- Sammy Jackson - News Announcer
- Joshua Shelley - Claude Whitley
- Luke Askew - Carl DeReatis
- Melinda O. Fee - Addie
- Caroline McWilliams - Beverly Conrad
- Donna Mills - Roberta Rhodes
- Wolf Roth - Mueller
- Jason Evers - Dr. Peter James
- Bob Crane - Dr. Jamison
- Gloria DeHaven - Doreen
- Phyllis Newman - Mrs. Ellis
- Fred Grandy - Milt Jordan
- Elaine Joyce - Louise
- Martine Bartlett - Sobriety Group Member
- Henry Darrow - Dr. Rivera
- Kelly Preston - Ginger Reeves
- Carl Betz - Attorney Paul Barkley
- William Sylvester - Joe Crawford
- Joe Louis - Joe Louis
- Brion James - Henry Moeller
- Roger Bowen - Babitch
- Van Johnson - Al Ringerman
- Jack Colvin - Bill Legget
- Hal Williams - Cody
- Roger Davis - Dr. Paul Taggart
- John Davis Chandler - Robert Gideon
- Kim Cattrall - Joy DeReatis
- Fernando Lamas - Moreno
- Monica Lewis - Mona Duffy
- Dimitra Arliss - Shirley
- Frank Parker - Jerry Wade
- Fritz Weaver - Sen. William Pike
- Pernell Roberts - Sheriff Connelly
- Bob Minor - Mark Berkich
- Harry Landers - Hughes
- Jack Ging - Mickey Langford
- Frank Aletter - Hugh Boudreau
- Linda Kelsey - Sue Courtland
- Walter Brooke - Dr. Max Gilliam
- Dick Wesson - Clarence
- Joey Forman - Harv Bracken
- Adrienne Barbeau - Carol Bowen - Rape Counselor
- Richard Libertini - Felsenfield
- William Windom - Arthur Brandeis
- Jesse White - Mechanic
- Barry Newman - Dr. Gabe McCracken
- E.J. Peaker - Michelle Rowan
- Robert Alda - Professor Wren
- Joby Baker - Donald Bigelow
- Joby Baker - Tim Morgan
- Lola Albright - Liz McKenna
- John Furlong - 1st Reporter
- Jerry Douglas - Johnson
- Allan Miller - Dr. Jeff Knight
- Paul Lambert - Wilson
- John Karlen - Agent Brice
- Dina Merrill - Claire Garner
- Collin Wilcox Paxton - Martha Harrison
- Corey Fischer - Doctor Alan Castle
- Harold Sylvester - Hal Borden
- Val Avery - Rawley Dinehart
- Marianne McAndrew - Dolores
- Peter Palmer - Lance Tucker
- Denny Miller - Ben Chase
- Jack Hogan - Roy Gordon
- Phillip Pine - Dr. Panucci
- Casey Kasem - Sy Wallace
- Don 'Red' Barry - Charlie Turner
- Ben Frank - Mr. Schroeder
- Buddy Hackett - Ronnie Fletcher
- Julie Adams - Sharon Ross
- Yuki Shimoda - Dr. Hiro
- Carol Lynley - Lynn Dressler
- Andrew Prine - Alex Kale
- Stephen Macht - Frank Hailey
- Martha Smith - Dianne Johnson
- William Daniels - Paul Reardon
- William Daniels - Dr. Charlie Volmer
- Don Keefer - Doc Watson
- Frank Marth - Roy Keefer
- Woodrow Parfrey - Bower
- Lynn Hamilton - Mrs. Kellough
- Lynn Hamilton - Olivia Allen
- Milt Kamen - Leo Burke
- Robert Webber - Dr. John Franklin
- Frank Maxwell - Dr. Michaels
- Priscilla Pointer - Nurse Kathy Benson
- Linda Carlson - Mrs. Niles
- Louise Sorel - Harriet Crawford
- Sid Haig - Hatch
- Joanna Barnes - Margo Bentley
- Joseph Campanella - Attorney Jules Draper
- Joseph Campanella - Charlie Barnes
- Nicolas Coster - Ted Markham
- Ellen Geer - Sarah Markham
- George Wyner - Asst. DA Richard Feldman
- George Wyner - Marcus
- Diana Muldaur - Dr. Janet Carlyle
- James Karen - Dr. Chet Rawlings
- Peggy McCay - Sister
- Hari Rhodes - Deputy Mayor Collins
- Donald Petrie - 2nd Officer
- Dennis Patrick - Tony Larson
- Frank Converse - Dr. Larry Pines
- Ron Masak - Ed Shannon
- Anthony Eisley - Jerry Friedman
- Elisha Cook Jr. - Mr. Charles Trout Sr.
- Michael Durrell - Dr. Tate Edmonds
- Bruce Gray - Dr. Robert Miles
- Ivor Francis - Howard Garfield
- Stanley Kamel - Max Cullis
- June Lockhart - Mrs. Clara Rhodes
- June Lockhart - Mrs. Hanover
- Jason Wingreen - Dr. Albert Freeman
- Paul Mantee - Fake Carl Hopwood
- Joseph V. Perry - Carl Ladin
- Tom Atkins - Gene Butler
- Tom Atkins - John Todd
- Jack Bannon - Morgue Attendant
- Creed Bratton - Young Man
- Jonathan Frakes - Leon Bohannon
- Jonathan Frakes - Young Surgeon
- Dennis Burkley - Tom-Tom Thomason
- Carlene Watkins - Girl #2
- Henry Slate - Fred
- Martin Kove - Joe Kirby
- Sheila Larken - Jane Lemner
- Sheila Larken - Dr. Rivlin
- Carmine Caridi - Dr. Byron Brown
- George O'Hanlon Jr. - Mr. Travis
- Judy Farrell - Rape Counselor Louise Porter
- Terri Lynn Wood - Lisa DiNardi
- Foster Brooks - Carriage Driver
- Chris Petersen - Boy
- Jeb Stuart Adams - Craig
- Len Bari - Frank Penner
- Tom Lowell - Fred
- Tina Andrews - Protestor
- Virginia Vincent - Mrs. Reed
- Hugh Farrington - Protestor / Kennedy
- Kristin Gamboa - Emily Stapleton
- Ed Begley Jr. - David Phillips
- Ed Begley Jr. - Kit Sawyer
- Frank Campanella - Max Wilbur - Insurance Investigator
- Alberto Morin - Lopez
- Linda Dangcil - Female Radical
- Philip Abbott - Bill Sullivan
- Clyde Kusatsu - Hokaido
- Henry Beckman - Chief Hartman
- Henry Beckman - Leonard 'Bell' Bellwood
- Henry Beckman - Max
- William O'Connell - Herman Elger
- Barry Sullivan - Dr. Herbert Stone
- Anita Gillette - Dr. Emily Hanover
- Anita Gillette - Helen Quincy
- Mark Goddard - Attorney Martin Borland
- Michael Callan - William Farrell
- Philip Baker Hall - Dep. DA Marty Shell
- Steve Franken - Dr. Kitei
- Sharon Acker - Barbara
- Sharon Acker - Lynne Montgomery
- Sharon Acker - Allison Sirella / Mary Latham
- Len Lesser - Dr. DeGroot
- Eddie Firestone - Frank Thayler
- Paul Picerni - Sloan
- Jeanette Nolan - Edna Brackett
- John McIntire - Roy Brackett
- Carole Cook - Winslow
- William Campbell - Doctor Sutter
- Jessica Walter - Jessica Ross
- John Ireland - Jerry Driskill
- John Ireland - Sheriff Ned Evers
- John Ireland - Attorney John Packard
- Barbara Tarbuck - Louise Asten
- Barbara Tarbuck - Claire Morgan
- Barbara Tarbuck - Mrs. Westlake
- Estelle Winwood - Muriel Prentiss
- Patrick Cranshaw - Mr. Coogan
- Paul Fix - Jason Randall
- Corinne Conley - Reporter
- Keye Luke - Otashi Hiyedo
- Ron Nyman - Sound Mixer
- Mako - John Moroshima
- Mako - Mr. Yamaguchi
- Soon-Tek Oh - Capt. Bob Nishimura
- Ina Balin - Stella Ross
- Ina Balin - Dr. Maria Pinaera
- John Fiedler - Howard Clausen
- John Fiedler - Mr. Weiss
- Ryan MacDonald - Clark
- Edward Andrews - Mayor Ed Joyner
- Stuart Whitman - Sheriff Parsons
- Joe Maross - Insurance Agent John Blake
- Marianna Hill - Lisa
- John Anderson - Justin DeWilde
- John Anderson - Movie Director
- John Anderson - Chief Frank Ollano
- Stewart Moss - Jack Taylor
- Richard Eastham - Baine
- Anne Haney - Alice
- Ted Gehring - Motel Manager
- Conlan Carter - Marty Bonham
- Albert Henderson - Judge
- Mark Russell - Bailiff
- Rosey Grier - Rosey Grier
- Frank Faylen - Janus
- J. Pat O'Malley - Mr. Barrington
- Regis Cordic - Judge
- John Saxon - Publisher Charles Desskasa
- John Dennis - Car Wash Boss
- John Dennis - 2nd Bartender
- John Dennis - Will Case
- Linden Chiles - Thomas Ainsley
- Linden Chiles - Monsignor
- George Sawaya - Jason Talmadge (uncredited)
- Jordan Rhodes - Kent
- Barbara Baldavin - Mrs. Roselli
- Sab Shimono - Ito
- Sab Shimono - Governor Tokamo
- Sab Shimono - Tokamo
- Mary Frann - Christine Hopwood
- Keene Curtis - Arthur Forsythe
- Norman Burton - Max
- Norman Burton - Dr. George Danner
- Susan Tolsky - Chemist
- Bob Harks - Detective (uncredited)
- Troy Melton - Carl Hopwood (uncredited)
- Carolyn Jones - Victoria Sawyer
- Carolyn Jones - Nurse Barbara Grayson
- Carolyn Jones - Sybil Presstin
- Allen Case - Stuart Harrison
- Barbara Babcock - Melissa Asten
- Dabney Coleman - Dr. Burt Travers
- Dabney Coleman - Officer Peter O'Neil
- Howard Hesseman - D.A. Jerry Douglas
- Joseph Gallison - TV News Director
- Lloyd Kino - Restaurant Owner
- Lloyd Kino - Gardner
- Don Ameche - Harry Whitehead
- Phillip R. Allen - Floyd Baker
- Kario Salem - Freddie Voss
- Robert Foxworth - Congressman Charles Sinclair
- Larry Carroll - Newsman
- Carla Borelli - Danielle de Soto
- Fred Villani - 3rd Reporter
- Ralph Smiley - Foreman
- Ray Ballard - 1st Newsman
- Monte Markham - Mr. Castle
- Sheilah Wells - Secretary
- Fred Sadoff - Arthur Ellis
- Andy Romano - Derrick Kendal
- Gloria Manon - Manager
- Jim Boles - Gus
- Pitt Herbert - Waterman
- Trent Dolan - Officer
- Kelly Flynn - Boyd
- Bobby Riha - Clerk
- Rick Podell - Peter Gordon
- Fay DeWitt - Nurse Audrey
- Jerry Daniels - 2nd Reporter
- Richard Sarradet - Stone
- Maria Elena Cordero - Maria
- Hubert Noël - Jacques
- Angus Duncan - Dr. Egan
- Peter Bourne - Norkwist
- Kipp Whitman - Masters
- Patti Chandler - Ann
- H.M. Wynant - Doyle
- H.M. Wynant - FBI Agent Maxwell
- Peter Brocco - Mr. Brown (uncredited)
- Peter Brocco - Advisor
- Lynnette Mettey - Lee
- Jan Shutan - Ginny
- Jan Shutan - Lorraine
- William Mims - Dr. Walter De Groot
- Sharon Cintron - Stormy
- Vince Howard - Hardee
- Nancy Fox - Sally Frier
- Nancy Fox - Peggy Tolan
- John Clavin - Hansen
- Phillip Simms - Maintenance Man
- Richard Caine - Security Guard
- Michael Keenan - Man
- Kelly Jean Peters - Charlene Taylor
- Stu Gilliam - Dr. Hiro's Driver
- Ned Wilson - Wilson's Assistant
- Joe Abdullah - Customs Officer
- Peter Dane - Morgue Assistant
- Peter Dane - Lab Technician
- Peter Dane - Dworkin
- Jo Ann Pflug - Mrs. Valerie Pines
- Jo Ann Pflug - Marsha
- Jo Ann Pflug - Maggie
- Anthony De Longis - Russell
- Renne Jarrett - Janet Martin
- Elizabeth Robinson - Robbi Parker / Carrie Taylor
- Ann Blyth - Velma Whitehead
- Ann Blyth - Dorothy Blake
- Than Wyenn - Dr. Redman
- Chanin Hale - Woman
- Ben Young - Customer
- Martin Rudy - Raitsky
- Aimée Eccles - Alice Ting
- June Dayton - Judge
- Lynn Tufeld - Nurse
- Jackie Russell - Policewoman Billings
- Harold Ayer - Gate Guard
- James Ingersoll - Assistant D.A.
- Hilarie Thompson - Jessie Casey
- Jack Kelly - Peter Devlin
- Barry Cahill - John Casey
- James Chandler - Judge Walker
- Jamie Lee Curtis - Girl in Dressing Room
- James Jeter - Jack Shannon
- Robert Brubaker - Bob Haviland
- Peter Virgo - Man At Store
- Larry Delaney - Frank
- Louis Guss - Spence
- Ron Thompson - Claude Stern
- Robert Weaver - Chip Hayden
- John Finnegan - Joe Ives
- Gus Corrado - Fred Burton
- Raymond O'Keefe - Worker
- Shane Sinutko - Joey Harrison / Joseph Stanley Harrison
- Paul Lichtman - Dr. Griffith
- Gregg Palmer - Sean Duffy
- Jessica Rains - Mrs. Sellers
- Patricia Joyce - Dr. Laura Kaplan
- Claire Brennen - Sara Kendall
- Wynn Irwin - David Levine
- Lee Weaver - Chambers
- Don Eitner - Paul Morton
- Jonathan Segal - George Talbot
- William Swan - Dr. Sharp
- Julie Rogers - Nurse
- Chuck Hicks - Sam Hutchinson
- James Wainwright - Arthur Lanz
- Ronald G. Joseph - Ray Sanchez
- Edith Diaz - Maria Sanchez
- Del Hinkley - Workman
- Lynne Marie Stewart - Nurse
- Eddie Garrett - Himself / Ed
- Mario Machado - Newscaster
- Bill McDonald - Frank
- Christopher Connelly - Paul Colby
- Danna Hansen - Nurse's Aide
- Joan Goodfellow - Miss Gordon
- Barbara Collentine - Nurse Fay Willard
- Shane Butterworth - Donny DeReatis
- Bob Golden - Court Clerk
- Penelope Willis - Nurse Gordy / Miss Gordy
- John Nolan - Bartender
- Lynne Topping - Girl #1
- Ellen Bry - Linda Hayes
- Dorothy Dells - 2nd Nurse
- Raymond Mayo - Ronald Litner
- Clifton James - Cliff Webb
- Peg Shirley - Bea Thatcher
- Robert Loggia - Prime Minister Harland DeVille
- Jay Varela - Arturo Dominguez
- Raymond St. Jacques - Dr. Charles Martin
- Kathryn Leigh Scott - Laura Ramsey
- Robert Emhardt - Karl Fresser
- Martine Beswick - Hanna Weiss
- Glen A. Larson
- Sam Egan
- Christopher Morgan
- Winrich Kolbe
- Jud Kinberg
- Michael Sloan
Brion James interpreta a Henry Moeller en la serie.
Jonathan Frakes hace el papel de Young Surgeon.
Philip Baker Hall interpreta a Dep. DA Marty Shell en la serie.
Jack Klugman hace el papel de Quincy.
Robert Ito hace el papel de Sam Fujiyama.
Val Bisoglio hace el papel de Danny Tovo.
John S. Ragin interpreta a Robert Asten en la serie.
Garry Walberg hace el papel de Frank Monahan.
Joseph Roman interpreta a Sergeant Brill en la serie.
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