- David Wilmot - Donald Artherton
- Jerome Flynn - Bennet Drake
- Matthew Lewis - Samuel Drummond
- Callum Turner - Philip
- Luke Allen-Gale - Ezekiel Bruton
- Hugh O'Conor - Mr. Eagles
- Jack Bannon - Caleb Sumner
- Norma Sheahan - Distressed Woman
- Laura Haddock - Lady Vera Montacute
- Steven Robertson - Christian Thwaites
- Mark Dexter - Sir Arthur Donaldson
- Geoff Bell - Joseph Smeaton
- Julian Bleach - Cecil Creighton
- Morgan Jones - Pornographer
- Garry Mountaine - Tour Guide
- Sarah Gallagher - Maude Thwaites
- Sean Duggan - Fight Umpire
- Joseph Gilgun - Carmichael
- Michael Smiley - George Lusk
- Beverley Klein - Mrs. Manby
- David Coon - Ernest Manby
- Pat Laffan - Judge
- Andy Kellegher - Prison Guard
- Simon Coury - Prison Chaplain
- David Cummins - Gang Child
- Alvaro Lucchesi - Victualler
- Patrick Baladi - Sidney Ressler
- Penny Downie - Flora Gable
- Simon Gregor - Claxton
- Stuart Bunce - Preacher
- Jennifer Laverty - Kathleen
- Dave Legeno - George
- Emma Griffiths Malin - Harlot
- Jonathan White - Madam
- Malcolm Adams - Porter
- Paul McGann - Stanley Bone
- Emma Catherine Rigby - Lucy Eames
- Jack Walsh - Denton
- Iain Glen - Madoc Faulkner
- Sam Hazeldine - George Doggett
- Julian Firth - Mr. Wheen
- Lalor Roddy - Birdseller
- Liam Carney - Lynch
- Michael James Ford - Range Master
- Derek Reid - Chatwood
- Gus McDonagh - Guard
- Peter Ferdinando - Peter Morris (Zotkin)
- Ferdinand Kingsley - Joshua Bloom
- David Verrey - Volsky
- Ignacy Rybarczyk - Daniel
- Edward Peel - Norwood
- Damien Devaney - Docker
- Tommy O'Neill - Heavy
- Oliver Cotton - Daniel Goldman
- Shauna Macdonald - Martha Fanthorpe
- Rod Hallett - Joshua Fields
- Eamon Rohan - Chief Stockholder
- Ciaran O'Grady - Charlie Pinkerton
- David Oakes - Victor Silver
- Ruta Gedmintas - Clara Silver
- Linal Haft - Joseph Lavender
- Kristian Nairn - Barnaby Silver
- Edoardo Ballerini - Frank Goodnight
- Rebecca Grimes - Streetwalker
- Anabel Sweeney - Mary
- Steven Hartley - Det. Sgt. Maurice Linklater
- Aaron Ly - Wong King-Fai
- Kunjue Li - Blush Pang
- Anthony Morris - Carsten
- Aidan Crowe - Copper
- Anton Lesser - Dr. Karl Crabbe
- Nicholas Woodeson - Dr. William Corcoran
- Tom Brooke - John Goode
- Elva Trill - Stella
- Imogen Bain - Lady Pettigrew
- Glenn Speers - Night Refuge Man
- Jonathan Delaney Tynan - Surgeon
- Guy Carleton - Watchman
- David O'Meara - Museum Porter
- Joseph Drake - Joseph Merrick
- Neve McIntosh - Raine
- Robert O'Mahoney - Walter de Souza
- Amber Jean Rowan - Ida
- Gary Murphy - Urwin
- David Murray - Ely
- Arthur Riordan - Pembury
- Karen Egan - Singer
- Ciaran O'Brien - Jack the Ripper
- Hannah Mamalis - Ettie
- Sheila Moylette - Agatha
- Stanley Townsend - Aiden Galvin
- James Wilby - Charles Broadwick
- Charlie Murphy - Evelyn Foley
- Martin McCann - Michael Donovan
- Michael Marcus - Sebastian Ferranti
- Guy Williams - Cecil Knightly
- Steve Gunn - Newgate Driver
- Mícheál Ó Dubhghaill - Bar Brawler
- Peter Sullivan - Franklin Stone
- Scott Handy - Solomon Quint
- Belinda Stewart-Wilson - Prudence Quint
- Andrew Tiernan - James Self
- Frankie McCafferty - Hotel Manager
- Alfie Stewart - David Goodbody
- Jassa Ahluwalia - Vincent Featherwell
- Alexander Cobb - Luke Nuttal
- David Crowley - Otto Roberts
- Dale Leadon Bolger - Harry Collins
- Stephen Jones - Charlie Frost
- Paul Kaye - Gabriel Cain
- Gina Bellman - Jemima Swann
- Chris Patrick-Simpson - Samuel Gaddis
- Kirsty Oswald - Maggie
- Liam Burke - Rabbi
- Gwynne McElveen - Church Goer
- Hazel Doupe - Flower Girl
- Simon O'Gorman - Drunken Man
- Frank Melia - Priest
- Robert Render - Afrikaner
- Paul Kennedy - Emcee
- Paul Kealyn - Gravedigger
- Noni Stapleton - Gracie
- Barbara Bergin - Streetwalker
- Frank Harper - Silas Duggan
- Michael Sheehan - Wainwright
- Michael Sheehan - Wainright
- David Costabile - Daniel Judge
- Justin Salinger - Nathaniel Hinchcliffe
- Robert Goodman - Werner
- Joel Gillman - Finkel
- Craige Els - Botha Brother
