- Lacey Chabert - Dr. Amy Shaw
- Matt Dallas - Fitch
- Mallory Jansen - Georgie Farlow
- Mimi Gianopulos - Angela
- Gracie Gillam - Megan
- Greg Grunberg - Ray Wheeler
- Robert Gant - Steve
- Chris O'Shea - Philip
- Christa B. Allen - Robyn
- Mary Hart - Self
- Maria Zyrianova - Milena
- David S. Lee - Henderson
- Amanda Detmer - Aunt Margot
- Phil Morris - Marshall Dobbs
- Kym Whitley - Margaret Jenson
- Cassandra Scerbo - Heather
- Kelly Stables - Kayla
- Briana Lane - Cassie
- Ashley Argota - Ava
- David Cade - Jack
- Ana Nogueira - Chloe
- Amber Stevens West - Izzy
- Melissa Tang - Katie
- Tuc Watkins - Hank
- Rose Abdoo - Nurse Dalrymple
- Wayne Brady - Chase Baxter
- Aaron Hill - Kevin
- Leslie Jordan - Edwin
- Caroline Rhea - Jennifer Perrin
- Antonio Sabàto, Jr. - Gerard
- Matt Cedeño - Javier
- Bailey De Young - Bailey
- Mo Gaffney - Hermione
- Lucy Hale - Piper Stockdale
- Gary Anthony Williams - Captain Walters
- Kelly Monaco - Kelly Monaco
- Michael Galante - Joshua
- Michael Lembeck - Director
- Adam J. Harrington - Mark Clements
- Bruce Thomas - Jim
- Dot-Marie Jones - Masha
- Kelsey Asbille - Stephanie
- Meagan Tandy - Vanessa
- Andy Buckley - Professor Roger Shaw
- Marta Cross - Sophia
- Tara R. Cook - Mrs. Andrews
- Braden Davis - Jeffrey
- Brad Lee Wind - Security Guard Jim
- Gina St. John - Flight Attendant
- Mirelly Taylor - Letty
- Peter Katona - Frank
- Michael Cory Davis - Agent Lawrence
- Aisha Dee - Olivia
- Isaiah Mustafa - Captain Hudson
- Ellen Wroe - Amber
- Jeffrey Marcus - Mr. Danvers
- Brittney Alger - Christine
- Maria Canals-Barrera - Carol Beltran
- Marylouise Burke - Mrs. Curtis
- Aimee Carrero - Sydney
- Courtney Parks - Logan
- Jasmine Di Angelo - Monica
- Allison Paige - Jenny DeLuca
- Mark DeCarlo - Frankie DeLuca
- Nicolas Bechtel - Little Ben
- Kim Coles - Vice Principal Peters
- Jason Sims-Prewitt - Security Guard
- Marieve Herington - Ticket Taker
- David DeLuise - David Brinkerhoff
- Gabrielle Dennis - Valerie Banks
- Dmitry Chaplin - Vladimir
- Assaf Cohen - Photographer
- Mark Charran - Alfred
- Michael Thurman - Frat Guy
- Justene Alpert - Samantha
- Taji Coleman - Joan Applewhite
- Garret Davis - Bob Applewhite
- Anthony Montgomery - Marcus
- Brianne Howey - Susie Kettle
- Hina Abdullah - April
- Brody Hutzler - Johnathan
- Anna Maria Perez de Tagle - Jenna
- Diedrich Bader - Winston Douglas
- Jessica Meraz - Ashley
- Chasty Ballesteros - Debbie
- Mary Pat Gleason - Aunt Betty
- Sonya Eddy - Priest
- Mario Diaz - Tattoo Artist
- Donovan Scott - Santa Claus
- Kennedy Thompson - Heidi
- Cali Fredrichs - Zoe
- Donnell Turner - Guy
- Ritesh Rajan - Softball Player
- George Sharperson - Bouncer
- Lance Barber - Tommy
- Drew Droege - Simon
- Trent Garrett - Gene
- Alec Medlock - Dave
- Alex Kapp - Jennifer Perrin
- Lindsey Gort - Ashley
- Brian Tee - Tommy Kwan
- Heather Fogarty - Danielle
- Marquise Brown - Customer
- Cole Gerdes - Justin
- Luke Cook - Ian
- Hilty Bowen - Jessica
- Scott Michael Morgan - Gary
- Richard Whiten - Dr. Davis
