- Evelyne Brochu - Delphine Cormier
- Matt Frewer - Dr. Aldous Leekie
- Skyler Wexler - Kira Manning
- Melanie Nicholls-King - Amelia
- Ron Lea - Lieutenant Gavin Hardcastle
- Daniel Kash - Tomas
- Natalie Lisinska - Aynsley Norris
- Eric Johnson - Chad Norris
- Michiel Huisman - Cal Morrison
- Matthew Bennett - Daniel Rosen
- Diana Salvatore - Bobby
- Millie Davis - Gemma Hendrix
- Drew Davis - Oscar Hendrix
- Jean Yoon - Janis Beckwith
- David Richmond-Peck - Olivier Duval
- Terra Hazelton - Sarah Stubbs
- Peter Outerbridge - Henrik "Hank" Johanssen
- Kristin Booth - Bonnie Johanssen
- Zoé De Grand Maison - Gracie Johanssen
- Julian Richings - Benjamin Kertland
- Patrick J. Adams - Jesse
- Andrew Gillies - Ethan Duncan
- Tom McCamus - Dr. Alan Nealon
- Amanda Brugel - Marci Coates
- Kyra Harper - Dr. Virginia Coady
- Justin Chatwin - Jason Kellerman
- Alison Steadman - Kendall Malone
- Sarain Boylan - Astrid
- Raymond Ablack - Raj Singh
- Allie MacDonald - Trina
- Rosemary Dunsmore - Professor Susan Duncan
- Joel Thomas Hynes - Dizzy
- James Frain - Ferdinand Chevalier
- Jessalyn Wanlim - Evie Cho
- Lauren Hammersley - Adele
- Inga Cadranel - Detective Angela "Angie" Deangelis
- Elizabeth Saunders - Dr. Anita Bowers
- Domenico Fiore - Police Captain
- Justin Skye Conley - Exec
- Nicholas Rose - Colin
- Ivan Sherry - Internal Affairs Suit
- Marqus Bobesich - Rockabilly Bob
- Jean-Michel Le Gal - Stephen Riggs
- Denika Ellis-Dawson - Little Girl
- Joanne Reece - Beth's Lawyer
- Dale Samms - Hotel Security
- Tyler Murree - Forensic Clerk
- Christopher Seivright - Bartender
- Jack Fulton - Trevor
- Jane Spence - Trevor's Mom
- Miriam McDonald - Madison
- Marty Adams - Spytech Clerk
- David Vena - Joao
- Priya Rao - Meera Kumar
- Earl McLean Jr. - Teddy
- Edsson Morales - Coat Check Boy
- Jeremy Hernandez - Clubber
- Sanjay Talwar - Dr. Aguda
- Jeff Yung - Orderly
- Billy Parrott - EMT
- Okiki Kendall - Nurse 1
- Jennifer Krukowski - Nurse 2
- Neil Girvan - Charity's Husband
- Louise Nicol - Donnie's Mother
- Kristi Angus - Charity Simms
- Alex Karzis - Alexander
- Anika Johnson - Pianist / Backup Singer
- Barbara Johnston - Kelsey / Backup Singer
- Kent Sheridan - Conrad
- Carter Hayden - Paul
- Conrad Bergschneider - Line Cook
- Brian Bisson - Damon
- Joshua Teixeira - Skate Punk
- Joseph Pierre - Detective Grigson
- Brendan Heard - Game Boy
- Dwight Ireland - Security Guard
- Allison Wilson-Forbes - Trauma Nurse
- Nora McLellan - Brenda
- Rob deLeeuw - Barry
- Darryl Flatman - Officer Carp
- Zachary Bennett - Officer Bowman
- Anthony Christian Potenza - Cashier
- Julian DeZotti - Greg Corson
- Murray Furrow - Pathologist
- Raven Dauda - Yvonne
- Roger Cross - Carlton
- David Benjamin Tomlinson - Troy
- Cynthia Galant - Young Rachel / Charlotte
- Kevin Dennis - Detective
- Jane Spidell - Deacon Bartlett
- Ryan Blakely - Reverend Mike
- Ryan Blakely - Reverend Mike (voice)
- Danielle Bourgon - Female Officer
- Michelle Forbes - Dr. Marion Bowles
- Dylan Trowbridge - Addict
- Bishop Brigante - Sammy
- Jamillah Ross - ND Officer
- Daniel Junghuan Park - Doctor #1
- Michael Brown - Swat Officer
- Lila Yee - Old Lady
- Vitalie Ursu - Doctor #2
- Allen Keng - Painmaker
- Sadie Munroe - Faith
- Anita La Selva - Dr. Parks
- Vanessa Burns - Nurse
- Diane Fabian - Ukrainian Landlady
- Carlos Diaz - Detective Diaz
- Peter Michael Dillon - Cop
- John Nelles - Male Nurse
- Earl Pastko - Bulldog
- Monica Dottor - Soccer Mom
- Trenna Keating - Vera
- Desmond Campbell - Guard One
- Chris Gallinger - Guard Two
- Natalie Krill - Patty
- Carlos Gonzalez-Vio - Dr. Silva
- Nicholas Campbell - Willard Finch
- David Fox - Jonah Appleyard
- Gavin Fox - Lionel
- Ksenia Solo - Shay Davydov
- Tom Barnett - David Benchman
- Andrew Priestman - Soldier
- Ryan Turner - Soldier Hastings
- Ryan Allen - Soldier Woods
- Jess Salgueiro - Luisa
- Michelle Arvizu - La Camarera
- Alejandro Ampudia - Hernan
- David Bronfman - Bob Buckingham
- Mary Kelly - Stacey Horowitz
- Lucie Guest - Zoie
- Taylor Price - German Doctor
- Nigel Bennett - Kassov
- Daniel Fathers - Terrance
- Brian Frank - Carl
- Brittany Drisdelle - DYAD Receptionist
- Ian Matthews - Frank
- Kimmy Choi - DYAD Orderly
- Miranda Edwards - Roxie
- Gord Rand - Detective Martin "Marty" Duko
- Michael Chwastiak - Vice Cop
- Alexis Koetting - Voting Wife
- Christy Bruce - Young Susan Duncan
- Jonathan Nathaniel - Dresser
- Jade Hassouné - Aaron
- Uni Park - Maggie Chen
- Calwyn Shurgold - Hell Wizard
- Francisco Trujillo - Surgeon
- Ivan Wanis-Ruiz - Martinez
- Jonathan Purdon - Driver
- Ellora Patnaik - Ultra Sound Technician
- Colton Gobbo - Teenager
- Joe Pingue - Detective Troy Collier
- Siobhan Murphy - Leslie
- Dmitry Chepovetsky - Dr. Henry A. Bosch
- Lindsey Connell - Portia Grossman
- Michelle Alexander - Clinic Receptionist
- Mary Pitt - Café Customer
- Aurora Browne - Margot
- Zoe Doyle - Melissa
- Bridget Wareham - Nicola
- Saad Siddiqui - Dr. Moffat
- Casey Hudecki - Denelle
- Taylor Trowbridge - Tabitha
- Janet Pinnick - Nurse
- Dharini Woollcombe - Young Nurse
- Nora Sheehan - Charge Nurse
- Sheila McCarthy - Connie Hendrix
- Sheila McCarthy - Connie Hendrix (voice)
- Glen Grant - Brightborn Security Guard
- Nicole Stamp - Rookie
- James Byron - Waiter
- Peaches - Herself
- Brooke Palsson - Elle
- James Cade - Tito
- Scott Wentworth - Dr. Ian Van Lier
- Sadie Alter - Gemma Hendrix' Friend
- Alex Spencer - Pedestrian
- Brendan Beiser - Friendly Guy
- Noah Dalton Danby - Threatening Neo
- Carlos Fortin - Detention Guard #1
- Chavis Brown - Detention Guard #2
- Géza Kovács - The Messenger
- George Stroumboulopoulos - Interviewer
- Lisa Codrington - Kendra Dupree
- Kiara Hunter - Mother
- David Gingrich - Father
- Holly Macintyre - Daughter
- Gavin MacIver-Wright - Son
- Shawn Ahmed - Reporter #1
- Frank Moore - Board Member #1
- Jenessa Grant - Mud
- Elyse Levesque - Detective Maddy Enger
- Andrea Runge - PR Flack
- Serje Basi - Suit
- Andrea Davis - Board Member #2
- Karine Ricard - Doctor #1
- Kim Nelson - Reporter #2
- Kirsten Alter - Detective Lindstein
- Andrew Moodie - Simon Frontenac
- David Christo - Reporter #2
- Stuart Hughes - Cooper
- Victor Gomez - Salvador
- Sirena Gulamgaus - Aisha Yasin
- Vas Saranga - Amar
- Andrew Musselman - The Creature / Janis
- Bobby Brown - Neo Agent #3
- Stephen McHattie - Percival "P. T." Westmorland
- Glenda Braganza - Dr. Slaight
- Simu Liu - Mr. Mitchell
- Karen Ivany - Vice Principal
- Bas Reitsma - Neo Agent
- Tim Beresford - Neo Agent
- Paula Barrett - Nurse Wennie
- Dalton Derek - Security Guard
- Jayne Eastwood - Nona Walker
- Illarion Michaels - Jake
- Lily Gail Reid - Esmae
- Marco Timpano - Forensics #1
- Sarah Orenstein - Dr. Elizabeth Perkins
- Varun Saranga - Neal
- Pip Dwyer - Cedar Ridge Nurse
- Doug Murray - Dr. Nimitz
- Dan MacDonald - Martin Funt
- Deborah Grover - Yolanda
- Humberly González - Ana
- Daniel Stolfi - Village Guard
- Cara Ricketts - Brie
- Lukas Engel - Boy
- Tom Cullen - Leonard "Len" Sipp
- Elie Gemael - Hashem Al-Khatib
- Andy Marshall - Technician
- Kent Staines - Ezra Lue
- Leon Aureus - Back Alley Surgeon
- Suresh John - Krishna
- Craig Henry - Steve
- Habree Larratt - Young Helena
- Cynthia Ashperger - Sister Olga
- Aviva Armour-Ostroff - Coady's Technician
- Nneka Elliott - News Reporter
- Mike Shara - Guard #2
- Ted Dykstra - Doctor
- Christopher Morris - Kiosk Guard
- Sally Cahill - Irish Friend
- Mark Sparks - Guard #3
- Bailey Corneal - Clone B
- Doug MacLeod - Justice of the Peace
- Courtenay Taylor - Michael
- Alex Ozerov-Meyer - Ramone
- Louise Hall
- Renée St. Cyr
- John Fawcett
- Gosia Kamela
- James Crouch
- Claire Welland
- Catherine Cooper
- Sharon Forrest
- Christopher Guglick
- Marco DiFelice
- Shaun Gratto
- Herwig Gayer
- Trevor Yuile
- Amon Tobin
Julian Richings interpreta a Benjamin Kertland en la serie.
Tatiana Maslany interpreta a Sarah / Cosima / Alison / Helena / Rachel en la serie.
Jayne Eastwood interpreta a Nona Walker en la serie.
Wil Wheaton interpreta a Self - Host en la serie.
David Fox hace el papel de Jonah Appleyard.
Stephen McHattie interpreta a Percival "P. T." Westmorland en la serie.
Justin Chatwin interpreta a Jason Kellerman en la serie.
Jordan Gavaris hace el papel de Felix 'Fee' Dawkins.
Josh Vokey interpreta a Scott Smith en la serie.
Maria Doyle Kennedy interpreta a Siobhan 'Mrs. S' Sadler en la serie.
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