- Timothy Spall - Ed Jacobson
- Rebecca Manley - Mary Jacobson
- Anthony Boyle - Sam Jacobson
- Rudi Dharmalingam - Bob Paine
- Tuppence Middleton - Linda
- Anne Reid - Martine Jenkins
- Ann Akinjirin - Dr. Simpson
- Hayley Squires - Waitress
- Tom Brooke - Tall man in light coat
- Marko Leht - Icelandic customer
- Matthew Raymond - Engaged man
- Naveed Khan - Helpful Pakistani man
- Jack Reynor - Brian Norton
- Benedict Wong - Ed Andrews
- Geraldine Chaplin - Irma Louise Gordon
- Justin Butcher - Linus Primo
- Georgina Campbell - Barbara
- Bekka Bowling - Synth Female Attendant
- Malik Ibheis - RB29
- Sidse Babett Knudsen - Jill
- Julia Davis - Sally Morris
- Joanna Scanlan - Su
- Lucian Msamati - Director
- Michael Socha - Noah
- Abraham Popoola - Recycle Driver
- Greg Kinnear - Father
- Jack Gore - Charlie Cotrell
- Mireille Enos - Mother
- Bryan Cranston - Silas Herrick
- Essie Davis - Vera Herrick
- Liam Cunningham - General Olin
- Ruth Bradley - Yaro Peterson
- Richard Madden - Agent Ross
- Holliday Grainger - Honor
- Anneika Rose - Mary
- Vera Farmiga - The Candidate
- Mel Rodriguez - Philbert Noyce
- Jason Mitchell - Lenny
- Glenn Morshower - Ed
- Juno Temple - Emily Zabriskie
- Janelle Monáe - Alexis
- David Lyons - Conrad Morrison
- Jay Paulson - Reverend Perine
- Terrence Howard - George
- Anna Paquin - Sarah
- Rachelle Lefevre - Katie
- Lara Pulver - Paula
- Jacob Vargas - Mario
- Sam Witwer - Chris
- Guy Burnet - Colin
- Maura Tierney - Irene Lee
- Noma Dumezweni - Senior Agent Okhile
- Tony Way - Carmichael
- Richard McCabe - Dr. Thaddeus Cutter
- Tom Mothersdale - Rathbone
- Paul Ritter - Franklyn
- Annes Elwy - Young Irma
- Khalid Abdalla - Interrogator
- William Gaminara - Dr. El Ganol
- Nathalie Armin - State's Advocate
- Ronan Vibert - Chief Judge
- Jamie Wilkes - Private Matthews
- Marc Danbury - Military Official
- Dean Ashton - Agent Lance
- Jessica D'Arcy - Agent Dov
- Remmie Milner - Teep Hooker
- Sarah Vevers - Teep
- Sophia Del Pizzo - Implanted Jill #1
- Scott Karim - Implanter
- Kerri McLean - Implanted Jill #2
- Adam Riches - Tour Guide
- Nick Eversman - Avishai Hahn
- Maximiliano Hernández - Lewis
- Rebecca Jordan - Susan
- Isis Davis - Jess
- Christian Isely - Harris
- Anton Bassey - Bakshi
- Shannon Merrill Brown - Rotko
- Alana Arenas - Detective Fernandez
- Terry Kinney - Mr. Dick
- Marc Grapey - Principal
- Brian Boland - Mr. Daltry
- Andrew Rothenberg - Captain Miller
- Eric C. Lynch - Golan
- Connor Paolo - Ethan
- Alice Lee - Milena
- Algee Smith - Kaveh
- Martin Donovan - Odin
- Emily Rudd - Kim
- Louis Herthum - Supervisor
- DuShon Monique Brown - Peace Sergeant
- Kathy Scambiatterra - Insurance Adjuster
- Kylan Conroy - Yellow Bonnet Girl
- Dale Rivera - Cowboy Shave Ad
- Bassam Abdelfattah - Brazilian Coffee Ad
- Lia D. Mortensen - Interviewer
- Mari Marroquin - Teacher
- Sarah Baker - Maggie Noyce
- Lauren Hobbs - Girl
- Philip K. Dick
- Ronald D. Moore
- Isa Dick Hackett
- Michael Dinner
- James Degus
Steve Buscemi hace el papel de Ed Morris.
Connor Paolo interpreta a Ethan en la serie.
Timothy Spall interpreta a Ed Jacobson en la serie.
Rebecca Manley interpreta a Mary Jacobson en la serie.
Anthony Boyle interpreta a Sam Jacobson en la serie.
Rudi Dharmalingam interpreta a Bob Paine en la serie.
Tuppence Middleton interpreta a Linda en la serie.
Anne Reid interpreta a Martine Jenkins en la serie.
Ann Akinjirin interpreta a Dr. Simpson en la serie.
Hayley Squires interpreta a Waitress en la serie.
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