- Emer Kenny - Penelope "Bunty" Windermere
- Alex Price - Sid Carter
- Ruby-May Martinwood - Brenda Palmer
- Nancy Carroll - Lady Felicia Montague
- Nancy Carroll - Lady Felicia Montague (voice)
- Tom Chambers - Inspector Sullivan
- Tom Chambers - Chief Inspector Sullivan
- Hugo Speer - Inspector Valentine
- Hugo Speer - Chief Inspector Valentine
- Adam Astill - Rev Wilfred Bohun
- Dan Fredenburgh - James Trewlove
- Ramon Tikaram - Umesh Varma
- Robert Cavanah - Leonard Quinton
- Katherine Dow Blyton - Annie Mace
- Camilla Power - Dominique Baxter
- Lorna Watson - Sister Boniface
- Pip Torrens - Geoffrey Bennett
- Stirling Gallacher - Emily Bennett
- Stella Gonet - Lady Margaret Galloway
- Sam Crane - William Knight
- Louise Brealey - Eleanor Knight
- Christopher Villiers - Justin De Vey
- Lizzy McInnerny - Charlotte McKinley
- Andrew Havill - Victor McKinley
- Peter Bramhill - Felix Underwood
- Robert Boulter - Alan Archer
- Marcia Warren - Miss Audrey Diggle
- Emma Stansfield - Violet Fernsley
- Joe Sims - Wilf Fernsley
- Clare Higgins - Dinah Fortescue
- James Rastall - Father Roland Eager
- Alice Henley - Alice Armstrong
- David Troughton - John Tatton
- Adam Long - Alfred Tatton
- Lisa Jackson - Phyllis Stanwyck
- Kobna Holdbrook-Smith - Marvin Morris
- Poppy Drayton - Selina McKinley
- Nicholas Jones - Colonel Cecil Gerard
- Bryony Afferson - Elizabeth Barnes
- Sam Hoare - Norman Bohun
- Oliver Ryan - Philip Walker
- Josephine Butler - Anne-Marie Adams
- Julian Wadham - Colonel Adams
- Amy Morgan - Ruby Adams
- Ryan Hawley - John Van Ert
- Ruth Gemmell - Martha Quinton
- Jennie Jacques - Violet Parnassus
- Simon Thorp - Mr. Harris
- Jonathan Sidgwick - Franz Prepffler
- Steffan Rhodri - Christy Nolan
- Rod Hallett - Father Franc
- Penny Downie - Rev. Mother Augustine
- Roberta Taylor - Sister Paul
- Selina Cadell - Sister Gregory
- Paddy Wallace - Tom Evans
- Joanna Horton - Joyce Evans
- Jenny Galloway - Sister Thomas
- Holly Earl - Ruth Bennet
- Jamie Glover - Dr. Michael Evans
- Melanie Kilburn - Alice Murphy
- Don Gilet - Douglas Taylor
- Stephen Boxer - Professor Patrick Galloway
- Peter McNeil O'Connor - Daniel Walsh
- Flora Spencer-Longhurst - Lucia Galloway
- Mark Dexter - Captain Clarence Clifton
- Jack Baggs - Thomas Dillcot
- Fern Deacon - Kathleen Knight
- Emma Hiddleston - Matilda Newell
- John Lightbody - Edwin Bloom
- Frank Grimes - Frank McCarthy
- Paul Warriner - Seth Wake
- Terence Booth - Dr. Ernest Miller
- Laura Main - Dorothy Underwood
- Helena Lymbery - Nurse Bridget Farrow
- Adrian Rawlins - Dr. Walter Henshaw
- Guy Williams - Arthur Danby
- Richard Hope - Sir St. John Pryde
- Caroline Blakiston - Lady Lavinia Pryde
- Susannah Fielding - Bunty Pryde
- Angus Imrie - Jago Pryde
- Stuart Laing - Charlie Denham
- Susan Brown - Ethel Fernsley
- Adam Sopp - Archie Fernsley
- Sylvestra Le Touzel - Archie Fernsley
- Anton Lesser - Father Ignatius
- Ben Wilby - Peter
- Janet Henfrey - Vera Thimble
- Annette Badland - Judith Bunyon
- David Calder - Sir Aaron Armstrong
- Justin Edwards - PC Hywel Pugh
