- Jack Donner - Arthur
- Robert Gant - Steve
- Tom Parker - Peter
- David Giuntoli - Tyler
- Barry Bostwick - Hugh
- Kristin Chenoweth - Courtney
- Cedric the Entertainer - Reverend Boyce
- Cybill Shepherd - Apryl
- Bonnie Franklin - Agnieszka
- Finn Carr - Wilbur
- Angela Kinsey - Mrs. Carson
- Jason Kravits - Dr. Ira Klein
- Dimitri Lekkos - Dr. Delacourt
- Dan Pfau - Andy
- Robert Wagner - Jim
- Ty Mayberry - Fred
- Alan Dale - Emmet
- Alex Trebek - Narrator
- Cameron Mathison - Bill
- Hal Linden - Alex
- Shirley Knight - Loretta
- Robin Thede - Janet
- Greg Winter - Neighbor
- Amy Yasbeck - Hailey Nash
- Shaughn Buchholz - Bartender
- Michelle Noh - Cynthia
- Vincent M. Ward - Bodyguard
- Bil Dwyer - Anders
- Eileen O'Connell - Flight Attendant
- Diane Sellers - Brianna
- Patrick Faucette - James
- Mark Indelicato - Zack
- Joel Lambert - Handsome Guy
- Chelsea Ricketts - Francesca
- Rand Holdren - Nooner
- Stephen Holland - Antiques Expert
- Maia Madison - Carol
- Luke Diliberto - Jack
- Diane Michelle - Guard
- Janet Varney - Ellen
- David Starzyk - Pete
- Kevin McCorkle - Father Ned
- Julie Lancaster - Linda
- Robert Towers - Winston
- John Senese - Bailiff
- Paul Hayes - Greg Trimmer
- Mark Capri - Justice of the Peace
- Tug Coker - Oliver
- Jason Boegh - Casting Director
- Melanie Griffith - Melanie Griffith
- Nicole Dalton - Judy
- Natalija Nogulich - Vadoma
- Jeffery Self - Waiter
- Peri Gilpin - Taylor
- Darnell Williams - Darnell Williams
- Creagan Dow - Dan
- Jimmy Kimmel - Jimmy Kimmel
- Leslie Grossman - Elise
- Blaine Vedros - Corpse
- Carlease Burke - Nurse
- Leslie Gilliam - Female Fairy
- John Ducey - Gordon
- John Schneider - Hank Szymborska
- Michael E. Knight - Michael E. Knight
- Charlie Adler - Director
- Jim Hanna - Dennis the A.D.
- Bob Rumnock - Dr. Morgan
- Arden Myrin - Jasmine Breeze
- Anthony Holiday - Ben
- Dan Bakkedahl - Jasper
- Isaiah Mustafa - Kevin
- Max Charles - Marcus
- Gregory Harrison - Dave
- Caitlin Carmichael - Annabelle
- Mandy June Turpin - Doreen
- Tom Yi - Dr. Joe
- Terrence Beasor - Old Man
- Mark Deklin - Kirk Stark
- Don Perry - Juror #8
- Stewart Skelton - Driver
- Joe Howard - Amish Man
- Stephen Dunham - Abner
- George Wendt - Yoder
- Monica Horan - Sarah
- Amy Sedaris - Heather Shaw
- Jeff Martin - Governor Shaw
- Mark Derwin - Gary
- Frank Caliendo - Kenny
- Richard Burgi - Timothy
- Vincent Ventresca - Dr. Doug
- Steve Lawrence - Jack
- Patrick Fabian - Richard
- Danielle Burgio - Susie
- Mindy Cohn - Cassie
