- Vic Perrin - Smith
- Osa Massen - Janet Morrisey
- George N. Neise - Adams
- Dawn Richard - Laurie Gates
- Catherine McLeod - Mildred Tyler
- Charles Bronson - Dan Rocco
- Addison Richards - Evanson
- James Best - Jack Milhoan
- Luis van Rooten - Grant
- Geraldine Brooks - Helen Lear
- Bobby Jordan - Connie Thorpe
- Joyce Compton - Waitress
- Tom Greenway - Lieutenant Peters
- Lester Matthews - Frank Grace
- Roscoe Karns - Ed Church
- Keye Luke - Dr. Lin Chang
- Gloria Talbott - Jenny
- Norman Alden - Ben Regan
- Catherine Warren - Mrs. Houseman
- Ken Mayer - Jeffries
- Don Beddoe - Lieutenant Stone
- Phyllis Coates - Monica Freeborn
- Mort Sahl - Self
- Walter Barnes - Herbie Sanford
- Marguerite Chapman - Norma Randall
- Whitney Blake - Laura Westly
- Wally Brown - Milkman
- Jean Carson - Gloria Bartlett
- Don Durant - Pat Sharkey
- Elisabeth Fraser - Dorian Crane
- Corinne Calvet - La Moneca
- James Westerfield - McAllister
- James Drury - Arthur Harding
- Joyce Meadows - Linda Graham
- Patricia Blair - Julie
- Willis Bouchey - Lew Morse
- Joey Bishop - Joey Kirk
- Abraham Sofaer - Constantine
- Ruta Lee - Louise Thompson
- Michael Strong - George Maxton
- Lilyan Chauvin - Clara
- Peter Brocco - Harry Tyler
- Ned Glass - Fred Rice
- John Alvin - Doc
- Syd Saylor - The Handyman (uncredited)
- Harry Bellaver - Al Turbo
- Jerome Cowan - Marvello
- John Lupton - Mark Larsen
- Stafford Repp - Charley London
- Rita Moreno - Maria Ferrari
- Brad Dexter - Wilton Mills
- Maureen Arthur - Bobby
- Philip Ahn - Ho-Lung
- Eve Miller - Kay Wilson
- S. John Launer - Dr. Norton
- Don Keefer - Reagan
- Edgar Barrier - Durant
- Kasey Rogers - Janet Marquis
- Dave Willock - Henry Wilkins
- Henry Corden - Turk Stell
- Vic Morrow - Joe Rovi
- Harry Lauter - Charles Decker
- Virginia Gregg - Vivian's Voice (voice)
- Nick Adams - Mickey Houseman
- Alexander Lockwood - Carl Waldron
- Sean McClory - Ted O'Malley
- Jack Cassidy - Danny Fortune
- Ed Kemmer - Frank Sonnett
- Olan Soule - Mr. Danzig
- Berry Kroeger - Raoul Lopez
- Richard Crane - Arnie Baselice
- Gil Perkins - Dan Vale (uncredited)
- John Anderson - Paul Russell
- Joi Lansing - Diane
- Jesse White - Walt Conlin
- Barry Gordon - Tommy
- Hayden Rorke - Frank Judson
- Harry Bartell - Manager
- Alan Reed - Paul Trumbo
- Jacqueline Scott - Jan Smith
- Allison Hayes - Angel Case
- Carol Ohmart - Sally Chandler
- Robert Karnes - Jack
- Herb Vigran - George
- Herb Vigran - Johnson
- John Hubbard - Ken Walsh
- James Coburn - Victor Tavo
- Max Showalter - Bill Henry
- Lyle Talbot - Victor Long
- Jeanette Nolan - Dr. Tesla
- Jeanette Nolan - Edna Shaw
- Marc Lawrence - Vito Doria
- Doris Singleton - Mrs. Farrell
- Regis Toomey - Lt. Dennis McGough
- William Schallert - Johnny Prescott (uncredited)
- William Schallert - Charlie Kane
- Mary Tyler Moore - Sam (voice) (uncredited)
- Nestor Paiva - Emilio Tomas
- Nestor Paiva - Axel
- John Doucette - Corky
- Don Haggerty - Harry Maxton
- Larry Thor - Michaud
- Jay Novello - Beanley
- James Flavin - Sam Cooper
- Hillary Brooke - Laura Renault
- Hillary Brooke - Winifred O'Hara
- Victor Sen Yung - Magan
- Lee Van Cleef - Ed Murdock
- Douglas Fowley - Bailey
- Robert Ellenstein - Kirsen
- Joe Conley - Joe
- Joe Conley - Bartender
- Byron Foulger - Mr. Legett
- Edward Binns - Lieutenant Larrabee
- Claude Akins - Kenny Lambert
- Jocelyn Brando - Celia Saxon
- Marc Platt - Norman King
- Peter Hansen - Frank Bonner
- Peter Hansen - Tim Wilson
- Mark Roberts - Rod Leighton
- Jack Albertson - Fernando Faillace
- Christopher Dark - Rudi Trekhala
- Christopher Dark - Mickey Farmer
- Charles Lane - Lt. Kevin Anders (uncredited)
- Gregory Gaye - Van Zandt
- Joseph Ruskin - Chick
- Jon Lormer - Gerald Wilkerson
- Lawrence Dobkin - Warburton Flagge
- Lawrence Dobkin - Joey Kane
- Dolores Donlon - Evelyn Ames
- Celia Lovsky - Senora del Vayo