- Nick Moran - Eddie Monk
- Andrew Knott - Peter Royce
- Matthew Ashforde - Jim Magnus
- Lynne Verrall - Hilda Magnus
- Simon Ginty - Edward Gerard
- Katie Leung - Jia-Li Gerard
- Emma Fielding - Ada Gerard
- Tim Wallers - Rupert Digby
- Philip Delancy - Henri Chapél
- James Fleet - Dr. Adam Crawford
- Charles Armstrong - Clerk of the Court
- Tracy-Ann Oberman - Audrey MacMurray
- Amelia Lowdell - Harriet Welsby
- Cian Barry - Gary Bakewell
- Nicholas Le Prevost - Count Fiskon
- Patrick Brennan - Mr. Dawson
- Leah Whitaker - Meg Le Broc
- William Ash - RSM Reginald Davis
- Amy Noble - Rosie Everton
- Rosalie Craig - Lady Vivien St Gardner-Verde
- Callum Dixon - Flynn Hardwick
- Daniel Adegboyega - Lenny Stamper
- Abhin Galeya - Doctor Raj Chandraty
- Maggie O'Neill - Mrs Kendall
- Kelly Harrison - Cathy Fawlter
- Callum Woodhouse - Randall Jones
- Miranda Hennessy - Henrietta 'Hetty' Hollingworth
- Jasper Jacob - Lord Henry Hollingworth
- Molly Hanson - Paulette Swain
- Mark Rice-Oxley - Norman Fawlter
- Jonathan Firth - Rex Bishop
- Deirdre Mullins - Bebe Fontaine
- David Schofield - Vivian Wolsey
- William Ellis - Billy Neville
- Barry Sloane - Simeon Barnes
- Madeleine Harris - Milly Le Broc
- Rupert Vansittart - Arthur Le Broc
- Oliver Dimsdale - Ned Le Broc
- Ashley Margolis - Jackie
- Ashley Campbell - Wesley Summerton
- Sarah Ingram - Barbara Curtley
- Daisy Maywood - Audrey Belchant
- Joseph Prowen - Nicholas Curtley
- Hugh Sachs - Lawrence Ashton
- Annabelle Apsion - Beattie May
- Pippa Haywood - Eileen Slither
- Grace Molony - Hannah Baxley
- Nigel Planer - Ronnie Grunion
- Julian Forsyth - Judge Gordon Pickering
- Alice Bailey Johnson - Margot Neville-Crowley
- Rob Callender - Max Neville-Crowley
- Ziggy Heath - Teddy Neville-Crowley
- Aki Omoshaybi - Charlie Reid
- Robert Portal - Bertie Quinton QC
- Nick Fletcher - Roger Sharpe QC
- Neil Pearson - Sir Toby Dobson
- Alexander Morris - Fred Dobson
- Paul Copley - Mr Feste
- Natey Jones - Doodle
- Emily Joyce - Edith Dobson
- Hannah Morrish - Pippa Thubron
- Simon Schatzberger - Alan Filchett
- Vincenzo Nicoli - Vincenzo Murgida
- Grant Masters - Trafalgar Devlin
- Nigel Betts - Samuel Hinds
- Graeme Hawley - Peter Bailey
- Niamh Cusack - Roisin Crayford
- Alison Pargeter - Anna Bailey
- Gabrielle Creevy - Polly Beavington
- Ian Puleston-Davies - Pat Lochlin
- Andrew Whipp - Roger Barford
- Bronté Norman-Terrell - Maeve Lochlin
- Hannah Yelland - Georgia Barford
- George Webster - Benjamin Milton
- Danielle Phillips - Rose Vickers
- Harriet Thorpe - Nanny Ribble
- Nick Waring - Sir Ralph Verde
- Ingvild Lakou - Camille Hogan
- Amanda Lawrence - Barbara Farrell
- Ben Lamb - Harvey St Gardner
- Cal MacAninch - George Oakley
- Gyuri Sarossy - Alistair Helmsley
- Susannah Wise - Emily Helmsley
- Andrew Turner - Daryl Cudlip
- Darryl Clark - Lenny Cudlip
- Cecilia Noble - Dame Bianca Norman
- Olivia Hallinan - Barbara Norman
- Chris Lew Kum Hoi - Tony Norman
- Jack Carroll - Tim Cudlip
- Selina Griffiths - Ruth Thundersby
- Rupert Holliday-Evans - Mervyn Glossop
- Abdul Salis - Enoch Rowe
- Laura Pyper - Phoebe Sims
- Jordan Metcalfe - Jamie Cheeseman
- Jeff Rawle - Professor Robert Wiseman
- Hayley Considine - Violet
- Mark Aiken - Major Basil Winthrop
- Maggie Steed - Dorothy Parnell
- Jonathan Broadbent - Archie Parnell
- Jemima Rooper - Lilith Crowe
- Lucy Pearson - Nell Winford
- Lauren O'Neill - Maude Riley
- Forbes Masson - Reverend Willard
- James Cartwright - Jimbo Riley
- Cassie Layton - Cecelia Orchid-Squires
- Amanda Drew - Miss Cynthia Rosewood
- Billy Postlethwaite - Edmund Noon
- Asmara Gabrielle - Jasmin Haggard
- Emily Woodward - Patricia Wintham
- Nigel Hastings - George Haggard
- Samuel Anderson - Alan Tylett
- Sean Gallagher - Len Blaisen
- Ami Metcalf - Alice Bonham
- Sean Campion - Patrick O'Leary
- Amy Robbins - Angelica Evans
- Ian Peck - Eddie Trist
- Abigail Davies - Francesca Chase
- Jack Wolfe - George Chase
- Selin Hizli - Maria Hardy
- Kevin Mains - Angus Boyde
- Lottie Tolhurst - Magdalena Stark
- Jennifer Hennessy - Sally Clegg
- Edward Dogliani - Titan Stark
- Roger Evans - Daffyd Clegg
- Mark Umbers - Nicholai Solovey
- Gil Kolirin - Yuri Galka
- Ben-Ryan Davies - Daniel Winks
- Chris Webster - William Sheppard
- Florence Hall - Marion Sheppard
- John Bett - Hugo Masters
- Chris MacDonald - Young Raleigh
- Genevieve Gaunt - Young Evelyn
- David Bamber - Walter Hubble
- Geraldine Alexander - Valerie Oliphant
- Nicholas Farrell - Sir Raleigh Beresford
- Poppy Corby-Tuech - Caterina Beresford
- Josh O'Connor - Leo Beresford
- Justine Michelle Cain - Laura Hope
- Joe Layton - Nicholas Wallis
- Guy Henry - Arthur Welkin
- James Laurenson - Professor Hilary Ambrose
- James Laurenson - Prof. Hilary Ambrose
- Sevan Stephan - Reggie Smythe
- Kiruna Stamell - Enid Flay
- Angus Wright - Colonel Laurence St Clare
- Jamie Ballard - Major David Rawlings
- Tom Chadbon - Major Wallander
- Perdita Avery - Daphne Wallander
- Haydn Gwynne - Professor Jane Milton
- Robbie O'Neill - Vince Lennon
- Darrell D'Silva - Max Scullion
- Dudley Sutton - Father Francis Palfreyman
- Ed Brody - Ciaran Wolfe
- Daniel Easton - Hugh McKenna
- James Dryden - Clarence Risley
- Tim Treloar - Father Emlyn Lewis
- Matthew Tennyson - Thomas Potts
- Polly Hemingway - Aggie
- Simon Williams - Jeremiah Moxley
- Philip McGinley - Alfons
- Nathalie Buscombe - Hannah Moxley
- Ben Deery - Harry Grandage
- Ace Bhatti - Syrus
- Michael Culkin - Dr Barashi
- Ronni Ancona - Madame Chania
- Rae Baker - Mimi
- Gareth Jewell - Henry Gibbs
- Georgina Leonidas - Emily Fletcher
- Emma Cunniffe - Mrs Mabel Grayson
- Sheila Reid - Lady Edna Forbes-Leith
- Daniel Ryan - Colonel Anthony Forbes-Leith
- Edward Akrout - Gregoire Bisset
- James Dreyfus - Binkie Cadwaller
- Anna-Louise Plowman - Rebecca Himelbaum
- David Gant - Claude Chabrol
- Alexandra Gilbreath - Georgina Francis
- Michael Maloney - Gerald Firth / Kalon
- Michael Maloney - Kalon
- Mark Lewis Jones - Arnold Francis
- Lucy Chappell - Angelica Francis
- Will Attenborough - Jacob Francis
- Holly Lucas - Ginnie Godden