- Wayne Knight - Rick
- Tom McGowan - Robert
- Antonio Sabàto, Jr. - Leandro
- Doris Roberts - Lydia
- Ariel Llinas - Ty
- Michael Dunn - Matthew
- Edward Stanley - Joe
- Keith Pillow - Potential Jefferey
- Tammie Brown - Pamela Anderson Drag Impersonator (uncredited)
- Lex Medlin - Elliot
- Willam Belli - Drag Impersonation Competitor (uncredited)
- Mason Cook - Austin
- Heather Prete - Eileen
- Dean Cochran - Sam
- George Newbern - Bill
- Alicia Hannah - Devon
- Shelli Boone - Lori
- Bart Johnson - Mark
- Buck Henry - Fred
- Eric André - Jeff
- Dick Van Patten - Lester
- Troy Metcalf - Policeman Mike
- C.J. Vana - Frat Guy
- Jack Axelrod - Ernie
- Barber Ali - Abdul-Hamid
- Kurt Ela - Moustachioed Man
- Danny Pudi - Tommy
- Don Rickles - Bobby
- Kathie Lee Gifford - Christal
- Kym Whitley - Jada
- Valerie Azlynn - Libby
- Laura San Giacomo - Caroline
- Sandra Bernhard - Nan
- Jennifer Ann Burton - Cassie
- Orson Bean - Dan
- Jake Martin - Male Mourner
- Marissa Jaret Winokur - Kim
- Yolanda Snowball - Pam
- Jimmy Smagula - Jerry
- Alex Ball - Ken
- Edward James Gage - Mike
- Sean O'Bryan - Andy
- Phil Morris - Lou
- Bette Rae - Mother
- Ryan Gaul - Hotel Employee
- David DeLuise - Jake
- Calli Ryals - Sally
- Tim Bagley - Larry
- Daniel Roebuck - Director Perkins
- Doug Savant - Scott
- Tim DeKay - Buddy
- Dan Cortese - Jimmy Armstrong
- Wendi McLendon-Covey - Nurse Sandy
- Willie Garson - Dr. Brotz
- Joe Jonas - Will
- Tamara Lynn Davis - Sara
- Tamara Lynn Davis - Waitress
- Randy Wayne - Mark
- Josh Hopkins - Waiter (uncredited)
- Baron Davis - Baron Davis
- Ryan McPartlin - David
- Steve Valentine - Drago
- Danielle Bisutti - Verena
- Barak Hardley - Ansel
- Sydney Mikayla - Little Girl
- Braden Davis - Sound Engineer
- Ernie Hudson - Ernie Hudson
- Lesley Nicol - Margaret
- Dave Allen - David Gates
- Steve Monroe - Sam
- Robert Neary - Ted
- Michael Edwin - Judge
- Max Greenfield - Steve
- Max Greenfield - Doug
- Ramone Hamilton - Danny
- Jon Lovitz - Artie
- Jon Lovitz - Opera Guy
- Jon Lovitz - Self
- Cheri Oteri - Dr. Deb
- Eric Allan Kramer - Milo
- Clint Culp - Ken
- Nick Armstrong - Derrick
- Enrico Colantoni - Julian
- Brody Hutzler - Andy
- Jeffrey De Serrano - Guard
- Sean Hayes - Chad
- Sean Hayes - Self
- Fred Willard - Doctor Hill
- Lauren Lapkus - Oscar
- Kelly Schumann - Sally
- Duane R. Shepard Sr. - Older Male Patron
- Jeffrey Doornbos - Handsome Guy
- Steven Shaw - Rabbit Owner
- Carl Reiner - Max
- Dan Gauthier - Nick
- Megan Grano - Alison
- Steven Weber - K.C.