- Dennis Cross - Skipper
- Phillip Pine - King Satchel
- Ben Wright - Maxwell
- Joan Banks - Lee Swinnerton
- Dabbs Greer - Scooter Jaffee
- Robert Quarry - Arnie Bullock
- Robert Quarry - Larry
- Robert Quarry - Charlie Wendell
- Tommy Farrell - Frank Connolly
- Hal Baylor - Sailor Jackson
- Benny Rubin - Max Birnbaum (uncredited)
- Nick Dennis - Chico Burns
- Frank Albertson - Stuart Simons
- Frank Albertson - Gerald Clayton
- Sandy Kenyon - Lt. Harry Baker
- Gordon Jones - Mike Gower
- Gordon Jones - Joel Finlay
- Ellen Corby - Miss Carter
- Ellen Corby - Harriet Smith
- Nan Leslie - Myran O'Malley
- Jack Elam - Perk Butler
- Jack Elam - Danny Boy
- Vaughn Taylor - Julian Tyler
- John Beradino - Marty Stopka
- Doris Dowling - Marion Carl
- Peggy Maley - Sally
- Peggy Maley - Claire Toujours
- Peggy Maley - Babs Felt
- Russ Conway - Lt. Pete Kile
- Russ Conway - Lieutenant Kile
- Russ Conway - Alec Bruce
- James Hong - Young Man
- James Hong - Chung Lin
- Gloria Winters - Jane Thomas
- Gloria Winters - Dixie Moore
- King Donovan - Hamilton Chase
- Bethel Leslie - Faith Dryden
- Bethel Leslie - Harriet Morrow
- Joseph Mell - Fred Wilkins
- Barbara Baxley - Marcy Murdock
- Chick Chandler - Jimmy White
- John Mitchum - Jimmy Logan (uncredited)
- John Hoyt - Harding
- John Hoyt - Burnison
- Steve Brodie - Ken Bronson
- Robert Gist - Joe Quincy
- Frank Ferguson - Captain Hoyt
- Ingrid Goude - Eve
- Billy Halop - Charlie Cole
- Barbara Stuart - Dee Dennis
- Carlos Romero - Jose
- Carole Mathews - Rita Kirk
- Charles Aidman - George Belden
- Charles Aidman - Joe Vale
- Dick Foran - David Steele
- Howard McNear - Dr. Braun
- Jack Kruschen - Max Schilling
- DeForest Kelley - Kenneth Porter
- DeForest Kelley - Sheriff
- Mickey Simpson - Harry Brice
- Mark Scott - Guard (uncredited)
- Jean Willes - Madge
- Patricia Donahue - Harriet Barnes
- Patricia Donahue - Mindy Parker
- Patricia Donahue - Bunny
- Lane Bradford - Sol Noonan
- Eddie Quillan - Mel Jones
- Merry Anders - Claudia Reed
- John Harmon - Jerry
- Jan Shepard - Betty Wilson
- Eleanor Audley - Agnes Wilton
- Eleanor Audley - Mrs. Deneken
- Patricia Huston - Myra Cantrell
- Ross Elliott - Bill Reade
- Ross Elliott - Walter Cummings
- Ross Elliott - Norman Dewitt
- Joanna Barnes - Joyce Long
- Bill Erwin - Sgt. Riker
- Ross Martin - Nate Muro
- Ross Martin - Tony Gino
- Dennis Moore - Motorcycle Cop
- Jack Lambert - Hammer Gus
- Clegg Hoyt - The Masseur
- Michael Fox - Paul Schofield
- Michael Fox - Ted Anthony
- Michael Fox - Brother Joshua
- Naura Hayden - Georgia
- Carol Morris - Myra Kendricks (uncredited)
- Kipp Hamilton - Yvette Greener
- Irene Hervey - Mary Forsythe
- Jack Shea - Officer
- Suzanne Alexander - Brunette
- Richard Reeves - Thug (uncredited)
- Richard Reeves - Willie Gibson
- Richard Reeves - Steve Gorgas
- Arthur Batanides - Chip Cooper
- Arthur Batanides - Wally
- Barbara Pepper - Mrs. Brody
- Barbara Pepper - Clara Chase
- Chris Alcaide - Robert Knight
- Chris Alcaide - First Thug
- Bartlett Robinson - Clifton
- Bartlett Robinson - Albert Gunther
- Bartlett Robinson - Otto Carl
- Bartlett Robinson - Paul Manners
- Peter Leeds - Harold Jason / Sidney Gordon
- Peter Leeds - Green
- Peter Leeds - Waldo Lattimer
- Peter Leeds - Frank
- Jana Lund - Marilyn Ann McAllister
Joey Bishop hace el papel de Joey Kirk.
Vaughn Taylor interpreta a Julian Tyler en la serie.
Marc Lawrence interpreta a Vito Doria en la serie.
Robert Ellenstein hace el papel de Kirsen.
Edward Binns interpreta a Lieutenant Larrabee en la serie.
Charles Bronson interpreta a Dan Rocco en la serie.
Jack Albertson hace el papel de Fernando Faillace.
Alan Reed interpreta a Paul Trumbo en la serie.
James Flavin interpreta a Sam Cooper en la serie.
Nick Dennis interpreta a Chico Burns en la serie.
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