- Paapa Essiedu - Kwame Acheamong
- Ansu Kabia - Derae
- Layo-Christina Akinlude - Sonia (Street Fan)
- Katherine Jakeways - Jacki (interviewer)
- Gualtiero Burzi - Max (waiter)
- Camille Dugay Comencini - Mathilda
- Alessandro Carbonara - Giovanni
- Alberto Brosio - Luigi
- Elise Palmer - Genevieve (hairdresser)
- Kadiff Kirwan - Officer Tom
- Tor Clark - Sarah
- Melissa Batchelor - Mary
- Ian Bonar - Martin
- Beverly Longhurst - Miss Mott
- Mark Weinman - Mr. McHale
- Jay Lycurgo - Marcus
- Aml Ameen - Simon
- Shiloh Coke - Checkout Assistant
- Antonia Clarke - Emily
- Noah Maxwell Clarke - Jamal
- Vivian Oparah - Bisola
- Fehinti Balogun - Damon
- Shalisha James-Davis - Loretta
- Jonathan Slinger - Doctor
- Fela Lufadeju - Rumi
- Andi Osho - Carrie
- Victor Oshin - Young Kojo
- Michelle Greenidge - Grace
- Tobi King Bakare - Nicholas
- Dada Ashi - Lenora
- Adwoa Akoto - Young Leonora
- Yinka Awoni - Kojo
- Rebecca Calder - Shirley (hospital patient)
- Karan Gill - Zain
- Ellie James - Sion
- Franc Ashman - Susy Henny
- Harriet Webb - Theodora
- Gaby French - Teen Theodora
- Danielle Vitalis - Teen Arabella
- Pearl Chanda - Nilufer
- Gershwyn Eustache Jnr - Tyrone
- Tyler Luke Cunningham - Kai
- Fergus O'Donnell - Homeless Man
- Georgina Higgins
- Natasha Phillips
- Donna Mabey
- Roberto Troni
- Simon Maloney
- Simon Meyers
- Philip Clarke
- Michaela Coel
- Ciara Elwis
- Matt Biffa
- Tom Deane
- Joe Beal
Weruche Opia interpreta a Terry Pratchard en la serie.
Paapa Essiedu interpreta a Kwame Acheamong en la serie.
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