- Steven Weber - Kyle
- Zach Lewis - Groom
- Kevin Nealon - George
- Kevin Nealon - Self
- Curtis Armstrong - Clark
- Christopher Gorham - Casey
- Gregg Berger - Barry the Parrot (voice)
- Reid Scott - Sam
- Cliff Chamberlain - Steve
- Annie Heller - OA Group Leader
- Max Shippee - Handsome Guy
- Ed Asner - Jameson
- James Patrick Stuart - Colin
- Alex Borstein - Preshi
- Maree Cheatham - Mrs. Filsinger
- D.C. Douglas - Peter Filsinger
- Rhea Perlman - Jacki
- Rick Springfield - Tom
- Andy Richter - Father Brian
- Gilles Marini - Captain Lebeau
- Paul Dooley - Bearded Man aka Santa
- Toussaint Waterman - Fireman
- Joey Honsa - Wheelchair Model
- Drew Droege - Stage Manager
- Jonathan Silverman - Dr. Minton
- Japheth Gordon - Cameron
- Nancy Berggren - 80 Year Old Victoria
- Todd Milliner - Self
- Christen Sussin - Shelley
- James Denton - Kerouac Cowboy
- Lyn Alicia Henderson - Lauren
- Rosa Blasi - Jessica
- Mel Rodriguez - Hector
- Echo Kellum - Johnny
- Echo Kellum - Aaron
- Francine York - Lady Natalie
- Albert Marrero Jr. - Luis
- David Spade - Christopher
- Elizabeth J. Carlisle - Shamed Woman
- Carol Herman - Mrs. Magee
- Regis Philbin - Pierre
- Alan Ruck - Reverend Lare
- Nic Bishop - Liam
- Heather Dubrow - Nikki
- Marshall Manesh - Yang
- Robbie Amell - Lloyd
- Michael Weaver - Brad
- Ed Begley Jr. - Yogi
- Kevin Farley - Ranger Murphy
- William Shatner - Sally
- Shirley Jones - Sophie
- Jean Smart - Bess
- Tim Conway - Nick
- Wally Kurth - Mark
- Julie Wittner - Perky Saleswoman
- Tom Arnold - Danny
- Jack Wagner - Dr. Aaron Everett
- Michael Urie - Jeffrey
- Alice Amter - Dr. Kapoor
- Pej Vahdat - Ravi
- Parvesh Cheena - Manu
- Chris Williams - Dr. Greenly
- Yeardley Smith - Margaret
- Valerie Harper - Angie
- Cloris Leachman - Peg
- Jesse Tyler Ferguson - Wes
- George Hamilton - Robin
- Ken Jeong - Dr. Kang
- Constance Zimmer - Lily
- John Mahoney - Roy
- John Mahoney - Self
- D.W. Moffett - Chester
- Albert Tsai - Scout
- Thomas Lennon - Agent Gilmore
- Jaime Pressly - Kelly
- Thomas Anthony Jones - Dr. Wilcox
- Ryan Culver - David
- Stephen Snedden - Chuck
- Matt Iseman - Mike
- Laird Macintosh - Ram
- Gary Anthony Sturgis - Cop
- Gary Anthony Sturgis - Officer Davenport
- Sam Daly - Milo
- Sam Daly - Justin
- Larry Miller - Larry
- Chris Elliott - Luke
- Peg Shirley - Alice Moore
- Jason Priestley - Corey
- Richard Ruccolo - Matt
- Sarah Hyland - Ivy
- Andy Gala - Jerry
- Dave Foley - Bob
- Dave Foley - Dr. Moore
- Asante Jones - Policeman
- Chris Isaak - Chase Jackson
- Tommy Dewey - Todd
- Shawn Carter Peterson - Bro-Man
- Kirstie Alley - Maddie Banks
- Roger Bart - Self
- Roger Bart - Jimmy
- Mark Valley - Jason
- Edward Hibbert - Collin Brett
- Emilio Borelli - Ron
- Jamie Denbo - Julie
- John Ross Bowie - Benny
- J.P. Manoux - Nate
- Joan Rivers - Self
- Joan Rivers - Anka
- Chevy Chase - Ross
- Rob Schneider - Chill
- Maggie Wheeler - Rachel
- Harry Van Gorkum - Daniel
- Nick Searcy - Warden Burkhalter
- Nick Searcy - Chief Barker
- Coby Bell - Baz
- Dan Castellaneta - Dr. McNally
- Lance Barber - Tyler
- Queen Latifah - Aunt Esther Jean Johnson
- Craig Bierko - Donald
- Bill Bellamy - Councilman Powell
- Dan Lauria - J.J.
