czerny - Arthur Izikoff
- Peggy Dunne - Woman (Block's Mom)
- Christian Lyon - EMT
- Doreen Calderon - Maid
- John Nicholas - Older Male Pathologist
- Amanda Leighton - Sophie Hornstock
- Rick Gonzalez - Jay Stottlemyre
- Delaina Mitchell - Mia Barnes
- Nick Steele - Darrin Barber
- Paul Norwood - Phil Barber
- Noah Nevins - Brody
- Juan Pablo Di Pace - Antonio Espada
- Yara Martinez - Julia Delgado
- Ricky Saenz - Jaime Herrera
- Dennis Cockrum - Salesman
- Matt Knudsen - Gabriel Haskell
- Pilar Holland - Maria De La Vina
- Mayra Leal - Latina Woman (Melissa Peña)
- Peter Spruyt - Weird Warren
- Rickey Brown - Lil' Ronnie
- Sam Huntington - Mitchie Mendelson
- Katherine Boecher - Jackie Sloan
- Cara Pifko - Barbara Gaines
- Nahesi Crawford - Runner on Beach
- Brian Balzerini - Bartender
- Antwon Tanner - Sylvester
- Christina Moses - Daphne
- Michael Traynor - Walter
- Drew Lipson - Steve
- Quincy Ndekwe - Billy
- Luke Rampersad - Deon
- Michael Meir Saltzman - Rude Patron
- Anthony Ma - Glenn
- J.R. Ramirez - Frank Escajeda
- Antonio Jaramillo - Vladimir Dominguez
- Bianca Bethune - ATF Tiffany
- Kamal Angelo Bolden - Joo Joo
- Kamal Angelo Bolden - Julius 'Joo Joo' Beeman
- Kamal Angelo Bolden - Julius 'Joo-Joo' Beeman
- Aria Sirvaitis - Kelly Downs
- Charles Dougherty - Older Man in Montage
- Tonya Kay - Dancer in Montage
- Scott Menville - Angry Man
- Sheryl Lee - Brenda Downs
- Salli Richardson-Whitfield - Dr. Aubrey Joseph
- Chris Johnson - Calvin Spitz / Carter Dobbs
- Michael William Freeman - Gene
- James Patrick Stuart - Dr. Saffron Fields
- Jonathan Craig Williams - Bank Manager
- Christopher Boyer - Older Seasoned Farmer
- Lauren Lakis - Clara Reesner
- Bret Grantham - Patient #2
- Wayne Sable - Patient #3
- Matthew Glave - Andre Ward
- Mark Rolston - Harvey
- Chad Lindberg - Louie Van Winkle
- Shi Ne Nielson - Carla Reid
- John Billingsley - Judge West Waters
- Carlos E. Campos - Sammy the Manager
- André Tardieu - Sebastian Le Mercie
- Adam Cabrera - Joe Campos
- Scout Taylor-Compton - Christa
- Yancey Arias - Mayor Ramon Esparza
- Timothy Granaderos - Lane Piven
- Micah Cohen - James Patton
- Danny Jacobs - Saul Bailey
- Alisha Wainwright - Cassie Hanson
- Robert Wisdom - Gerald Kelly
- Robert Wisdom - Gerald
- Jake Nutty - Idiot Frat Brother
- Ashley Jackson - Betsy
- Alex Lombard - Linda Esparza
- Jeff Sumner - Forensic Tech E.G. Attie
- Nishi Munshi - Jenny Williams
- Tate Ellington - Troy Randolph
- Andy Favreau - Danny Williams / Connor Thorne
- Greg Vrotsos - Luke Firth
- Antony Del Rio - Nate Higuera
- Erica Luttrell - Milia Mae
- Josh Fingerhut - Biff
- Amanda Grace Jenkins - Liz the Sexy Waitress
- Gabriel Luna - Eddie Lunez
- Wallace Langham - Duncan Jacott
- Benny Ciaramello - Anthony
- Don Stark - Captain Roy Murillo
- Marque Richardson - Bennie
- Ken Garito - Man #1 / DEA Agent #1
- David Paladino - Man #2 / DEA Agent #2
- Garren Stitt - Oliver Jacott
- Tim Cummings - Principal Neff Garrity
- Robert Catrini - Trainer
- Farley Jackson - Tatted Up Boxer
- Natalie Ceballos - Lucia
- Izzy Martinez - Cameron
- Alain Mesa - Masked Man
- Tiffany Yvonne Cox - Stewardess
- Dawn Richard - Girl Singer
- P.J. Marino - Henchman #1
- Victor Winters-Junco - Henchman #3
- LeToya Luckett - Tawnya
- Tracey Fairaway - Bree Jones
- David Clayton Rogers - Karl Benson
- Carlos Leal - Edgar Moreno
- Josh Zuckerman - Cody Tucker
- Jay Huguley - David B. Jones
- David Atkinson - Billy Blackmar
- Faye Viviana - Selfie Girl
- Trevor David - Producer
- Eric Edwards - Male Patron
- Edwin Garcia II - Another Prisoner
- Eric Winter - Adrian Webb
- Amy Price-Francis - Jillian Russell
- Edwin Hodge - Doug Russell
- Michael Weaver - Hunter
- Joel Stoffer - Nick Holmes
- Adam Zolotin - Malcolm the Messenger
- Eric Satterberg - Joseph Marks
- Nathan Parsons - Nip-Tuck
- Brando Eaton - Star Lord
- Abhi Sinha - Robo Doc
- Bess Rous - Lara
- Amanda Clayton - Jodi Carvel
- Rubén Garfias - Carlos Santiago
- Bonnie Burroughs - Lynn Spencer
- Gabriela Lopez - Elena Santiago
- Chanel Marriott - Misty Spencer
- Justin James Hughes - Vaz Dera
- Sandra Hinojosa - Sadie
- Randolph Thompson - Lab Tech
- Miles Gaston Villanueva - Ken Daltry
- Kim Hawthorne - Ronna Burke
- Nathan Sutton - Andrew Meyers
- Harry Van Gorkum - Dr. Greg Hawking
- Chasty Ballesteros - Carina Radnor
- Leonard Robinson - Handsome Chess Player
- Aaron Leddick - Freddy
- Jack Benza - Schlubby Guy
- Shahaub Roudbari - Photographer
- Carlos Antonio - Assistant Director
- Nicholas Anthony Reid - Michael
- Jully Lee - Jennifer
- Marshall Allman - Ben Kapono
- J. J. Soria - Duane Posada
- Noemi Gonzalez - Leticia Covarrubias
- Scottie Thompson - Simone Kilgore
- Renwick D. Scott II - Ike Cantwell
- Scotty Tovar - Ricky Dawson
- Leah Briese - College Girl #1
- Carla Gallo - Daisy Wick
- Joy Brunson - Michelle Kelly
- James Harvey Ward - Harley
- Daniel Roebuck - Ernie Portnoy
- Roberto 'Sanz' Sanchez - Lorenzo 'Lo Down' Veras
- Jerry Kernion - Barnabas Rudd
- Christopher Rivas - Manny
- Nathaniel Kweku - Lonnie Kelly
- Andy Martinez, Jr. - Gunnar Tiegen
- Sammy Busby - Guard
- Jay Jackson - Reporter #2
- Michael Weston - Owen Panitch
- Dawn Olivieri - Agent Harrows
- Julianna Guill - Astrid
- Daniel Buran - Duke
- Vince Cefalu - Officer Brodhead
- Heath McGough - Walter Panitch
- Rico E. Anderson - Agent Fitzpatrick
- Briana Cap - Barbara Dicasoli
- Cuyle Carvin - Young Agent
- Janel Parrish - Selena Monet
- Philip Anthony-Rodriguez - Jamil Luther
- Francia Raísa - Lena Price
- Allen Maldonado - Victor 'Lil V' Rivera
- Angell Conwell - Keke Fairbanks
- Matt Pascua - Chase Austin
- Juan Pacheco - Jeff 'El Jefe' Rodriguez
- Patrick Hume - Leland Evan Manson
- Steven Allerick - Marcus the Bartender
- Robert Roldan - Damon Knox
- Hardy Awadjie - Music Video Director
- Tamera Kissen - Kitty
- Melissa L. Williams - Woman #1
- Spencer Locke - Danni Wagner
- Kendrick Sampson - Nathan Turner
- Joel Swetow - Zavier Salvas
- Adam Chambers - Kristoff Kade
- Maurice Mejia - Emilio Sanchez
- Jay Pickett - Lukas Nilsson
- Ashley Gallegos - Lily Zhukov
- Paul Thomas Arnold - Mick Furman
- Lawrence Mandley - Dr. James Mitchka
- Katee Shean - Tina
- Brett Edwards - Dealer
- Natalia Abelleyra - Waitress
- Phil Tyler - Head of Security
- Octavio Solorio - Pool Maintenance Guy
- Maura M. Knowles - Woman in the Crowd
- Ashley St. George - Hot Girl
- Katharine Isabelle - Naomi Bauer
- Wilke Itzin - Dmitry
- Patrick Cage - Craig
- Lony'e Perrine - Greta
- Pat Towne - Ian Alexander
- Kevin Sifuentes - Judge Diaz
- Brent Pope - Building Manager
- Emily Berry - Nurse
- Claire Gordon-Harper - Colleen Brady
- Chandler Rylko - John Teller
- Patrick Fischler - Chuck Furwell
- Derek Mio - Rick Wu
- Justin Bruening - Micah Holmes
- Matt Doherty - Alan Rast
- Mario López - Himself
- Rezeta Veliu - Alina
- Matthew Gottlieb - Eduardo Klein
- Casey Ford Alexander - EMPD Tech
- Eric Ladin - Ivan Keller
- Phillip Rhys - Raymond Larsen
- Bruce Nozick - Gavin Eauclaire
- Chen Tang - Bradley Morgan
- Cameron Kelly - Sarah Anders
- Jacqui Calloway - Model #3
- Felisha Terrell - Erin Given
- Aaron Himelstein - Pete Harmon
- Thom Rivera - Mayer Monteverde
- Jean Paul San Pedro - Jude Manifort
- Brian Takahashi - Tech #1
- Brian Takahashi - EMPD Tech
- Andy Milder - Howard Godfrey
- Orson Chaplin - Victor Jones
- Martin Papazian - EMT
- Manny Montana - Marcos Villa
- Matthew Yang King - Jason Hiyashi
- Nicholas Gonzalez - Rodrigo Vargas
- Andrew Borba - Ram Esposito
- Sarah Power - Evie Hower
- Gene Farber - Yuri Cvetko
- TJ Linnard - Vince Hanna
- Angie Patterson - Laura Ann Hill
- Edwin H. Bravo - Airport Worker
- J. Francisco Rodriguez - Migrant Worker #1
- Adam Aseem Tiwari - Physical Therapist
- Ginifer King - Veronica Collins
- Gina Hecht - Paula Benjamin
- Ellen Wroe - Gretchen Benjamin
- Kim Matula - Leanne Forrest
- Lauren Shaw - Ashley Morrison
- Sally Hughes - Diane Bartram
- Arturo del Puerto - Ian Gutierrez
- Blake Shields - Asa Stratton
- Terri Hoyos - Izzy Vermundo
- Pablo Soriano - Older Patron
- Sarah Alami - Waitress
- Dana Ashbrook - Jeff Groves
- Diandra Lyle - Sheriff Amy Potts
- Alexandra Kyle - Sandy Langford
- Scott Michael Campbell - Earl Langford
- Nicole Lynn Evans - Beverly
- Fitz Houston - Townsperson
- Patrick Gallagher - Captain Marino
- Carmela Zumbado - Thanny Torres
- Emily Tosta - Yaselyn
- Al Carabello - Sherman Camp
- Christopher Cho - Medical Examiner
- Cazimir Milostan - Officer
- Chris Candy - Patrolman Magintoter
- Kelly LaMarr - Elderly Officer
- Jay Giannone - Newspaper Guy
- Jonathan Silverman - Bastion Bleiweiss
- Betsy Beutler - Myra Reeves
- Austin Dillon - Wayne Cirito
- Eli Michael Kaplan - Rico Hornstock
- Elizabeth Sandy - Martha Hornstock
- Akrosia Samson - Nkechi
- Erica Vogelvang - Detective True
- Paul Archer - Officer Paul Jackson
- Yaani King Mondschein - Nadine
- Nicholas Ryan Hernandez - Jacob
- Michael Hogan - Skip Rogers
- Ashley Park - College Girl #2
- Laura Julian - Older Female Pathologist
- Ken Teaney
Anthony Michael Hall interpreta a Detective Willet en la serie.
Morris Chestnut interpreta a Dr. Beaumont Rosewood, Jr. en la serie.
Anna Konkle interpreta a Tara Milly Izikoff (aka TMI) en la serie.
Lorraine Toussaint hace el papel de Donna Rosewood.
Domenick Lombardozzi hace el papel de Captain Ira Hornstock.
Jaina Lee Ortiz hace el papel de Det. Annalise Villa.
Gabrielle Dennis hace el papel de Pippy Rosewood.
Eddie Cibrian hace el papel de Captain Ryan Slade.
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