- John Pinette - Hank Kohler
- Anne Bloom - Judy Lewis
- Jennifer Guthrie - Annie Sloan
- Alla Korot - Mary Lou
- Luke Perry - Luke Perry
- Tori Spelling - Tori Spelling
- Juliet Landau - Lucinda
- Jason Priestley - Jason Priestley
- Gabrielle Carteris - Gabrielle Carteris
- Ian Ziering - Ian Ziering
- Linda Shayne - Mrs. Steiner
- Gregory Eugene Travis - Remmel
- Debra Stipe - Rebecca
- Martin Mull - Mr. Tompkins
- Chris Demetral - Pauley
- Macka Foley - Gym Coach
- Ken Osmond - Eddie Haskell
- Rodney Eastman - Jimmy Joe Trout
- Tiffanie Poston - Janice
- Dee Booher - Maxine
- Jayson Kane - Host
- Robert Trebor - Mr. Lite
- Kristin Dattilo - Rita
- Tyren Perry - Miss Barr
- Andrew Pine - Rex Huston
- Sharon Case - Donna Sue
- Tamara Olson - Pepsi Girl
- Vincent Schiavelli - Guy Zapoleon
- Shannon Tweed - Ms. Mason
- Marc Riffon - Brian Popko
- Sonny Bono - Colin David
- Stacy Haiduk - Claire
- Lori Sebourn-Carhart - Pretty Girl
- Mary Cadorette - Cathy Lee Austin
- Roger Aaron Brown - Coach Tripp
- Eve Brenner - Hausefrau
- Mitchell Fink - Mitchell Fink
- Jennifer Roosendahl - Student #2
- Karen Fineman - Jezebel
- Brian Bradley - Eric
- Wendy J. Cooke - Jezebellie #2
- Laura Jacoby - Jezebellie #1
- John T. Quern - Robert
- Kaitlyn Walker - Emily
- Robert Zemeckis - Robert Zemeckis
- Lesley Boone - Harriet Guzman
- Bobbie Phillips - Melinda
- Anne Cooper - Harriet's Mom
- Lindsay Price - Cheyenne Thomas
- Marisa Theodore - Laura Beatty
- Francesca Marie Smith - Elaine Leffler
- Tanya Wright - Girlfriend
- Dave Thomas - Lionel Tower
- Lorna Scott - Mrs. Hamilton
- Rusty Gray - Jock
- Rusty Gray - Ruderman
- Anjul Nigam - Anjul
- Dennis Stewart - Cellmate
- Ken Kerman - Guard
- Gerrit Graham - Dr. Pankow
- Sam McMurray - Mr. Rips
- Ashley Gardner - Eve
- Jordan Brady - Robert Wilkes
- David Rosen - Albert Einstein
- Rodney Allen Rippy - Customer #2
- Barbara Perry - Auntie Em
- Brian Bonsall - Andrew Keaton
- Harry Anderson - Ronny Ray Rasmussen
- Robert Greenberg - Mr. Loopman
- Michael Weiner - Sixties Jerry
- Robert Cavanaugh - Jury Foreman
- Cassandra Peterson - Elvira
- Christopher Neame - Warrior
- Kristopher Logan - Joe
- Sharyn Leavitt - Customer #1
- Shannen Doherty - Shannen Doherty
- Jennie Garth - Jennie Garth
- Brian Austin Green - Brian Austin Green
- Andrea Roth - Carly Riordan
- Mary Woronov - Officer Gwen
- Michael D. Arenz - Football Player
- Asher Metchik - Mikey at 5
- B.J. Barie - Badge
- Charles Fowlkes - Delivery Man
- Dom Irrera - Joey Pants
- Curtis Armstrong - Curtis Armstrong
- Martha Quinn - Celebrity Host
- Mark J. Goodman - Dr. Carroll
- Jim Jensen - Reporter
- Joseph Whipp - Railroad Executive
- Paul Johansson - Nick Comstock
- Bill Stevenson - Pizza Man
- Jerry Mathers - Theodore Musso
- Bryan Spicer
- Larry Shaw
Vincent Schiavelli interpreta a Guy Zapoleon en la serie.
Corin Nemec interpreta a Parker Lewis en la serie.
Billy Jayne interpreta a Mikey Randall en la serie.
Troy Slaten interpreta a Jerry Steiner en la serie.
Melanie Chartoff hace el papel de Grace Musso.
Maia Brewton interpreta a Shelly Lewis en la serie.
Abraham Benrubi interpreta a Larry Kubiac en la serie.
Timothy Stack interpreta a Martin Lewis en la serie.
Mary Ellen Trainor hace el papel de Judy Lewis.
John Pinette interpreta a Hank Kohler en la serie.
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