- Nicole Kidman - Robin
- Betty Gilpin - Amelia
- Judy Davis - Rosey
- Daniel Dae Kim - Harry
- Cynthia Erivo - Ambia
- Alison Brie - Rebecca Moss
- Jake Johnson - Greg
- Hugh Dancy - Detective Bobby Bronson
- Christopher Lowell - Detective Chris Durst
- Jillian Bell - Christina
- Fivel Stewart - Jane
- Meera Syal - Anu
- Bernard White - Vikas
- Julie White - Barbara
- Peter Facinelli - Second Husband
- Rizwan Manji - Third Husband (Raoul)
- Merritt Wever - Elisa
- Justin Kirk - Larry the Duck (voice)
- Ego Nwodim - Carole Andrews
- Van Crosby - Chad
- Evan Gamble - Todd
- Jennifer Lafleur - Tina
- Malcolm Bowen - Male Officer
- Issa Rae - Wanda Shepard
- Griffin Matthews - Blake
- Lauren E. Banks - Lu
- Nick Kroll - Doug
- Greg Keller - Aaron Fishman
- Damian Joseph Quinn - Brian
- Allan McLeod - Nick
- Adwin Brown - Andre
- Zackry Colston - Hipster
- Lola Paja - Swanky Receptionist
- Michael James Lazar - Carl
- Grace Demarco - Saleswoman
- Rose Lane - Young Wanda
- Sheila Shaw - Older White Woman
- Ho-Kwan Tse - Don
- Tom McComas - VR Cop #1
- Danielle Marie Thompson - Customer
- Simon Baker - Adam
- Kai Lewins - Todd
- Jude Hyland - Henry
- Dalara Williams - Park Employee
- Annie Sertich - Salesperson
- Amelie Zazik - Young Amelia
- Jennica Schwartzman - Young Amelia's Mom
- Ana Rey - Housekeeper
- Dani Oliveros - Girl on Beach
- Jameel Shivji - Boy on Beach
- Stephen L. Wilson - Guy Outside Amelia's Store
- Brooke Ashley Rose Johnson - Woman Outside Amelia's Store
- Christine Lin - Woman with Daughter
- Alyssa Abiera - Daughter
- Riki Lindhome - Lil
- Jason Mantzoukas - Dave / Animal Control
- Lon Gowan - Proctor
- Roshni Shukla - Sareena
- Gregg Binkley - Clark
- Sweta Keswani - Pushpa
- Gita Reddy - Deepti
- Moonie Fishburn - Udaya
- Veena Bidasha - Nalini
- Eden Riegel - Journalist
- Garikayi Mutambirwa - Maurice
- Troy Vincent - Sal
- Maz Siam - Ibrahim
- Phillip-Charlie Daniell - Shopper (uncredited)
- Kara Hayward - Millie
- Alfred Molina - Silas McCall
- Eddie Shin - Jim
- Leslie David Baker - Johnny Spoons
- Rex Linn - Sheriff
- Adrian Sparks - Old Doc Henry
- Soyana Pigniat - Eleanor
- Ellodee Carpenter - Frannie
- Michael Villar - Jed
- Dean Sharpe - Elijah
- Bruna Papandrea
- Carly Mensch
- Theresa Park
- Per Saari
- Halley Feiffer
- Steve Hutensky
Nicole Kidman hace el papel de Robin.
Betty Gilpin interpreta a Amelia en la serie.
Judy Davis hace el papel de Rosey.
Daniel Dae Kim interpreta a Harry en la serie.
Cynthia Erivo hace el papel de Ambia.
Alison Brie interpreta a Rebecca Moss en la serie.
Jake Johnson hace el papel de Greg.
Hugh Dancy interpreta a Detective Bobby Bronson en la serie.
Christopher Lowell interpreta a Detective Chris Durst en la serie.
Jillian Bell hace el papel de Christina.
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