- Maya Grant - Sylvia Swann
- Mark Benton - PC Walt Everett
- Nigel Cooke - Malcolm Driscoll
- Sandy McDade - Marjorie Shipton
- Richard Hawley - Alf Gastrell
- Jonathan Rigby - Radio Newsreader (voice)
- Jonathan Rigby - Radio Commentator (voice)
- Jonathan Rigby - Mr. Edward Appleby
- Jonathan Rigby - Commentator
- Jonathan Rigby - Radio Announcer (voice)
- William Gaminara - Samuel Harrogate
- Michael Jibson - Martin Wheeler
- James Burrows - Thomas Brandon
- Alexander Rain - Stephen Browning
- Kirsty Besterman - Julia Flanders
- Yolanda Kettle - Natasha Farrango
- Malcolm Storry - Bishop Talbot
- Aden Gillett - Bentley Duke
- Bill Buckhurst - Peter Redhill
- Tom Knight - Winston Grater
- Harry McEntire - Frank Albert
- Adrian Scarborough - Clive Trueman
- Ron Donachie - Jock Hamilton
- Natasha Little - Harriet Greensleeves
- Jay Villiers - Jeffrey Greensleeves
- Gareth Hale - Commissioner Busby
- Robert Daws - Robert Twyman
- Paul Bown - Mordaunt Jackson
- Oscar Dunbar - Calvin Twyman
- Dean Williamson - Lester Wallace
- Cornelius Macarthy - Emmanuel Jannitte
- Claire Prempeh - Voodouisant
- Michelle Asante - Yveline Lafond
- Paul Thornley - Joseph Sinclair
- Tosin Olomowewe - Lloyd Bennett
- Tom Morley - Tommy Sinclair
- Paul Lacoux - Dr Harris
- Eleanor Wyld - Catherine Blackstone
- Pooky Quesnel - Ruth Moore
- Will Richardson - Alexander Moore
- Ryan Watson - Ian Moore
- Richard Lumsden - Peter Blackstone
- Rosemary Boyle - Grace Fitzgerald
- Sean Blowers - Martin Cartwright
- Tristan Beint - Harry Fitzgerald
- Katie Griffiths - Rose Kane
- Rob Jarvis - Henry Lee
- Adie Allen - Iris Lightman
- John Duttine - George Hammond
- Charlotte Randle - Edie Lee
- Toby Longworth - Uncle Mirth
- Richard Braine - Henry Kirkov
- Oona Kirsch - Annabelle Marcel
- Laurence Kennedy - Sir Mortimer
- Reanne Farley - Eve Telford
- Sam O'Mahony - Jacob Doyle
- Gina Bramhill - Marianne Delacroix
- Jo Stone-Fewings - Nero Hound
- Colin McFarlane - Cardinal Papillon
- Roger Ashton-Griffiths - Cardinal Bonipogio
- Michael Pennington - Bishop Reynard
- Sarah Ball - Matron Baxter
- Rachel Teate - Peggy Fletcher
- Dominic Mafham - Sir Malcolm Braithwaite
- Faye Castelow - Flora Honeywell
- Gillian Bevan - Mrs Steel
- Ben Mansfield - Dr Tony Fairfax
- John Branwell - Albert Garrity
- Raymond Coulthard - John Langton
- Zannah Hodson - Diana Langton
- Isla Blair - Nanny Langton
- Elliott Jordan - George Parkin
- Dean Andrews - Michael Negal
- Christos Lawton - Basil Urquhart
- Maddy Hill - Hannah Parkin
- Mary Keegan - Matron
- Max Beesley Snr - Norman Vanderlande
- Claudia Jessie - Joan Vanderlande
- Frances Barber - Davina Malmort
- Ed Cooper Clarke - Robert Malmort
- Jonathan Ryland - Chester Logan
- Hara Yannas - Lillith Lafitte
- Oliver Gilbert - Reverend Peter Allsworthy
- John Sessions - Reverend Adam Gillespie
- Sally Dexter - Selina Crow
- Ken Bones - Eugene Bone
- Chris Gordon - Jeb Cornish
- Samuel Rush - Connor McNeive
- Bill Fellows - Teddy O'Connell
- Ewa Jenson - Rita Simmons
- Martin Kemp - Dennis Nelson
- Pablo Raybould - Master of Ceremonies
- Mens-Sana Tamakloe - Devon Hoyle
- Dane Foxx - Corner Man
- Hetty Baynes - Lucia Morell
- Sam Cox - Friar Novak
- Claire Brown - Mildred Nook
- Kristoffer Olsen - James Lansford
- Nicola Thorp - Scarlet Finch
- Carol Royle - Lady Ursula Lansford
- Grace Chilton - Rebecca Cooper
- Benjamin Fisher - Raymond Worrall
- Roger May - Canon Damian Fox
- Roger May - Canon Fox
- Mariah Gale - Agnes Lesser
- Colin Mace - DCI Webb
- David Yelland - Wilber Lesser
- Chloe Howman - Lucy Lesser
- Jude Owusu - Daniel Abeson
- Sonia Saville - Florence Lesser
- Alex Sawyer - Oscar Bergeres
- Letty Butler - Verity Persby
- Peter Stark - Janek Lasocki
- William Travis - Maurice Cranage
- Emily Atack - Fifi Caviara
- Eva Feiler - Joselyn O'Donnell
- Keith Osborn - Sergeant Albright
- Thomas Pickles - Lewis Ward
- Andrew Greenough - Graham Cartwright
- Elizabeth Berrington - Margaret Cartwright
- Darren Strange - The Alchemist
- Richard Southgate - Timothy Hargreaves
- Danny Webb - Malcolm Pendle
- Steve Furst - Stanley Crawford
- Emerald O'Hanrahan - Victoria Nicholson
- Simon Shepherd - Edward Reese
- David Reed - Giles Foster
- Alex Felton - Randolph Reese
- Susie Trayling - Lydia Reese
- Arthur Bostrom - Richie Queenan
- John Henshaw - Barny Butterfield
- Jessica Turner - Joyce Merriman
- Jon Glover - Jacob Rothstein
- Simon Bubb - Jeremy Mayhew-Bowman
- Lynda Baron - Mrs Rudge
- Pepter Lunkuse - Grace Kemp
- Richard Huw - Aldous Kemp
- Shaun Prendergast - George Murray
- Gary Oliver - Frank Hammond
- Bradley Hall - John Hammond
- Miles Jupp - Wynford Collins
- Allegra Marland - Charlotte Bayley
- Nick Dunning - William Bayley
- Kiran Sonia Sawar - Alisha Prasad
- David Sturzaker - Dr Joseph Ashley
- Sam Jackson - Sean Crimp
- Ian Reddington - Samuel Jacobs
- Eric Carte - Judge
- Harry Long - Douglas Bovary
- Orlando Wells - Eugene Cornelius
- Lucy Briers - Prudence Bovary
- Charlotte Lucas - Rose Marie Sturgess
- Laura Pitt-Pulford - Scarlett Dreyfuss
- John Bowler - Bob Sturgess
- Stephanie Fayerman - Ada Clough
- Kate O'Flynn - Katherine Corven
- Paul Cawley - Robin Gladwell
- Karen Meagher - Mother Winifred
- Alan Williams - Blind 'Arry
- Sophie Duval - Julia Webb
- Neal Barry - Ben Webb
- Amerjit Deu - Deepak Chatterjee
- Jessie Cave - Pandora Pott
- Martyn Ellis - Buddy Arnold
- Doreen Mantle - Miss Tibby
- Janet Dale - Freda Knight
- Roisin O'Neill - Caitlin O'Casey
- Badria Timimi - Matron Sophia
- Paul Greenwood - Charlie Coulter
- Wanda Ventham - Ellen Jennings
- Daniel Hawksford - Seth Knight
- Richard Harrington - Benedict Northam
- Daniel Flynn - Daniel Whittaker
- Mary Antony - Lara Winslow
- Richard Cunningham - Alfred Lane
- Sam Callis - Alec Frobisher
- Éva Magyar - Christina Worcester
- Adam Kotz - Eric Worcester
- Jacqueline Defferary - Shirley Krieger
- Chris Larkin - Roger Frobisher
- Clive Wood - Inspector George Ironside
- Jarred Ellis Thomas - Alexander Walgrave
- Holly Weston - Lucy Dawes
- Diana Kent - Lady Rose
- Rosie Holden - Merryn Tyrell
- Robert Vernon - Jack Coll
