- Esther Coles - Kim Beardsmore
- Adrian Lukis - Dr. David Shearer
- Gray O'Brien - Dr. Tom Deneley
- Gary Mavers - Dr. Andrew Attwood
- Simon Shepherd - Dr. Will Preston
- Joseph Millson - Dr. Sam Morgan
- Deborah Grant - Carol Johnson
- Tony Audenshaw - Peter Castle
- Caroline Catz - Carol Dart
- Minnie Driver - Sue Keel
- Vincent Regan - Peter Doland
- Daniel Ryan - Damien
- Ian Mercer - 'Clarkey' Clarke
- Hugh Bonneville - Dominic Kent
- Tony Doyle - Bob Massey
- Judy Loe - Sheila Massey
- Albert Welling - Ross Bain
- Amanda Walker - Elaine Deneley
- Paul Popplewell - Greg Crinham
- James Murray - Marcus Johnson
- John McEnery - Ken Willett
- Matthew Marsh - Mr. Lockwood
- Andrew Knott - Steve
- Marshall Lancaster - Paul Lynch
- Ace Bhatti - Specialist
- Frank Middlemass - Arthur Broughton
- Sam Kelly - Frank Watkins
- Andrew Havill - Alan Baxter
- Andrew Buckley - Geoff
- Richard Durden - George Morgan
- Joanna Scanlan - Midwife
- Barry Jackson - Gordon Wright
- Suzanne Bertish - Dr. Brodie
- Guy Henry - Dr. Martin Bryford
- Sarah-Jane Potts - Maddie Taylor
- Steven Elder - DC Mullins
- Shaun Dooley - Paramedic
- Alan Williams - Kevin Coles
- Art Malik - Mr. Hussain
- James Noble - Mr. Naughton
- Stanley Townsend - Keith Johnson
- Siobhan Finneran - Caroline Royal
- Tom Chadbon - Patrick Hargreave
- Philip Martin Brown - Colin Meadows
- Tony Maudsley - Ian Fair
- David Ryall - Ben Jones
- Lesley Nicol - Sally Buxton
- Benjamin Whitrow - Dr. Laurence Reeve
- Jason Hughes - Robbo Gibbs
- Sophie Ward - Lorna Goodley
- Richard Bremmer - Nick Bowman
- Jack Deam - Joey Cox
- Peter Sullivan - Richard Beamer
- Daniel Casey - Colin Bentley
- Ruth Sheen - Pauline Wadham
- Jason Done - Mark Rogers
- Zoe Telford - Sarah O'Shaughnessy
- Sean Pertwee - Francis Barrat
- Hermione Norris - Penny
- Con O'Neill - Nick Gillespie
- Mark Williams - Roland Grogan
- Tim Dutton - Alan 'Tommo' Tomlins
- Bill Nighy - Alan Sinclair
- Richard Hope - Roy Shearer
- Hugh Fraser - Marcus Menzies
- Pip Torrens - Harry Kenyon
- John Woodvine - Jackie Brown
- Lucy Cohu - Gina Johnson
- Chris Roebuck - Toby Wilson
- Toby Kebbell - Graham
- Ben Maguire - Sean Gillespie
- Dean Gatiss - Toby Greaves
- Jennifer Wilson - Dr. Baxter
- David Williams - Mr. Dillon
- Agatha Hurle - Sisu Walanda
- Walter Muparutsa - Jacob
- Amelda Brown - Sue Barnes
- Rebecca Callard - Jazz Elliott
- Andrew Wilde - Ted Barnes
- Paul Broughton - Dave Elliott
- Kate Lock - Jan Elliott
- Iain Mitchell - Mr. George Cuthbert
- John Pennington - Coroner
- Vass Anderson - Vicar
- Tim Wylton - Menzies Wilson
- Glen Davies - Chef
- Julian Gartside - Mr. Hobbs
- Oliver Young - Derek
- Kate Doherty - Staff Nurse Smythe
- Natalie Morse - Gemma Sinclair
- Susannah Corbett - Dr. Kerri Davidson
- Susannah Corbett - Kerri Davidson
- Susannah Corbett - Vanessa Machin
- Frances Low - Maureen Sinclair
- James Warrior - Hargreaves
- Crispin Harris - Pianist
- Wayne Foskett - Ray Mason
- Elizabeth Edmonds - Val Mason
- George Raistrick - Ken Waight
- Richard Brinkmann - Kevin
- James Snell - GP Lecturer
- Tom Beard - Dr. Daniel Acres
- Jaye Griffiths - Dr. Rhiann Lewis
- John Lynch - Father Mel Davey
- Tilly Vosburgh - Marjorie
- Margery Withers - Hilda Lyons
- Bernard Strother - John Barber
- Elaine Donnelly - Liz Barber
- Bruce Alexander - Father Clement
- Rio Fanning - Bishop Stirland
- Eileen O'Brien - Mrs. Haines
- Kate Percival - Sylvie O'Neill
- Desmond Stokes - Customer
- Desmond Stokes - Samson
- Danielle Tilley - Susan Davey
- Chris Sanders - Derek
- Michael Thomas - Peter Thorn
- Tim Briggs - Hannibal Lecter Student
- Tim Briggs - Casualty Officer
- James Hooton - Footballer
- Edward Clayton - Referee
- Steven Brough - Man
- Sean Gallagher - Ian Hilliard
- Jayne Ashbourne - Marie
- Thomas Craig - Paul
- Phil Smeeton - Graham
- Madelaine Newton - Irene
- Colin Wells - John Adams
- Judy Liebert - Head Teacher
- Chris Stanton - Dr. David Ashmore
- Peter Armitage - Rob Clulow
- Leonard Preston - Senior House Officer
- Leonard Preston - Casualty Officer
- Francis Lee - David Clulow
- Maurice Denham - Douglas Hart
- Maurice Denham - Mr. Hart
- Chris Sullivan - Wedding Guest
- Miles Anderson - Dominic Jenkins
- Gavin Abbott - Ginge
- Alan David - Richard Morris
- Roland Oliver - Brian Drake
- Michael Cadman - Ian Hart
- Stan Nelson - Security Guard
- Max Mason - Tutor
- George Malpas - Veteran
- Colin Bower - Organiser
- George Irving - Martin Keel
- James Peachey - Matthew Keel
- Gabrielle Reidy - Senior Registrar
- Dearbhla Molloy - Karen Eastman
- Kieron Forsyth - Gavin
- Dorothy Atkinson - Woman Driver
- Catherine Terris - Liz
- Tim Stanley - Footballer
- Tim Stanley - Pal
- Michael Greatorex - Riding Instructor
- Doreen Mantle - Mary Eastman
- Tenniel Evans - David Eastman
- Larrington Walker - Bus Driver
- Brian Southwood - Lorry Driver
- Nicholas Caunter - Alan
- Donal McCann - Michael
- Elizabeth Chadwick - Lisa
- Louise Delamere - Susie
- Alan Westaway - Man
- Donna King - Angela Wilkes
- Jack Klaff - Drew Wilkes
- Nicholas Pinnock - Ben
- Janet Crawford - Prospective Buyer
- Jonathan Hyde - Dr. Stuart Mosely
- Oliver Smith - Swan
- Samantha Morton - Abbey / Pauline Jones
- Bill Gavin - Alf
- Christopher Baines - Stevens
- Howard Grace - Drinker
- Fiona Johnson - Girl
- Tam Hoskyns - Annie Kent
- Hilary Lyon - Sarah
- Valentine Pelka - Michael Massey
- Robert Demeger - Frank Hooley
- Simon Corris - John
- Elizabeth Hickling - Abigail
- David Warwick - Pasco
- Karen Gledhill - Geraldine
- Tracy Brabin - Lou Clarke
- Tim Meats - Clerk of the Court
- Bunny May - Milkman
- Kitty Scopes - Eve
- Gary Sefton - Andy Corrigan
- Mark Ryan - Chris Palmer
- Mick Barnfather - John Cleary
- Meryl Hampton - Marie McKenner
- Mary Reid - Alison McKenner
- Eric Flynn - Paul Hanlon
- Pip Donaghy - Geoff Welland
- James Mair - Philip Ridgeway
- Freddie Fletcher - George Milton
- Simon Slater - Gilzean
- Roger Avon - Angus Belfer
- Carol Leader - Pam Milton
- Justin Brady - James Dewar
- Matyelok Gibbs - Muriel Blakeley
- John Normington - Freddie Cartwright
- Petra Markham - Cissy Banks
- Peggy Shields - Iris
- Eric Potts - Compere
- Caroline Loncq - Lisa Harding
- Stuart MacKenzie - Doctor
- Stuart MacKenzie - Monroe
- Charlotte Clarke - Louise Harding
- Sean Murray - Martin Harding
- Peter Benson - Terry Alston
- Anna Keaveney - Cath Dawson
- Leena Dhingra - Dr. Seema Gupta
- Sylvia Syms - Isabel de Gines
- Dave Hill - Phil Cullam
- Kate O'Malley - Amanda Stokes
- Andrew Lancel - Mark Stokes
- Anastasia Mulrooney - WPC Helen Stuart
- Merelina Kendall - Dr. Elspeth Beattie
- Kate Binchy - Ann Grainger
- Ralph Nossek - Frank Sturgess
- Graham Turner - John Wadham
- Martin Sadler - Adam Kitchener
- Kathy Kuleya - Elizabeth
- Veronica Quilligan - Francine Sinclair
- Charles Mucheriwa - Mr. Ondeniyki
- Paul Butterworth - Minister
- Paul Butterworth - Ambulanceman
- Jeff Shankley - Jeff Brodie
- Peter Dineen - Phil Tebbs
- Phil Croft - Bill Pearson
- Gena Kawecka - Trish Hoskins
- Gaynor Faye - WPC Benson
- Dorothy Vernon - Carol Wright
- Sasha Paul - Janey Cooper
- Paola Dionisotti - Nancy Thurston
- Stephen Oxley - Dr. Rhodes
- Grant Masters - Doug Thurston
- Howard Ward - Sgt Eddie Williams
- Gregory Chisholm - Joe
- Phillip Manikum - Fred Murray
- Ron Davies - Father Peter Kerry
- Eva Pope - Claire Brightwell
- Eva Pope - Sally Gillespie
- Eva Pope - Karen
- Heather-Jay Jones - Josie Davis
- Rosalind March - Heather Ayres
- Garry Cooper - Alan Davis
- Henry Moxon - Mr. Benn
- Henry Moxon - Magistrate
- Dee Sadler - Claire Davis
- Beth Goddard - Leanda Sharpe
- Nicholas Hewetson - Gary Donalds
- Kacey Ainsworth - Julia
- Andrew Powell - Corporal Gary Groves
- Caroline Langrishe - Dr. Susan Lees
- Caroline Langrishe - Anna Bradshaw
- Polly York - Kate Godfrey
- Jo Kendall - Rose Godfrey
- Julian Kerridge - Matthew Godfrey
- Mark Whiteley - Glen Hughes
- Mark Whiteley - Mark Platt
- Pamela Ruddock - Theresa McNeagh
- Chris Gascoyne - Joe Rawlings
- Stephanie Turner - Doreen Rawlings
- Andrew Ray - Dr. John Reginald
- Ian Kirkby - Edward Turrell
- Peter Harding - Sgt Alan Goodman
- Martin Milman - Mr. Haworth
- Leslie Meadows - Man
- Tim Dantay - David Frankland
- Elizabeth Ash - Gill Frankland
- Anthony Milner - Dougie Greaves
- Rosie Cavaliero - Rachel Adams
- Rosie Cavaliero - Gwenda O'Keefe
- Chris Barnes - Morris Sligo
- Michael Haughey - Frank Barrington
- Jon Glover - Greg Miller
- William Chubb - Keith Llewellyn
- Lorraine Ashbourne - Tina Greaves
- Beverly Hills - Monika Gaye
- Michael Bertenshaw - Dr. Sharland
- Michael Bertenshaw - Casualty Officer
- John D. Collins - David Cornish
- Jo Dow - Martin Beckham
- Shaun Prendergast - Trevor Sharpe
- David Michaels - Mick Priest
- Michelle Chadwick - Marie
- Michelle Chadwick - Melanie
- Aidan McCann - Ambulanceman
- Polly Kemp - Casualty Sister
- Denise Stephenson - Cathy Priest
- Jacqueline Leonard - Sarah Preston
- Tina Harris - Staff Nurse
- Brian Smith - Mr. Wearing
- Paul Moriarty - Sgt Dave Taylor
- Jonathan Kerrigan - Ewan Harvey
- Ken Jones - Edward Fellows
- Glyn Owen - Dr. Philip Ramsden
- Sophie Walker - Emma Davies
- Darren Campbell - Steve
- Edward Atterton - Dan Copeland
- Ron Welling - Peter Gilmore
- James Tomlinson - Stuart Reynolds
- Greg Hicks - Barry Reynolds
- Philip Whitchurch - Vinnie Kern
- Philip Whitchurch - Eric Clarkson
- David Hargreaves - Rev Neil Winters
- David Hargreaves - Charlie Fields
- Martin Reeve - Malcolm
- Derek Benfield - Fred Hargrave
- Brenda Peters - Rose Hargrave
- James Lailey - Peter Dobson
- Jane Whittenshaw - Mrs. Hardinge
- Linda Armstrong - Mary Ingham
- Martha Cope - Danni
- Anna Jaskolka - Claire Curtis
- Nicola Sanderson - Trish Fielding
- Billy Geraghty - Harry Fielding
- Andy Joseph - Dr. Simon Geoffries
- Christine Mackie - Helen Marsh
- Martin Walsh - Neil Evans
- Mark Kingston - Roy Bennet
- Selina Boyack - Dr. Barbour
- Bruce Byron - Des Manningham
- Judy Flynn - Linda Manningham
- Esther Hall - Maria
- Ian East - Brian Buxton
- Edward Hardwicke - Patrick Siddons
- Elisabeth Sladen - Dr. Pat Hewland
- Ian Burfield - Steve Mellor
- Frances White - Margaret Shaw
- Bryan Pringle - Jim Barraclough
- Jane Wood - Dr. Roberts
- Shane Fox - Neil Rushton
- Shane Fox - Tom Harding
- Mia Soteriou - Hilary Jenkins
- Kevin McGowan - Dr. Hyde
- Sarah Howe - Jean Russell
- Jane Hollowood - PE Teacher
- Susan Tordoff - Consultant
- Tom Georgeson - Bill Jackson
- Georgie Glen - Myra Eburne
- Ann Aris - Mrs. Whaley
- Alwyne Taylor - Consultant
- Ronald Herdman - Mr. Cochrane
- Ian Aspinall - Simon Rollason
- Gillian Bevan - Julie Evans
- Ewan Hooper - Derek Lomas
- Stephen Noonan - Postman
- Adjoa Andoh - Dr. Nixon
- Duncan Wisbey - Perry
- Sam Loggin - Stacy
- Andy Secombe - Dr. Alan Stark
- Maggie Wells - Liz Montgomery
- Hugh Munro - Old Man
- Allan Surtees - Frank Gladstone
- Angela Forrest - Chris Mayer
- Jan Ruppe - Nurse
- Glyn Grain - Consultant
- Patsy Byrne - Mrs. Burns
- Karen Ford - Dr. Grant
- Ray Stevenson - Joe Higson
- Ruth Gemmell - Christine Higson
- Paul Kavanagh - Man
- Rashid Karapiet - Dr. Choudhury
- Bob Mason - Roger Wyatt
- Bob Mason - John Bannerman
- Brian Peck - Dr. Geoffrey Smith
- John Warnaby - Dr. Norton
- Louise Beattie - Alison Beckwith
- Danny Cunningham - Malcolm Wallace
- Danny Cunningham - Steve
- Kenneth Colley - Stan Jordan
- Jonathan Bond - Pete Ingles
- Rosemary Martin - Joyce Jordan
- Mark Moraghan - Phil Young
- Toby Eddington - Consultant
- Ravi Aujla - Proprietor
- Philip Cox - Warden
- Paddy Joyce - Mr. Austen
- Ken Christiansen - Dr. Charnock
- Will Knightley - Dan Jakes
- Sally Adams - Committee Member
- Pat Keen - Molly
- Keeley Forsyth - Trish - Nurse
- Geoffrey Freshwater - Policeman
- Grant Russell - Eddie Penrose
- David McAlister - Mike Walton
- Margot Leicester - Dr. Wellington
- Muriel Lawford - Old Woman
- Valerie Gogan - Melissa Hollingsworth
- Charlie Roe - Dr. Watkins
- Alexander Hanson - Alex Hollingsworth
- Graham Pountney - John Griffin
- Tony Vogel - Freddie Fairburn
- Michael Gunn - Sam Marsh
- Fraser Cains - Mick
- Sukie Smith - Kirsty Attwood
- Polly Hemingway - Nancy Fairburn
- Roger Bingham - Old Man
- Roger Bingham - Frank
- Roger Bingham - Patient
- Roger Bingham - Barrel-Rolling Official
- George Little - Professor Alan Digby
- George Little - Alan Murdoch
- Joe Jones - Tony
- David Prosho - Chris Ackroyd
- Stephen Critchlow - Rugby Player
- Yolanda Vazquez - Clare Shearer
- Joanna Phillips-Lane - Glenda Reeves
- Joanna Phillips-Lane - Karen Turner
- Nick Bagnall - Daniel Kern
- Sharon Duce - Carol-Anne Kern
- Ben Marshall - Paul Kelsey
- Jenny McCracken - Linda Kelsey
- John Flanagan - Brian Kelsey
- Robert Hands - Terry Summerscales
- Sian Gibson - Sandra
- Paul Barnhill - Sean
- Kevin Dyer - Steven Evans
- Kate Isitt - Kay Beamer
- Robert Weatherby - Ron Ridges
- Daniel Flynn - Dr. Henry Little
- Ava Hunt - Teacher
- Tony Barton - Alan Thompson
- Mary Healey - Val
- Elizabeth Rider - Anne Meadows
- Elizabeth Rider - Patricia Davey
- Elizabeth Rider - Alison Farnham
- Jeffrey Robert - Jimmy
- Vanessa Hadaway - Sam
- Brian Capron - Henry Lewis
- Martina Laird - Dr. Toray
- Timothy Watson - Bob Hansen
- Jeremy Colton - Jamie
- Jeremy Colton - Casey Dewar
- Catherine Carter - Waitress
- Deirdre Costello - Mrs. Heap
- Lucinda Gane - Wendy Lewis
- Anna Darvas - Policewoman
- Veronica Leer - Nurse
- Alec Newman - Sean Hollings
- Robert Hudson - Police Inspector
- Robert Hudson - Sergeant Bob Carrigan
- Jean Heywood - Edna Sturgess
- Jean Heywood - Beryl Otley
- Colin MacLachlan - Geoff Pearce
- Sean McKenzie - PC Martin
- Sean McKenzie - Bob O'Keefe
- Chris Walker - Danny Jackson
- Chris Walker - Hugh Mitchell
- Stephen Guilfoyle - Chris Lyle
- Paul Ridley - Lawrence Johns
- Paul Ridley - Stephen Joyce
- Diane Adderley - Dr. Joan Thacker
- Andy Robb - Matt Gibson
- Geoffrey Hutchings - Jake Pearson
- Ladene Hall - Tina
- Ladene Hall - Nurse
- Peter Geddis - Bob Doyle
- John Phythian - Peter Doyle
- Sally Baxter - Carol Doyle
- Simon Sherlock - Lawrence
- Susan Cookson - Ward Sister
- Susan Cookson - Alison Fletcher
- Mairead McKinley - Ann Channon
- Kadie Savage - Jade Channon
- Glyn Grimstead - Jack Butler
- Zienia Merton - Jennifer Kemp
- Stephen Churchett - Mr. Anthony Millington
- Graham Padden - Colin Rose
- Carolina Giammetta - Police Officer
- Geoffrey Beevers - Stuart Johnson
- Mary Tempest - Mrs. Louis
- Helen Anderson - Deborah Miles
- Gail Kemp - Nurse
- Gail Kemp - Shop Assistant
- Irene Sutcliffe - Maisie
- David Aldous - Driver
- Marlene Sidaway - Hospital Matron
- Marlene Sidaway - Rosie Pritchard
- Jim Norton - Father Matthew Corlon
- Tracy Gillman - Kath Johnson
- Eamon Boland - Duggie
- Eamon Boland - Inspector Rossiter
- Alison Skilbeck - Consultant
- Del Henney - Frank Attwood
- Barbara Ewing - Rosaleen Attwood
- Thomas Lockyer - Dr. Nick Goodson
- Janet Dale - Mary Willett
- Janet Dale - Jean Thurston
- Joan Campion - Mrs. Fletcher
- Simon Markey - Gordon Miles
- Simon Markey - Consultant
- Simon Markey - Dr. Cooper
- Maggie Jones - Dr. Landstone
- Keith Marsh - Mr. Jordan
- Adam Bareham - Mr. Christopher Mayhew
- Adam Bareham - Brian Freeman
- Andrina Carroll - Gillian Goodson
- Joanne Howarth - Bella Goodson
- Angela Saul - Mrs. Jordan
- Paul Bown - James 'Mac' Macarty
- Toby Ross-Bryant - Callum Macarty
- Anthony Clarke - Sean Turnbull
- Anthony Clarke - Intruder
- Crissy Rock - Marion Richards
- Crissy Rock - Marion Daley
- Melanie Kilburn - Liz Pullen
- Melanie Kilburn - Irene Brodie
- Breffni McKenna - Patrick Connor
- Bernard Gallagher - Arthur Bannerman
- Dione Inman - Josie Connor
- Peter Stockbridge - Billy Gillespie
- Peter Stockbridge - Secretary
- Peter Gordon - Jack Morris
- John Statham - Marshal
- John Statham - Contractor
- John Statham - Referee
- Alan Leith - Man at Docks
- Melvyn Bedford - Neighbour
- Zena Walker - Mary Melchett
- Howard Southern - Frank Brown
- Eileen Davies - Registrar
- Eileen Davies - Mrs. Roberts
- Eileen Davies - Mrs. Treasure
- Eileen Davies - Patient
- Richard Hawley - Steve Fletcher
- Eve Steele - Tricia Fletcher
- Sarah Nash - Waitress
- George Camiller - Mario
- Jenni Gallagher - Emma Shearer
- Jenni Gallagher - Holly Taylor
- Mark Lingwood - Police Officer
- Philip Childs - MC
- Philip Childs - Vicar
- Peter Cleall - Police Inspector
- Roy Barraclough - Mayor Joss Brown
- Roy Barraclough - Joe Wilson
- Kate Fenwick - Lizzie Tate
- James Gaddas - Ian Tate
- Dean Lennox Kelly - Martin Beasley
- Richard Butler - Sam Wilson
- Julia Ford - Sandra Jordan
- Julia Ford - Liz Thurston
- Oliver Jackson - Tom
- Eleanor Caird - Radiographer
- Ian Lavender - Mr. Neville
- Helena Little - Dr. Rostle
- Vincent Pickering - Rob McBride
- Frank Windsor - Ken Alton
- Frank Windsor - Peter Osborne
- Richard Bates - Surgeon
- Richard Bates - Doctor
- Jon Fenner - Colin
- John Hudson - Mr. Leach
- John Hudson - MRI Doctor
- John Hudson - Eye Unit Manager
- Edmund Moriarty - Paul
- Carole Nimmons - Prof Pauline Donalds
- Godfrey Jackman - Peter Cunningham
- Diane Beck - Receptionist
- Jean Ainslie - Mrs. Winkle
- Mark Brignal - Major Watts
- Eric Allan - Bill Rawlings
- Eric Allan - Ken Larke
- Marcello Walton - Waiter
- Andrew C. Wadsworth - Peter Lewis
- Geoffrey Bayldon - Alby James
- Noreen Kershaw - Kate Lewis
- Katharine Page - Nora Oaks
- Richard Platt - James White
- Hazel Ellerby - Chloe White
- Dickon Tolson - Lee Simms
- Clive Swift - Norman Shorthose
- Matthew Barker - Adrian
- Matthew Barker - Will
- Edward Jewesbury - Bob Hampton
- Veda Warwick - Martha Hampton
- Jane Lowe - Jayne Swift
- David Hatton - Mr. Marber
- Liz Whiting - Hazel James
- Ian Gain - Christopher James
- Geoff Holman - Chairperson
- Geoff Holman - Surgeon
- Neal Swettenham - Mr. Georgeson
- Kate Fitzgerald - Chrissy Booth
- Caroline Berry - Margaret
- Trevor Dwyer-Lynch - Wes
- Ralph Riach - Malcolm McReadie
- Ralph Riach - Mr. Rees
- Bridget Fry - Sarah
- Elaine Pyke - Dr. Rachel Howe
- Jason O'Mara - Billy Matters
- Roger May - Senior House Officer
- Roger May - Mr. James Stokes
- Duggie Brown - Brian Neale
- Paul Viragh - Graham Hyde
- Paul Viragh - Chris Myers
- Stanley Kowalski - Derek Mullins
- Adam Maxwell - Paramedic
- Michael Webber - Mr. Tupper
- Helen Atkins - A&E Nurse
- Peter Ashdown - Doctor
- Damian Myerscough - Phil
- Gilly Gilchrist - Keith Rudge
- Gilly Gilchrist - Fred Rudge
- Richard Morant - Mr. Dunfield
- Steve Ramsden - Jimmy Flynne
- Steve Ramsden - John
- David Hounslow - George Chadwick
- David Hounslow - Lou Collinson
- David Roper - James Crick
- Nigel Cooke - Michael Moore
- Anne Raitt - Mary Crick
- Laura Crossley - Sarah Chadwick
- Laura Crossley - Susan Jakes
- Peter Yapp - Dr. Traylen
- Peter Martin - Ernie Page
- Peter Martin - Alex Freeman
- Brian Hickey - Nick Soames
- Frank Mills - Eric Johnson
- Richard Leaf - Dr. Patrick Berry
- Sara Poyzer - Mother
- Amanda Loy-Ellis - Susan Gibney
- Philip Anthony - Rev. Briggs
- Judith Davis - Liz
- Paul Copley - DS Patrick Hopkins
- Paul Copley - Tim Shardlow
- Ralph Brown - Stephen Westwood
- Joanna Kanska - Helena Westwood
- Judith Barker - Marion Shaw
- Finlay Robertson - Peter Shaw
- Nicholas Harvey - Tom Shearer
- Annette Ekblom - Patricia Davey
- Angela Lonsdale - Kate Wallace
- Georgia Tennant - Nicki Davey
- Paul Blackthorne - Liam McGregor
- John Alderton - Harry Capper
- Emily Raymond - Hilary McNeill
- Susan Bovell - Janet Heath
- Susan Bovell - Elizabeth Faire
- Andrew Loudon - Geoff McNeill
- Michael Simkins - Larry Simms
- Robert Perkins - Adam Weaver
- Robert Perkins - Dave Kelly
- Peter Caffrey - Barney
- Julie Bramall - Ali Sinclair
- Jane Slavin - Georgy Kepler
- Andrew Callaway - Paediatrician
- Victoria Carling - Sue Lawton
- Elizabeth Mellor - Sarah Blane
- Roger Sloman - Mr. Potts
- James Masters - John Crier
- James Masters - Registrar
- Nick Stringer - PC Pete Greenhalgh
- Ben Smith - Gary
- Trevor Fox - Steve Henson
- Trevor Fox - Audiologist
- Howard Crossley - Manning
- Howard Crossley - Des
- Charlotte Bicknell - Stella Dawson
- John Axon - Tony Capman
- Ian Lindsay - Keith Gadd
- Ian Lindsay - Bernard Gould
- Bill Rodgers - Bill Collins
- Shirley Dixon - Rosemary Doyle
- Shirley Dixon - Irene Ashenden
- Angela Curran - Liz Chapman
- Marguerite Hardiman - Val Greenhalgh
- David Savile - Consultant
- Rowena Cooper - Megan Hunter
- Fiona Gillies - Clare Shearer
- Rosalind Bailey - Miranda Peters
- David Shimwell - Derek Green
- Barbara Wilshere - Carol Munroe
- Lindsay Carr - Julie Munroe
- Eddie O'Connell - Sgt Dave Paxford
- Colette O'Neil - Sylvia Gadd
- Colette O'Neil - Mother Abbess
- Mo Sesay - Lance Cpl Terry Elvy
- Charlie Condou - Private Benedict Grinter
- Sarah Churm - Donna
- Roy Smiles - Steve
- Tim Harris - Luke
- Barry McCarthy - Don Spencer
- Barry McCarthy - Peter Shaw
- Paula Wilcox - Amanda Blake
- Leslie Randall - Malcolm
- Tim Barker - Bill Hutch
- Claire Harman - Cassie Myers
- Hamish McColl - Danny Givens
- Joe Simpson - Hospital Porter
- Robin McCallum - Doctor
- Jonathan Linsley - Ben
- Carolyn Pickles - Kate Loughton
- Robin Pirongs - Paul Templeton
- Kate Duchêne - Jenny Ryan
- Harry Jones - Jack Smethurst
- Lesley Dunlop - Sally Freeman
- Jim Millea - Arthur Crabtree
- Maggie O'Brien - Vet
- Roger Braban - Coroner
- Emily Aston - Rachel Kenyon
- Mark Powley - Louis Marsden
- Mark Powley - Adam
- Ivor Roberts - Mr. Dobson
- Mike Rogers - Dr. Gordon Blane
- Joanna Van Gyseghem - Psychologist
- Sue Cleaver - Julie Watkins
- Gillian Barge - Grace Longfield
- Clare Clifford - Celia, Nurse
- Helen Cotterill - Sonia
- Kish Sharma - Consultant
- Craig Heaney - Richard Watkins
- Tom Butcher - Mickey Parker
- Raquel Cassidy - Cheryl Parker
- Christian Burgess - Martin Henderson
- Jo Stone-Fewings - Jeff Loudon
- Patrick Gordon - Dave Blackstaff
- Howard Goorney - Old Man
- Marc Ryan-Jordan - Trent Rudge
- Glyn Whiteside - Doctor
- Rupert Procter - Ronnie Neale
- Ian Bailey - Bandleader
- Ian Bailey - Pathologist
- Jill Halfpenny - Kelly
- Grace Mitchell - Margery Mason
- Grace Mitchell - Old Lady
- Grace Mitchell - Janet
- Angeline Ball - Anna Templeton
- Lucy Akhurst - Lucy
- Ned Irish - Alan Hogan
- Evie Garratt - Maude Hogan
- Colin Wyatt - Pete
- Dickon Tyrrell - John Mellors
- Caroline Pegg - Fiona Mellors
- Valerie Lilley - Interviewee
- Paul McCleary - Billy
- Paul McCleary - Dr. James Michaelson
- Mark Elstob - Environmental Health Officer
- Susie McKenna - Amanda Hogan
- Dafydd Hywel - George Drew
- Gwyneth Powell - Rose Meredith
- Gwyneth Powell - Annie Gibson
- Ian Reddington - Jack Crinham
- Frances Cox - Molly
- Annette Bentley - Jean Crinham
- Kate Baines - Duty Manager
- Perry Fitzpatrick - Paul
- Federay Holmes - Nurse
- Cate Fowler - Doctor
- Hannah Waterman - Mel
- Moya Brady - Madeline Castle
- Bruce McGregor - Kevin Moor
- Bruce McGregor - Keith Moor
- Bruce McGregor - Steve Penlington
- Edna Doré - Maisie Jutson
- Edna Doré - Maisie Pullen
- Ben Miles - Rob Sinclair
- Debra Redcliffe - Pat
- Debra Redcliffe - Teresa Thorpe
- Shelagh McLeod - Kate Preston
- Shelagh McLeod - Kate Webster
- Sonia Ritter - Sally Spinx
- Sonia Ritter - Margaret Bannerman
- Amber Noble - Maria
- Anna Carteret - Dr. Yvonne Marshall
- Walter Sparrow - William
- Iain Rogerson - Jim Warner
- Samantha Power - Christine Lynch
- Joanna Brookes - Cheryl
- Ian Redford - Morris Freeman
- Susan Tracy - Anne Peterson
- Geoffrey Leesley - Crosby
- Peter Faulkner - Carl
- Kathryn Howden - Lydia
- Lisa Coleman - Sharon Willett
- Tilly Blackwood - Meg Deneley
- Ella Jones - Stacey
- Amelia Lowdell - Tina
- Tom Keller - Farmer
- Karen Ascoe - Claire
- Simon Day - Consultant
- Janet Greaves - Foster Parent
- Roy Alon - Man
- Andy Rashleigh - Dennis Higgins
- Meg Johnson - Freda Norton
- Paul Chahidi - Pharmacist
- John McArdle - Clive Richards
- George Waring - Mr. Crawford
- Keith Barron - Jeff Barton
- Victoria Scarborough - Jane Barton
- Mark Sproston - Roy
- Nina Marc - Lynne Hegarty
- Carol Drinkwater - Helen Barton
- Amelia Curtis - Kathy Barton
- Daniel Ainsleigh - Frankie Flynne
- Jacquetta May - Annie Chadwick
- Richard Stacey - Johnny Flynne
- Ryan McCluskey - Radiologist
- Jonathan Guy Lewis - Ian Lloyd
- Finn Atkins - Sarah Lloyd
- Abigail Thaw - Pam Lloyd
- Stephen Moyer - Chris Rhodes
- Katy Cavanagh - Lynne Rhodes
- Patsy Rowlands - Grace Page
- Karl Morgan - Adrian
- Karl Morgan - Lee Cooper
- Sophie Trott - Becky Thomson
- Aden Gillett - Bill Thomson
- Jane Gurnett - Sheila Thomson
- Marian McLoughlin - Ann Garwood
- Lisa McNaught - Nurse
- Stuart Goodwin - Leo Ashenden
- Dylan Brown - Lab Technician
- Dylan Brown - Jack
- Felicity Montagu - Marian Lowther
- Norman Mills - Shopkeeper
- Norman Mills - Pharmacist
- Norman Mills - Alan
- David Schaal - Graham
- David Schaal - Jack Farrel
- David Schaal - Liam
- Michael Lees - Walter Machin
- Ifan Meredith - Johnny Reynolds
- Lynne Verrall - Barbara Stone
- Anthony Higgins - Paul Redman
- Grant Ibbs - Dr. Taplin
- Akim Mogaji - Anaesthetist
- Verity Hewlett - Nurse
- Jenna Russell - Gillian Saville
- Conor O'Brien - Joe Deneley
- Tom Watson - Harry Deneley
- Lynsey Baxter - Kate Turner
- Tom Hodgkins - Peter Broadbent
- Laura Brattan - Committee Secretary
- Jenifer Armitage - Lay Member
- Hassani Shapi - Professor Vassant Desai
- Jonathan Newth - Sir Malcolm Harvey
- Christopher Bowen - Ian Shelley
- Helen Bourne - Victoria Price
- Catherine Holman - Lucy Turner
- Stuart Bunce - Adam Prince
- Julia Hills - Kay
- Ben Heathcote - Tony Mitchell
- Heather Bleasdale - Jane Mitchell
- Micaiah Dring - Emma
- Vicki Hopps - Irene
- Catherine Bailey - Helen Randle
- Rebecca Clay - Karen Gillespie
- Colin Hurley - Keith Jordan
- Duncan Preston - Martin Wilson
- Gabrielle Drake - Viv Wilson
- Joe Dempsie - Leon
- Susan Brown - Clare Bain
- Josie Kidd - Annie Larke
- Eve Robertson - Charmaine
- Timmy Lang - Russell
- Nicholas Monu - Tyrone Wells
- Wendy Kweh - Dr. Annie Drewitt
- Lyndsey Marshal - Natalie Pearce
- John Duttine - Larry Pearce
- Lynn Farleigh - Moira Pearce
- Charles Simon - Alf Rogers
- Amanda Bairstow - Sister
- Denise Black - Jenny Davidson
- Joyce Henderson - Obstetrician
- Joyce Henderson - Ultrasonographer
- Danielle Watson - Kylie Thorpe
- Tony Bluto - Warren Thorpe
- Kazia Pelka - Gabby
- Doyne Bird - Consultant
- Danny Seward - Jon
- David Mallinson - Richard Turner
- Brenda Kempner - Physiotherapist
- Emma Amos - Sandy Kelly
- Robert Whitelock - Paul Haynes
- Ann Beach - Eunice Gould
- William Tapley - Brian Melton
- George Costigan - Roy Telford
- David Hobbs - Mr. Lewis
- Drew Mulligan - John Milne
- Gemma Saunders - Nurse
- Andy Nyman - Rob Hallett
- Andy Nyman - Rob Hallet
- Stuart Richman - Mr. Griffiths
