- Angus Sampson - Chief
- Bob Odenkirk - Greg
- J.K. Simmons - Leo
- Mackenzie Davis - Patricia
- Daniel Zolghadri - Mason
- Bridget Everett - Special Agent Bonnie Lehman
- Michaela Watkins - Erin
- Will Ferrell - Adrian
- Jake Johnson - DEA Agent John Haldeman
- Alexandra Rodriguez - Gabriella
- Arturo Castro - Miguel
- Travis Guba - Officer Dubovisnitch
- Darren Gilshenan - Tony
- Adrian Martinez - Roberto
- Joe Hardesty - Police Photographer
- Courtenay Taylor - Officer Eastman
- Amy Schumer - Janice
- Keegan-Michael Key - Officer Charles Brock
- Elle Fanning - Madison
- Samara Weaving - Sue
- Joe Keery - Officer Reinhardt (voice)
- Joe Keery - Officer Reinhardt
- Hannah Simone - Terry (voice)
- Yoshi Nurijumi - Detective
- Mark Berry - Officer Gus
- Nina Pedrad - Helen
- Efka Kvaraciejus - Ebenezer Splooge
- Brian Patrick Farrell - Cop One
- Jessica Alba - The Actress
- Alison Bell - Leary
- John Leary - Robert
- Raymond Anthony Thomas - Jamal
- Frank Gallegos - Pedro
- Chris Gethard - Zach
- Jack Axelrod - Steve
- Gregory Garcia - Agent Swanson
- Matt Walsh - Larry Turnbull
- Max Greenfield - Cotric
- Joe Manganiello - Dugan
- Tara Copeland - Detective Finnegan
- Clint Culp - Officer Menard
- Exie Booker - Officer Oliviera
- Treisa Gary - Detective Quian
- Kevin Kane - Joseph Farrell
- Erin Pineda - Doris Silva
- Saidah Arrika Ekulona - Flight Attendant
- Christopher Chen - Tony
- Seth Coltan - Ken
- Jama Williamson - Nurse
- Ken Palmer - Veteran
- Bunny Levine - Yaya Westbrook
- Lilian Tapia - Housekeeper
- Daniel Sobieray - Male Paramedic Stripper
- Harriet Dyer - Hazel
- Harriet Dyer - Hazel (voice)
- Rebecca Galarza - Female Paramedic Stripper
- Steve Berg - Phil
- Joe Wengert - Michael
- Alex Cuthbertson - Bob
- Tom Berninger - Officer Moses (Sleeping Cop)
- Beth Behrs - Sophie Beyers
- Paula Pell - Daisy
- Paula Pell - Trucker
- Lidia Porto - Eileen (Diner Waitress)
- Jillian Bell - Risoli (voice)
- Will Forte - Dirk (voice)
- Kimberly Hebert Gregory - Fuller (voice)
- Óscar Núñez - (voice)
- Diona Reasonover - (voice)
- Joe Farrell - (voice)
- Keith Ferguson - (voice)
- Jason Spisak - (voice)
- D'Arcy Carden - Erika (voice)
- Matt Berninger - (voice)
- Sherri Shepherd - Carol (voice)
- Rob Delaney - Magnolia (voice)
- Andy Karl - Yohan (voice)
- Kevin Bacon - Kevin Bacon (voice)
- Lamorne Morris - Officer Cooper (voice)
- Damian O'Hare - (voice)
- Aaron Serotsky - Duncan (voice)
- Eugene Cordero - Jarrod (voice)
- June Squibb - (voice)
- Stephen Tobolowsky - (voice)
- Louie Anderson - (voice)
- André Sogliuzzo - (voice)
- Gary Anthony Williams - (voice)
- John Gemberling - (voice)
Capítulo disponible en las siguientes plataformas:
