- Tony Todd - Larry
- Davie-Blue - Jennifer
- Ethan Kent - Ralph
- Gavin Kent - Ralphie
- Ross Partridge - Bradley
- Onur Tukel - Erol
- Abby Ryder Fortson - Elle
- Josephine Decker - Rosie
- Luke Wilson - Remus
- Christine Woods - Roma
- Logan Miller - Logan
- Mark Duplass - Graham Husker
- Jillian Bell - Sam
- Dave Bautista - Raw Dog Avalanche
- Melissa Fumero - Eva
- Kevin Nealon - Harry
- Shannon Purser - Megan
- Kendra Carelli - Casey
- Gary Cole - Chip Crawford
- Linda Lavin - Enid
- Harvey Guillén - Luke
- Cobie Smulders - Scientist
- Lily Gladstone - Abby
- Mary Mouser - Adrienne
- Meilee Condron - Sonia (Girl)
- Macon Blair - George
- Carl De Gregorio - Dad
- Jay Duplass - Daniel
- Will Tranfo - Patrick
- Frank Ashmore - Older Patrick
- Karan Soni - Anish
- Poorna Jagannathan - Divya (voice)
- Darin De Paul - Man On Tape (voice)
- Dendrie Taylor - Housekeeper
- Jenny Leonhardt - Larry
- Sarah Hay - Girl
- Matthew Bellows - Man (voice)
- Adam Foster - Noah
- Nat Wolff - Joseph
- Amy Landecker - Joan
- Mae Whitman - Liza
- Spencer Garrett - Dr. Dan Benich
- Konstantin Lavysh - Boris
- Veronica Falcón - Rosa
- Biff Wiff - Edgar
- Keir Gilchrist - Alex
- Jennifer Lafleur - Karen
- Jennifer Lafleur - Diane (voice)
- Hugo Armstrong - Steve
- Marieve Herington - Reporter (voice)
- Jason Hightower - Reporter (voice)
- Cheryl Texiera - Reporter (voice)
- Natalie Morgan - Greta
- Keta Meggett - Rayna
- Mark Kelly - Contractor
- Stephen Rannazzisi - JR (voice)
- Channon Dade - Front Desk Receptionist
- Jesse Springer - Fight Commentator
- Faruq Tauheed - Man In Next Room
- Philip Baker Hall - Charlie
- Ellen Geer - Lorraine
- Jacqueline Wright - Elaine (voice)
- Charlyne Yi - Gracie
- Kristina Harrison - Mother
- Kristina Harrison - MOM
- Tom Lenk - Matty
- Rainn Wilson - Jim
- Frank Ellis - Mr. Mulvahill
- Michael Shannon - Nathan
- Judy Greer - Darla Andrews
- Katya Zamolodchikova - Ochin'priyatna
- Jon Bass - Hamster
- Jon Bass - Dustin
- Tom Clark - Burly Cop
- Fred Maske - Scrawny Cop
- Kent Osborne - Dan
- Mark Proksch - Gene
- Michole Briana White - Officer Pankin
- Dolly Wells - Catherine
- Brian Tyree Henry - Arnold
- Ginger Gonzaga - Vicki
- Phil Matarese - P-Dawg
- Chris McLaughlin - Chris
- Jeffrey G. Barnett - Masked Man
- Marlene Forte - Mom
- Natalie Morales - Jess
- Stephanie Allynne - Sarah
- Katie Aselton - Helen
- Julian Grant - Roger
- Sheaun McKinney - Charles
- Mahershala Ali - Franco
- James Earl - Ollie
- Joel Allen - Donovan
- Anita Kalathara - Emily
- Zane Pais - Jon
- Mary Wiseman - Josie
- Eric Edelstein - Swofford
- Dale Dickey - Sharon
- Robert Longstreet - Allan
- Tom Woodruff Jr. - Elmer
- Arturo Castro - Craig
- François Chau - Dr. Blake
- Gina Gallego - Denise
- Iyana Halley - Zohara
- Catalina Sandino Moreno - Maria
- James Babson - Willis
- Sam Richardson - Greg
- Steve Little - Randy
- Fred Melamed - Narrator (voice)
- Atsuko Okatsuka - Woman
- Tony Plana - Bracamonte
- Angie Cepeda - Dolores
- Timm Sharp - Brandon
- Julian Acosta - Older Brother
- Rhoda Pell - Ghost Mother
- Josh Fadem - Ted
- Marielle Scott - Nina
- David Paymer - Robert
- Jeremy Guskin - Young Robert
- Mario Revolori - Lou
- Lily Mae Harrington - Beth
- Susanna Harter - Veronica
- Aislinn Paul - Young Jean
- June Squibb - Jean
- Paul F. Tompkins - Louis
- Aasif Mandvi - Mediator
- David Boat - (Voice)
- Hari Nef - Katherine
- Bernard David Jones - Justin
- Griffin Morgan - Kid
- Josie M. Parker - Young Sam
- Natalie Woolams-Torres - Tamara
- Vivian Bang - Jaimie
- Finn Roberts - Walker
- Dana Adam Shapiro - Derek
- Breeda Wool - Poppy March
- Jason David - Will
- Skylar Gray - Maddie
- Sadie Stanley - Ashley Kaul / Jules
- Pia Shah - Tanya
- Mel Eslyn
- Jay Duplass
Michael Shannon interpreta a Nathan en la serie.
Philip Baker Hall interpreta a Charlie en la serie.
Tony Todd interpreta a Larry en la serie.
Davie-Blue interpreta a Jennifer en la serie.
Ethan Kent hace el papel de Ralph.
Gavin Kent interpreta a Ralphie en la serie.
Ross Partridge hace el papel de Bradley.
Onur Tukel hace el papel de Erol.
Abby Ryder Fortson hace el papel de Elle.
Josephine Decker hace el papel de Rosie.
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