- James Tupper - David Clarke
- Barry Sloane - Aiden Mathis
- Hiroyuki Sanada - Satoshi Takeda
- Cary-Hiroyuki Tagawa - Satoshi Takeda
- Henry Czerny - Conrad Grayson
- Amber Valletta - Lydia Davis
- Elena Satine - Louise Ellis
- Brian Hallisay - Ben Hunter
- LaMonica Garrett - Agent Stiegel
- Shannon McClung - Reporter
- Amy Landecker - Dr. Michelle Banks
- Christopher Goodman - Driver
- Ciara Hanna - Amy
- Adrienne Barbeau - Marion Harper
- Brian Goodman - Carl Porter
- Michael Trucco - Nate Ryan
- JR Bourne - Kenny Ryan
- Annabelle Stephenson - Sara Munello
- Derek Ray - Lee Moran
- James McCaffrey - Ryan Huntley
- CCH Pounder - Warden Sharon Stiles
- Jamal Duff - Big Ed
- Wendy Crewson - Helen Crowley
- Michael Nardelli - Trey Chandler
- William Devane - Edward Grayson
- James Morrison - Gordon Murphy
- Roger Bart - Mason Treadwell
- Ashton Holmes - Tyler Barrol
- Dilshad Vadsaria - Padma Lahari
- Jennifer Jason Leigh - Kara Wallace Clarke
- Margarita Levieva - Amanda Clarke
- Max Martini - Frank Stevens
- Robbie Amell - Adam Connor
- Matthew Glave - Bill Harmon
- Courtney B. Vance - Benjamin Brooks
- Yancey Arias - Tom Kingsly
- Vic Chao - Mr. Wu
- Ben Bode - Dean Todd Walton
- Sherri Saum - Donna Carlisle
- Susan Park - Edith 'Fa1c0n' Lee
- Courtney Love - White Gold
- R. Keith Harris - Doug Reid
- Christina Chang - Karrie Thurgood
- Nicholas Stargel - Young Jack
- Nicole Pulliam - Diane Kingsly
- Alex Carter - Michael Davis
- Cassius M. Willis - Detective Robert Gunther
- Ed Corbin - Bull
- Gary Kraus - Teddy
- Alicia Coppola - Melissa Andetson
- Gina Gallego - Dr. Aguilar
- Sybil Temchen - Detective West
- Braden Fitzgerald - Young Aiden
- Danielle Rayne - Heather
- John Billingsley - Roger Halsted
- Davida Williams - Brenda
- Michael Medico - Bartender
- Julie Dretzin - Dr. Buchanan
- Ken Lally - Hired Gun
- B.J. Clinkscales - EMT
- Chris Gann - Guard
- Tom Riordan - SWAT Leader
- Emily Alyn Lind - Young Amanda Clarke
- Emily Alyn Lind - Young Amanda
- Gina Torres - Natalie Waters
- John Cothran - Kern
- Bryan Dodds - Hotel Clerk
- John Barbolla - Sergeant Nelson
- John Barbolla - Chief Nelson
- Tommy Flanagan - Malcolm Black
- Nestor Serrano - Chief Edward Alvarez
- Courtney Ford - Agent Kate Taylor
- Iris Bahr - Detective Adams
- David Moses - Pastor Saunders
- Carolyn Hennesy - Penelope Ellis
- Sebastian Pigott - Lyman Ellis
- Ed Quinn - James Allen
- Kim Richards - Stephanie
- Jennifer Birmingham Lee - Maria
- Rod McCary - Judge Miller
- Don Fischer - Mayor Laken
- Angie DeGrazia - Reporter
- Dan Sachoff - Manager
- Hannah McCloud - Young Louise
- Chris Prascus - Staff Member
- Holly Hawkins - Dr. Angela Sturman
- Diogo Morgado - Dr. Jorge Velez
- E.J. Bonilla - Marco Romero
- Lizet Garcia - Photo Girl (uncredited)
- Brianne Howey - Eve
- Tom Virtue - Doctor
- Lindsey Garrett - Melissa
- Greg Perrow - Malcolm
- Amy Parrish - Kate Reynolds
- Raymond Shepard - Prison Guard
