- Emer Kenny - Penelope "Bunty" Windermere
- Alex Price - Sid Carter
- Ruby-May Martinwood - Brenda Palmer
- Nancy Carroll - Lady Felicia Montague
- Nancy Carroll - Lady Felicia Montague (voice)
- Tom Chambers - Inspector Sullivan
- Tom Chambers - Chief Inspector Sullivan
- Hugo Speer - Inspector Valentine
- Hugo Speer - Chief Inspector Valentine
- Adam Astill - Rev Wilfred Bohun
- Dan Fredenburgh - James Trewlove
- Ramon Tikaram - Umesh Varma
- Robert Cavanah - Leonard Quinton
- Katherine Dow Blyton - Annie Mace
- Camilla Power - Dominique Baxter
- Lorna Watson - Sister Boniface
- Pip Torrens - Geoffrey Bennett
- Stirling Gallacher - Emily Bennett
- Stella Gonet - Lady Margaret Galloway
- Sam Crane - William Knight
- Louise Brealey - Eleanor Knight
- Christopher Villiers - Justin De Vey
- Lizzy McInnerny - Charlotte McKinley
- Andrew Havill - Victor McKinley
- Peter Bramhill - Felix Underwood
- Robert Boulter - Alan Archer
- Marcia Warren - Miss Audrey Diggle
- Emma Stansfield - Violet Fernsley
- Joe Sims - Wilf Fernsley
- Clare Higgins - Dinah Fortescue
- James Rastall - Father Roland Eager
- Alice Henley - Alice Armstrong
- David Troughton - John Tatton
- Adam Long - Alfred Tatton
- Lisa Jackson - Phyllis Stanwyck
- Kobna Holdbrook-Smith - Marvin Morris
- Poppy Drayton - Selina McKinley
- Nicholas Jones - Colonel Cecil Gerard
- Bryony Afferson - Elizabeth Barnes
- Sam Hoare - Norman Bohun
- Oliver Ryan - Philip Walker
- Josephine Butler - Anne-Marie Adams
- Julian Wadham - Colonel Adams
- Amy Morgan - Ruby Adams
- Ryan Hawley - John Van Ert
- Ruth Gemmell - Martha Quinton
- Jennie Jacques - Violet Parnassus
- Simon Thorp - Mr. Harris
- Jonathan Sidgwick - Franz Prepffler
- Steffan Rhodri - Christy Nolan
- Rod Hallett - Father Franc
- Penny Downie - Rev. Mother Augustine
- Roberta Taylor - Sister Paul
- Selina Cadell - Sister Gregory
- Paddy Wallace - Tom Evans
- Joanna Horton - Joyce Evans
- Jenny Galloway - Sister Thomas
- Holly Earl - Ruth Bennet
- Jamie Glover - Dr. Michael Evans
- Melanie Kilburn - Alice Murphy
- Don Gilet - Douglas Taylor
- Stephen Boxer - Professor Patrick Galloway
- Peter McNeil O'Connor - Daniel Walsh
- Flora Spencer-Longhurst - Lucia Galloway
- Mark Dexter - Captain Clarence Clifton
- Jack Baggs - Thomas Dillcot
- Fern Deacon - Kathleen Knight
- Emma Hiddleston - Matilda Newell
- John Lightbody - Edwin Bloom
- Frank Grimes - Frank McCarthy
- Paul Warriner - Seth Wake
- Terence Booth - Dr. Ernest Miller
- Laura Main - Dorothy Underwood
- Helena Lymbery - Nurse Bridget Farrow
- Adrian Rawlins - Dr. Walter Henshaw
- Guy Williams - Arthur Danby
- Richard Hope - Sir St. John Pryde
- Caroline Blakiston - Lady Lavinia Pryde
- Susannah Fielding - Bunty Pryde
- Angus Imrie - Jago Pryde
- Stuart Laing - Charlie Denham
- Susan Brown - Ethel Fernsley
- Adam Sopp - Archie Fernsley
- Sylvestra Le Touzel - Archie Fernsley
- Anton Lesser - Father Ignatius
- Ben Wilby - Peter
- Janet Henfrey - Vera Thimble
- Annette Badland - Judith Bunyon
- David Calder - Sir Aaron Armstrong
- Justin Edwards - PC Hywel Pugh