- Alison Burrows - Linda Campbell
- Lynda Baron - Joan Campbell
- Romy Baskerville - Sylvia Davidson
- Russell Dixon - John Davidson
- Angela Douglas - Hilary Morgan
- Cherry Morris - Millie Gaunt
- Bridget Turner - Ruth Gaunt
- Rachel Leskovac - Dionne Harrison
- Paul Opacic - Mark Kershaw
- Jacinta Mulcahy - Helen Saunders
- Jenny Seagrove - Sister Frances
- Felicity Dean - Yvonne Palmer
- David Horovitch - Eric Hawkins
- Glynis Brooks - Margaret Brown
- Carol Starks - Paula Ferris
- Aileen Gonsalves - Khavita
- Ian Dunn - Sean Ferris
- Jim Barclay - Martin Lucas
- Michael Norris - Rory Lucas
- Gary Cady - Jim Barnes
- Lynda Rooke - Irene Barnes
- Andrea Lowe - Zoë Thomson
- Chris Vance - John
- Chris Vance - SHO
- Scott Maslen - Andy Reece
- Emily Hillier - Clare Donahue
- Mary Cunningham - Mrs. Schofield
- Steve Huison - Simon Horsefield
- Paul Slack - Ken Harris
- Caroline O'Neill - Susie Horsefield
- Terence Harvey - Ted Beaumont
- Moira Brooker - Marie Thorpe
- Donald Douglas - Coroner
- Nick Burnell - Francis Forsythe
- William Scott-Masson - Tony Goodley
- Jean Fergusson - Mary Newson
- Teddie Thompson - Helen Galbraith
- John Catterall - Billy Galbraith
- Steven Webb - Kurt Galbraith
- Gabrielle Glaister - Hazel Myers
- Julia Mallam - Jane Greenwood
- Karl Davies - Nick Pullen
- Julia Haworth - Julie Pullen
- John Bowler - Mike Pullen
- John Rowe - Mr. Faraday
- Robert East - Commanding Officer
- Jessica Harris - Teri
- Charles Richards - Custody Sergeant
- Adam Croasdell - Tony Preston
- Lucy Robinson - Abbey Preston
- Tyler Butterworth - Keith Shaw
- Jack Carr - Ralph Trescott
- Stephen Chapman - Frank
- Charlotte West-Oram - Eileen Potter
- Richard Wills-Cotton - Danny
- Holly Lucas - Elizabeth
- Victoria Wicks - Judy
- Gordon Reid - Harry Chadwick
- George Innes - Ron Harris
- Adam Meggido - Davy
- Timothy Walker - Simon Fieldhouse
- Rosie Ede - Home Help
- Kenneth MacDonald - Neil Jones
- Aidan David - Stuart Jones
- Pippa Guard - Sandra Jones
- Luke Shaw - Doctor
- Mike Goodenough - Len
- Charlotte Emmerson - Dawn Cole
- Sarah Badel - Sheila Spencer
- Nick Reding - Steve Grantham
- William Howe - Luke Grantham
- Jethro Skinner - Andy McDermot
- John Elmes - John Blackton
- Roger Walker - Len Shackleton
- Patricia Villa - Harriet Shackleton
- Brett Fancy - Thomas 'Tosca' Scatterley
- Rob Dixon - Colin Spinx
- Romla Walker - Sarah Gascoyne
- James Doherty - Alan Reeves
- Vicky Ogden - Joy Coles
- Sian Webber - Louise
- David Peart - Dr. Wilson
- Sophie Stanton - Christine Wyatt
- Nick Miles - Gary Wyatt
- Becky Simpson - Rachel Henderson
- Robert Freeman - Jason
- Will Barton - Estate Agent
- Lindy Whiteford - DS Barry
- Stuart Wells - Charlie Webster
- Richard Beale - Julian Rankin
- Philip Fox - Brian Wood
- Sean Chapman - James Strickland
- Fred Ridgeway - Policeman
- John Rhys-Davies - Mike King
- Victor McGuire - Shaun Carter
- Jamie Bamber - Dr. Matt Kendal
- Margery Mason - Alice North
- Graeme Garden - Sidney
- Christopher Brown - Rob Barnes
- Patrick O'Connell - Gerard
- Rob Evans
- Nicholas Laughland
- Mark Roper
- Sue Dunderdale
- Simon Meyers
- John Woods
- Lucy Gannon
- Tony Etchells
- Chris Fewtrell
- Patrea Smallacombe
- Maria Jones
- Deborah Cook
Danny Cunningham interpreta a Malcolm Wallace en la serie.
Bill Nighy hace el papel de Alan Sinclair.
John Rhys-Davies interpreta a Mike King en la serie.
Anthony Higgins interpreta a Paul Redman en la serie.
Samantha Morton interpreta a Abbey / Pauline Jones en la serie.
Edward Hardwicke hace el papel de Patrick Siddons.
Victor McGuire interpreta a Shaun Carter en la serie.
Jean Heywood interpreta a Beryl Otley en la serie.
Stuart Wells interpreta a Charlie Webster en la serie.
Denise Stephenson interpreta a Cathy Priest en la serie.
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