- Estelle Getty - Sophia Petrillo
- Mayim Bialik - Laurie Kincaid
- Angie Dickinson - Jackie Sheridan
- Judith Marie-Bergan - Janet
- Adrian Zmed - Gary
- Rue McClanahan - Blanche Devereaux
- Nancy Cartwright - Ann
- Katherine Cannon - Dr. Kenney
- Bea Arthur - Dorothy Zbornak
- Marla Adams - Elna
- Stephen Dorff - Billy at 14
- Craig Richard Nelson - The Waiter
- Ian Abercrombie - Captain Burke
- Harold Gould - Dr. Stanfield Weston
- Matthew Perry - Bill at 18
- Betty White - Rose Nylund
- Ann Ryerson - Mrs. Bridges
- Elmarie Wendel - Agnes
- Elmarie Wendel - Vivian
- Ami Foster - Wanda Sue
- Grace Zabriskie - Eva Barrett
- Robin Pearson Rose - Mrs. Fogal
- Victor DiMattia - Rocco
- Leo Geter - Dr. Ross
- Thom Sharp - Dr. Mitch Helpern
- Lindsay Parker - Jennifer
- Mark Schiff - The Anesthesiologist
- Ruth Silveira - The Nurse
- Richard Fancy - The Lieutenant
- Dean Fortunato - Cop
- David Correia - Cop #2
- John DeMita - Cop #3 (as John Demita)
- Jan Rabson - Cop #4
- Sam McMurray - Brent
- Marcia Rodd - The Woman
- Tommy Hinkley - The Bartender
- Lela Ivey - Debbie
- Abdul Salaam El Razzac - The Piano Player
- Joe Hart - The Man
- Jason Bernard - Mr. Noack
- Brandon Quintin Adams - Peter (as Brandon Adams)
- Tim Haldeman - The Waiter
- Grace Albertson - The Woman
- Donnelly Rhodes - Leonard
- Diane Racine - Mother
- Billy Gallo - Delivery Man
- Lee Wilkof - The Electrician
- Barbara Babcock - Paula Conroy
- Edan Gross - Jeffrey Millstein
- Dierk Torsek - Mr. Millstein
- Jarrett Lennon - Little Boy
- Brad Hall - Chuck
- Susan Anspach - Dr. Diane Hardy
- Charles Levin - Stan
- Jana Marie Hupp - Tracy
- Nike Doukas - Liz
- Whit Hertford - Alec (as Whitby Hertford)
- Rand Stone - Jeff
- Franc Luz - Eric
- Tom Nibley - The Waiter
- Paul Sand - Poko
- Eva Charney - Michelle
- Eva Charney - Miss Clark
- Diana Webster - Mrs. Lundquist
- Nicky Rose - Little Girl
- Ray Buktenica - Alan
- Raye Birk - Albert
- Raye Birk - Judge Talmadge
- Greg Kean - Brad (as Greg Kean Williams)
- Michael Garfield - Doug
- John Scott Clough - Jim
- Cynthia Steele - Mother #1
- Mary Garripoli - Mother #2
- Christopher Robin - Coughing Child (as Christopher Chas Robin)
- Linda Thorson - Janice Brattle
- James Staley - Ted
- Jane Galloway - Lucy
- Tony Longo - Stan
- Gregory Itzin - Frank
- Peter Hobbs - Dr. Garrison
- Kat Sawyer-Young - Woman Doctor
- William Bogert - Doctor #1
- Milt Oberman - Doctor #2
- Christine Belford - Fran
- Ed Hooks - Mailman
- Francis Guinan - Dr. Mitchell
- Jake Jundef - The Boy
- Richard Kind - Elton Sexton
- Debra Engle - Mrs. Sexton
- Billy O'Sullivan - Billy at 5
- Aeryk Egan - Billy at 11
- Zachary Benjamin - Little Kid
- James Duane Polk - Delivery Man
- David Rasche - Jack Trenton
- Holly Fields - Little Carol
- Candi Milo - Mrs. Ortiz
- Teresa Ganzel - Sharon
- Jon Patrick Walker - Acid
- Gil Junger
- Paul Junger Witt
- Tony Thomas
Nancy Cartwright interpreta a Ann en la serie.
Angie Dickinson hace el papel de Jackie Sheridan.
Richard Mulligan hace el papel de Dr. Harry Weston.
Dinah Manoff hace el papel de Carol Weston.
David Leisure interpreta a Charley Dietz en la serie.
Park Overall interpreta a LaVerne Todd en la serie.
Marsha Warfield interpreta a Dr. Maxine Douglas en la serie.
Estelle Getty interpreta a Sophia Petrillo en la serie.
Capítulo disponible en las siguientes plataformas:
