- Alex Carter - Yannis Kalvos
- Andrea Davis - Administrator
- Andrew Moodie - Police Captain Jules Charloix
- Christian Bako - Niko Kalvos
- James Downing - Bernard Clarke
- Jasmine Chen - Receptionist
- Marie Ward - Beth Miller
- Nneka Elliott - Reporter
- Tom Barnett - Vince Miller
- Tomaso Sanelli - Jason Miller
- Jess Salgueiro - Marisol
- Jane Perry - Jane Ferguson
- Sheena Bhattessa - NSA Special Agent Karen Stokes
- Demore Barnes - Todd Kendall
- Sebastian Pigott - Gerry Reed
- Kevin McGarry - Michael Reed
- Ian Porter - Joe Hearst
- Zahra Bentham - Lisa Newham
- Mikhail Safronov - Victor Volynets
- Yennis Cheung - Jaden Chin
- Thomas Chaanhing - Xiao Wei-Shing
- Joel Phillimore - Charles
- Caroline Boulton - Therapist
- Peter Schueller - Fan
- Amanda Arcuri - Taylor
- Declan Prior - Nolan
- Rosie Fellner - Anita
- Anthony Howell - Lucas
- Felix Scott - Randall
- Marjorie Yates - Frances
- Terence Maynard - Tony
- Julia Lalonde - Angelica
- Attila Beros - Jack
- Gage Munroe - Chris
- Thamela Mpumlwana - Liam
- Bobby Lockwood - Sean
- Marc Bendavid - Bruno Lessio
- Robinne Fanfair - Becky
- Ari Cohen - Coach McDougall
- Ted Whittall - Captain Tremblay
- Natalie Lisinska - Fiona Stemkowska
- David Lloydy - Cop
- Morgan Kohan - Evie Beaumont
- Trenna Keating - Simone Merriweather
- Marianthi Evans - Rose Klein
- Dávid Miller - Timbo Baltazar
- Leilah Isaac - Leila Behbahani
- Amira El Sayed - Sofia Cardenas
- Demetri Goritsas - Stan Merker
- Bruce Ramsay - Carson James
- Nicholas Wittman - Mechanic
- Jeroen Spitzenberger - Daniel
- Claire De Boer - Lana
- Tamás Szabó Sipos - Young Man
- Márton Nagyszokolyai - Bodyguard
- Márton Vincze - Paramedic
- Tobias Nierop - Elian
- Jan Hammenecker - Ira Janssen
- Márk Hankó - Guard
- Shawn Doyle - Vincent Keough
- Craig Arnold - Ryan McNamara
- Jonathan Whittaker - Detective Colton Meyers
- Nola Augustson - Lydia March
- Gretchen Egolf - Shannon Smith
- Christopher Bowen - Ben Smith
- Eddie-Joe Robinson - James Smith
- Ethan Pugiotto - Cody Hallam
- Erica Deutschman - Brooke Reid
- Jenessa Grant - Evie
- Amber Goldfarb - Wendy Vaughan
- Nicolette Pearse - Keeva Wyman
- Katia Bokor - Brenda
- Ben Radcliffe - Henry Cummings
- Anita Nittoly - Hostage
- Brianna Goldie - Hostage
- Christopher Cordell - Hostage
- Dewshane Williams - Jaquan Lewis
- Kim Roberts - Mrs. Lewis
- Krista Bridges - Mary Hofstedter
- Philip Riccio - Marvin Hofstedter
- Jeff Roop - Mike Hallam
- Mouna Traoré - Kim Newham
- Julie Khaner - Dr. Helen Rowe
- Scott Cavalheiro - Bradley Blair
- Debra McCabe - Merton Bulla
- Sarah DaSilva - Amy Hallam
- J.C. Kenny - Reporter
- Christef Desir - Fan
- Athena Karkanis - Angie Rose
- Joris Jarsky - Zachary Smith
- Daniel Kash - Teddy Grimes
- Neil Napier - Bill Winks
- Claire Rankin - Commander Nina Sellars
- Sherry Miller - Elizabeth Bloom
- Al Sapienza - Deputy Commissioner Patrick Fletcher
- Drew Carnwath - Donald Winston
- Enrico Colantoni - Joe Morris
- Steve Byers - Fraser
- Natalie Krill - Addison Reid
- Anna Hopkins - Annie Kapila
- Greg Bryk - Rand Govender
- Natalia Payne - Cheryl Morris
- Piper Howell - Hayley Morris
- Nadine Whiteman - Cross Guard
- Rothaford Gray - Edgar Yates
- Herschel Andoh - DEA Officer
- Jessica Parker Kennedy - Charlotte Walker
- Nicolas Van Burek - FBI Tactical Team Lead
