- Tyner Rushing - Samantha Massey
- Sarah Jones - Tracy Stevens
- Svetlana Efremova - Irina Morozova
- Wrenn Schmidt - Margo Madison
- Daniel Stern - Eli Hobson
- Casey W. Johnson - Danny Stevens
- Sonya Walger - Molly Cobb
- Benton Jennings - Judge
- Deniz Akdeniz - Paul Santoro
- Brandon Bales - Winston Blake
- Vanessa Lyon - Graciana Rosales
- Paolo Cesar - Guide
- Curtis Fortier - Reporter #1
- Laura Patalano - Teresa
- Frank Gallegos - Angel
- Margarita Reyes - Elena
- Colton Castaneda - Jim
- Saul Rubinek - Rep. Charles Sandman
- David Andrews - Admiral Scott Uken
- Jeff Branson - Neil Armstrong
- Steven Pritchard - Pete Conrad
- Shaw Jones - Capcom
- Jeffrey Muller - Del
- Max Barsness - Tommy
- Jason Denuszek - Magazine Photographer
- Rachel Rosenbloom - Doris
- Jessica Amlee - Ginger
- Janelle Froehlich - Pauline
- Laura Long - Trish
- Cass Buggé - Patty Doyle
- Nick Echols - Chaddie
- Brian Stepanek - Shorty Powers
- Matt Battaglia - John Glenn
- Tony Lewellen - Coop
- Darin Cooper - Businessman
- Daniel Robbins - Hank Poppen
- Michael Harney - Jack Broadstreet
- Jason David - Young Daniel Stevens
- Korey Simeone - Doctor Chase
- Nick Wechsler - Fred
- Nick Heyman - Sentry
- Eric Ladin - Gene Kranz
- Colm Feore - Wernher von Braun
- Ben Begley - Charlie Duke
- Ryan Kennedy - Michael Collins
- Martin Grey - Scott Kraus
- Michael James Bell - Principal Mike Russell
- Matthew Downs - Police Officer
- Edwin Hodge - Clayton Poole
- John Rubinstein - Doctor Marsten
- David Gautreaux - Barry Newsome
- Scott Alan Smith - Dr. David Josephson
- Tait Blum - Shane Baldwin
- Germain Arroyo - Anthony
- Brian D. Johnson - Grush
- Kevin Glikmann - Jerry Biddle
- Jan Munroe - Dr. Weddle
- Stephen Oyoung - Harrison Liu
- James Urbaniak - Gavin Donahue
- Aria Song - Cecilia Liu
- Tracy Mulholland - Gloria Sedgewick
- Chris Bauer - Deke Slayton
- Mark Ivanir - Mikhail Mikhailovic
- Mason Thames - Daniel Stevens
- Rebecca Wisocky - Marge Slayton
- Wallace Langham - Harold Weisner
- Charlie Hofheimer - Dennis Lambert
- Olivia Trujillo - Aleida Rosales
- Zakary Risinger - Jimmy Stevens
- Brian McGrath - Sam
- Krystal Torres - Cata
- Carin Chea - Penny Chen
- Dan Warner - General Arthur Weber
- Ben Solenberger - LMSYS
- Alex Skinner - Telex Guy
- Theo Iyer - Carl Reid
- Mel Fair - Reporter 1
- Stephen Jared - Reporter 2
- Chi-Lan Lieu - Reporter 3
- James Thomas Gilbert - Protest Man
- Clint Culp - Guy at Bar
- Spencer Garrett - Roger Scott
- Megan Dodds - Andrea Walters
- Penny O'Brien - Doreen Campbell
- Steve Olson - Astronaut #1
- Marianne Lu - Astronaut #2
- Jay Liu - Adam
- Don Brunner - Rotary Member 1
- Robbie Troy - Rotary Member 2
- Fred Cross - CAPCOM
- Anand Mahalingam - ASCAN #1
- Bjørn Alexander - Wubbo Ockels
- Tyler Lofton - Corey
- Mindy Montavon - Waitress
- Ian McQuown - Photographer
- Brad Beyer - Carl Cartwright
- Caitlyn Knisely - Instructor Sarah
- Yaani King Mondschein - Rae Poole
