- Abigail Spencer - Dr. Misha Nelson
- Greg Allan Martin - Carl Sorenson
- Raquel Davies - Mallory
- Declan Whaley - Asher Foster
- Eddie Diaz - Bartender
- Matthew Glave - Tommy Flynn
- Camille Chen - Naomi Lee
- Jalen Thomas Brooks - Sean
- Jeff Doucette - Daniel
- Adam Arkin - Mark Duncan
- Leif Gantvoort - Rex Tayler
- Shirley Jordan - Willa
- Geoffrey Kennedy - Davis
- Mary McDonnell - Helen Peterson
- Mary McDonnell - Helen
- Michelle LaRue - Lily Duncan
- Karina Noelle Castillo - Associate
- Rand Holdren - Emcee
- Christine Hassay - Amy
- Diana Tanaka - Judge
- Nicola Lambo - Marta Dawson
- Tricia Munford - Talia
- Nelson Cheng - Adam Walker
- Alma Martinez - Maria
- Conner Marx - Jordon
- Misty Marie - Protester
- Sandra Cevallos - Jill Putnam
- Debbie Fan - Jin Kim
- Mo McRae - Amir
- Mo McRae - Amir Johnson
- Dan Bucatinsky - Professor Jason Erickson
- Thomas Crawford - Fred Harper
- Jodi Harris - Teri Hilliard
- Mayuri Bhandari - Nurse Kelly
- Sharon Lawrence - Angela Foyer
- Nina Millin - Judge Katerina Bobiak
- Angela Lin - Christine Bautista
- Hunter Stiebel - Allan
- Stephen Jared - Tim Park
- Sunita Param - Louise
- Nardeep Khurmi - Parham Kabir
- Shaw Purnell - Glenda
- Dorian Missick - Rick
- Frankie Zabilka - Matthew Hilliard
- Nancy Youngblut - Maria Sorenson
- Laird Macintosh - Marvin
- Elena Campbell-Martinez - Dr. Gloria Cortez
- Georgina Reilly - Tamsin Pless
- Cinda Adams - Donna Young
- Angela Fornero - Pathology Tech
- Irene Choi - Kate Foster
- Larry Sullivan - Cameron Foster
- Chloé Wepper - Carmen
- Eva Tamargo - Sharon Cruz
- David Clayton Rogers - Victor Gibson
- Leonard Roberts - Randall Vokelberg
- Elijah Mahar - Security Guard
- Peter Paige - Karsten Vokelberg
- Eliza Shin - Doctor
- Dwayne Colbert - Intake Nurse
- Juli Cuccia - Witness
- Julie Schmid - Reporter
- Jennifer Field - Reporter
- Monika Casey - Organizer
- B Z Cullins - Bailiff
- Lauren Letherer - Melanie Milcher
- Tyee Tilghman - Steve Rainey
- Ian Nunney - Danny Irwin
- Howard Grigsby
- Marc Webb
- Erin Brockovich
Mary McDonnell hace el papel de Helen Peterson.
Katey Sagal interpreta a Annie “Rebel” Bello en la serie.
John Corbett interpreta a Grady Bello en la serie.
Andy García interpreta a Cruz en la serie.
James Lesure hace el papel de Benji.
Tamala Jones interpreta a Lona en la serie.
Lex Scott Davis interpreta a Cassidy en la serie.
Ariela Barer interpreta a Ziggie en la serie.
Kevin Zegers interpreta a Nate en la serie.
Sam Palladio interpreta a Luke en la serie.
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