- Nicole Kidman - Robin
- Betty Gilpin - Amelia
- Judy Davis - Rosey
- Daniel Dae Kim - Harry
- Cynthia Erivo - Ambia
- Alison Brie - Rebecca Moss
- Jake Johnson - Greg
- Hugh Dancy - Detective Bobby Bronson
- Christopher Lowell - Detective Chris Durst
- Jillian Bell - Christina
- Fivel Stewart - Jane
- Meera Syal - Anu
- Bernard White - Vikas
- Julie White - Barbara
- Peter Facinelli - Second Husband
- Rizwan Manji - Third Husband (Raoul)
- Merritt Wever - Elisa
- Justin Kirk - Larry the Duck (voice)
- Ego Nwodim - Carole Andrews
- Van Crosby - Chad
- Evan Gamble - Todd
- Jennifer Lafleur - Tina
- Malcolm Bowen - Male Officer
- Issa Rae - Wanda Shepard
- Griffin Matthews - Blake
- Lauren E. Banks - Lu
- Nick Kroll - Doug
- Greg Keller - Aaron Fishman
- Damian Joseph Quinn - Brian
- Allan McLeod - Nick
- Adwin Brown - Andre
- Zackry Colston - Hipster
- Lola Paja - Swanky Receptionist
- Michael James Lazar - Carl
- Grace Demarco - Saleswoman
- Rose Lane - Young Wanda
- Sheila Shaw - Older White Woman
- Ho-Kwan Tse - Don
- Tom McComas - VR Cop #1
- Danielle Marie Thompson - Customer
- Simon Baker - Adam
- Kai Lewins - Todd
- Jude Hyland - Henry
- Dalara Williams - Park Employee
- Annie Sertich - Salesperson
- Amelie Zazik - Young Amelia
- Jennica Schwartzman - Young Amelia's Mom
- Ana Rey - Housekeeper
- Dani Oliveros - Girl on Beach
- Jameel Shivji - Boy on Beach
- Stephen L. Wilson - Guy Outside Amelia's Store
- Brooke Ashley Rose Johnson - Woman Outside Amelia's Store
- Christine Lin - Woman with Daughter
- Alyssa Abiera - Daughter
- Riki Lindhome - Lil
- Jason Mantzoukas - Dave / Animal Control
- Lon Gowan - Proctor
- Roshni Shukla - Sareena
- Gregg Binkley - Clark
- Sweta Keswani - Pushpa
- Gita Reddy - Deepti
- Moonie Fishburn - Udaya
- Veena Bidasha - Nalini
- Eden Riegel - Journalist
- Garikayi Mutambirwa - Maurice
- Troy Vincent - Sal
- Maz Siam - Ibrahim
- Phillip-Charlie Daniell - Shopper (uncredited)
- Kara Hayward - Millie
- Alfred Molina - Silas McCall
- Eddie Shin - Jim
- Leslie David Baker - Johnny Spoons
- Rex Linn - Sheriff
- Adrian Sparks - Old Doc Henry
- Soyana Pigniat - Eleanor
- Ellodee Carpenter - Frannie
- Michael Villar - Jed
- Dean Sharpe - Elijah
- Bruna Papandrea
- Carly Mensch
- Theresa Park
- Per Saari
- Halley Feiffer
- Steve Hutensky
Nicole Kidman interpreta a Robin en la serie.
Betty Gilpin interpreta a Amelia en la serie.
Judy Davis hace el papel de Rosey.
Daniel Dae Kim interpreta a Harry en la serie.
Cynthia Erivo interpreta a Ambia en la serie.
Alison Brie interpreta a Rebecca Moss en la serie.
Jake Johnson hace el papel de Greg.
Hugh Dancy hace el papel de Detective Bobby Bronson.
Christopher Lowell hace el papel de Detective Chris Durst.
Jillian Bell interpreta a Christina en la serie.
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