- Leon Russom - Dr. Seymour
- Scott Coffey - Recruit #5, Gary Greer
- Lesli Kay - Tina (as Leslie Kay Sterling)
- Nicholas Pryor - Phil
- Melanie Smith - Young Pauline
- Ted Levine - Dave 'Eddie' Powers
- Bernie McInerney - Father Ralph Thomas
- David Brisbin - Driver
- John Hillard - Cop
- George DelHoyo - The Supervisor
- Heather Dubrow - Woman #2 (as Heather Paige Kent)
- Alexandra Kenworthy - Woman #3
- Mariah O'Brien - Nurse
- Greg Wrangler - Husband
- Steven Novak - Security Guard
- Mimi Craven - Ellen Combs
- Phil Reeves - Dr. Alan Haynes
- Raf Nazario - Motel Clerk
- Sharon Mitchell - Conditioning Nurse
- Jerry Basham - Mac
- Ernie Garrett - Peter
- Chris Mastrandrea - Adam
- Jeanette Aguilar Harris - Nurse
- Mike Starr - Bert Williams
- Zachary McLemore - Derek Bartholomew Williams (as Zachery McLemore)
- Tim DeZarn - Harry Corners
- Michael Fetters - Pete (as Michael E. Fetters)
- Curt Hanson - Cigar Smoker
- Barbara Irvin - Norma
- Betty Moyer - Woman
- George Rankins - The Man
- Dylan Taylor - Ned
- Carrie-Anne Moss - Karin Stoltz (as Carrie Ann Moss)
- Raphael Sbarge - Dr. Moen
- Todd Hermanson - Paramedic
- Marilyn Faith Hickey - Nurse #1
- Russ Fast - Dr. Hamilton
- Michael Tucker - Dr. Bellamy (voice) (uncredited)
- Michael Tucker - Dr. Bellamy
- Saxon Trainor - Deirdre 'Dee' Cotrera
- Stephen Meadows - Paul
- Kelly Brown - Security Guard #2
- Mario DePriest - Cory
- Ian Hendry - Car Kid
- Eric Hull - Roy
- Mary Kane - Gardening Woman
- Burl Ross - Mowing Man
- Richard Kind - Max Webb
- Kate Hodge - Nancy / Angie
- Michael Maguire - Robert / Lenny
- Steve Restivo - Gino
- Lance J. Holt - Alyson's Husband
- Eric Newsome - Man in Suit
- Galen Schrick - Hotel Clerk
- Sean Whalen - Scott Jordon
- Karen Moncrieff - Pam Peterson
- Jeanne Sanders - Carla
- Kyle Long - Bruce
- Bill Harper - Jimmy
- Tobias Anderson - Sammy
- Tobias Anderson - Monk
- Rod James - Elderly Man
- Elizabeth Fournier - Prostitute
- Elizabeth Fournier - Girl in Red Bathing Suit
- Bryan Cranston - Sheriff Norman Wade
- Price Jackson - Kyle Mencks (as Jackson Price)
- James McDonnell - The Headmaster
- Jennifer Banko - Vickie
- Marco Gould - Seth
- Glen Baggerly - Recruit #3
- Glen Baggerly - Man with Gun
- Danny Stoltz - Brad
- Karen Rasor - Kid #2
- Tony Melson - Kid #3
- Dean Stockwell - Gus Shepard
- Dinah Leffert - Mary
- Steven Jaquith - Yuppie Man (as Steven Jacquith)
- Joe Ivy - Dr. Richards
- Cork Hubbert - Wino
- Sam A. Mowry - Mr. Simmons (as Sam Mowry)
- Sam A. Mowry - Detective Coleman (as Sam Mowry)
- Dean Jones - Jonathan Crane
- Donna Bullock - Beth Crane
- Joseph Carberry - Morris
- Gary Rooney - Marty
- Michael Taylor Donovan - Business Executive
- Michael Taylor Donovan - Security Guard (as Michael Donovan)
- Dennis Adkins - Doctor Hal
- Grant Alan Ouzts - Johnny's Teammate (as Grant Ouzts)
- Tyrone Henry - Umpire
- Raye Birk - Tobe Alder
- James Lashly - Ed Durrant (as James Lasly)
- Geof Prysirr - Major Deward
- Geof Prysirr - Shadow One (as Geoff Prysirr)
- Linda Burden-Williams - Lillian
- Jan Burrell - Hazel
- Randy Thompson - Mr. Hardy
- Jeff Gorham - Mark
- Carol Huston - Sandra Wilson
- Mary Gregory - Mrs. Veil
- Jay Arlen Jones - Inmate
- Jay Arlen Jones - Joe 'J.C.' Carter / Dr. Novak
- Willie C. Carpenter - Rick
- W. Earl Brown - Roy
- John Kenower - Bumped man
- Joe Lambie - Richard Grace (as Joseph Lambie)
- Hank Cartwright - Hanks
- J.W. Crawford - Night Manager
- Paul Fitzgerald - Joey
- Daniel W. Barringer - Another Cop (as Dan Barringer)
- James Tolkan - Commander Cyrus Quinn
- Patrick Kilpatrick - C.W. Knox
- J.R. Knotts - Jaxon
- Derek Sitter - Recruit #1
- Peter Paige - Recruit #4
- Charles Taylor Gould - Recruit #2
- Danny Bruno - Crew Member #1
- Terry Ward - Suited Man
- Robert Blanche - Chauffeur
- Robert Blanche - Security Guard
- Edith Fields - Older Pauline
- Mark Vincent - Master of Ceremonies
- Mark Vincent - Policeman #1
- Freda Foh Shen - Nurse Whiteford
- Paul Marin - Rudy
- Zoe McLellan - Mary
- Ron Simons - Attendant
- Jerry Carlton - Cop
- Ian Chisholm - Other Cop
- Jamie Tolbert - Maid
- Ron Reaves - Orderly
- Robin Sachs - The Voice (uncredited)
- Robin Sachs - Alexander Hale
- James Lew - Thug with knife
- Marty Ryan - Customer
- Marty Ryan - Special Agent
- Dorie Barton - Helen Meyerson
- Joe Cronin - Alex
- Joe Cronin - Commander
- Roy Brocksmith - Bud Atkins
- Tom McCleister - Hank Bower
- Bill Geisslinger - Prof. John Meyerson
- David Meyers - Steve Weaver
- Chrisse Roccaro - Mrs. Thames (as Chris Roccaro)
- Cliff DeYoung - Jim Hubbard
- Karen Lorre - Janet Cowan (as Karen Witter)
- Billy O'Sullivan - Michael
- George Gerdes - Sheriff Wilkes
- Bob Morrisey - Ed Marlowe
- Dan Vhay - TV Control Tech (uncredited)
- Matt Williams - TV Show Host (uncredited)
- Jon Bebe - Young Guard #1
- Dwight Schultz - Harrison Barton
- Anthony Guzman - Luis Borjes
- Tracy Conklin - Sgt. Rock
- William Earl Ray - Lt. Anson
- Allen Nause - Shadow Two
- Michael Blain-Rozgay - Waiter
- Fulvio Cecere - Sgt. Dirksen
- Jamie Rose - Claire Hillard
- Mia Korf - Jane Butler
- Richard Penn - Detective Tanner
- Laura Leigh Hughes - Lucy
- Raissa Fleming - Rachel
- Brendan Quinlan - Bartender
- Brian Boe - Don
- Brian Boe - Manager
- Patrick DeSantis - FBI Agent (uncredited)
- Sydney Walsh - Laura
- Victor Morris - Cop Hansen
- Victor Morris - Sergeant
- Sam Anderson - The Man
- Monica Lacy - Teenage Laura (as Monica Creel)
- Trever O'Brien - Young Tom
- Julia Whelan - Young Laura
- Louanne Moldovan - Wailing Woman
- Trevor Goddard - Mackie
- Dan Martin - Father Ray
- Maurice Chasse - Bradley
- Jan Brehm - Woman
- Louis A. Lotorto - Intern (as Louis Lotorto)
- George O'Mara - Samaritan
- Johnny Useldinger - Vendor
- Constance Frenzen - Nurse
- Andrea Thompson - Corrina (voice) (uncredited)
- Robert Cicchini - Michael Kramer
- Bruce Gray - Dr. Gilmore
- Don Alder - Dr. Madison
- Melvin Jones - Alan (as Mel Jones)
- Edmund Stone - Patient
- Mark Tassoni - Dave
- Wendy Westerwelle - Waitress
- Elisabeth Adwin - Nurse
- Nancy Wilson - Female Guard
- Jerry L. Buxbaum - 2nd Orderly
- David Bodin - Dr. North
- Susannah Mars - Nurse #1 (as Suzannah Mars)
- Nicolas Surovy - Stanley Robman
- Kayla Blake - Jenny Tsu
- Barbara Lusch - Brenda
- Oz Tortora - Sparky
- Michael Behrens - Flannel
- Gene Otis - Operative #1
- Mark Schwahn - Technician
- Ross Huffman-Kerr - Bum
- Sven-Ole Thorsen - Assassin (uncredited)
- Hal Linden - Senator Wallace
- Francis X. McCarthy - Robert Barton
- Edward Edwards - Iverman
- Alexandra Boyd - Wallace's Aide
- Laura Michelle Kelly - Wallace's Secretary
- David Angus MacDonald - Suit
- Cheryl Yamaguchi - Female Passerby
- Barbara CasementMaid - Maid
- Mark Friedrichsen - Uniform #2
- Choppy Guillotte - Ben Dobbs
- William Harper - Jimmy
- Michael Shawn Lucas - Security Guard
- Don Burns - Elmer
- Don Burns - Earl
- Jason Waters - Teenage Tom
- Joel Surnow
- Lawrence Hertzog
- Jan DeWitt
Carrie-Anne Moss interpreta a Karin Stoltz (as Carrie Ann Moss) en la serie.
James Tolkan interpreta a Commander Cyrus Quinn en la serie.
Maria Bello interpreta a Emily Noonan en la serie.
Dean Stockwell interpreta a Gus Shepard en la serie.
Bruce Greenwood interpreta a Thomas Veil en la serie.
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