- Anthony Reynolds - SWAT Member
- Leon Pridgen - Paramedic
- Jason Davis - Doctor
- Camille Robinson - Tiffany
- Diane Mizota - Anchor
- Elena Evangelo - Valerie
- Brandon P. Bell - Steven Gordon
- Nina Fehren - Cameron Lang
- Kim Swennen - Erin
- John Roderick Davidson - FBI Agent
- Kati Sharp - Kim
- Candace Kita - Rosemary Cabot
- Leslie Stevens - Miriam
- Carly Thomas Smith - Everly
- Judy Echavez - Reporter
- Michael Gambino - Delivery Man
- Cecelia Specht - Woman
- Bodie Newcomb - Fisherman
- Tracey Rooney - Nurse
- Maya Hazen - Hikari
- Margot Farley - Uniformed Cop
- Erin Underwood - Child Services Worker
- Merrin Dungey - Barbara Snow
- David Monahan - Dr. Alexander Barrol
- Angel Murphy - Police Officer
- Dig Wayne - Interviewer
- Kerry Knuppe - Redhead
- Marcus Choi - Photographer
- Veronica Cartwright - Judge Elizabeth Blackwell
- Elena Fabri - Reporter
- Mel Fair - Newscaster
- Leif Gantvoort - Bartender
- Jeremy Shouldis - Officer Rivers
- Barbara Williams - District Attorney
- Shevaun Kastl - Ann Woodbury
- Jessica Vilchis - Flashback Reporter
- Andy Manning - Officer Jordan
- Keana Hall - Maid
- Michael Reilly Burke - Agent John McGowen
- Barry Livingston - Headmaster
- Cynthia McFadden - Cynthia McFadden
- Gena Shaw - Kyla
- Tara Platt - Becca
- Logan Bartholomew - Dude
- Rachel DiPillo - Jaime Cardaci
- Marcus Giamatti - Dr. Ray Clemons
- Thomas Daniel Smith - Dealer
- Laura Kelly - Flight Attendant
- Barbara Eve Harris - Connie Bales
- Suzanne Rico - Reporter
- Benjamin Schrader - Computer Guy
- Alyvia Alyn Lind - Young Amanda
- Olivier Martinez - Pascal LeMarchal
- Todd Grinnell - Dr. Jeffrey Thomas
- Gita Reddy - Receptionist
- Michael Albala - Andrew Parker
- Hugh Holub - Detective
- Sabin Rich - Employee
- Latarsha Rose - Rachel Fisk
- Ariel Llinas - Security Guard
- Brittany Alexis Phillips - Destiny
- Alejandro Furth - Inspector
- Peter James Smith - ER Doctor
- Grace Caroline Currey - Victoria Harper
- Grace Caroline Currey - Young Victoria
- Matt Riedy - Ben Greevey
- Matt Riedy - Ben Greevy
- Danny Vasquez - EMT
- Carmen Mormino - Doctor
- Greg Collins - Mick
- Rick Fitts - Officiant
- Stephanie Maura Sanchez - Reporter
- Stephanie Maura Sanchez - News Anchor
- Catherine Kamei - Investor
- Jonathan Adams - Matt Duncan
- Amanda Brooks - Young Marion Harper
- Nate Gill - Teenage Boy
- Nate Gill - Rocco
- Timothy V. Murphy - Dmitri Bladov
- Salvator Xuereb - Sergei Lvovsky
- Michael Rose - Joe Ryan
- Stephen Snedden - Thomas
- Joaquim de Almeida - Salvador Grobet
- Daniel Graves - Priest
- Geoff Pierson - Robert Barnes
- Clare Carey - Patricia Barnes
- Jay Seals - Eddie Solomon
- Nick Lee - James Palmer
- Dylan Walsh - Jason Prosser
- Sean Whalen - Skeet
- Gary Carlos Cervantes - Auctioneer
- Stephanie Jacobsen - Niko Takeda
- Gemma Massot - Colleen Mathis
- Burn Gorman - Trask
- Maya Goodwin - Guard
- Collins Pennie - Eli James
- Bruno Amato - Fred Harris
- Michael Tennant - Wes Rogers
- Kendall Clement - Insurance Adjuster
- Dendrie Taylor - Meredith Hayward
- Anjul Nigam - Zahir Lahari
- Myra Turley - Rebecca Gallagher
- Seychelle Gabriel - Regina George
- Marcos A. Ferraez - Detective Durand
- Page Leong - Doctor
- Brandon Keener - Evan Spradlin
- Kate Herman - Sloane Hanover
- Jack Guzman - Officer
- Jack Guzman - Guard
- Eric Zuckerman - Tom Mullen
- Jessica Tuck - Alison Stoddard
- JuJu Chang - Self
- Phil Tyler - Cop
- Falk Hentschel - Gregor Hoffman
- Donna Rusch - Newscaster
- Bill Seward - Newscaster
- Marc Istook - Newscaster
- Brian Lally - Security Guard
- Guy Nardulli - Security Guard
- Louis Herthum - Agent Gentry
- Larry Sullivan - Dr. Norton
- Charles Carpenter - Fireman
- Rosemary Dominguez - Maid
- Rosemary Dominguez - Theresa
- David Lim - Fireman
- Barry W. Levy - Security Guard
- Justin Hartley - Patrick Osbourne
- James Le Gros - Paul Whitley
- Jim Jansen - Monk
- Nick Heyman - Waiter
- Kathleen York - Sheila Lurie
- Conor Leslie - Bianca
- Brianna Brown - Lacey
- Jack Merrill - Detective March
- Victoria Park - Anna
- Kavita Patil - Lucinda Martin
- Mustafa Speaks - Paramedic
- Tiffany Jeneen - Nurse
- Sal Landi - Mr. Marino
- Paris Benjamin - Boutique Owner
- Donnell Turner - Investor
- Gloria Votsis - Morgan Holt
- Ana Ortiz - Bizzy Preston
- Brendan Ford - Jeff Preston
- Anil Kumar - Rohan Kamath
- Alex Solowitz - Blackmailer
- Robert Mitchell - James Dennis
- Julian Barnes - Anderson
- Gregory Zarian - Benny
- Matt McAbee - Waiter
- Nazneen Contractor - Jessica Roche
- Juan Alfonso - Delivery Guy
- David Wells - Priest
- Louie Alegria - Reporter
- Fredric Lehne - Detective
- Joel Bryant - Police Officer
- Caroline Whitney Smith - Police Officer
- John Knox - Fisherman
- Daniel Steven Gonzalez - Cop
- Gail O'Grady - Stevie Grayson
- Brett Cullen - Jimmy Brennan
- Jayne Brook - Loretta Deaton
- Dar Dixon - Dr. Derek Robinson
- Joe Abraham - Man
- Tina Casciani - Larissa
- Steven Strait - Brooks
- Travis Myers - Mickey
- Paul Norwood - Paul Charney
- Gonzalo Escudero - Stefano Leone
- Jessica Clark - Pretty Woman
- Henri Esteve - Javier Salgado
- David L. King - Richard
- Morgan Fairchild - Teresa
- Kristin Carey - Sophie
- Jesse Bernal - Dealer
- Michael Rubenstone - Bartender
- Claire Jacobs - Harriet Mathis
- Len Cordova - Alberto Loya
- Jessie Lande - Maid
- Tim DeKay - Luke Gilliam
- John Prosky - Brenda Evans / Oscar Chapman
- Tessa Munro - Maria
- Linc Hand - Kurt Renner
- Bree Condon - Kristiana Rubins
- Anthony Palermo - Detective
- Kai Braden - Sexy Nerd
- Tyler Jacob Moore - Detective Brian Hosko
- Melanie Lewis - Nanny
- Nicola Lambo - Reporter
- Daniel Zovatto - Gideon LeMarchal
- John Rubinstein - Judge Rivers
- David Starzyk - Conrad's Lawyer
- Monique Gabriela Curnen - Detective Reyes
- Wade Williams - Officer Jim Mostrowski
- Scott Alan Smith - Dr. Johnson
- Anthony Alabi - Officer Rinella
- Marc Forget - French Official
- Jay Jackson - News Anchor
- Yeardley Smith - Phyllis
- Alicia Lagano - Nancy
- Ned Vaughn - Dennis Foley
- Allison McAtee - Jennifer Foley
- Ray Proscia - Dr. Miller
- Chasty Ballesteros - Kaya
- Nicholas James - Mark Keller
- Irene Roseen - Olga
- Ryan P. Shrime - Buyer
- Jean-Christophe Febbrari - Francois
- Christopher Grove - Jerry Thomas
- Kamala Jones - Vanessa
- Aria Pullman - Brunette
- Kandis Mak - Hostess
- Rochelle Robinson - Waitress
- Al Coronel - Officer
- Bradley Snedeker - Miles VanBuren
- Jussie Smollett - Jamie
- Michael Greco - Simon
- Stephen Apostolina - Fire Investigator
- Reshaun Jones - EMT
- Lola Glaudini - Susan Luke
- Cloie Wyatt Taylor - Officer Townsend
- Andy Favreau - Cameron
- Chris Wolfe - News Anchor
- Eltony Williams - Sergeant Kokame
- Payson Lewis - Bellhop
- Kal Bennett - Simone
- Evan Holtzman - Waiter
- Shannon Barney - Beach Club Waitress (uncredited)
- Charles Shaughnessy - Charles Dawson
- Rebecca Tilney - Buffy Van Pelt
- David Terrell - Detective
- Jason Sims-Prewitt - Guard
- Anzu Lawson - Dr. Albright
- Chase Kim - Yang
- Matthew Yang King - Agent Lin
- Phil Abrams - Estate Lawyer
- Julissa Calderon - Waitress
- Al Carabello - Miguel
- Sarah Lancaster - April Hunter
- Trenton Rostedt - Wes Perkins
- Joanna Sotomura - Phoebe
- Paul Sanchez - Officer Vasquez
- Pilar Holland - Reporter
- Bradley White - George Easton
- Lucinda Jenney - Judge Leanne Knowles
- Tim Powell - Alexander Strouse
- Maria McCann - Doctor
- Liz Jenkins - Lab Tech
- Christopher Wiehl - Kevin Hunter
- Helen Sadler - Brigitte
- M.J. Karmi - Donna
- Matt Corboy - Agent Baker
- Matthew Lenhart - Doctor
- Allen Warchol - Detective Yamada
- Carmella Riley - Detective Harris
- Clint Carmichael - Chief Kowalski
- Asante Jones - Fireman
- Ian Vogt - Fire Marshal
- Eugene Young - CSI Tech
- Marc Valera - Officer Peretti
- Tom Amandes - Lawrence Stamberg
- Drew Rausch - Daryl
- Angela Elayne Gibbs - ADA Ganz
- Stephen Mendel - Judge Moss
- Dee Baldus - Gail
- Jayden Lund - Gus
- Stewart Skelton - Henri
- Ajarae Coleman - Jail Guard
- Josh Breeding - Morgue Clerk
- Cazimir Milostan - Desk Sergeant
- George Ketsios - Mascelli
- Cassandra Relynn - Rothman
- Joseph Will - Surgeon
- Jensen LeFlore - Young Man
- Chad Bennett - SWAT Member
- Christopher Allen - EMT
- David Jason Perez - July
- Mark S. Glick
Connor Paolo hace el papel de Declan Porter.
Tommy Flanagan interpreta a Malcolm Black en la serie.
Ashton Holmes interpreta a Tyler Barrol en la serie.
Emily VanCamp hace el papel de Emily Thorne.
Madeleine Stowe hace el papel de Victoria Grayson.
Joshua Bowman interpreta a Daniel Grayson en la serie.
Nick Wechsler interpreta a Jack Porter en la serie.
Gabriel Mann interpreta a Nolan Ross en la serie.
Christa B. Allen interpreta a Charlotte Grayson en la serie.
Karine Vanasse interpreta a Margaux LeMarchal en la serie.
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