- Sharon Acker - Agnes Carter
- Jo Van Fleet - Annie Crabtree
- Jack Cassidy - Perry Lemko
- Michael Ansara - Ray Abruzzi
- Linda Marsh - Louise Semple
- Zara Cully - Mrs. Jones
- Herbie Faye - Devlin
- Maudie Prickett - Clerk
- Lynne Marta - Lila Fraser
- Lee Montgomery - Cricket
- Stephen Young - Kip Hanson
- Beverlee McKinsey - Evelyn Ellis
- Richard Kiley - Vincent Warren
- Jim Backus - Emile Wade
- Harry Basch - Dr. Brandon, Psychologist
- Woodrow Parfrey - Harvey Durko
- Len Lesser - Burns
- Fritz Weaver - John Palmer
- Barney Phillips - Cliff Whittaker
- Murray MacLeod - Bucks
- Harold Gould - Lester Chennery
- Byron Foulger - Arthur Quinn
- Jack Ging - Dave Derman
- Mills Watson - Ken Lacey
- Nehemiah Persoff - Nick Master
- Richard Eastham - Harrison Cochran
- Brooke Bundy - Deborah Martin
- George Murdock - Price
- Carolyn Jones - Lisa Whittaker / Ginny
- Robert Easton - Gus Weldon
- Herb Vigran - Doctor
- Mark Goddard - Roy Tilson
- Mark Goddard - Doug Allen
- Norman Alden - Parker
- Alan Oppenheimer - Bob Ross
- Dennis Patrick - Carson Alexander
- Dennis Patrick - Frank Farrell
- Daniel J. Travanti - Milo
- Corey Fischer - Mr. Grossman (uncredited)
- Russ Conway - Dr. Jay Milton
- Dabney Coleman - John
- Joseph Mell - Pawnbroker
- Clu Gulager - Dustin Ellis
- Chick Chandler - Karnes
- Michael Anderson Jr. - Troy Eldridge
- Edward Faulkner - Griff
- Jed Allan - Kurt Raider
- Florence Halop - Nurse
- Art Metrano - Parking Lot Attendant
- Betty Lynn - Nurse Kearny
- Stanley Kamel - Knight
- Bo Hopkins - Arnie
- William Smith - Jack Harper
- J. Pat O'Malley - Mr. Oswald
- Julie Adams - Samantha Semple
- Joseph Ruskin - George Bates
- David Cassidy - Brad Johnson
- Tom Stern - Kurt
- Diana Ewing - Karen Westphal
- Marlene Clark - Judy
- Marlene Clark - Ruthie Rush
- Beverly Powers - Wanda
- Lawrence Dane - Major Sarif
- Brooke Mills - Janet Thompson
- Brooke Mills - Donna Pierson
- Sheldon Collins - Mark Alpert
- Jerry Ayres - Robbie Larson
- Suzanne Alexander - Saleslady
- Lada Edmund Jr. - Charlene Grant
- Kevin O'Neal - G.I.
- Tina Andrews - Laurie Jameson
- Susan Howard - Gillian Francis
- Joseph R. Sicari - Tip Garrison
- George Brenlin - Philly Enders
- Arthur Franz - Dr. Sam Berger
- Arthur Franz - Sims
- Arthur Franz - William Jeffers Sr.
- Arthur Franz - Arthur Westphal
- Carmen Zapata - Mrs. Gomez
- Allan Melvin - Fred Croft
- Robert Yuro - Chuck
- Tom Steele - Caretaker (uncredited)
- Valerie Allen - Mrs. Crowley
- Yvonne Craig - Tara Chapman / Lila Mason
- Della Reese - Paula
- Andy Griffith - George Carter
- Victor Izay - Bartender
- Barbara Rush - Mrs. Hamilton
- Diane McBain - Melba Norwood
- Danny Thomas - The Good Friend
- Leo Gordon - Unit Leader
- Leo Gordon - Keller
- Anthony James - Charlie Inch
- Ruth Roman - Irene Morris
- John Karlen - Johnny Wexford
- Leslie Nielsen - Rusty Bryson
- Bill Fletcher - Sgt. Joe McCurdy
- Vikki Carr - Valetta Hall
- Martin Sheen - Danny Morgan
- Mark Tapscott - Chief Roberts
- Mark Tapscott - Prison Sergeant
- Jean Hale - Marion Calder
- Robert Patten - Daniel S. Wade
- Lewis Charles - Hank
- Charles Seel - Neighbor
- Martine Bartlett - Mrs. Farrell
- Harry Hickox - George
- Marjorie Bennett - Landlady
- Marjorie Bennett - Mrs. MacCready
- Martin E. Brooks - Richard Clark
- Brock Peters - Johnny Pell
- Frank Parker - Father Jeremy Hogan
- Troy Melton - Max Taylor
- Greg Mullavey - Dirk
- Don Dubbins - Teddy Capp
- Don Dubbins - Leonard Gault
- Tony Dow - Frank Parks
- Marvin Kaplan - Sol Alpert
- Andy Romano - Wilson
- Steve Franken - Rabbi Elliott Tannenbaum
- Bob Harks - Customer (uncredited)
- Bob Harks - Cameraman (uncredited)
- Bob Harks - Teacher (uncredited)
- Bob Harks - Airline Passenger (uncredited)
- Vince Howard - Phil Jackson
- Wayne Heffley - Walters
- Michael Warren - Lon
- Louis Gossett Jr. - Smitty
- Louis Gossett Jr. - Charley Jameson
- Louis Gossett Jr. - Lloyd
- Larry D. Mann - Harry Burns
- Ed Call - Graff
- Nicholas Georgiade - Case
- Russell Arms - Frank Johnson
- John Dennis - Bike Shop Owner
- Charles Napier - Broker (uncredited)
- Robert Donner - George Thomas
- Robert Donner - Emory
- Lynn Loring - Melissa Laker
- Lynn Loring - Sue Ann Eldridge
- Kermit Murdock - Abe Turson
- Ray Walston - J.B.
- Rex Holman - Eddie Pickett
- Foster Brooks - Will Jackson
- Bill Zuckert - Del Vecchio
- Skip Ward - Harry Ayres
- William Windom - Fred Williams
- Michael Harris - Sergeant
- Ben Murphy - Bob
- James B. Sikking - Political Science Professor
- James B. Sikking - Major Bernard
- James B. Sikking - Dr. Webber
- Tom Nardini - Mike Sierra
- Michael Burns - Rick Landis
- Martha Scott - Belle Fuller
- Paul Bryar - Car Wash Owner
- Julio Medina - Montoya Sr.
- Patrick Waltz - Evans
- Hank Jones - Herbie Hughes
- Peter Brocco - Mr. Vlachos
- Joseph V. Perry - Joe
- Desi Arnaz Jr. - Vincent Emory
- Gary Dubin - Scooter Emory
- Kevin Dobson - Howie
- Mark Russell - Reporter (uncredited)
- Aaron Spelling
- Tony Barrett
- Danny Thomas
- Harve Bennett
Brock Peters hace el papel de Johnny Pell.
Nehemiah Persoff interpreta a Nick Master en la serie.
Anthony James interpreta a Charlie Inch en la serie.
Beverly Powers interpreta a Wanda en la serie.
Jim Backus hace el papel de Emile Wade.
Ray Walston interpreta a J.B. en la serie.
Peggy Lipton hace el papel de Julie Barnes.
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