- Justice Leak - Peter
- Chris L. McKenna - Doug Price
- Bruce Weitz - William Waverly
- Lori Dorfman - Bartender
- Rob Norton - Sgt. John Perkins
- Heather McPhaul - Nurse
- Yakov Kolontarov - Russian Guard
- Dan Donohue - Thomas Paine
- Endre Hules - Soviet Chief Engineer
- Robert Werner - Victor, Engineer
- Carolyn Crotty - Coral Hiscoe
- Andrew Gonzalez - Leland Davis
- Troy Metcalf - Uniformed Security Guard
- Jeff Denton - Pendle
- Irina Maleeva - Marta
- Wendy Schenker - Dr. Mitchell
- Long Nguyen - Kelly's Dad
- Lauren Sweetser - Jewel
- Dustin Seavey - Lee Atwater
- Andre Boyer - Jason Wilhelm
- Jinny Chung - Liz Phang
- Alim Kouliev - Soviet Diplomat
- Leonora Pitts - Irene Hendricks
- John Marshall Jones - General Nelson Bradford
- Michael Benz - Gary Piscotty
- Ellen Wroe - Sally Ride
- Nikola Đuričko - Stepan Petrovich Alexseev
- Alexander Babara - Radislav Semenovich Orlov
- Joe Sobalo Jr. - Jonathan Gatos
- Dave Power - Frank Sedgewick
- Nick Toren - Tim 'Bird Dog' McKiernan
- Michaela Conlin - Helena Webster
- Connor Tillman - Vance Paulson
- Jeff Hephner - Sam Cleveland
- Chris Cortez - Steve Lopez
- Tim Jo - Steve Pomeranz
- Charlie Schlatter - Paul Michaels
- Linda Park - Amy Chang
- Kayla Blake - Dr. Kouri
- Josh Duvendeck - Nathan Morrison
- Alex Alomar Akpobome - Paul DeWeese
- Eugene Alper - Colonel Viktor Tsukanov
- Juliet Brett - Natalie Bishop
- Timothy Ware-Hill - Cameron Wolfgeher
- Ashley Jones - Yvonne
- Brooke Burgstahler - Chelsea
- Mariel Taren - Controller Whitney
- Ian Bamberg - Byron
- David Chan - Rin
- Jarod Bainbridge - Dean Lyman
- Erika Fong - Renee
- Umberto Celisano - Hans
- Derek Webster - Commander Rich LaPorte
- Andres Londono - Joaquin Asencio
- Thomas Crawford - Pastor Dirkson
- John Ruby - Controller John
- Sean Muramatsu - Controller Steven
- Lola Paja - Polaris Crew Member
- Jonny Coyne - Peter Strauss
- Samantha Boscarino - Jenna
- Brian Oblak - Officer
- Selah Victor - NASA Flight Controller / NASA CAPCOM
- Tempany Deckert - Engineer 1
- Jay Charan - Engineer 2
- Matt Lagan - London Bartender
- James Kang - Elevator Passenger
- Tony Curran - Clarke Halladay
- Heidi Sulzman - Sylvie Kaplan
- Debbie Pollack - Zizzo Glover
- Alexander Neher - Davey Kowalski
- Alexander Jo - Cal
- Jessica Galinas - Anne Baranov
- Wade Harlan - Sergeant Jamie O'Neal
- Patricia Mizen - Reporter 1
- Lenny Jacobson - Wayne Cobb
- Sean Patrick Thomas - Corey Johnson
- Diane Dehn - Jean Williamson
- Thomas Steven Varga - Guido - NASA
- Monica Bhatnagar - Controller - Helios
- Joseph Beck - Karl Rove
- Michael McMillian - Elliott Lewis
- Patrick Labyorteaux - Congressman Willie Baron
- Scott Michael Campbell - Alex Rossi
- Bonnie Bailey-Reed - Mary Meineke
- Blair Hickey - Richard 'Dicky' Hilliard
- John Forest - Jeremy Zielke
- Andrew Brian Carter - Cliff Berger
- Daniel David Stewart - Nick Corrado
- Pawel Szajda - Alexei Poletov
- Ayinde Howell - Benjamin Harmon
- Casey Feigh - John Blystone
- Chris Gann - William Piltz
- Nate Corddry - Larry Wilson
- Arturo del Puerto - Octavio Rosales
- Stewart Skelton - Speaker of the House
- Michelle Bonilla - Victoria Rodriguez
- Larry Sullivan - Ryan Bauer
- Allison Dunbar - Jenna Leigh
- Larry Clarke - Bill McGann
- Kaipo Schwab - Ex-NASA Astronaut
- Meghan Leathers - Pam Horton
- Noah Harpster - Bill Strausser
- Teya Patt - Emma Jorgens
- David Chandler - Jimmy Stevens
- Zac Titus - Charles Bernitz
- Madeline Bertani - Amber Stevens
- Jorge Diaz - Victor Diaz
- Tiago Martinez - Javier Diaz
- Sahana Srinivasan - Nuri Prabakar
- Jessica Tuck - Christine Francis
- Cheyenne Perez - Heather
- Lev Gorn - Grigory Kuznetsov
- Vera Cherny - Lenara Catiche
- Ken Rudulph - Edward Kline
- John Hartmann - Administrator Richard Truly
- Alexander Sokovikov - Rolan Efimovitch Baranov
- Robert Bailey Jr. - Will Tyler
- Taylor Dearden - Sunny Hall
- Amol Shah - Adarsh Sethi
- Anne Beyer - Louisa Mueller
- Nick Boraine - Lars Hagstrom
- Mandy Levin - Sandy Bostik
- William Cowart - Hal
- Goran Ivanovski - Dr. Dimitri Mayakovsky
- Randy Oglesby - Governor/Vice President Jim Bragg
- C.S. Lee - Lee Jung-Gil
- Aleisha Force - NASA Engineer #1 - Melanie Stanton
- Scott Rosendall - NASA Engineer #3 - Steven
- Zedrick Restauro - NASA Controller - Andrew
- Mark Weiler - NASA Security
- Chet Dixon - Helios Engineer #1 - Geoffrey Keller
- Cole Stratton - Helios Employee - Warren
- Leah Zhang - Helios Employee - Gwen
- Eric Satterberg - Helios Employee - James
- Jason Her - North Korean Cosmonaut - Park Chol
- Andrew Ghai - Reporter #2
- Shannon Lucio - Amanda Dale
- Masha Mashkova - Svetlana Zakharova
- Mac Brandt - Tom Parker
- David Theune - Tom Gamon
- Jay Paulson - Colonel George Peters
- Santiago Veizaga - Javier Diaz
- Gediminas Adomaitis - Kirill Semenov
- Constantine Gregory - Artem
- Nick Von Schlippe - Baker
- Ellie Grace Pomeroy - Avery Stevens
- Piper Rubio - Lily Dale
- Irina Dubova - Olga Poletova
- Zylan Brooks - Flight Director Jen Hughes
- Caity Ware - Controller - Mars Ops Com
- Matthew Um - Props
- Alex Demkin - Russian Controller
- Alex Alexander - Helios Receptionist
- Alex Cioffi - Tim
- Keith Barber - Delmar
- George Zlatarev - Customer
- Vladimir Dimitrov - Father
- Piotr Adamczyk - Sergei Orestovich Nikulov
- Dimiter D. Marinov - Ilya Breshov
- Myk Watford - Palmer James
- Rhian Rees - Joanna Chapman
- Salvador Chacon - Gerardo Ortiz-Niño
- Moses Jones - Rich Waters
- Jo Kelly - Maya Estime
- Brandon Ford Green - Shaun Arlee
- Charles Kim - Cmdr. Cho Byung Ho
- Alex Parkinson - Owen Stanwood
- Heather L. Tyler - Astronaut's Wife
- Michael Joplin - Charlie Parfitt
- Theodor Papazov - Soviet Policeman #2
- Kiril Boyadzhiev - Defiant Man
- Hristo Terziev - Younger Man
- Tania Raymonde - Athena
- Konstantin Lavysh - Lieutenant Stepan Gura
- Nikolai Tsankov - Colonel Vidor Kolikoff
- Nick Gracer - Petros Khorenatsi
- Eduard Osipov - Vasily Galkin
- Noor Razooky - Faiza Khatib
- Lisa Dobbyn - Supervisor
- Donovan Patton - Controller #2
- Danielle Nottingham - Vera Martil
- Jim O'Brien - Lockheed Martin Executive
- Atul Singh - Northrop Grumman Executive
- Jennifer Popagain - Raytheon Executive
- Kristin Carey - Arlene
- Hristo Petkov - Moscow Police (Van)
- Billy Lush - Mike Bishop
- Kathe Mazur - Katherine Hobson
- אניה בוקשטיין - Tatyana Volkova
- Rachael Thompson - Leia Ascott
- Alexander Terentyev - Lev Babanin
- Luke Barnett - Mike Shaw
- Nicholas Kolev - Yevgeniy
- Emil Markov - Leonid
- Danny Yang - Controller
- Martina Vachkova - Cashier
- Yasen Atanasov - Engineer #1
- Thea Andrews - Zoey Chase
- Valeri Ross - Malaika Ayesa
- Dustin Ingram - Brandt Darby
- Sebastiano Pigazzi - Luka Gurino
- Jon Levine - Ron Klain
- Steph Evison Williams - Geraldine Middaugh
- Libby Baker - Kate Marsteller
- Rami Essa - Ramsey
- Ian Gary - Helios Crew Member
- Reid Rathore - Off-duty Helios Worker
- Gene Silvers - Henry Keck
- Nikita Bogolyubov - Timur Avilov
- Yuji Hasegawa - Kenji Okumura
- Deepti Gupta - Kapalna Naran
- Yaron Shavit - Helios Worker
- Vinny Chhibber - Ravi Vaswani
- David Bowe - CIA Dep. Director Robert Burks
- Cindy Jackson - Holly 'Sparks' Edmondson
- Chris Jaymes - Nick Jennings
- Sean Patrick Murphy - Nate Lowry
- Yavor Gadzhev - Pasha
- Amy Schloerb - Tech Director
- Katarína Morháčová - Nina Rozhenkova
- Andrew Hansen - Ops Controller - Howard
- Vivan Dugré - Ops Controller - Quintero
- Michael Gaines - Helios Shift Worker
- Ely Henry - Dr. Seth Razack
- Heather Lee - Muriel Bezukhov
- Elliott Ross - Maximus Taylor
- Timothy E. Goodwin - Cliff Hooper
- Autumn Bell - Bethany
- Eli Fucile - Harry
- Mark Kwak - Park Chui Moo
- Brooks Anne Hayes - Bobbie
- Emil Beheshti - Hotel Waiter
- Hedyeh Falsafi - Natalie Talmadge
- Rafiq Batcha - Ops Radar Controller
- Sasha Golberg - Ops Ranger CAPCOM
- Matt Jennings - Crew Member - Mars Ops Com
- Jennifer L. Marshall - Lynn Hegarty
- Kurt Quinn - Frank Tuttle
- Suzanne H. Smart - Motel Clerk
- Leo Seo - Kim Byung Soo
- Chen Chen Julian - Nam Moon Yeong
- Alex Cacho - Ops Comm Controller
- Emi Nishimura - Ops JAXA Controller
- Mustafa Haidari - Atilla Yucer
- Lukas Ettlin
- Jovan Robinson
- Libby Goldstein
- Ronald D. Moore
- Junie Lowry-Johnson
- Ben Nedivi
- Paul Doucette
- Jeff Russo
Chris Bauer hace el papel de Deke Slayton.
Saul Rubinek interpreta a Rep. Charles Sandman en la serie.
Tony Curran interpreta a Clarke Halladay en la serie.
Joel Kinnaman interpreta a Ed Baldwin en la serie.
Toby Kebbell interpreta a Miles Dale en la serie.
Krys Marshall hace el papel de Danielle Poole.
Edi Gathegi interpreta a Dev Ayesa en la serie.
Cynthy Wu hace el papel de Kelly Baldwin.
Coral Peña hace el papel de Aleida Rosales.
Tyner Rushing interpreta a Samantha Massey en la serie.
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