- Keke Palmer - Rochelle Hillhurst (voice)
- Keke Palmer - Connie's Friends #2 (voice)
- David Thewlis - Lionel St. Swithens (voice)
- David Thewlis - Memory Bank Manager (voice)
- Pamela Adlon - Sonya Poinsettia
- Pamela Adlon - Sonya Poinsettia (voice)
- Brandon Kyle Goodman - Walter Las Palmas (voice)
- Brandon Kyle Goodman - Dev (voice)
- Brandon Kyle Goodman - Sarah's Clients #1
- Maya Rudolph - Connie LaCienega (voice)
- Maya Rudolph - Dante's Dick (voice)
- Maya Rudolph - Grace (voice)
- Maya Rudolph - Traci (voice)
- Maya Rudolph - Bonnie LaCienega (voice)
- Nick Kroll - Maury Beverley (voice)
- Nick Kroll - Rick (voice)
- Nick Kroll - Adolf Hitler (voice)
- Nick Kroll - Todd (voice)
- Nick Kroll - Spaghetti Man (voice)
- Nick Kroll - Anthony Pinata (voice)
- Nick Kroll - Cocky Balls-Boa (voice)
- Nick Kroll - Moneyballs (voice)
- Nick Kroll - Ethan (voice)
- Nick Kroll - Priest (voice)
- Thandiwe Newton - Mona (voice)
- Mark Rivers - (voice)
- Casey Wilson - Empathy Mulholland (voice)
- James Adomian - Becca's Baby's Need Demon (voice)
- Ashley London - (voice)
- Ashley London - Dept. of Magical Thinking Announcer (voice)
- Helen Mirren - Shame Wizard Rita St. Swithens (voice)
- Max Silvestri - (voice)
- Ariana DeBose - Danielle (voice)
- Sabrina Jalees - Nadia (voice)
- John Mulaney - Andrew Glouberman (voice)
- James III - Cat Stevens (voice)
- Mitra Jouhari - (voice)
- Kayvan Novak - Arsalan (voice)
- Lupita Nyong'o - Shame Wizard Asha (voice)
- Chris O'Dowd - Flanny the Lovebug (voice)
- Chris O'Dowd - Flanny O'Lympic (voice)
- Godfrey - (voice)
- Janelle Monáe - Claudia (voice)
- John Gemberling - Tyler Pico (voice)
- Nidah Barber - Yara (voice)
- Ahmed El-Mawas - Amir (voice)
- Harvey Guillén - José the Spider Receptionist (voice)
- Mike Birbiglia - Barry (voice)
- Hugh Jackman - Dante (voice)
- Gil Ozeri - Gil (voice)
- Ali Wong - Becca Lee (voice)
- Tim Robinson - Doug (voice)
- Ulka Simone Mohanty - Nabilah (voice)
- Maria Bamford - Tito Taylor Thomas / Kitty Dukakis / Becca's Need Demon (voice)
- Maria Bamford - Tito the Anxiety Mosquito (voice)
- Josie Totah - Natalie (voice)
- Florence Pugh - Sarah Crumbhorn (voice)
- Joe Wengert - Joe (voice)
- Joe Wengert - Doctor (voice)
- Joe Wengert - Daycare Teacher (voice)
- Joe Wengert - Blonde Zombie #2 (voice)
- Joe Wengert - Young Blonde's Husband (voice)
- Joe Wengert - Mr. Questions (voice)
- Bobby Cannavale - Gavin Reeves (voice)
- Rosie Perez - Petra the Ambition Gremlin (voice)
- Miley Cyrus - Van the Logic Rock (voice)
- Niecy Nash-Betts - Hope (voice)
- Cole Escola - Montel (voice)
- Eugene Levy - Paul Crumbhorn (voice)
- Caleb Hearon
- Andrew Goldberg
- Monique Mosee
- Max Silvestri
- Victor Quinaz
- L.E. Correia
- Kelly Galuska
- Andrew Goldberg
- Nick Kroll
- Kelsey Cressman
- Jennifer Flackett
- Mark Levin
Nick Kroll interpreta a Maury Beverley (voice) en la serie.
Kayvan Novak interpreta a Arsalan (voice) en la serie.
Rosie Perez interpreta a Petra the Ambition Gremlin (voice) en la serie.
Brandon Kyle Goodman interpreta a Walter Las Palmas (voice) en la serie.
Aidy Bryant hace el papel de Emmy Fairfax (voice).
Randall Park hace el papel de Pete Doheny (voice).
Keke Palmer hace el papel de Rochelle Hillhurst (voice).
David Thewlis hace el papel de Lionel St. Swithens (voice).
Maya Rudolph interpreta a Connie LaCienega (voice) en la serie.
Pamela Adlon hace el papel de Sonya Poinsettia.
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