- Hal Sparks - Danny Davis Jr.
- Ernie Grunwald - Benjamin
- Laz Alonso - Manny
- David Shatraw - Martin
- Common - Darius
- Ivana Miličević - Rayna
- Laila Ali - Herself
- Mablean Ephriam - Judge
- Christine Lakin - Erin
- Brandy Norwood - Michelle McGinty
- Romeo Miller - Eric Kerr
- Lil' Zane - Self
- Joe Brown - Self
- Melinda Sward - Sandi
- Tanja Reichert - Sassy
- Dana Davis - Meg
- Mystro Clark - Red Galloway
- Paul Wight - Miles
- Melissa De Sousa - Natalie
- Jason Earles - Brad
- Bill Walton - Bill Walton
- Reagan Gomez-Preston - Bernadette
- Travis Wester - Ty
- Vanessa Bell Calloway - Michelle McCall
- Holly Robinson Peete - Stacy
- Josh Henderson - Josh
- Anthony Hamilton - Anthony Hamilton
- Angie Stone - Angie Stone
- Giuliana Rancic - Tammy Townsend
- Haylie Duff - Mandy
- John Salley - John Salley
- Saskia Garel - Danielle
- Leila Arcieri - Lila
- Danielle Savre - Brittany
- Mindy Cohn - Ms. Sorel
- Duane Martin - Elliott
- Robin Riker - Connie
- Solange - Charlotte
- Tessie Santiago - Hannah
- Mercedes Yvette - Java
- Denzel Whitaker - Young Duane
- Rachel Specter - Carlotta
- Kadeem Hardison - Director
- Lisa Leslie - Rochelle
- Jackée Harry - Sherri St. Croix
- Chris Brown - Self
- Jeremy Ray Valdez - Raffy
- David Garrison - Jack Sherwood
- Maria Menounos - Glenda
- Kel Mitchell - Manny
- Tichina Arnold - Nicole Barnes
- Marques Houston - Kevin Barnes
- Darius Miles - Darius Miles
- Tamala Jones - Tonya
- Patricia Belcher - Dr. Gilkes
- Curtis Armstrong - Matt
- Zilah Mendoza - Esperanza
- Felicia Day - Sarah
- Tim Meadows - Leroy Ballard
- Joy Bisco - Nurse Girl
- Guy Torry - Flim-Flam
- Laird Macintosh - Craig Simpson
- Jennia Fredrique - Natasha
- Diane Delano - Officer Esther Justice
- Evan Parke - Carl
- Kevin Frazier - Kevin Frazier
- David O'Donnell - Hanalito
- India.Arie - Self
- Niecy Nash-Betts - Darla
- Daryl Sabara - Jeffy
- Method Man - Self
- Shari Headley - Pamela
- Alfonso Ribeiro - Lenny
- Chingy - Taz
- Tami-Adrian George - Dominique
- Andrew McFarlane - Keith
- Mario - Marvin
- Stephanie Hodge - Jackie
- DeVaughn Nixon - Tracy
- Cole Petersen - Timmy
- Caroline Aaron - Cheryl Ballard
- Toby Huss - Hank
- Claudia Jordan - Claudia Jordan
- Kim Fields - Ms. Swain
- Dorian Brown Pham - Hannah
- Tamara Taylor - Judy
- Jennifer Freeman - Alicia
- B.J. Britt - Calvin
- Emmanuel Lewis - Emmanuel Lewis
- Brandon Molale - Policeman
- Omar Gooding - Malik
- Shanice Wilson - Chocolate Kisses Lead Singer
- Michael Irvin - Dan McCracken
- Kym Whitley - Liza
- Clifton Powell - Coach Guillory
- Marisa Lauren - Stephanie Ballard
- Charlie Murphy - Senator Larry Eldredge
- Jascha Washington - Flex Jr.
- Shane Ryan-Reid - Bartender
- Benjamin Stephens - Yusef
- Monica Allison - Belinda
- Jeffrey Sharmat - Chester
- PaSean Wilson - Sonya
- Mark Tymchyshyn - Greg
- Nancy Linehan Charles - Miss Braxton
- Alley Mercedes - Catherine Rose
- Marie Caldare - Waitress
- Stacy Meadows - Bobby Arthur
- Tracy Vilar - Ms. Moody
- Alexis Fields - Tiffany
- Jacory Gums - Reo
- Joan Pringle - Eunice Barnes
- Omarion - Nytmare
- Omarion - Darius
- Ron Canada - Richard Barnes
- Alice Alyse - High School Student
- Tim Bagley - Phantom / Stuart
- Lawrence LeJohn - Stage Manager
- Mia Riverton - Jennifer
- Kasan Butcher - Ishmael
- David Leisure - Frank
- Mark Daniel Cade - Dr. Hepburn
- Alicia Lagano - Alicia
- Matt Price - Darryl
- Dawn Stern - Yolanda
- Dan Warner - Cop
- Tracy Douglas - Denise
- Lauri Johnson - Mrs. Vishanisavik
- Lauri Johnson - Eccentric Woman
- Nate Dogg - Self
- Amy Hill - Ms. Kim
- Chris Butler - Luke
- Cookie - Judge
- James Black - Black Gold Member
- Enya Flack - Louise
- Kenny Johnson - Brandon
- Gina St. John - Sonya
- Yvonne Farrow - Donatella
- Lela Lee - Reporter
- Colby French - Reporter
- Darius Cottrell - Guest Bachelor
- James Aaron Smith - Lewis
- Nigel Thatch - Derrick
- André Carthen - Craig
- Chiara Fudge - Josie
- Renée Elise Goldsberry - Paulette
- Johari Johnson - Charlotte
- Shondrella Avery - Candy Taylor
- Shondrella Avery - Nurse Fine
- J. D. Pardo - Posse Member
- Danny Erskine - Malcolm Seal
- Tembi Locke - Dr. Tiddlehorn
- Khanya Mkhize - Ginger
- Rashaan Nall - Walt Powell
- Greg Cipes - Butter
- Greg Cipes - Jesse
- Teck Holmes - Vidal Banks
- Roshawn Franklin - Jack Payton
- Annie O'Donnell - Miss Odessa
- Heather Salmon - Celeste
- Marc Evan Jackson - The Store Clerk
- Larry Thomas - Akhmad the Taxi Driver
- Kim Coles - Leilani Jones
- Weston Mueller - Teenager
- Braden Williams - Teenager
- Lester Speight - The Guard
- Bob Glouberman - Howard McIntyre
- Tessa Ludwick - Amber
- David Faustino - Chad
- David Faustino - Ian
- Zuhair Haddad - Vendor
- David Ramsey - Jayden
- Rachel Snow - Kendra
- Cooper Thornton - Maitre'd
- Rolonda Watts - Dr. Taylor
- Cynthia Frost - Mrs. Goldstein
- Sundy Carter - Beautiful Woman
- Marisa Theodore - Brandy
- Gene Whittington - Mr. Parsons
- Keith Hamilton Cobb - Clay
- Jeff Dunham - Benny / Kenny
- Ja'net DuBois - Queen Esther
- Robbin M. Quevedo - Skater Boy
- Sharon Sachs - Dr. Ellis
- Brian Scolaro - Torian
- Jason Winer - Pete
- Jack Plotnick - Dr. Medway
- Brian Dietzen - Bellhop
- Eric Dearborn - Denver
- Joyful Drake - Rhonda
- Edward Fordham, Jr. - Ace
- Lorna Scott - Lynn
- Sonya Leslie - MaLyssa
- Tami Roman - Elizabeth
- Brent Hinkley - Hale
- Angell Conwell - Amanda
- Mehcad Brooks - Mustafa
- Peter MacKenzie - Blaine Lockraven
- Rhys Coiro - Zorbo Vishanisavik
- Adam Gregor - Mr. Vishanisavik
- Dedee Pfeiffer - Colleen Bay
- John J. York - Dave Smith
- Tamara 'Gingir' Curry - Janay
