- Kenneth Lonergan - Herbert Greenleaf
- Simona Senzacqua - Mrs. De Silva
- Bruno Crucitti - Chiropracter
- Bill Connington - Man with Hat
- Pernell Walker - SRO Clerk
- Steven Randazzo - Mr. Reddington
- Zac Jaffee - NY Banker
- Liam Craig - Shipyard Man
- Ann Cusack - Emily Greenleaf
- Freddy Drabble - Dentist
- Antonio Friello - Currency Clerk
- Alessandro Scepi - Naples Cab Driver
- Francesca Romana Bergamo - Ermelinda
- Pasquale Esposito - Pucci
- Loredana Piedimonte - Shopkeeper
- Arcangelo Iannace - Giulio
- Vittorio Viviani - Matteo
- Eliot Sumner - Freddie Miles
- Bokeem Woodbine - Alvin MacCarron
- Hildegard De Stefano - Mina
- Sara Magalotti Mondello - Teresa
- Renato Solpietro - Carlo
- Marco Mario De Notaris - Fausto
- Francesco Formichetti - Sanremo Desk Clerk
- Daniele Amendola - Sanremo Boatman
- Michaela Gargiullo - Sanremo Housekeeper
- Danilo Capuzi - Sanremo Taxi Driver
- Gioele Rotini - Capotreno
- Alessio Gallo - Carlo's Guy 1
- Andrea Venditti - Carlo's Guy 2
- Giuseppe Gentile - Excelsior Doorman
- Massimo De Lorenzo - Excelsior Desk Clerk
- Luca Della Bianca - Excelsior Porter
- Corrado Fortuna - Bolivar Desk Clerk
- Mauro Marino - Watchmaker
- Giacomo Zito - Rome Bank Teller
- Francesco Biscione - Rome Banker
- Franco Silvestri - Emilio Braganzi
- Paolo Maria Scalondro - Priest
- Anna Tangredi - American Express Clerk
- Andrea Lolli - American Express Clerk
- Margherita Buy - Sig. Silvana Buffi
- Alessandra Borgia - Neighbor
- Leonardo Sbragia - Dogman
- Maurizio Lombardi - Inspector Pietro Ravini
- Louis Hofmann - Max Yoder
- Lorenzo Lazzarini - Via Appia Policeman
- Antonio Bandiera - Dispatcher
- Giovanni Serratore - Coroner
- Ivan Alovisio - Car Rental Agent
- Gualtiero Burzi - Sergeant Trento
- Giacomo Colavito - Rome Desk Officer
- Germano Bellavia - Naples Officer
- Enrico Roccaforte - Palma Desk Clerk
- Alessandro Giallocosta - Nightclub Bouncer
- Claudio Camilli - Pensione Clerk
- Toni Pandolfo - Tabloid Reporter
- Francesco La Mantia - Savona Clerk
- Francesco Foti - Tenente Ferrara
- Tony Allotta - Palermo Police Officer
- John Malkovich - Reeves Minot
- Daniele Rienzo - Caravaggio
- Luca Di Prospero - Real Estate Agent
- Vittoria Scognamiglio - Anna
- Emanuele Barresi - Ugo
- Massimo De Santis - Tenente Moretti
- Eros Galbiati - Araldi Party Art Agent
- Lara Balbo - Araldi Party Actress
- Gabriel Lo Giudice - Party Artist
- Carola Abdalla Said - Party Actress
- Raffaele Braia - Venice American Express Clerk
- Fisher Stevens - Edward T. Cavanach, Esq. (uncredited)
- Austin Green - Mail Carrier
- Peter Thorell
- Patricia Highsmith
- Garrett Basch
- Kevin Fogarty
- Benjamin Forkner
- Sharon Levy
- Francesco Vedovati
- Enzo Sisti
- Jake O'Brien
- Jeff Russo
Andrew Scott interpreta a Tom Ripley en la serie.
Dakota Fanning hace el papel de Marge Sherwood.
Johnny Flynn hace el papel de Dickie Greenleaf.
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