- James Wilby - Sefton Scott
- Milo Twomey - Philip Hart
- Sammy Moore - Daniel Gates
- Toto Bruin - May Lewis
- Alicia Charles - Sheila Barnett
- Guy Paul - Raylan Reeve
- Jane Hazlegrove - Hermione Harvey
- Ty Glaser - Tamara Reeve
- Marcus Griffiths - Michael Nelson
- John Light - Hercule Flambeau
- John Light - Captain Flynn / Hercule Flambeau
- Amy Lawrence - Morgana Reeve
- Sara Martins - Lisandra Flambeau
- Oliver Ford Davies - Bishop Golding
- Richard Dillane - Sir Charles Hakeworth
- Alexander Hanson - Lord ‘Monty’ Montague
- Gemma Page - Lady Agnes Hakeworth
- Caleb Frederick - Dr Elliot Muthomi
- Nicholas Audsley - Robert Earl of Finchmore
- Diana Quick - Lady Cecily
- Anna Munden - Arabella Darlington
- Jude Monk McGowan - Charles Huxton
- Melissa James - Shelly McGowan
- Craig Conway - Bill Devlin
- Marcus Onilude - Gideon Fredericks
- Denise Black - Penny Langdon
- Robert Hands - Walter Penmark
- Leon Ockenden - Richard Belcroft
- Penny Layden - Nora Banks
- Jackie Clune - Thelma Bryce
- Matthew Marsh - Lord Arthur Hawthorne
- Sara Stewart - Lady Margot Hawthorne
- Will Hislop - Sandy Beauchamp
- David Rees Talbot - Griff Grimshaw
- Zita Sattar - Mavis Jug
- Ted Robbins - Jock McCudgeon
- Lesley Nicol - Majorie Chummy
- Catherine Russell - Cecilia Watson
- Laura Rollins - Helen Delaney
- Robyn Addison - Elsie Peters
- Jennifer Hyde - Lola Briggit
- Ryan Gage - Finbar Finch
- Steven Elder - Tobias Faulkner
- Edward Wolstenholme - Dr. Bainbridge
- John Thomson - John Banks
- Gerard Mcdermott - William Gracy
- Michael Cooke - Ned Hannigan
- Tafline Steen - Celeste Shelton
- Raffaello Degruttola - Ispettore Mario Angelini
- Aneirin Hughes - Cardinal Ratcliffe
- Elizabeth Bennett - Agnes Burns
- Clare-Louise English - Jennifer Mossop
- Lucas Hare - Joe Telford
- Ash Hunter - Brendan Streatham
- Witney White - Scarlett Streatham
- Aidan McArdle - Harry Grover
- Roger Barclay - Jasper Granford
- David Webber - John Harrow
- Emma Davies - Charlotte Granford
- Joseph Potter - Albert "Bertie" Granford
- Lu Corfield - Moira Barns
- Elaine Paige - Mrs. Octavia Eden
- Jasmine Hyde - Miss Lizzy Eden
- Kaye Wragg - Miss Noele Schama
- Rosalind March - Mrs. Marjorie Mulch
- Philip Martin Brown - Mr. John Mulch
- Paul Forman - Gabriel Wadey
- Anna Wilson-Jones - Duchess
- Celine Arden - Sylvia Garcia
- Scott Handy - Reverend Duncan
- Alex Waldmann - Professor Garcia
- Geoffrey Newland - Lester Garrick
- Eddie Eyre - Joe Bloom
- Jolyon Coy - Sebastien Fleming / Edwin Blythe
- Cora Kirk - Lila Tate
- Sarah Smart - Ms Amanda Clement
- Howard Ward - Mayor Anthony Wood
- Tristan Gemmill - Inspector Neil Beckett
- Kara Tointon - Elizabeth Barnes
- Gary Lilburn - Raymond 'Ray' Harrison
- Olivia Benjamin - Princess Margaret
- Sam Phillips - Patrick Maidland
- Mark Fleischmann - Jeremy Sandford
- Sonita Henry - Charlotte 'Charlie' Maidland
- Elizabeth Roberts - Millie Tucker
- Jack Loxton - Thomas Church
- Helena Barlow - Penny Briggs
- Sophie Colquhoun - Ruby Nellins
- Jasmyn Banks - Betty Hartigan
- Bob Barrett - Oswald Hartigan
- Rowan Polonski - Jake Hunt
- Stephen Kennedy - Stan Hoskens
- Amy Cudden - Agnes Morris
- Jamie Bacon - Billy Turner
- Joshua Griffin - Roger Norton
- Trevor Cooper - Denny Beaton
- Dominic Jones - Lance South
- Michael Akinsulire - Ricky 'Crafty' Taylor
- Ciarán Owens - Martin Jackson
- Jay Taylor - George Kavanagh
- Jonny Phillips - Detective Superintendent Alan Alford
- Chris Pybus - Harry Davenport
- Luke Nunn - Gabe Hawthorne
- Zephryn Taitte - Father Featherstone
- Evan Milton - Stanley Buchanan
- Sylvester McCoy - Dr. Angus McClurgy
- Barney Wilkinson - Eddie Devine
- Amy Trigg - Shirley Warner
- Kelvin Fletcher - Brian Fleming
- Toby Williams - Dr. Geoffrey Fleming
- Esh Alladi - William Redshaw
- Erin Shanagher - Patty Denmore
- Barbara D'Alterio - Ursula Fanshaw
- Ingrid Oliver - Gaynor Garfield
- Lydia Larson - Meryl Plunkett
- Kenneth Collard - Cyril Frogmore
- Edward Bennett - Marmaduke Snell
- Melanie Walters - Dotty Finglesham
- Owen Brenman - Lord St John Sprockett
- Nick Blakeley - Edward Wainbody
- Jasmine Bayes - Susan Payne
- Aron von Andrian - Friedrich Von Bach
- Sarah Alexander - Harriet Sykes
- Jasmine Chiu - Lei Yen
- Nav Sidhu - Rafi Faridi
- Dominic Rowan - Chester Gates
- Ian Midlane - Radio Announcer
- Ian Midlane - Olimpicks Announcer
- Tim Hudson - Hugo Pearl-Blythe
- Ian Gelder - Gabriel Hawksworth
- Jacob Greenway - Elliot Tucker
- Aaron Sidwell - Luther Underwood
- Adrian Schiller - Drake Underwood
- Emily Redpath - Grace Tucker
- Julian Harries - Osric Wolf
- Amanda Mealing - Lady Violet
- Michael Simkins - Kingsley Wilmot
- Jake Simmance - Jack Wilmot
- Samuel Jordan - Walter Mitford
- Gemma Lawrence - Miss Lipton
- Paul McEwan - William Harrow
- David Burnett - Ralph Blackthorn
- Kate Bracken - Ella Blackthorn
- Silas Carson - Professor Alexander Prichard
- Angela Terence - Pauline Highbury
- Steven Meo - Robert Highbury
- Adam Rhys-Charles - Derek Fletcham
- Saskia Strallen - Gillian Fletcham
- Tom McCall - Mario Cantoloni
- Kevin Clifton - The Talent Scout
- Bethan Leyshon - Louisa Ross
- Cliff Barry - Sam Wadey
- Miranda Howard-Williams
- Jennie Paddon
- Ruth Carney
- Dominic Keavey
- Niall Fraser
- Ian Barber
- Dan Muirden
- Gilbert Keith Chesterton
- Nicola Wilson
- Tahsin Guner
- Rachel Flowerday
- Dominique Moloney
- Ceri Meyrick
- John Yorke
- Jonny Phillips
- David Lewis Richardson
- Julia Crampsie
- Stephen Moore
- Debbie Wiseman
- Jason Devlin
- Matt Owen
- Andrew Jones
Sara Stewart interpreta a Lady Margot Hawthorne en la serie.
Adrian Rawlins interpreta a Dr. Walter Henshaw en la serie.
Badria Timimi hace el papel de Matron Sophia.
David Schofield hace el papel de Vivian Wolsey.
Rupert Vansittart interpreta a Arthur Le Broc en la serie.
Hugo Speer interpreta a Chief Inspector Valentine en la serie.
Nick Moran hace el papel de Eddie Monk.
Selina Cadell interpreta a Sister Gregory en la serie.
Isla Blair interpreta a Nanny Langton en la serie.
Mark Williams hace el papel de Father Brown.
Capítulo disponible en las siguientes plataformas:
