- Sophia Myles - Agnes Fleming
- Tim Dutton - Edwin Leeford
- Annette Crosbie - Mrs Bedwin
- Keira Knightley - Rose Fleming
- Alun Armstrong - Mr. Fleming
- Roger Lloyd Pack - Mr. Sowerberry
- Alex Crowley - Artful Dodger
- Isla Fisher - Bet
- Liz Smith - Sally
- Sarah Flind - Homely Maid
- Sam Kelly - Giles
- Calum MacPherson - Blacksmith Bignall
- Marlene Sidaway - Woman in street
- Maria Doyle Kennedy - Irish Shop Assistant
- Annette Badland - Chertsey Cook
- Andrew Schofield - Toby Crackitt
- Daniel Brocklebank - Board Clerk
- James Bradshaw - Noah Claypole
- Clive Russell - Scottish Lawyer
- Ger Ryan - Mrs. Sowerberry
- Cathy Murphy - Vigil Keeper
- David Ryall - Mr. Fang, magistrate
- Colin Higgins - Bookseller
- Sebastian Abineri - Kindly Policeman
- John Grillo - Mr Grimwig
- Roland Manookian - Charley Bates
- Morgan Jones - Brittles
- David Bark-Jones - Dr Losberne
- Rosalind March - Mrs Corney
- Alan Pentony - Pedlar
- Hilary Sesta - Martha
- Ysanne Churchman - Woman in the Street
- Michael Bertenshaw - Dr Butchard
- Alex McAvoy - Well-Dressed Man
- Simon Kunz - James Matthews
- David Foxxe - Limkins
- Desmond Barrit - Flinders
- Richard Howard - Dr Critchley
- Richard Syms - Board Man
- Ken Parry - Board Man
- Hugh Lloyd - Elderly Vicar
- John Quarmby - Richard Leeford
- Jakob Schwarz - Italian Doctor
- Ricky Grover - Turnkey
- Tracey Murphy - Charlotte
- Ian Taylor - Mr Temple
- Geoffrey Larder - Clerk of Court
- Andrea Miltner - Nurse
- Renny Rye
- Alan Bleasdale
- Charles Dickens
- Keith Thompson
- Alison Barnett
- Rebecca Eaton
- Michele Buck
- Martin Trevis
- Paul Pritchard
- Gareth Bull
- Paul McFadden
Sam Smith interpreta a Oliver Twist en la serie.
David Ross interpreta a Mr. Bumble en la serie.
Julie Walters hace el papel de Mrs. Mann.
Marc Warren hace el papel de Monks.
Lindsay Duncan interpreta a Elizabeth Leeford en la serie.
Michael Kitchen interpreta a Mr. Brownlow en la serie.
Robert Lindsay hace el papel de Fagin.
Andy Serkis hace el papel de Bill Sikes.
Emily Woof hace el papel de Nancy.
Sophia Myles hace el papel de Agnes Fleming.
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