- Mary-Kate Olsen - Michelle Tanner
- Andrea Barber - Kimmy Gibbler
- Ashley Olsen - Michelle Tanner
- Scott Weinger - Steve Hale
- Chelsea Noble - Samantha
- Phillip Glasser - Young Danny
- Michael Gregory - Mr. Cuccinello
- Steve Bond - Todd Masters
- Cristi Harris - Rachel Taylor
- Lucy Lee Flippin - Ms. Agbabian
- Scott Baio - Pete Bianco
- Nancy Dussault - Dr. Marion Steiner
- Cindy Herron - Cindy Daniels
- Christopher Darga - Waiier
- Mike Binder - Steve
- Scott Curtis - Kevin Gwin
- Julia Montgomery - Adult Steph
- Alice Hirson - Claire Tanner
- Beverly Sanders - Mindy
- Fabiana Udenio - Adrianna
- Michelle Nicastro - Roxanna
- Judie Aronson - Raven
- Jackie Joseph - Mrs. Payton
- Eddie Barth - Lou
- Elizabeth Keifer - Corrina Spicer
- Belita Moreno - Ronnie Gardner
- Wendy Schaal - Vivian
- Darcy DeMoss - Jill
- Phyllis Diller - Phyllis Diller
- Bob Perlow - Announcer
- Jason Marsden - Nelson Burkhard
- Miko Hughes - Aaron
- Whit Hertford - Walter
- Jurnee Smollett - Denise
- James Hampton - Mr. Malatesta
- Lydia Cornell - Linda Mosley
- Luis Ávalos - Mr. Santana
- Richard Paul - Mr. Strowbridge
- Kari Michaelsen - Stacey Fleetwood
- Barry Van Dyke - Eric Trent
- Tyra Ferrell - Miss Petrie
- Rhonda Shear - Adult Kimmy
- Tony Longo - Tough Prisoner
- Paul Willson - Stu
- Candace Hutson - Becky
- Ernie Hudson - Reggie "The Sandman" Martin
- Jandi Swanson - Karen
- Kristian Alfonso - Robin
- Ed Alonzo - Ed Alonzo
- Kirk Cameron - Steve
- Blake McIver Ewing - Derek
- Ami Foster - Nina
- Jonathan Brandis - Michael Monford
- Helen Martin - Shirley
- Andrew Kavovit - Paul
- Roger Lodge - Roger
- Bert Kramer - Mr. Kiner
- Dana Sparks - Cynthia Ryan
- Jayne Modean - Adult Michelle
- Jeannie Wilson - Ms. Garland
- Sorrell Booke - Lionel
- Michelle Collins - Abby
- Dot-Marie Jones - Muscular Woman
- J.D. Daniels - Charles
- Rif Hutton - Sergeant
- Cyndi Pass - Laker Girl #2
- Mike Love - Self - The Beach Boys
- Danielle Judovits - Girl in Toy Store
- John Aprea - Nick Katsopolis
- Greg Collins - Second Prisoner
- Christie Claridge - Vanessa
- Laura Reed - Ms. Lewis
- Rhoda Gemignani - Irene Cochran
- Charlie Spradling - Rhonda
- Yvonne Wilder - Irene Katsopolis
- Peter Kwong - The Dentist
- Bill Wiley - Jeb
- Stacey Alden - Secretary
- Bruce Johnston - Self - The Beach Boys
- Brian Wilson - Self - The Beach Boys
- Carl Wilson - Self - The Beach Boys
- Rebeccah Bush - Denise
- Kristi Somers - The Stewardess
- Zachary Bostrom - Jimmy
- Robin Greer - Crystal
- Eileen Conn - Julie
- Annette Sinclair - Miss Borland
- Brandon Crane - Sheldon
- Lisa Aliff - Patty Fogerty
- Max Alexander - Dr. Rueben Wynager
- Malachi Pearson - Brian Kagan
- Doris Roberts - Claire Tanner
- Wayne Powers - Frank Flood
- Raf Mauro - Mechanic
- Barry Kivel - Michael Kagan
- Anne Marie McEvoy - Kathy Santoni
- Angella Kaye - Girl at Party
- Angella Kaye - Girl at Dance
- Wendy Cutler - Mrs. Hardesty
- Jeanine Jackson - Mary Anne
- Peter Isacksen - Waiter
- Jack Kruschen - Iorgos
- Vera Lockwood - Gina
- Josh Blake - Sylvio
- Alison Armitage - Girl on Bike
- Jennifer Gatti - Elena
- Jennifer McAllister - Zoey
- Melanie Vincz - Adult D.J.
- Fiona Landers - Sophia
- Bruce Baum - Emcee
- Bruce Baum - Paul
- Mary Pat Gleason - Mrs. Sianski
- Nancy Mulford - Yvonne
- Michele Laybourn - Vega
- Lisa Savage - Paula
- Joan Leizman - Joanie
- Barbara Cameron - Barbara
- Benji Schwimmer - Benji
- Michael McManus - Paul
- Greg Callahan - Mr. Benton
- Joshua Cadman - Stage Manager
- Mark Costello - Anchorman
- Elizabeth Olsen - Girl with Flowers
- Deborah Gorman - Julie Stratton
- Michelle Smith - Laker Girl #1
- Trent Olsen - Boy with Flowers
- Karen Kopins - Linda Stratton
- Brian Byers - Ted
- Gary Griffin - Gary
- Bill Morey - Mr. Pearson
- Arlene Lorre - Marilyn
- Bobbie Eakes - Diane
- Christie Mossman - Pam Katsopolis Tanner (as Christie Houser)
- Sandra Wild - Waitress
- Tom Burkhard
- Marc Warren
- Robert L. Boyett
- Don Van Atta
- Dennis Rinsler
- Tom Amundsen
Jack Kruschen interpreta a Iorgos en la serie.
John Stamos hace el papel de Jesse Katsopolis.
Bob Saget hace el papel de Danny Tanner.
Dave Coulier interpreta a Joey Gladstone en la serie.
Candace Cameron Bure interpreta a D.J. Tanner en la serie.
Jodie Sweetin interpreta a Stephanie Tanner en la serie.
Lori Loughlin hace el papel de Rebecca Katsopolis.
Mary-Kate Olsen interpreta a Michelle Tanner en la serie.
Andrea Barber hace el papel de Kimmy Gibbler.
Ashley Olsen interpreta a Michelle Tanner en la serie.
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