- LaToya Tonodeo - Diana Tejada
- Berto Colon - Lorenzo Tejada
- Paton Ashbrook - Jenny Sullivan
- Alix Lapri - Effie
- Justin Marcel McManus - Jabari Reynolds
- Naturi Naughton - Tasha St. Patrick
- Paige Hurd - Lauren
- Paige Hurd - Lauren Baldwin
- Quincy Tyler Bernstine - Tameika Washington
- Daniel Sunjata - Mecca
- Larenz Tate - Councilman Tate
- Moriah Brown - Kiki Travis
- Monique Gabriela Curnen - Blanca Rodriguez
- Keesha Sharp - Professor Harper Bonet
- David Walton - Lucas Weston
- Michel Vidal - Gustavo Castillo
- Aida Turturro - Judge Janine Galanti
- Jack Gilpin - Martin Saxe
- Leslie Hendrix - Caroline Cooper Saxe
- Kelly Rutherford - Colleen Saxe
- Shea Buckner - Cameron Saxe
- Glynn Turman - Gabriel
- David Zayas - Uncle Frank
- Chuck Cooper - Reverend Macedon
- Ian Lassiter - Ricky
- Sung Kang - John Mak
- Jeanette Branch - Laila Jones
- Ryan Bourque - Scott
- Jackie Burns - Professor Deva
- Cooper Koch - Chase
- Rey Lucas - Marcos Garza
- Elizabeth Rodriguez - Paz Valdes
- Brandon Brown - Malcolm
- Luenell - Ms. Richards
- Shalim Ortiz - Officer Danilo Ramirez
- Shalim Ortiz - Detective Danilo Ramirez
- Princess Adenike - Ally
- Ra Val Davis - Shaundria
- Bruce Altman - Oliver Simmons
- Shari Abdul - Sylvia
- John Palladino - Bishop
- Tonye Patano - Dean Ida Brooks
- Joseph Sikora - Tommy Egan
- Preston Christopher Lawrence - Owl
- Kathleen Garrett - Judge Nina Larkin
- De'Adre Aziza - Marshal Gwen Meredith
- Laz Alonso - Detective Samuel Santana
- Jackie Long - Rico Barnes
- Zephani Idoko - Stephanie
- Greg Kaston - Detective
- Marcos Palma - Flex
- Soledad O'Brien - Soledad O'Brien
- Alex Stein - Plainclothes Officer
- Kisha Barr - Reporter #2
- Seth Andrew Bridges - Reporter #1
- Claire D'Angelo - Alanna
- Yvonne Perry - Medical Examiner
- Yvonne Perry - Medical Investigator
- Abubakr Ali - Sebastian 'Bash' Kamal-Stern
- Brit Whittle - Coach Wallace
- Jemele Hill - Jemele Hill
- Truck Hudson - Gold Grill
- Victor Garber - Simon Stern
- James T. Alfred - LeShaun
- Nicholas Delany - Hank
- Jill Durso - Apartment Manager
- Biko Eisen-Martin - Nuff
- Debbi Morgan - Estelle Green
- Joel Haberli - Judge Arnold Miller
- Jamad Mays - C.J.
- Sherri Saum - Paula Matarazzo
- Luna Lauren Velez - Evelyn Castillo
- Michelle Beck - Camille
- Don Castro - Dean Wong
- Iliana García - Tiff
- Marcus Anderson - Lil' Guap
- Ambre Anderson - Sheryl Baldwin
- Angel Reda - Nicole Weston
- Massimo Cannistraro - Doorman
- Lance Daniels - Sweaty
- Benton Greene - Sterling Baldwin
- Teniece Divya Johnson - Raqui
- Matthew Paul Martinez - K.C.
- Glenn Morizio - Jackie Cho
- 50 Cent - Kanan
- Jimmie Saito - Chef Eric Kamura
- La La Anthony - Lakeisha Grant
- Marcus Callender - Ray Ray
- Jerry Ferrara - Proctor
- Cory Jeacoma - Trace Weston
- Donshea Hopkins - Raina St. Patrick
- Mark Feuerstein - Steven Ott
- Scott Cohen - Congressman Rick Sweeney
- Jeff Hephner - Detective Kevin Whitman
- Frank Whaley - Judge Lucas
- Mu-Shaka Benson - Mecca Soldier #2
- Charles Justo - Carlito
- Juvian Marquez - Mecca Soldier #1
- Gemma McIlhenny - Bailiff
- Geoffrey Owens - Daniel Warren
- Bradley Gibson - Everett
- Bradley Gibson - Everett Neal
- Redman - Theo Rollins
- Christine Renee Miller - Trinity Cho
- Omar Salazar - Go-Go
- Lahmard J. Tate - Kamaal Tate
- Caroline Chikezie - Noma
- Jeff Auer - Robert Weston
- Hope Blackstock - Angela Davis
- Bria Condon - Claire
- Wesley Han - Pinky
- Lil' Mo - Singer
- Petey McGee - Salim Ashe Freeman
- Afsheen Misaghi - Dr. Patel
- Sean Nelson - Kai
- Michael Reagan - Simon
- Garrett Richmond - Wyatt
- Alanna Smith - Janae
- Austin Weyant - Thomas Beverly
- Sam Ashby - Chad
- Brandon Carrillo - Personal Trainer Nick
- Dario Torres - International Guap
- B. Todd Johnson - Cop #1
- Steve Belanger - Cop #2
Chuck Cooper interpreta a Reverend Macedon en la serie.
Michael Rainey Jr. interpreta a Tariq St. Patrick en la serie.
Shane Johnson hace el papel de Cooper Saxe.
Mary J. Blige interpreta a Monet Stewart Tejada en la serie.
Woody McClain hace el papel de Cane Tejada.
Gianni Paolo interpreta a Brayden Weston en la serie.
Method Man hace el papel de Davis Maclean.
Lovell Adams-Gray hace el papel de Dru Tejada.
LaToya Tonodeo interpreta a Diana Tejada en la serie.
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