- Sophia Myles - Agnes Fleming
- Tim Dutton - Edwin Leeford
- Annette Crosbie - Mrs Bedwin
- Keira Knightley - Rose Fleming
- Alun Armstrong - Mr. Fleming
- Roger Lloyd Pack - Mr. Sowerberry
- Alex Crowley - Artful Dodger
- Isla Fisher - Bet
- Liz Smith - Sally
- Sarah Flind - Homely Maid
- Sam Kelly - Giles
- Calum MacPherson - Blacksmith Bignall
- Marlene Sidaway - Woman in street
- Maria Doyle Kennedy - Irish Shop Assistant
- Annette Badland - Chertsey Cook
- Andrew Schofield - Toby Crackitt
- Daniel Brocklebank - Board Clerk
- James Bradshaw - Noah Claypole
- Clive Russell - Scottish Lawyer
- Ger Ryan - Mrs. Sowerberry
- Cathy Murphy - Vigil Keeper
- David Ryall - Mr. Fang, magistrate
- Colin Higgins - Bookseller
- Sebastian Abineri - Kindly Policeman
- John Grillo - Mr Grimwig
- Roland Manookian - Charley Bates
- Morgan Jones - Brittles
- David Bark-Jones - Dr Losberne
- Rosalind March - Mrs Corney
- Alan Pentony - Pedlar
- Hilary Sesta - Martha
- Ysanne Churchman - Woman in the Street
- Michael Bertenshaw - Dr Butchard
- Alex McAvoy - Well-Dressed Man
- Simon Kunz - James Matthews
- David Foxxe - Limkins
- Desmond Barrit - Flinders
- Richard Howard - Dr Critchley
- Richard Syms - Board Man
- Ken Parry - Board Man
- Hugh Lloyd - Elderly Vicar
- John Quarmby - Richard Leeford
- Jakob Schwarz - Italian Doctor
- Ricky Grover - Turnkey
- Tracey Murphy - Charlotte
- Ian Taylor - Mr Temple
- Geoffrey Larder - Clerk of Court
- Andrea Miltner - Nurse
- Renny Rye
- Alan Bleasdale
- Charles Dickens
- Keith Thompson
- Alison Barnett
- Rebecca Eaton
- Michele Buck
- Martin Trevis
- Paul Pritchard
- Gareth Bull
- Paul McFadden
Sam Smith interpreta a Oliver Twist en la serie.
David Ross interpreta a Mr. Bumble en la serie.
Julie Walters interpreta a Mrs. Mann en la serie.
Marc Warren hace el papel de Monks.
Lindsay Duncan interpreta a Elizabeth Leeford en la serie.
Michael Kitchen interpreta a Mr. Brownlow en la serie.
Robert Lindsay hace el papel de Fagin.
Andy Serkis hace el papel de Bill Sikes.
Emily Woof hace el papel de Nancy.
Sophia Myles interpreta a Agnes Fleming en la serie.
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