- Amy Wren - Celina Walker
- Matt Rippy - Dylan Figgis
- Ariane Zantain - Noëlle Alli
- Marie-France Alvarez - Lucie Planchais
- Martial Bezot - Antoine
- Serge Dupire - David
- Erik Knudsen - Lucas Hamil
- Greta Onieogou - Keri Madsen
- Shauna MacDonald - Alexis Duspleis
- Munro Chambers - Cameron Duspleis
- Matthew Bennett - Bryce Corman
- Andy Yu - Victor
- Richard Fitzpatrick - Dr. Donald Prentice
- Joanne Reece - Margaret
- Chris George - River
- Tzi Ma - Lormong Vang
- Patrick Kwok-Choon - Kaus Cheng
- Jacky Lai - Michelle Vang
- Greg Chan - Sawm Cheng
- Donald Heng - Ryan Cheng
- Mung-Ling Tsui - Sun Lin Vang
- Nicole Law - Nalanie Kim
- Samantha Madely - Ellen Folger
- Billy Parrott - Uniformed Officer
- Megan Jones - Mia
- Thierry René - Jean-Luc
- Ruth Gemmell - Laurie
- Robert Cavanah - Rafael Blauch
- Dean Ashton - Carlo Davies
- Lucy Gaskell - Aunt Gina
- Florence Coste - Julia
- Jade Fortineau - Charlotte
- Isalinde Giovangigli - Trudi
- Julien Faure - Enforcer
- Louis-Emmanuel Blanc - Guard
- Léonard Rollin - Steward
- Kristen Hager - Isabelle Kalish
- Aaron Ashmore - Sydney Graves
- Jake Epstein - Jasper Edwards
- Arnold Pinnock - Eugene
- Melissa O'Neil - Drita Jakupi
- Darrin Baker - Arnaud 'Arnold' Castel
- Sonja Smits - Gwyneth Davenport
- James Palmer - Dr. Reynolds Baker
- Sophie Simnett - Sofia Bonnar
- Aron Tager - Grandfather
- Steve Cumyn - Larry Walker
- Juliette Dol - Camille Lambert
- Joshua Dickinson - Boyd Ferguson
- Severn Thompson - Fiona Walker
- Leo Suter - Simon Holman
- Anna Bullard - Britta Mauer
- Risha Nanda - High School Teacher
- Christopher Colquhoun - Gavin Nichols
- Paul Adeyefa - Logan Smythe
- Trevor Sellers - Andrew Holman
- Ophélie Koering - Caroline Lambert
- Jérôme Pradon - Jacques Lambert
- Andrea Schieffer - Katharina Mauer
- Oliver Dimsdale - Christian Bonnar
- Joséphine de la Baume - Maria
- Neet Mohan - Dede
- Yann Sundberg - Jakob
- Carlo Rota - Damian Delaine
- Emma de Caunes - Nathalie Denard
- Michael Ironside - Freddie Woods
- Pippa Nixon - Victoria Locke
- Adam Astill - Marcus Edwards
- Scott Thrun - FBI Agent
- Daniel Malik - Sam Rigaud
- Ádám Farkas - FBI Guard at Hospital
- Peter Outerbridge - Tanner Donovan
- Noam Jenkins - Thomas Kent
- Ted Atherton - Travis Beaton
- Tony Nappo - Dale McIntosh
- Sabrina Grdevich - Heidi Ambrose
- Jefferson Brown - Jonah Preston
- Zoie Palmer - Jasmine Bradshaw
- Gianpaolo Venuta - Malcolm Raskin
- Janet Porter - Anna Sutherland
- Raymond Ablack - Piers Allard
- Alicia Dea Josipovic - Dawn Eastman
- Scott Anderson - Oscar
- Richard J. Lewis
- Sturla Gunnarsson
- Laurence Katrian
- April Mullen
- Frédéric Forestier
- Paul A. Kaufman
- Annmarie Morais
- Roslyn Muir
- Vincent Shiao
- Steve Cochrane
- Rachel Anthony
- Faisal Lutchmedial
- Frank Spotnitz
- Jennifer Kawaja
- Julia Sereny
- Odile McDonald
- Valerie Pechels
Kim Roberts interpreta a Mrs. Lewis en la serie.
Erik Knudsen interpreta a Lucas Hamil en la serie.
Emma de Caunes interpreta a Nathalie Denard en la serie.
Greg Bryk interpreta a Rand Govender en la serie.
Luke Roberts interpreta a Eric Beaumont en la serie.
Brandon Jay McLaren interpreta a Oliver Yates en la serie.
Nazneen Contractor hace el papel de Zara Hallam.
Karen LeBlanc hace el papel de Cynthia Walker.
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