- Joe Macaulay - Botha Brother
- Gary Egan - Barton
- Keith Skinner - Skinner
- Cathal Pendred - Duggan's Henchman
- Francis Magee - Davies
- Raymond Waring - Gregory Enright
- Paul Ready - Frederick Treves
- Paul Ready - Dr. Frederick Treves
- Dermot Magennis - Herbert Cree
- Kelly Campbell - Mother
- Andy Gathergood - Signalman
- Mark Mooney - Necropolis Driver
- Charlie Creed-Miles - Horace Buckley
- Phil McKee - Clyde Kendrick
- Marie Critchley - Clara Buckley
- Jason Manford - Alexander Le Cheyne
- Philip Arditti - Ezra Marvell
- Georgina Rich - Olivia Wakefield
- Philip Judge - William Wakefield
- Sophia La Porta - Juniper Kohl
- Alicia Gerrard - Charity
- John Heffernan - Ronald Capshaw
- Dean-Charles Chapman - Harry Ward
- Patrick J Molloy - Punter
- Daniel Fearn - Victualler
- Mairin O'Donovan - Agatha the Crone
- Sam Gittins - Teddy Shipman
- Billy Cook - Walter Shipman
- Naomi Battrick - Lily Timpson
- Phelim Drew - Serenader
- Steve Wilson - Bartleby
- Tim Faraday - Snelling
- Martin White - Grimes
- Charles Edwards - Lord Montacute
- Daniel Kendrick - Tom Denton
- Richard Goulding - Edgar Morton
- Alex Cusack - Matron
- Haydn Gwynne - George Tait
- Martin Compston - Edwin Havelock
- Peter McDonald - Dr. Anthony Rolle
- Emily Taaffe - Mary Tait
- Daniel Cerqueira - Mr. Glyn
- Bradley Hall - Apprentice
- Brendan Morrissey - Doorman
- Ian McElhinney - Theodore Swift
- Josh O'Connor - P.C. Bobby Grace
- Louise Brealey - Dr. Amelia Frayn
- Anton Giltrap - Arthur
- Elliot Levey - Ralph Ackerman
- Barbara Adair - Queen Victoria
- Ian Gelder - Joseph Chamberlain
- Andrew Brooke - Roy Teague
- Derek Riddell - Constantine
- Clare Foster - Elenora Freeman
- Izzy Meikle-Small - Valerie Freeman
- Stewart Scudamore - Risaldar-Major Haroun al-Qadir
- Ronny Jhutti - Imran Hafeez
- Sonya Cassidy - Leda Starling
- Jamie Ballard - Cornelius Wilde
- Charley Palmer Rothwell - Redskin Jake
- Jon Øigarden - Bo Nystrom
- Billy Seymour - Percy Orton
- Robert Donnelly - Arthur
- Noelle Brown - Workhouse Matron
- Julia Rosnowska - Magdalena Dobrowski
- Ed Hughes - Dr. Carlyle Probyn
- Dylan Smith - Tristram Blanchard
- Emelia Devlin - Camille Blanchard
- Janice Byrne - Agniezka
- Owen Teale - Felix Hackman
- Rob Compton - Wilbur Wren
- Jack McEvoy - Charlie Tanner
- Jake Mann - Thomas Gower
- David Warner - Rabbi Max Steiner
- Lynn Rafferty - Margaret Artherton
- Annabell Rickerby - Brazen Woman
- Anna Burnett - Mathilda Reid
- Anna Burnett - Alice
- Lucy Cohu - Deborah Goren
- David Threlfall - Abel Croker
- Brandon Maher - Croker's Boy
- Ian Pirie - Jenkins
- Bob Kelly - Uniformed Officer
- Fionna Hewitt-Twamley - Boarding House Manageress
- Conor Lambert - Human Billboard
- Eddie Jackson - Sparks
- Jodie McNee - Myrtle Waters
- Ross Armstrong - Leonard Waters
- Rupert Procter - Hospital Porter
- Paul Elliot - 'A' Division Officer 1
- Clive Russell - Fred Abberline
- Maeve Dermody - Prudence Sumner
- Gerry O'Brien - Jasper Sumner
- Joseph Mawle - Jedediah Shine
- Laurence Foster - Doctor Lennon
- Eoin Lynch - Coster
- Anna Koval - Rachel Castello
- Benjamin O'Mahony - Det. Sgt. Frank Thatcher
- Ellie Haddington - Agatha Chudleigh
- Ruairí Heading - Const. Moulton
- Lydia Wilson - Mimi Morton
- Jonas Armstrong - Nathaniel
- Joseph Harmon - Robin Sumner
- Killian Scott - Asst. Commissioner Augustus Dove
- Matthew O'Brien - Const. Renshaw
- Patrick Drury - Col. Sir Edward Bradford
- Marko Leht - George Chapman
- Jennifer Aries - Mary Jane Cox
- Michael Liebman - Theakson
- Andrew Lowe
- Ed Guiney
David Warner interpreta a Rabbi Max Steiner en la serie.
Frank Harper hace el papel de Silas Duggan.
Matthew Macfadyen interpreta a Edmund Reid en la serie.
Adam Rothenberg interpreta a Homer Jackson en la serie.
MyAnna Buring interpreta a Long Susan Hart en la serie.
Charlene McKenna interpreta a Rose Erskine en la serie.
Matthew Lewis hace el papel de Samuel Drummond.
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