- Annalisa Cochrane - Seventeen-Year-Old Emma
- Mercedes Cornett - Dr. Lily
- Marcus Choi - Tourist
- Kathleen Meyer - Woman in Waiting Room
- Anthony Marciona - Mailman
- Charles Carpenter - Peter
- Nefetari Spencer - Kate
- Dan Castellaneta - Peter Oliver
- Jill Basey - Margaret
- Hank Chen - Jonathan
- Gemma Brooke Allen - Young Riley
- Brekkan Spens - Young Danny
- Kara Crane - Heidi
- Jonna Walsh - Zoey
- Tiffany Panhilason - Beautiful Girl
- Marc Fajardo - Towel Boy
- Daniella Monet - Sam
- Michael S. Chambers - Bobby Sherwood
- Alec Mapa - Todd
- Eddie Cibrian - Ross Goodman
- Eddie Cibrian - Ross Goodson
- Tim Seitter - Mary Hart Producer (voice)
- Ginifer King - Joan Carpenter
- Tom Fitzpatrick - Mr. Bender
- Kimberly Hebert Gregory - Miss Abigail
- Cody Callahan - Ludo
- Bryce Durfee - Blake
- Cedric Yarbrough - Tim Turner
- Jonathan Silverman - Malcolm
- Rob Silverman - Aaron
- Bruno Amato - Officer Harris
- Tammy Dahlstrom - Juror #1
- Dioni Michelle Collins - Juror #2
- Catherine Toribio - Giselle
- Alisa Allapach - Rhonda
- Jamie-Lynn Sigler - Sarah Gilcrest
- David Storrs - Coach Dinardo
- Karen Y. McClain - Mrs. Kimmel
- Loni Anderson - Nana Lyle
- Tim Bagley - Stanley Dexenberry
- Nicola Lambo - Mrs. Simonson
- Kathy Kinney - Judy
- Alicia Sanz - Elena Rios
- Jeremy Hudson - Bartender
- Juan Monsalvez - Luis Gustamonte
- Juan Monsalvez - Luis Bustamonte
- Nikki Tuazon - Hostess
- Brad Grunberg - Morty
- Davida Williams - Adrienne
- Terry Sweeney - Henry
- Reba McEntire - Charlotte Sweeney
- Indira G. Wilson - Customer
- Chelsea Harris - Renee
- Natalie Dreyfuss - Olivia
- Victoria Park - Amanda
- Paolo Andino - Dr. Mash
- Nathalia Castellon - Kiki
- Shalini Bathina - Rachel
- Nakia Burrise - Janet
- Chase Kim - FBI Agent
- John Hennigan - Ryan Davidson
- Peter Porte - Brad
- Peter Porte - Tad
- Zoë Hall - Anita
- Nick Hart - Jim
- Tricia O'Kelley - Dr. Joanne Dobbs
- Deonte Gordon - Emcee
- Anton Narinskiy - Gustav
- Alden Ray - Director
- Michelle Janine - Princess Victoria
- Donna Pieroni - Park Ranger
- Carlos E. Campos - Timothy
- Russell Pitts - Joe
- Christopher Shefstad - Customer
- Alex Frnka - Annabelle
- Tacey Adams - Helen
- Halleta Alemu - Vikki
- Chuck Lacey - Edgar
- Jose Moreno Brooks - Roger
- Jackée Harry - Judge Johnson
- Beth Fraser - Melinda
- Kunal Dudheker - Delivery Guy
- Rachna Khatau - Sondra
- Katie Gill - Elle
- Alycia Grant - Elle #2
- Rane Jameson - Shady Guy
- Michael Cotter - Mr. Stevens
- Thea Andrews - Pamela
- Lizz Carter - Marry Ann
- Brian Unger - Jason Bowman
- Frank Gallegos - Salesman
- Brian McGovern - Television Executive
- Dan Berendsen
- Heidi Clements
- Michael Lembeck
- Vince Cheung
- Ben Montanio
Dan Castellaneta interpreta a Peter Oliver en la serie.
Jean-Luc Bilodeau hace el papel de Ben Wheeler.
Tahj Mowry hace el papel de Tucker Dobbs.
Derek Theler hace el papel de Danny Wheeler.
Melissa Peterman hace el papel de Bonnie Wheeler.
Chelsea Kane interpreta a Riley Perrin en la serie.
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