- Megan Mullally - Mrs. Dodds / Alecto
- Virginia Kull - Sally Jackson
- Timm Sharp - Gabe Ugliano
- Glynn Turman - Mr. Brunner / Chiron
- Hiro Kanagawa - Headmaster
- Azriel Dalman - Young Percy Jackson
- Olivea Morton - Nancy Bobofit
- Simon Chin - Super (Eddie)
- Manoj Sood - Principal
- Malcolm Anthony Clarke - Snickering Kid #2
- Mateo Deuma - Kid #3
- Peyton Amelia Feltham - Nancy's Friend #1
- Valencia Budijanto - Nancy's Friend #2
- Jason Mantzoukas - Mr. D / Dionysus
- Jason Gray-Stanford - Maron
- Kathleen Duborg - Helena
- Garfield Wilson - Leneus
- Jessica Parker Kennedy - Medusa
- Suzanne Cryer - Echidna
- Adam Copeland - Ares
- Timothy Omundson - Hephaestus
- Nick Boraine - Voice in Dream (voice)
- Nick Boraine - Kronos
- Jay Duplass - Hades
- Toby Stephens - Poseidon
- Lance Reddick - Zeus
- Lin-Manuel Miranda - Hermes
- Lin-Manuel Miranda - Hermes (uncredited)
- Jennifer Shirley - Oracle
- Darla Fay - Cashier
- Ryan Cowie - Chaperone
- Alessandro Juliani - Transit Cop #1
- Ely Jackson - Transit Cop #2
- Gayle Yamamoto - Mom
- Winson Won - Dad
- Joyce Robbins - Fate #1
- Cindy Piper - Fate #3
- Ted Dykstra - Augustus
- Julian Richings - Procrustes
- Andrew McIlroy - Administrator
- Jenaya Ross - Asphodelian
- Bola Omodara - Security Guard
- Daphne Olive
- Rick Riordan
- Ellen Goldsmith-Vein
- Pablito Tancinco
- Bert Salke
- Douglas Burzynski
- Candice Elzinga
- Jet Wilkinson
- Bear McCreary
Julian Richings interpreta a Procrustes en la serie.
Walker Scobell hace el papel de Percy Jackson.
Leah Sava Jeffries hace el papel de Annabeth Chase.
Aryan Simhadri interpreta a Grover Underwood en la serie.
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