- Anita Barone - Lisa
- Andrew Leeds - Tom
- Nicole Parker - Jessica
- Gabriel Tigerman - James
- Perez Hilton - Teddy
- Andrew Friedman - Dr. Rayner
- Debra Monk - Loretta
- Mac Brandt - Mike
- Tim Daly - Mitch
- Luke Perry - Trevor
- Chris Harrison - Chris Harrison
- Marion Ross - Olga
- Stephen Root - Brian
- Romy Rosemont - Marcie
- Mario López - Mario López
- Andrew J. West - Cooper
- Timm Sharp - Zed
- Bryce Johnson - Dylan
- Tyler Poelle - Louis
- Casey Washington - Shane
- Ben Vereen - Mayor Deacon
- Will Sasso - Frankie
- Rhys Darby - Jack
- Sophie Winkleman - Jill
- Mackenzie Phillips - Kaylin
- Brian Baumgartner - Claude
- Missi Pyle - Canadian Joy
- Amber Valletta - Ashley
- Gladys Knight - Miss Shonda
- Timothy Omundson - Mark
- Andy Milder - Dr. Laird
- Garry Marshall - Ari
- Ray Abruzzo - Phil
- William Baldwin - Dane
- Matt Walsh - Arnie
- Craig Ferguson - Simon
- Michael McMillian - Owen
- Kurt Fuller - Gerald
- Kelen Coleman - Andie
- Yvette Nicole Brown - Lily
- Jenny O'Hara - Helen
- Marla Gibbs - Marcia
- Dennis Haskins - Reverend Bowen
- Laurel Coppock - Emily
- Jim O'Heir - Ross
- Georgia Engel - Mamie
- Georgia Engel - Self
- Michael Burger - Frank
- Michael Burger - Self - Audience Warm Up
- Marla Sokoloff - Chloe
- Tate Ellington - Kameron
- John Kassir - The Pope
- Reamy Hall - Heidi
- Carol Burnett - Penny
- Chris Colfer - Tony Chase
- Todd Grinnell - Nicky
- Juliet Mills - Philipa
- Stacy Keach - Alex Chase
- Tyler Ritter - Bart
- Bob Newhart - Bob Sr.
- Thomas Gibson - Tom
- Jennifer Love Hewitt - Emmy Chase
- Darlene Hunt - Phyllis
- Andy Cadiff - Self
- Amy Paffrath - L.A. Actress
- George Ketsios - Professor Oliver
- Barrett Perlman - Neck Tattoo Girl
- Ally Maki - Brooke
- Justin Wade - Deshawn
- Susan Lucci - Susan Lucci
- Cassandra Scerbo - Lindsay
- Pat Harrington, Jr. - Mr. Sherden
- Huey Lewis - Johnny Revere
- Francesca Catalano - Devon
- Michael Shepperd - Scott
- Jay Harrington - Alec
- Heather Locklear - Chloe
- Federico Dordei - Fabrice
- Carter Oosterhouse - Carter Oosterhouse
- Riley B. Smith - Jacob
- Millicent Martin - Agnes Bratford
- Jet Jurgensmeyer - Anthony
- Mason Douglas - Boy
- Eddie Cibrian - Sean
- Ben Kronen - Sal
- Nicole Randall Johnson - Eleanor
- Samantha Martin - Jenna
- Gary Anthony Williams - Coach Taylor
- Veronica Taylor - Kim
- David Trainer
- Andy Cadiff
- Michael Lembeck
- Phill Lewis
- Shelley Jensen
- John Whitesell
- Alex Herschlag
- Aaron Shure
- Sebastian Jones
- Lisa Slopey
- Sam Johnson
- Robert Heath
- Suzanne Martin
- Anne Flett-Giordano
- Chuck Ranberg
- Vanessa McCarthy
Kirstie Alley interpreta a Maddie Banks en la serie.
Willie Garson hace el papel de Dr. Brotz.
Cybill Shepherd hace el papel de Apryl.
Missi Pyle hace el papel de Canadian Joy.
Thomas Lennon interpreta a Agent Gilmore en la serie.
Stacy Keach interpreta a Alex Chase en la serie.
Sandra Bernhard hace el papel de Nan.
Alan Ruck interpreta a Reverend Lare en la serie.
Orson Bean interpreta a Dan en la serie.
Carl Reiner interpreta a Max en la serie.
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