- Nick Stellate - Officer
- Kyle Cease - Arnie
- Ken Land - Doctor
- Nichole Lennstrom - Woman
- Oris Erhuero - Man
- Brenda Song - Asoniti
- Ashlie Brillault - Regina
- Chris Gardner - Todd
- Smokey Robinson - Duane's Father
- Beth Littleford - Geraldine Murphy
- Jenny McCarthy-Wahlberg - Holly Spears
- Gary Grubbs - Jack Crawford
- Robin Givens - Sheila Kerr
- Jason Delane Lee - Bill
- Rhyon Nicole Brown - Angela
- Steve Kramer - Janitor
- Frederic Tucker - Minister
- Chad Einbinder - Policeman
- Tanya Raisa - High School Student
- Crystal Kwon - Lynn
- Clyde Kusatsu - Yoon
- Eve - Ida
- Avant - Avant
- Ruben Studdard - Ruben Studdard
- David Youse - Steven
- Orlando Brown - DeWayne
- Eric Dickerson - Eric Dickerson
- Stuart Scott - Stuart Scott
- Patricia Place - Mrs. Cabbot
- Summer Simmons - Felicia
- Helen Slayton-Hughes - Carol
- Katie Fountain - Jennifer
- WC - Hypnotiq
- Lewis Dix Jr. - Mr. Adams
- Shannon Elizabeth - Tiffany Sherwood
- Wayne Wilderson - Evan
- La La Anthony - Kendra
- Alexander Folk - Mr. Joe
- Mark Deklin - Helmut
- Edwin 'EdVanz'd' Morrow - Johnny Bulbank
- Portia Realer - Stephanie
- Karl Yune - Emcee
- Loon - Self
- Wynonna Smith - Flight Attendant
- Wynonna Smith - Marcia
- Kendre Berry - Young Flex
- Devika Parikh - DeeDee
- Brian Palermo - Mr. Evans
- Daniel Graves - MC
- Amanda Carlin - Mrs. Sullivan
- Darlene Hunt - Carla
- Licia L. Shearer - Mrs. Fisher
- Melinda Sullivan - Helayna
- Max Julien - Dr. G Mack
- Kiyano La'vin - DJ
- Bruce Gerard Brown Jr. - Radio DJ
- Sharon Swainson - Rebecca
- Madeleine Wade - Beth
- Jessica Barth - Attractive Woman
- Vincent Foster - White Guy
- Cynthia Ferrer - Manager
- Vanessa Born - Girl
- Susanne Wright - Woman
- Tiffany Jackson - Cat Vixen
- Matt T. Baker - Pirate Guy
- Napiera Groves - Tracy
- Rachel Sterling - Summer
- Cristián de la Fuente - Andrew
- Nate Torrence - Water Guy
- Nate Torrence - Ralph
- Cole Smith - Brooke
- Bobby V - Self
- Dana Woods - Rudolph
- Eric Payne - Man
- Retha Jones - Nurse
- Mitch Silpa - Blane
- Andrew Ableson - Faculty Member
- Michael J. Pagan - Greg
- Yvette Brooks - Female Customer
- Michelle Haner - Mime
- Valerie Azlynn - Rachel
- Michelle Van Der Water - Melanie
- Charlene Amoia - Shelley
- Wendy Worthington - Helga
- Charmaine DeGraté - Hayley
- David Ryan Harris - Self
- Louisa Abernathy - Grandma (voice)
- Wallace Demarria - Clown
- Martavious Gayles - Chuck
- David Janollari
- Flex Alexander
Kyla Pratt interpreta a Breanna Barnes en la serie.
Kelly Perine interpreta a Duane Odell Knox en la serie.
Robert Ri'chard hace el papel de Arnaz Ballard.
Sicily Johnson interpreta a Spirit Jones en la serie.
Camille Mana interpreta a Lisa Sanchez en la serie.
Jonathan Chase interpreta a Cash Bagen en la serie.
Ray J interpreta a D-Mack en la serie.
Nicole Paggi interpreta a Sara Crawford en la serie.
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