- Carl Benton Reid - Calhoun
- Wendy Hiller - Anne Hutchinson
- Lester Rawlins - Daniel Webster
- Frederick O'Neal - Haines
- Ford Rainey - Bird
- Alan Baxter - Traine
- Rae Allen - Miss Darvon
- James T. Callahan - Barnes
- George Furth - Stanley
- Peggy McCay - Margaret
- Paul Fix - William Brownlow
- Frank Silvera - Lemus
- Tol Avery - William Jennings Bryan
- Kent Smith - Charles Evans Hughes
- James Westerfield - Sen. Samuel Pomeroy
- Barbara Feldon - Frances Cleveland
- Martine Bartlett - Caroline
- William Bakewell - Wythe
- Edith Atwater - Mrs. Andrews
- Howard St. John - Hinrichsen
- Paul Stewart - Louis D. Brandeis
- Nancy Wickwire - Louisa Adams
- Gary Merrill - John Marshall
- Janice Rule - Prudence Crandall
- Sue Randall - Joan Owens
- John Howard - Sen. Crittenden
- Booth Colman - Aaron Burr
- King Donovan - Rev. Mr. May
- Robert Hooks - Frederick Douglass
- Herschel Bernardi - Gen. Daniel Sickles
- David Brian - Charlton
- Wesley Addy - Hellinger
- George Macready - General Fairchild
- Sidney Blackmer - Oscar W. Underwood
- Meg Wyllie - Eliza
- Harry Bellaver - Hale
- Henry Jones - Hamilton Fish
- Phyllis Love - Abigail Adams
- Betsy Jones-Moreland - Sally
- Dan O'Herlihy - Professor Richard T. Ely
- Noah Keen - Throckmorton
- John Kerr - Whitlock
- Conlan Carter - Robert Johnson
- Christopher Dark - Hay
- Lee Tracy - Senator Robert A. Taft
- Tim O'Connor - Rigdon
- Leonard Nimoy - Burr Jones
- J.D. Cannon - Sam Houston
- Andrew Prine - Josiah Quincy
- Carroll O'Connor - Grover Cleveland
- Brian Keith - Thomas Hart Benton
- Strother Martin - Senator James Wadsworth
- Bradford Dillman - Edmund G. Ross
- Torin Thatcher - Sewall
- Torin Thatcher - Cannon
- Sandy Kenyon - Webster
- Rosemary Harris - Mary S. McDowell
- Peter Mark Richman - Rawlins
- Burgess Meredith - John Peter Altgeld
- Michael Pate - John Wilson
- Tom Bosley - Senator George W. Norris
- Parley Baer - Hillhouse
- Philip Ober - Anderson
- Neil Hamilton - Gov. John Winthrop
- John Cassavetes - Parsons
- Donald Harron - John Cotton
- Donald Harron - Governor Randolph
- Simon Oakland - Captain Bogart
- Simon Oakland - Perry Fuller
- Peter Whitney - Gronna
- Laurence Naismith - John Adams
- Laurence Naismith - George Mason
- George Grizzard - Judge Ben Barr Lindsey
- Albert Salmi - Mr. Schneider
- Kevin Hagen - Sweet
- Geraldine McEwan - Jesse
- George Lindsey - Black
- David McCallum - John Adams
- Loring Smith - Roger Marsden
- Woodrow Parfrey - Governor William Brandon
- Woodrow Parfrey - Principal Ralston
- Harry Townes - Coffin
- Paul Lambert - Whitney
- Whit Bissell - Myles
- Whit Bissell - Woodrow Wilson
- Alfred Ryder - Garrison
- Alfred Ryder - Senator Nicholson
- Victor Jory - Charles Carlin
- Slim Pickens - Rogers
- Michael Constantine - Watson
- Marsha Hunt - Mrs. Ely
- Barry Morse - Thaddeus Stevens
- Arthur Franz - James Madison
- George Rose - Sen. Thomas Corwin
- Rhys Williams - William Hutchinson
- Peter Lawford - Gen. Alexander Doniphan
- Lamont Johnson - Fremont
- George Mitchell - Mr. Broomell
- Paul Comi - Samuel Quincy
- Milton Selzer - Schilling
- Warren Stevens - Lt. Gov. Edward Clark
- John Abbott - Senator Wigfall
- Joseph Ruskin - French
- David Opatoshu - Max Goldman
- Karl Swenson - Chynoweth
- Walter Matthau - Gov. John Slaton
- Walter Matthau - Andrew Johnson
- Frances Sternhagen - Miss Koeller
- Jason Wingreen - Hanson
- Frank Marth - Grant
- Roy Barcroft - Judge
- John Hoyt - Mr. Finchley
- John Hoyt - Lodge
- John Colicos - Patrick Henry
- Peter Hobbs - Lindbergh
- Ed Asner - President Ulysses S. Grant
- Ed Asner - Oliver E. Wells
- Russell Collins - Adams Sr.
- Russell Collins - Foote
- Herb Voland - La Follette
- Herb Voland - Peckham
- Robert Saudek
Peter Lawford interpreta a Gen. Alexander Doniphan en la serie.
Philip Ober interpreta a Anderson en la serie.
Leonard Nimoy hace el papel de Burr Jones.
William Bakewell interpreta a Wythe en la serie.
Capítulo disponible en las siguientes plataformas:
