- Allison Hossack - Constance Merrick
- Scott Vickaryous - Bobby Warner
- Ron Halder - George Roper
- Nick Mancuso - Reverend Abraham Hawking
- John Novak - Patrick Corrigan
- Jerry Wasserman - Dr. Patterson
- David Cubitt - Kyle Vance
- Garry Chalk - Sheriff Hank Parker
- Kaj-Erik Eriksen - Joseph Dawkins
- Nicole de Boer - Samantha Wallace
- Frank Grillo - Jerry Tate
- Gabrielle Rose - Esther
- Anthony Heald - Damon Ballard
- William Sadler - Shamus Bloom
- Myles Ferguson - Young Derek Rayne
- Jay Brazeau - Sam MacAllister
- Joely Collins - Emily
- Andrew Kavadas - Jailer
- David Fredericks - Bartender
- Christopher Gray - Michael Ballard
- Sandrine Holt - Ellen
- Janne Mortil - Sarah
- Hagan Beggs - Old Eugene
- Chad Krowchuk - Connor Corrigan
- Fred Keating - Dr. Ahrens
- Robert Wisdom - Daniel Euwara
- Philip Maurice Hayes - Sheriff Cutter
- Jordan Bayne - Julia Walker
- Daniel Pilon - Winston Rayne
- William Morgan Sheppard - Grave Digger
- José Vargas - Peruvian Man
- Ingrid Torrance - Party Girl
- Curtis Bechdholt - Young Eugene
- Don Thompson - Ezra
- Richard Sali - Henchman
- Karin Konoval - Woman
- Molly Parker - Liz Barrow
- William deVry - Kevin Sumner
- Matthew Walker - Dr. Brendan Slade
- Lenno Britos - Manuel Sanchez
- William B. Davis - Dr. Bill Nigel
- Ben Cross - Samuel Warden
- Anna Hagan - Mrs. Stickley
- Tony Sampson - George
- Jorge Vargas - Arthur
- Jennifer Carmichael - Kimberley
- Terence Kelly - Mr. Klein
- Tobias Mehler - Brad
- Julian Stone - John Doe / Samuel Hartford
- Jayme Knox - Dr. Thomas
- Andrew Wheeler - Dr. Cannon
- Chilton Crane - Caroline
- Betty Linde - Martha
- Michael Dobson - Chuck
- Tim Henry - Bartender
- Richard Lautsch - First Mate
- Bill Croft - First Convict
- Luc Corbeil - Second Convict
- Stephen Dimopoulos - Dpckmaster
- David Ogden Stiers - Randolph Hitchcock
- Earl Pastko - John Harper
- Christina Jastrzembska - Monica
- William MacDonald - Jones
- Mark Saunders - Conway
- Howard Storey - Fire Chief
- Suki Kaiser - Lisa Ballard
- Walter Marsh - Mr. Ballard
- Joel Palmer - David
- Judith Maxie - Judge Kern
- Fiona Hutchison - Nakties Davisia, Mistress of Endless Night
- Alex Green - Adolfas Vance
- Babe Dolan - Lena Vance
- David Longworth - Joseph Vance
- Lori Triolo - Connie
- Doug Abrahams - Dix
- Scott Swanson - Judge Druckner
- Ben Immanuel - Kyle's Attorney
- Roy Thinnes - Clayton Wallace
- Terry David Mulligan - Dr. Barzman
- Sarah Strange - Tina
- Reese McBeth - Gang Kid
- Brian George - Turkish shopkeeper
- Michelle Beaudoin - Wendy Barton
- Ken Kramer - Cyrus Barton
- Nuno Antunes - Brian Cass
- Alex Diakun - Hank
- Alexa Gilmour - Janet
- Colleen Rennison - Senephra
- Chapelle Jaffe - Miss Clark
- Jennifer O'Neill - Lorraine Compton
- Camille Mitchell - Sister Ingrid Rayne
- Katie Stuart - Patty Greer
- Lorraine Landry - Jan Cassidy
- Chantal Strand - Vickie
- Brent Sheppard - Plasser
- Ingrid Tesch - Monica Greer
- Jenn Griffin - Old Witch
- Victor Wong - Lee Tzin-Soong
- Christina Ma - Mei Ling
- Benita Ha - Gao Ziyan
- Ed Hong-Louie - Zhou Zhan
- J. Douglas Stewart - Jensen
- Eric Keenleyside - Miller
- Robert Lewis - Jake
- Aaron Pearl - Hal
- Colin Foo - Street Vendor
- Barbara Tyson - Miranda Blake
- Michael Ryan - Anton Lazaroff
- Joy Coghill - Mrs. Blake
- Lloyd Berry - Mr. Jenkins
- Anthony Harrison - George Wood
- Anthony Harrison - First Officer
- Jason Griffith - Cook's Helper
- Alan Rachins - Victor Arkadi
- Frank Moore - Dr. Warren Sloan
- Linda Sorensen - Sister Jehann
- Peter Hanlon - Dr. Stanley Cornell
- Kim Restell - Dr. Frances Carlton
- Michael J Rogers - Dawson
- Tom Schanley - Tom Davace
- J.C. MacKenzie - Stan Davace
- Peter LaCroix - Zach
- Darcy Laurie - Bum
- Xantha Radley - Hard Woman
- Johanna Marlowe - Woman
- Derek Hamilton - Man
- Sarah McLachlan - Woman
- Laurie Holden - Cora Jennings / Sarah Browning
- Art Hindle - Professor Jordan Slater
- Frank C. Turner - Reverend Josiah Blood
- Vanessa Morley - Abigail Browning
- Lawrence Bayne - Detective Longbow
- John F. Parker - Dominick Fitzgerald
- Mike Crestejo - Amer-Asian Man
- Hilary Strang - Mother
- Kevin Kilner - David Praeger
- Peter Bryant - Sgt. Mapes
- Terry Arrowsmith - Engineer
- Kim Kondrashoff - The Signalman / Douglas Praeger
- Tony Burton - Simon Walters
- Don S. Davis - Harold Taggart
- Tim Dixon - Reverend Manderville
- David Castro - Matthew Cortland
- Heather Hanson - Rebecca
- Bethoe Shirkoff - Rebecca - 73 Yrs.
- Alexandra Purvis - Katherine 'Kat' Corrigan
- Andrew Johnston - Joshua Cantwell
- Alison Matthews - Miss McHugh / Kat's Teacher
- Zelda Rubinstein - Christina
- Shaina Tianne Unger - Marcy
- Patrick Fitzgerald - Father Philip Callaghan
- Philip Granger - Charles Banyon
- Susan Hogan - Clare Spencer
- Lawrence Dane - Sir Edmund Tremain
- Sean Day Michael - Rimbau
- Andre Benjamin - Orderly
- Shane Kelly - Deputy Sheldon
- Gavin Buhr - Excavation Foreman
- J. Winston Carroll - (as J.W. Carroll)
- Alandra - Marion Wood
- Cynde Harmon - Lisa Gannon
- Carly McKillip - Amber
- Sebastian Spence - Noah Wilkes
- Jesse Moss - Peter Hoth
- Graham Greene - Charlie
- Laura Harris - Tracy Lasker
- Brad Turner
- Ken Girotti
- Helen Shaver
- Brenton Spencer
- Martin Cummins
- Paul Lynch
- Robert Masello
- Mark Stern
- Bill Froehlich
- Frederick Rappaport
- Grant Rosenberg
- James Cappe
Martin Cummins interpreta a Nick Boyle en la serie.
Eric Keenleyside interpreta a Miller en la serie.
Derek de Lint interpreta a Derek Rayne, Ph.D. en la serie.
Robbi Chong interpreta a Alexandra Moreau en la serie.
Capítulo disponible en las siguientes plataformas:
