- Joy Bryant - Jasmine Trussell
- Dax Shepard - Crosby Braverman
- Miles Heizer - Drew Holt
- Max Burkholder - Max Braverman
- Tyree Brown - Jabbar Trussell
- Savannah Paige Rae - Sydney Graham
- Xolo Mariduena - Victor Graham
- Melanie Chandra - KIRSTEN MATAI
- Chloe Csengery - Emily
- Erinn Hayes - Racquel
- Minka Kelly - Gaby
- Amanda Kimmel - Party Girl
- Michael B. Jordan - Alex
- Matt Lauria - Ryan York
- Anthony Carrigan - Cory Smith
- Scott Michael Foster - Gary
- Aloma Wright - Natalie
- Hayden Byerly - Micah Watson
- Jeremy Shada - First Baseman
- Asher Book - Steve Williams
- Jacob Bertrand - Boy
- Phil Abrams - Phil Lessing
- Ian Kahn - Harry Lerner
- Amanda Foreman - Suze Lessing
- Steven Lee Allen - Scott Morris
- Allen Alvarado - Shortstop
- Samantha Boscarino - Lindsay
- Rafi Gavron - Troy Quinn
- Rafi Gavron - Troy Quinn (voice)
- Michael Emerson - Andy Fitzgerald
- Wen Yann Shih - Dr. Gibbon
- Erick Avari - Leon Dengraff
- Julian Starks - Mr. Mason
- Rich Ceraulo Ko - Dr. Bartlett
- Ryan Hansen - Luke
- Jamie Kaler - Paul Ellis
- Keith Campbell - Construction Worker #1
- William Duffy - Mr. Carlson
- Dennis L.A. White - Mista Ray
- Jurnee Smollett - Heather Hall
- Paul Dooley - Rocky
- John Corbett - Seth Holt
- David Walton - Will Freeman
- Tina Holmes - Kiara's Mother
- Munda Razooki - Mold Professional
- Josh Stamberg - Carl Fletcher
- Skyler Day - Amy Ellis
- Kurt Fuller - Dr. Bedsloe
- Brooklyn McLinn - Sekou Trussell
- Joyce Guy - Pastor Jones
- Chris Flanders - Coach Fulton
- William Baldwin - Gordon Flint
- Phil Levesque - Jack Spencer
- Kathryn Winslow - Dean Sharon Lourde
- David L. King - Principal Radford
- Barry Corbin - Ernie
- Matthew Atkinson - Zach
- David Denman - Ed Brooks
- Googy Gress - Doug
- Googy Gress - Jeff Wormley
- Nick Krause - Berto
- Alexandra Barreto - Karen Fillman
- Tom Amandes - Dr. Pelikan
- Roshon Fegan - Chad Love
- Annabeth Gish - Melody York
- Jonathan Tucker - Bob Little
- Rose Abdoo - Gwen Chambers
- Sonya Walger - Meredith Peet
- Zachary Knighton - Evan Knight
- Carol Abney - Michelle Chambers
- Tavi Gevinson - Lauren
- Tyson Ritter - Oliver Rome
- Tate Ellington - Griffin
- Jason Ritter - Mark Cyr
- Betsy Brandt - Sandy
- Coby Ryan McLaughlin - Chris Jeffries
- Matthew Glave - Mr. Jones
- Anita Barone - Mrs. Jones
- Tina Lifford - Renee Trussell
- Ray Romano - Hank Rizzoli
- Courtney Grosbeck - Ruby Rizzoli
- Lyndon Smith - Natalie
- Libe Barer - Kiara
- Leland Crooke - Dr. Leland Gordon
- Alexia Ioannides - Dylan Jones
- Rhiannon Giddens - Rhiannon Giddens
- Lily Mae Silverstein - Little Girl
- Jose Barba IV - Jose Rodriguez
- Max Ehrich - Bradley
- Mia Allan - Nora Braverman
- Frances Sternhagen - Blanche Braverman
- Rebecca Creskoff - Carly Barow
- Jillian Bach - Andie
- John Rubinstein - Principal Liam Taylor
- Joaquim de Almeida - Matthew Biscali
- Angela Rawna - Dr. Schecter
- Cole Sand - Jensen
- Jasmine Alveran - Amy G.
- Eva Bella - Sienna
- Richard Dreyfuss - Gilliam T. Blount
- Paula Newsome - Dr. Robertson
Michael Emerson interpreta a Andy Fitzgerald en la serie.
Peter Krause interpreta a Adam Braverman en la serie.
Monica Potter interpreta a Kristina Braverman en la serie.
Lauren Graham interpreta a Sarah Braverman en la serie.
Erika Christensen interpreta a Julia Braverman-Graham en la serie.
Craig T. Nelson interpreta a Zeek Braverman en la serie.
Bonnie Bedelia interpreta a Camille Braverman en la serie.
Mae Whitman interpreta a Amber Holt en la serie.
Sam Jaeger hace el papel de Joel Graham.
Joy Bryant interpreta a Jasmine Trussell en la serie.
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