- Peter Serafinowicz - SAM (voice)
- Peter Serafinowicz - S.A.M. (voice)
- Jonny Coyne - Craig
- Gilli Nissim - Sybil
- Dave Allen - Crowley Morehouse
- Brie Larson - Katerin
- Carly Chaikin - Brittany
- Kathryn Hahn - Marge
- J.K. Simmons - Frank Forrest
- Casey Wilson - Ghost Gabber
- Gil Ozeri - College Kid 3-D
- Marco Morales - Delivery Man
- Whitney Teubner - Roommate
- Jonathan Stern - Lab Teacher
- Courtney Jones - The Conduit
- John Cho - Chip
- Ed Helms - Eddie
- Kerri Kenney - 4-Sight
- Rich Fulcher - Elena
- Johnny Ray Meeks - Guard (as Johnny Meeks)
- Elizabeth Ann Koshak - Party Guest (uncredited)
- Adam Scott - Van Damm
- Martin Kove - Cell Leader
- Sonny Surowiec - Bad Guy #1
- Erik Betts - Bad Guy #2
- Theo Kypri - Tree Salesman
- Jon Daly - Chad
- Johanna Parker - Housewife
- Deanna Cheng - Neighbor's Wife (as Deanna Raphael)
- Laura Chinn - Mitzi (uncredited)
- Marcus Shultz - Kyle Lang (uncredited)
- Tony Hale - Dr. Karl
- Mark Hamill - Lundgren (voice)
- John Gemberling - Bruce
- Danielle Schneider - Betty
- Gabrielle Union - Sandy Canyons
- Lorenzo Lamas - Felipe Calderon
- Esteban Cueto - Guard
- Kelly Brook - Anna
- Aubrey Plaza - The Rememberer
- Paul Scheer
Mark Hamill interpreta a Lundgren (voice) en la serie.
Paul Scheer interpreta a Trent Hauser en la serie.
Rob Riggle interpreta a President of the Navy en la serie.
June Diane Raphael interpreta a Piper Ferguson en la serie.
Kate Mulgrew interpreta a Kove en la serie.
Martin Starr interpreta a Sam Stern en la serie.
Peter Serafinowicz interpreta a SAM (voice) en la serie.
Karen Gillan interpreta a Daisy en la serie.
Brandon Johnson interpreta a Alphonse en la serie.
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