- Nick Moran - Eddie Monk
- Andrew Knott - Peter Royce
- Matthew Ashforde - Jim Magnus
- Lynne Verrall - Hilda Magnus
- Simon Ginty - Edward Gerard
- Katie Leung - Jia-Li Gerard
- Emma Fielding - Ada Gerard
- Tim Wallers - Rupert Digby
- Philip Delancy - Henri Chapél
- James Fleet - Dr. Adam Crawford
- Charles Armstrong - Clerk of the Court
- Tracy-Ann Oberman - Audrey MacMurray
- Amelia Lowdell - Harriet Welsby
- Cian Barry - Gary Bakewell
- Nicholas Le Prevost - Count Fiskon
- Patrick Brennan - Mr. Dawson
- Leah Whitaker - Meg Le Broc
- William Ash - RSM Reginald Davis
- Amy Noble - Rosie Everton
- Rosalie Craig - Lady Vivien St Gardner-Verde
- Callum Dixon - Flynn Hardwick
- Daniel Adegboyega - Lenny Stamper
- Abhin Galeya - Doctor Raj Chandraty
- Maggie O'Neill - Mrs Kendall
- Kelly Harrison - Cathy Fawlter
- Callum Woodhouse - Randall Jones
- Miranda Hennessy - Henrietta 'Hetty' Hollingworth
- Jasper Jacob - Lord Henry Hollingworth
- Molly Hanson - Paulette Swain
- Mark Rice-Oxley - Norman Fawlter
- Jonathan Firth - Rex Bishop
- Deirdre Mullins - Bebe Fontaine
- David Schofield - Vivian Wolsey
- William Ellis - Billy Neville
- Barry Sloane - Simeon Barnes
- Madeleine Harris - Milly Le Broc
- Rupert Vansittart - Arthur Le Broc
- Oliver Dimsdale - Ned Le Broc
- Ashley Margolis - Jackie
- Ashley Campbell - Wesley Summerton
- Sarah Ingram - Barbara Curtley
- Daisy Maywood - Audrey Belchant
- Joseph Prowen - Nicholas Curtley
- Hugh Sachs - Lawrence Ashton
- Annabelle Apsion - Beattie May
- Pippa Haywood - Eileen Slither
- Grace Molony - Hannah Baxley
- Nigel Planer - Ronnie Grunion
- Julian Forsyth - Judge Gordon Pickering
- Alice Bailey Johnson - Margot Neville-Crowley
- Rob Callender - Max Neville-Crowley
- Ziggy Heath - Teddy Neville-Crowley
- Aki Omoshaybi - Charlie Reid
- Robert Portal - Bertie Quinton QC
- Nick Fletcher - Roger Sharpe QC
- Neil Pearson - Sir Toby Dobson
- Alexander Morris - Fred Dobson
- Paul Copley - Mr Feste
- Natey Jones - Doodle
- Emily Joyce - Edith Dobson
- Hannah Morrish - Pippa Thubron
- Simon Schatzberger - Alan Filchett
- Vincenzo Nicoli - Vincenzo Murgida
- Grant Masters - Trafalgar Devlin
- Nigel Betts - Samuel Hinds
- Graeme Hawley - Peter Bailey
- Niamh Cusack - Roisin Crayford
- Alison Pargeter - Anna Bailey
- Gabrielle Creevy - Polly Beavington
- Ian Puleston-Davies - Pat Lochlin
- Andrew Whipp - Roger Barford
- Bronté Norman-Terrell - Maeve Lochlin
- Hannah Yelland - Georgia Barford
- George Webster - Benjamin Milton
- Danielle Phillips - Rose Vickers
- Harriet Thorpe - Nanny Ribble
- Nick Waring - Sir Ralph Verde
- Ingvild Lakou - Camille Hogan
- Amanda Lawrence - Barbara Farrell
- Ben Lamb - Harvey St Gardner
- Cal MacAninch - George Oakley
- Gyuri Sarossy - Alistair Helmsley
- Susannah Wise - Emily Helmsley
- Andrew Turner - Daryl Cudlip
- Darryl Clark - Lenny Cudlip
- Cecilia Noble - Dame Bianca Norman
- Olivia Hallinan - Barbara Norman
- Chris Lew Kum Hoi - Tony Norman
- Jack Carroll - Tim Cudlip
- Selina Griffiths - Ruth Thundersby
- Rupert Holliday-Evans - Mervyn Glossop
- Abdul Salis - Enoch Rowe
- Laura Pyper - Phoebe Sims
- Jordan Metcalfe - Jamie Cheeseman
- Jeff Rawle - Professor Robert Wiseman
- Hayley Considine - Violet
- Mark Aiken - Major Basil Winthrop
- Maggie Steed - Dorothy Parnell
- Jonathan Broadbent - Archie Parnell
- Jemima Rooper - Lilith Crowe
- Lucy Pearson - Nell Winford
- Lauren O'Neill - Maude Riley
- Forbes Masson - Reverend Willard
- James Cartwright - Jimbo Riley
- Cassie Layton - Cecelia Orchid-Squires
- Amanda Drew - Miss Cynthia Rosewood
- Billy Postlethwaite - Edmund Noon
- Asmara Gabrielle - Jasmin Haggard
- Emily Woodward - Patricia Wintham
- Nigel Hastings - George Haggard
- Samuel Anderson - Alan Tylett
- Sean Gallagher - Len Blaisen
- Ami Metcalf - Alice Bonham
- Sean Campion - Patrick O'Leary
- Amy Robbins - Angelica Evans
- Ian Peck - Eddie Trist
- Abigail Davies - Francesca Chase
- Jack Wolfe - George Chase
- Selin Hizli - Maria Hardy
- Kevin Mains - Angus Boyde
- Lottie Tolhurst - Magdalena Stark
- Jennifer Hennessy - Sally Clegg
- Edward Dogliani - Titan Stark
- Roger Evans - Daffyd Clegg
- Mark Umbers - Nicholai Solovey
- Gil Kolirin - Yuri Galka
- Ben-Ryan Davies - Daniel Winks
- Chris Webster - William Sheppard
- Florence Hall - Marion Sheppard
- John Bett - Hugo Masters
- Chris MacDonald - Young Raleigh
- Genevieve Gaunt - Young Evelyn
- David Bamber - Walter Hubble
- Geraldine Alexander - Valerie Oliphant
- Nicholas Farrell - Sir Raleigh Beresford
- Poppy Corby-Tuech - Caterina Beresford
- Josh O'Connor - Leo Beresford
- Justine Michelle Cain - Laura Hope
- Joe Layton - Nicholas Wallis
- Guy Henry - Arthur Welkin
- James Laurenson - Professor Hilary Ambrose
- James Laurenson - Prof. Hilary Ambrose
- Sevan Stephan - Reggie Smythe
- Kiruna Stamell - Enid Flay
- Angus Wright - Colonel Laurence St Clare
- Jamie Ballard - Major David Rawlings
- Tom Chadbon - Major Wallander
- Perdita Avery - Daphne Wallander
- Haydn Gwynne - Professor Jane Milton
- Robbie O'Neill - Vince Lennon
- Darrell D'Silva - Max Scullion
- Dudley Sutton - Father Francis Palfreyman
- Ed Brody - Ciaran Wolfe
- Daniel Easton - Hugh McKenna
- James Dryden - Clarence Risley
- Tim Treloar - Father Emlyn Lewis
- Matthew Tennyson - Thomas Potts
- Polly Hemingway - Aggie
- Simon Williams - Jeremiah Moxley
- Philip McGinley - Alfons
- Nathalie Buscombe - Hannah Moxley
- Ben Deery - Harry Grandage
- Ace Bhatti - Syrus
- Michael Culkin - Dr Barashi
- Ronni Ancona - Madame Chania
- Rae Baker - Mimi
- Gareth Jewell - Henry Gibbs
- Georgina Leonidas - Emily Fletcher
- Emma Cunniffe - Mrs Mabel Grayson
- Sheila Reid - Lady Edna Forbes-Leith
- Daniel Ryan - Colonel Anthony Forbes-Leith
- Edward Akrout - Gregoire Bisset
- James Dreyfus - Binkie Cadwaller
- Anna-Louise Plowman - Rebecca Himelbaum
- David Gant - Claude Chabrol
- Alexandra Gilbreath - Georgina Francis
- Michael Maloney - Gerald Firth / Kalon
- Michael Maloney - Kalon
- Mark Lewis Jones - Arnold Francis
- Lucy Chappell - Angelica Francis
- Will Attenborough - Jacob Francis
- Holly Lucas - Ginnie Godden
- Maya Grant - Sylvia Swann
- Mark Benton - PC Walt Everett
- Nigel Cooke - Malcolm Driscoll
- Sandy McDade - Marjorie Shipton
- Richard Hawley - Alf Gastrell
- Jonathan Rigby - Radio Newsreader (voice)
- Jonathan Rigby - Radio Commentator (voice)
- Jonathan Rigby - Mr. Edward Appleby
- Jonathan Rigby - Commentator
- Jonathan Rigby - Radio Announcer (voice)
- William Gaminara - Samuel Harrogate
- Michael Jibson - Martin Wheeler
- James Burrows - Thomas Brandon
- Alexander Rain - Stephen Browning
- Kirsty Besterman - Julia Flanders
- Yolanda Kettle - Natasha Farrango
- Malcolm Storry - Bishop Talbot
- Aden Gillett - Bentley Duke
- Bill Buckhurst - Peter Redhill
- Tom Knight - Winston Grater
- Harry McEntire - Frank Albert
- Adrian Scarborough - Clive Trueman
- Ron Donachie - Jock Hamilton
- Natasha Little - Harriet Greensleeves
- Jay Villiers - Jeffrey Greensleeves
- Gareth Hale - Commissioner Busby
- Robert Daws - Robert Twyman
- Paul Bown - Mordaunt Jackson
- Oscar Dunbar - Calvin Twyman
- Dean Williamson - Lester Wallace
- Cornelius Macarthy - Emmanuel Jannitte
- Claire Prempeh - Voodouisant
- Michelle Asante - Yveline Lafond
- Paul Thornley - Joseph Sinclair
- Tosin Olomowewe - Lloyd Bennett
- Tom Morley - Tommy Sinclair
- Paul Lacoux - Dr Harris
- Eleanor Wyld - Catherine Blackstone
- Pooky Quesnel - Ruth Moore
- Will Richardson - Alexander Moore
- Ryan Watson - Ian Moore
- Richard Lumsden - Peter Blackstone
- Rosemary Boyle - Grace Fitzgerald
- Sean Blowers - Martin Cartwright
- Tristan Beint - Harry Fitzgerald
- Katie Griffiths - Rose Kane
- Rob Jarvis - Henry Lee
- Adie Allen - Iris Lightman
- John Duttine - George Hammond
- Charlotte Randle - Edie Lee
- Toby Longworth - Uncle Mirth
- Richard Braine - Henry Kirkov
- Oona Kirsch - Annabelle Marcel
- Laurence Kennedy - Sir Mortimer
- Reanne Farley - Eve Telford
- Sam O'Mahony - Jacob Doyle
- Gina Bramhill - Marianne Delacroix
- Jo Stone-Fewings - Nero Hound
- Colin McFarlane - Cardinal Papillon
- Roger Ashton-Griffiths - Cardinal Bonipogio
- Michael Pennington - Bishop Reynard
- Sarah Ball - Matron Baxter
- Rachel Teate - Peggy Fletcher
- Dominic Mafham - Sir Malcolm Braithwaite
- Faye Castelow - Flora Honeywell
- Gillian Bevan - Mrs Steel
- Ben Mansfield - Dr Tony Fairfax
- John Branwell - Albert Garrity
- Raymond Coulthard - John Langton
- Zannah Hodson - Diana Langton
- Isla Blair - Nanny Langton
- Elliott Jordan - George Parkin
- Dean Andrews - Michael Negal
- Christos Lawton - Basil Urquhart
- Maddy Hill - Hannah Parkin
- Mary Keegan - Matron
- Max Beesley Snr - Norman Vanderlande
- Claudia Jessie - Joan Vanderlande
- Frances Barber - Davina Malmort
- Ed Cooper Clarke - Robert Malmort
- Jonathan Ryland - Chester Logan
- Hara Yannas - Lillith Lafitte
- Oliver Gilbert - Reverend Peter Allsworthy
- John Sessions - Reverend Adam Gillespie
- Sally Dexter - Selina Crow
- Ken Bones - Eugene Bone
- Chris Gordon - Jeb Cornish
- Samuel Rush - Connor McNeive
- Bill Fellows - Teddy O'Connell
- Ewa Jenson - Rita Simmons
- Martin Kemp - Dennis Nelson
- Pablo Raybould - Master of Ceremonies
- Mens-Sana Tamakloe - Devon Hoyle
- Dane Foxx - Corner Man
- Hetty Baynes - Lucia Morell
- Sam Cox - Friar Novak
- Claire Brown - Mildred Nook
- Kristoffer Olsen - James Lansford
- Nicola Thorp - Scarlet Finch
- Carol Royle - Lady Ursula Lansford
- Grace Chilton - Rebecca Cooper
- Benjamin Fisher - Raymond Worrall
- Roger May - Canon Damian Fox
- Roger May - Canon Fox
- Mariah Gale - Agnes Lesser
- Colin Mace - DCI Webb
- David Yelland - Wilber Lesser
- Chloe Howman - Lucy Lesser
- Jude Owusu - Daniel Abeson
- Sonia Saville - Florence Lesser
- Alex Sawyer - Oscar Bergeres
- Letty Butler - Verity Persby
- Peter Stark - Janek Lasocki
- William Travis - Maurice Cranage
- Emily Atack - Fifi Caviara
- Eva Feiler - Joselyn O'Donnell
- Keith Osborn - Sergeant Albright
- Thomas Pickles - Lewis Ward
- Andrew Greenough - Graham Cartwright
- Elizabeth Berrington - Margaret Cartwright
- Darren Strange - The Alchemist
- Richard Southgate - Timothy Hargreaves
- Danny Webb - Malcolm Pendle
- Steve Furst - Stanley Crawford
- Emerald O'Hanrahan - Victoria Nicholson
- Simon Shepherd - Edward Reese
- David Reed - Giles Foster
- Alex Felton - Randolph Reese
- Susie Trayling - Lydia Reese
- Arthur Bostrom - Richie Queenan
- John Henshaw - Barny Butterfield
- Jessica Turner - Joyce Merriman
- Jon Glover - Jacob Rothstein
- Simon Bubb - Jeremy Mayhew-Bowman
- Lynda Baron - Mrs Rudge
- Pepter Lunkuse - Grace Kemp
- Richard Huw - Aldous Kemp
- Shaun Prendergast - George Murray
- Gary Oliver - Frank Hammond
- Bradley Hall - John Hammond
- Miles Jupp - Wynford Collins
- Allegra Marland - Charlotte Bayley
- Nick Dunning - William Bayley
- Kiran Sonia Sawar - Alisha Prasad
- David Sturzaker - Dr Joseph Ashley
- Sam Jackson - Sean Crimp
- Ian Reddington - Samuel Jacobs
- Eric Carte - Judge
- Harry Long - Douglas Bovary
- Orlando Wells - Eugene Cornelius
- Lucy Briers - Prudence Bovary
- Charlotte Lucas - Rose Marie Sturgess
- Laura Pitt-Pulford - Scarlett Dreyfuss
- John Bowler - Bob Sturgess
- Stephanie Fayerman - Ada Clough
- Kate O'Flynn - Katherine Corven
- Paul Cawley - Robin Gladwell
- Karen Meagher - Mother Winifred
- Alan Williams - Blind 'Arry
- Sophie Duval - Julia Webb
- Neal Barry - Ben Webb
- Amerjit Deu - Deepak Chatterjee
- Jessie Cave - Pandora Pott
- Martyn Ellis - Buddy Arnold
- Doreen Mantle - Miss Tibby
- Janet Dale - Freda Knight
- Roisin O'Neill - Caitlin O'Casey
- Badria Timimi - Matron Sophia
- Paul Greenwood - Charlie Coulter
- Wanda Ventham - Ellen Jennings
- Daniel Hawksford - Seth Knight
- Richard Harrington - Benedict Northam
- Daniel Flynn - Daniel Whittaker
- Mary Antony - Lara Winslow
- Richard Cunningham - Alfred Lane
- Sam Callis - Alec Frobisher
- Éva Magyar - Christina Worcester
- Adam Kotz - Eric Worcester
- Jacqueline Defferary - Shirley Krieger
- Chris Larkin - Roger Frobisher
- Clive Wood - Inspector George Ironside
- Jarred Ellis Thomas - Alexander Walgrave
- Holly Weston - Lucy Dawes
- Diana Kent - Lady Rose
- Rosie Holden - Merryn Tyrell
- Robert Vernon - Jack Coll
- James Wilby - Sefton Scott
- Milo Twomey - Philip Hart
- Sammy Moore - Daniel Gates
- Toto Bruin - May Lewis
- Alicia Charles - Sheila Barnett
- Guy Paul - Raylan Reeve
- Jane Hazlegrove - Hermione Harvey
- Ty Glaser - Tamara Reeve
- Marcus Griffiths - Michael Nelson
- John Light - Hercule Flambeau
- John Light - Captain Flynn / Hercule Flambeau
- Amy Lawrence - Morgana Reeve
- Sara Martins - Lisandra Flambeau
- Oliver Ford Davies - Bishop Golding
- Richard Dillane - Sir Charles Hakeworth
- Alexander Hanson - Lord ‘Monty’ Montague
- Gemma Page - Lady Agnes Hakeworth
- Caleb Frederick - Dr Elliot Muthomi
- Nicholas Audsley - Robert Earl of Finchmore
- Diana Quick - Lady Cecily
- Anna Munden - Arabella Darlington
- Jude Monk McGowan - Charles Huxton
- Melissa James - Shelly McGowan
- Craig Conway - Bill Devlin
- Marcus Onilude - Gideon Fredericks
- Denise Black - Penny Langdon
- Robert Hands - Walter Penmark
- Leon Ockenden - Richard Belcroft
- Penny Layden - Nora Banks
- Jackie Clune - Thelma Bryce
- Matthew Marsh - Lord Arthur Hawthorne
- Sara Stewart - Lady Margot Hawthorne
- Will Hislop - Sandy Beauchamp
- David Rees Talbot - Griff Grimshaw
- Zita Sattar - Mavis Jug
- Ted Robbins - Jock McCudgeon
- Lesley Nicol - Majorie Chummy
- Catherine Russell - Cecilia Watson
- Laura Rollins - Helen Delaney
- Robyn Addison - Elsie Peters
- Jennifer Hyde - Lola Briggit
- Ryan Gage - Finbar Finch
- Steven Elder - Tobias Faulkner
- Edward Wolstenholme - Dr. Bainbridge
- John Thomson - John Banks
- Gerard Mcdermott - William Gracy
- Michael Cooke - Ned Hannigan
- Tafline Steen - Celeste Shelton
- Raffaello Degruttola - Ispettore Mario Angelini
- Aneirin Hughes - Cardinal Ratcliffe
- Elizabeth Bennett - Agnes Burns
- Clare-Louise English - Jennifer Mossop
- Lucas Hare - Joe Telford
- Ash Hunter - Brendan Streatham
- Witney White - Scarlett Streatham
- Aidan McArdle - Harry Grover
- Roger Barclay - Jasper Granford
- David Webber - John Harrow
- Emma Davies - Charlotte Granford
- Joseph Potter - Albert "Bertie" Granford
- Lu Corfield - Moira Barns
- Elaine Paige - Mrs. Octavia Eden
- Jasmine Hyde - Miss Lizzy Eden
- Kaye Wragg - Miss Noele Schama
- Rosalind March - Mrs. Marjorie Mulch
- Philip Martin Brown - Mr. John Mulch
- Paul Forman - Gabriel Wadey
- Anna Wilson-Jones - Duchess
- Celine Arden - Sylvia Garcia
- Scott Handy - Reverend Duncan
- Alex Waldmann - Professor Garcia
- Geoffrey Newland - Lester Garrick
- Eddie Eyre - Joe Bloom
- Jolyon Coy - Sebastien Fleming / Edwin Blythe
- Cora Kirk - Lila Tate
- Sarah Smart - Ms Amanda Clement
- Howard Ward - Mayor Anthony Wood
- Tristan Gemmill - Inspector Neil Beckett
- Kara Tointon - Elizabeth Barnes
- Gary Lilburn - Raymond 'Ray' Harrison
- Olivia Benjamin - Princess Margaret
- Sam Phillips - Patrick Maidland
- Mark Fleischmann - Jeremy Sandford
- Sonita Henry - Charlotte 'Charlie' Maidland
- Elizabeth Roberts - Millie Tucker
- Jack Loxton - Thomas Church
- Helena Barlow - Penny Briggs
- Sophie Colquhoun - Ruby Nellins
- Jasmyn Banks - Betty Hartigan
- Bob Barrett - Oswald Hartigan
- Rowan Polonski - Jake Hunt
- Stephen Kennedy - Stan Hoskens
- Amy Cudden - Agnes Morris
- Jamie Bacon - Billy Turner
- Joshua Griffin - Roger Norton
- Trevor Cooper - Denny Beaton
- Dominic Jones - Lance South
- Michael Akinsulire - Ricky 'Crafty' Taylor
- Ciarán Owens - Martin Jackson
- Jay Taylor - George Kavanagh
- Jonny Phillips - Detective Superintendent Alan Alford
- Chris Pybus - Harry Davenport
- Luke Nunn - Gabe Hawthorne
- Zephryn Taitte - Father Featherstone
- Evan Milton - Stanley Buchanan
- Sylvester McCoy - Dr. Angus McClurgy
- Barney Wilkinson - Eddie Devine
- Amy Trigg - Shirley Warner
- Kelvin Fletcher - Brian Fleming
- Toby Williams - Dr. Geoffrey Fleming
- Esh Alladi - William Redshaw
- Erin Shanagher - Patty Denmore
- Barbara D'Alterio - Ursula Fanshaw
- Ingrid Oliver - Gaynor Garfield
- Lydia Larson - Meryl Plunkett
- Kenneth Collard - Cyril Frogmore
- Edward Bennett - Marmaduke Snell
- Melanie Walters - Dotty Finglesham
- Owen Brenman - Lord St John Sprockett
- Nick Blakeley - Edward Wainbody
- Jasmine Bayes - Susan Payne
- Aron von Andrian - Friedrich Von Bach
- Sarah Alexander - Harriet Sykes
- Jasmine Chiu - Lei Yen
- Nav Sidhu - Rafi Faridi
- Dominic Rowan - Chester Gates
- Ian Midlane - Radio Announcer
- Ian Midlane - Olimpicks Announcer
- Tim Hudson - Hugo Pearl-Blythe
- Ian Gelder - Gabriel Hawksworth
- Jacob Greenway - Elliot Tucker
- Aaron Sidwell - Luther Underwood
- Adrian Schiller - Drake Underwood
- Emily Redpath - Grace Tucker
- Julian Harries - Osric Wolf
- Amanda Mealing - Lady Violet
- Michael Simkins - Kingsley Wilmot
- Jake Simmance - Jack Wilmot
- Samuel Jordan - Walter Mitford
- Gemma Lawrence - Miss Lipton
- Paul McEwan - William Harrow
- David Burnett - Ralph Blackthorn
- Kate Bracken - Ella Blackthorn
- Silas Carson - Professor Alexander Prichard
- Angela Terence - Pauline Highbury
- Steven Meo - Robert Highbury
- Adam Rhys-Charles - Derek Fletcham
- Saskia Strallen - Gillian Fletcham
- Tom McCall - Mario Cantoloni
- Kevin Clifton - The Talent Scout
- Bethan Leyshon - Louisa Ross
- Cliff Barry - Sam Wadey
- Miranda Howard-Williams
- Jennie Paddon
- Ruth Carney
- Dominic Keavey
- Niall Fraser
- Ian Barber
- Dan Muirden
- Gilbert Keith Chesterton
- Nicola Wilson
- Tahsin Guner
- Rachel Flowerday
- Dominique Moloney
- Ceri Meyrick
- John Yorke
- Jonny Phillips
- David Lewis Richardson
- Julia Crampsie
- Stephen Moore
- Debbie Wiseman
- Jason Devlin
- Matt Owen
- Andrew Jones
Sara Stewart hace el papel de Lady Margot Hawthorne.
Adrian Rawlins hace el papel de Dr. Walter Henshaw.
Badria Timimi hace el papel de Matron Sophia.
David Schofield hace el papel de Vivian Wolsey.
Rupert Vansittart interpreta a Arthur Le Broc en la serie.
Hugo Speer hace el papel de Chief Inspector Valentine.
Nick Moran interpreta a Eddie Monk en la serie.
Selina Cadell interpreta a Sister Gregory en la serie.
Isla Blair interpreta a Nanny Langton en la serie.
Mark Williams interpreta a Father Brown en la serie.
Capítulo disponible en las siguientes plataformas:
