- Alistair Cooke - Self - Host
- Alistair Cooke - Himself - Host
- Gene Reynolds - Archie Goodwin (segment "The Fine Art of Murder")
- Charlton Heston - Self - Presenter
- Alan Badel - Fool
- Helen Hayes - Bessie Arlington
- Lynn Loring - Eva
- Herb Voland - M. Dupin (segment "The Fine Art of Murder")
- Jonathan Harris - Courcelles
- James Dean - Bronco Evans
- James Mason - Napoleon
- Jeff Donnell - Helen
- Jessica Tandy - Self - Reader
- Jessica Tandy - Louisa Catherine Johnson
- Beatrice Straight - Goneril
- Nita Talbot - Letitia
- Conrad Janis - Self
- Bruce Kirby - (segment "The Fine Art of Murder")
- Lloyd Bochner - First Gentleman
- Bramwell Fletcher - Earl of Kent
- Eartha Kitt - Self - Singer (segment "Eartha Kitt")
- Eartha Kitt - Salome (segment "Salome")
- Joanne Woodward - Ann Rutledge
- Orson Welles - King Lear
- James Daly - Narrator (segment "The Fine Art of Murder")
- Gene Kelly - Self (segment)
- Natasha Parry - Cordelia
- Arnold Moss - Duke of Albany
- Wesley Addy - King of France
- Ludi Claire - segment "The Fine Art of Murder"
- Dennis Hoey - Arthur Conan Doyle (segment "The Fine Art of Murder")
- Rex Stout - Himself (segment "The Fine Art of Murder")
- Micheál Mac Liammóir - Poor Tom
- Audrey Christie - Miss Kingsley
- Jack Benny - Athanael
- Lester Matthews - The Chief
- Byron Foulger - Horatio
- Harry Shearer - Johnny
- Beverly Washburn - Angela
- Ann Doran - Angela's Mother
- Shepperd Strudwick - Charles Francis Adams
- Lilli Palmer - Anne Boleyn
- Richard Kiley - The Prosecuting Attorney
- Richard Kiley - Actor
- Eva Marie Saint - Actress
- Katharine Bard - Lizzie Borden
- E.G. Marshall - Actor
- Robert Saudek
James Dean hace el papel de Bronco Evans.
Bruce Kirby hace el papel de (segment "The Fine Art of Murder").
Alistair Cooke interpreta a Self - Host en la serie.
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