- Mary-Kate Olsen - Michelle Tanner
- Andrea Barber - Kimmy Gibbler
- Ashley Olsen - Michelle Tanner
- Scott Weinger - Steve Hale
- Chelsea Noble - Samantha
- Phillip Glasser - Young Danny
- Michael Gregory - Mr. Cuccinello
- Steve Bond - Todd Masters
- Cristi Harris - Rachel Taylor
- Lucy Lee Flippin - Ms. Agbabian
- Scott Baio - Pete Bianco
- Nancy Dussault - Dr. Marion Steiner
- Cindy Herron - Cindy Daniels
- Christopher Darga - Waiier
- Mike Binder - Steve
- Scott Curtis - Kevin Gwin
- Julia Montgomery - Adult Steph
- Alice Hirson - Claire Tanner
- Beverly Sanders - Mindy
- Fabiana Udenio - Adrianna
- Michelle Nicastro - Roxanna
- Judie Aronson - Raven
- Jackie Joseph - Mrs. Payton
- Eddie Barth - Lou
- Elizabeth Keifer - Corrina Spicer
- Belita Moreno - Ronnie Gardner
- Wendy Schaal - Vivian
- Darcy DeMoss - Jill
- Phyllis Diller - Phyllis Diller
- Bob Perlow - Announcer
- Jason Marsden - Nelson Burkhard
- Miko Hughes - Aaron
- Whit Hertford - Walter
- Jurnee Smollett - Denise
- James Hampton - Mr. Malatesta
- Lydia Cornell - Linda Mosley
- Luis Ávalos - Mr. Santana
- Richard Paul - Mr. Strowbridge
- Kari Michaelsen - Stacey Fleetwood
- Barry Van Dyke - Eric Trent
- Tyra Ferrell - Miss Petrie
- Rhonda Shear - Adult Kimmy
- Tony Longo - Tough Prisoner
- Paul Willson - Stu
- Candace Hutson - Becky
- Ernie Hudson - Reggie "The Sandman" Martin
- Jandi Swanson - Karen
- Kristian Alfonso - Robin
- Ed Alonzo - Ed Alonzo
- Kirk Cameron - Steve
- Blake McIver Ewing - Derek
- Ami Foster - Nina
- Jonathan Brandis - Michael Monford
- Helen Martin - Shirley
- Andrew Kavovit - Paul
- Roger Lodge - Roger
- Bert Kramer - Mr. Kiner
- Dana Sparks - Cynthia Ryan
- Jayne Modean - Adult Michelle
- Jeannie Wilson - Ms. Garland
- Sorrell Booke - Lionel
- Michelle Collins - Abby
- Dot-Marie Jones - Muscular Woman
- J.D. Daniels - Charles
- Rif Hutton - Sergeant
- Cyndi Pass - Laker Girl #2
- Mike Love - Self - The Beach Boys
- Danielle Judovits - Girl in Toy Store
- John Aprea - Nick Katsopolis
- Greg Collins - Second Prisoner
- Christie Claridge - Vanessa
- Laura Reed - Ms. Lewis
- Rhoda Gemignani - Irene Cochran
- Charlie Spradling - Rhonda
- Yvonne Wilder - Irene Katsopolis
- Peter Kwong - The Dentist
- Bill Wiley - Jeb
- Stacey Alden - Secretary
- Bruce Johnston - Self - The Beach Boys
- Brian Wilson - Self - The Beach Boys
- Carl Wilson - Self - The Beach Boys
- Rebeccah Bush - Denise
- Kristi Somers - The Stewardess
- Zachary Bostrom - Jimmy
- Robin Greer - Crystal
- Eileen Conn - Julie
- Annette Sinclair - Miss Borland
- Brandon Crane - Sheldon
- Lisa Aliff - Patty Fogerty
- Max Alexander - Dr. Rueben Wynager
- Malachi Pearson - Brian Kagan
- Doris Roberts - Claire Tanner
- Wayne Powers - Frank Flood
- Raf Mauro - Mechanic
- Barry Kivel - Michael Kagan
- Anne Marie McEvoy - Kathy Santoni
- Angella Kaye - Girl at Party
- Angella Kaye - Girl at Dance
- Wendy Cutler - Mrs. Hardesty
- Jeanine Jackson - Mary Anne
- Peter Isacksen - Waiter
- Jack Kruschen - Iorgos
- Vera Lockwood - Gina
- Josh Blake - Sylvio
- Alison Armitage - Girl on Bike
- Jennifer Gatti - Elena
- Jennifer McAllister - Zoey
- Melanie Vincz - Adult D.J.
- Fiona Landers - Sophia
- Bruce Baum - Emcee
- Bruce Baum - Paul
- Mary Pat Gleason - Mrs. Sianski
- Nancy Mulford - Yvonne
- Michele Laybourn - Vega
- Lisa Savage - Paula
- Joan Leizman - Joanie
- Barbara Cameron - Barbara
- Benji Schwimmer - Benji
- Michael McManus - Paul
- Greg Callahan - Mr. Benton
- Joshua Cadman - Stage Manager
- Mark Costello - Anchorman
- Elizabeth Olsen - Girl with Flowers
- Deborah Gorman - Julie Stratton
- Michelle Smith - Laker Girl #1
- Trent Olsen - Boy with Flowers
- Karen Kopins - Linda Stratton
- Brian Byers - Ted
- Gary Griffin - Gary
- Bill Morey - Mr. Pearson
- Arlene Lorre - Marilyn
- Bobbie Eakes - Diane
- Christie Mossman - Pam Katsopolis Tanner (as Christie Houser)
- Sandra Wild - Waitress
- Tom Burkhard
- Marc Warren
- Robert L. Boyett
- Don Van Atta
- Dennis Rinsler
- Tom Amundsen
Jack Kruschen interpreta a Iorgos en la serie.
John Stamos interpreta a Jesse Katsopolis en la serie.
Bob Saget interpreta a Danny Tanner en la serie.
Dave Coulier hace el papel de Joey Gladstone.
Candace Cameron Bure hace el papel de D.J. Tanner.
Jodie Sweetin hace el papel de Stephanie Tanner.
Lori Loughlin interpreta a Rebecca Katsopolis en la serie.
Mary-Kate Olsen interpreta a Michelle Tanner en la serie.
Andrea Barber hace el papel de Kimmy Gibbler.
Ashley Olsen interpreta a Michelle Tanner en la serie.
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