- Anna Gunn - Glynis Brooks
- Paul Simon - Paul Simon
- Seth Meyers - Chad Koop
- Paul Reubens - Weirdos' Lawyer
- Miranda July - Two Girls, Two Shirts Owner
- Kristen Wiig - Gathy
- Andy Samberg - Andy
- Steve Buscemi - Milton
- Steve Buscemi - Marty
- Steve Buscemi - Book Store Customer
- James Callis - James Callis
- Olivia Wilde - Brit
- Olivia Wilde - Ecoterrorist
- Eddie Vedder - Eddie Vedder
- Ronald D. Moore - Ken Reynolds
- Edward James Olmos - Edward James Olmos
- Shohreh Aghdashloo - Nelofar Jamshidi
- Jack McBrayer - Whole Foods Customer
- Dana Millican - Wedding Planner
- Bill Hader - Birdman
- Chloë Sevigny - Alexandra
- Joshua Homme - Carrie's Brother
- Nick Swardson - Nick
- Kyle MacLachlan - Mayor
- Tessa Thompson - Bailey
- Jane Lynch - Barbecue Planner
- Alia Shawkat - Mayor's Kid
- Dolly Wells - Dolly
- Cherry Jones - Bridge Manager / New Mayor
- Aubrey Plaza - Bookstore Customer
- Aubrey Plaza - Beth
- Sarah McLachlan - Herself
- Aimee Mann - Herself
- Selma Blair - Frannie Walker
- Jenny Conlee - Sparkle Pony
- Heather Graham - Heather
- Nick Kroll - Daniel Prison
- Sean Hayes - Sean
- St. Vincent - Annie (as Annie Clark)
- Amber Tamblyn - Intern
- Ehren McGhehey - Motorcycle Guy
- Ehren McGhehey - Man on Line
- Kumail Nanjiani - SoCal Waiter
- Kumail Nanjiani - Human Bandwidth Manager
- Kumail Nanjiani - Denim Salesman
- Kumail Nanjiani - Cell Phone Salesman
- Kumail Nanjiani - Birthday Loan Officer
- Roseanne Barr - Interim Mayor
- Roseanne Barr - The New Mayor
- Joanna Newsom - Harpist
- Danny Belrose - Billy Burnside
- Jeff Goldblum - Vocal Coach
- Jeff Goldblum - The Pull-Out King
- Jeff Goldblum - The Doily Shoppe Proprietor
- Jeff Goldblum - Beet Accident Man
- Penny Marshall - Barbara
- Johnny Marr - Johnny Marr
- Greg Louganis - Greg Louganis
- Sierra Quitiquit - Girl on Line
- Vanessa Bayer - Speaker System Customer
- Vanessa Bayer - Ms. Praeger
- Steve Jones - Hammersmith
- Tim Robbins - Excellency
- Mara Hernandez - Dancer
- Jack White - Jack White
- Bobby Moynihan - Robert
- Matt Lucas - Stu
- Jim Gaffigan - Donald
- Kurt Loder - Kurt Loder
- Jason Sudeikis - Aliki
- Jason Sudeikis - Kim
- Matt Pinfield - Matt Pinfield
- Tabitha Soren - Tabitha Soren
- Martina Navratilova - Martina Navratilova
- Gwen Stefani - Gwen Stefani
- Tony Kanal - Tony Kanal
- Tom Dumont - Tom Dumont
- Adrian Young - Adrian Young
- Michael Patrick O'Brien - Michael Patrick O'Brien
- Patton Oswalt - Thor83
- Matt Berry - Squiggleman
- Juliette Lewis - Darcy
- George Wendt - George Heely
- J. Mascis - J. Mascis
- Rose Byrne - Fred's Girlfriend
- Katie O’Grady - Teacher
- Jay Pharoah - Jay-Z
- Silas Weir Mitchell - FBI
- Lance Bangs - Lance Bangs
- Jello Biafra - Jello Biafra
- Duff McKagan - Duff McKagan
- Mark Proksch - Sean
- Ed Begley Jr. - Dr Ravich
- Ed Begley Jr. - Cafe Owner
- Ed Begley Jr. - Priest
- Kim Gordon - Kim Gordon
- Maya Rudolph - Anita
- Jeff Tweedy - Jeff Tweedy
- Damian Lillard - Damian Lillard
- Natasha Lyonne - Carrie's Friend #2
- Natasha Lyonne - Madison
- Natasha Lyonne - Danielle
- Natasha Lyonne - Laura's Friend
- Paul Allen - Paul Allen
- Gus Van Sant - Gus Van Sant
- Ebbe Roe Smith - Seller Husband
- Ebbe Roe Smith - Ebbe
- Ebbe Roe Smith - Swinger Husband
- Ebbe Roe Smith - Ebbe (as Ebbie Rowe)
- Dan Savage - Dan Savage
- October Moore - Andrea
- k.d. lang - Peggy
- Brigitte Nielsen - Brigitte Nielsen
- Shepard Fairey - Shepard F.
- Matt Groening - Matt Groening
- Parker Posey - Branding Expert
- Caroll Spinney - Oscar the Grouch (voice)
- Paul McGinnis - Additional Muppets
- Nancy Cartwright - Bart Simpson (voice) (uncredited)
- Wayne Coyne - Wayne Coyne
- Steven Drozd - Steven Drozd
- Ron Lynch - Ron Lynch
- Glenn Danzig - Radu
- Betty Moyer - Gynecologist
- Jillian Bell - Car Rental Clerk
- Moshe Kasher - Bruce
- Zoë Kravitz - Kendall
- Elizabeth Tulloch - Taxi Customer
- Louis C.K. - Louis C.K.
- Haley Talbot - Commercial Director
- Kevin Corrigan - Kevin
- Mitchell Hurwitz - Dr Hopkins
- Mitchell Hurwitz - Dr. Geremy Nish-Amarau
- Mitchell Hurwitz - Dr. Karl
- Robert Smigel - Jarvis
- Claire Danes - Joan
- Killer Mike - Killer Mike
- Rachael Perrell Fosket - Cafe Owner
- Rachael Perrell Fosket - Rachael
- El-P - El-P
- Ryan Hansen - Dax
- John Early - Funeral Director
- Sean Tarjyoto - Assistant
- Jessica St. Clair - Squirrel
- Judy Greer - Shawna
- Steve Buscemi
- Fred Armisen
- Bill Oakley
- Jonathan Krisel
- Karey Dornetto
- Carrie Brownstein
- Lorne Michaels
- Allison Silverman
Chloë Sevigny hace el papel de Alexandra.
Edward James Olmos interpreta a Edward James Olmos en la serie.
Steve Buscemi hace el papel de Book Store Customer.
Juliette Lewis interpreta a Darcy en la serie.
Brigitte Nielsen interpreta a Brigitte Nielsen en la serie.
Aimee Mann hace el papel de Herself.
Cherry Jones interpreta a Bridge Manager / New Mayor en la serie.
Jeff Goldblum hace el papel de The Pull-Out King.
Fred Armisen interpreta a Various Characters en la serie.
Nancy Cartwright interpreta a Bart Simpson (voice) (uncredited) en la serie.
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