- Ben Platt - Ethan Streiber
- Ayo Edebiri - Eve Stone
- Tracee Ellis Ross - Rayna Bradshaw
- Jermaine Fowler - Darren Williams
- Melissa Saint-Amand - Vanessa Delacroix
- Jon Bernthal - Chase Milbrandt
- Boyd Holbrook - Aaron
- Beau Bridges - William
- Amy Landecker - Trish
- Lucas Hedges - Jesse Wheeler
- Kaitlyn Dever - Abbi Miller
- O'Shea Jackson Jr. - Cooper
- Ed Asner - Mr. Holmes
- Brendan Scannell - Caleb Rose
- Grace Song - Susie Xu
- Lola Kirke - Allegra
- SoKo - Beth
- Sylvia Grace Crim - Woman in the Bathroom
- Daniel Dae Kim - Daniel Jung
- Eric Lange - Eli Spector
- Bryan Batt - Charles
- George Wallace - Principal Wallace
- Talia Balsam - Prosecutor
- Martin Covert - Judge
- Randal Gonzalez - Jury Foreman
- Scott Takeda - Doctor Hopkins
- Taylor Shurte - Ex-Girlfriend 1
- Patrick Kirton - Ethan's Dad
- Andy Dylan - Arresting Officer
- Desus Nice - Daniel 'Desus Nice' Baker
- The Kid Mero - Joel 'The Kid Mero' Martinez
- Emily Nelson - Keri Piña
- Michelle Jubilee Gonzalez - NGL Security Guard
- Matthew Osborne - NGL Co-Worker #1
- Jenny Tran - Jenny
- Erin Flannery - NGL Employee
- David Douglas - Mr. Decherd
- Kyle Langdon-Weyrich - Student
- David Paladino - Hugh Clark
- Rose Bianca Grue - Juror
- Bridget Malbrough - Juror
- Ronnie Yelverton - Reporter
- Andrew Penrow - Civil Rights Attorney
- Julia Goldani Telles - Kailey
- Devin Sidell - Assistant Principal
- Megan Truong - Kelly Kim
- Michael Graziadei - Pastor Jack
- Carrie Bernans - Naomi
- Jeff Grays - Security Guard
- Monica R. Harris - Meredith
- Jariah Johnson - Student
- Scott Green - Paunchy Office Worker
- Laura Cayouette - Susie
- Pierce Kang - Young Daniel
- Corin Scialabba - Young Eli
- Cindy L. Jefferson - Gail
- Joanna Daniel - Alice
- Jonas Chartock - Troy
- Freedom Bridgewater - Marcus
- Lorrie Chilcoat - Sandra
- Jason Bayle - Focus Grouper
- Nadiya Khan - Alexa
- Dan Savage - Dan Savage
- Asa Akira - Asa Akira
- Andy Cohen - Andy Cohen
- B.J. Novak
Beau Bridges interpreta a William en la serie.
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