- Estelle Getty - Sophia Petrillo
- Mayim Bialik - Laurie Kincaid
- Angie Dickinson - Jackie Sheridan
- Judith Marie-Bergan - Janet
- Adrian Zmed - Gary
- Rue McClanahan - Blanche Devereaux
- Nancy Cartwright - Ann
- Katherine Cannon - Dr. Kenney
- Bea Arthur - Dorothy Zbornak
- Marla Adams - Elna
- Stephen Dorff - Billy at 14
- Craig Richard Nelson - The Waiter
- Ian Abercrombie - Captain Burke
- Harold Gould - Dr. Stanfield Weston
- Matthew Perry - Bill at 18
- Betty White - Rose Nylund
- Ann Ryerson - Mrs. Bridges
- Elmarie Wendel - Agnes
- Elmarie Wendel - Vivian
- Ami Foster - Wanda Sue
- Grace Zabriskie - Eva Barrett
- Robin Pearson Rose - Mrs. Fogal
- Victor DiMattia - Rocco
- Leo Geter - Dr. Ross
- Thom Sharp - Dr. Mitch Helpern
- Lindsay Parker - Jennifer
- Mark Schiff - The Anesthesiologist
- Ruth Silveira - The Nurse
- Richard Fancy - The Lieutenant
- Dean Fortunato - Cop
- David Correia - Cop #2
- John DeMita - Cop #3 (as John Demita)
- Jan Rabson - Cop #4
- Sam McMurray - Brent
- Marcia Rodd - The Woman
- Tommy Hinkley - The Bartender
- Lela Ivey - Debbie
- Abdul Salaam El Razzac - The Piano Player
- Joe Hart - The Man
- Jason Bernard - Mr. Noack
- Brandon Quintin Adams - Peter (as Brandon Adams)
- Tim Haldeman - The Waiter
- Grace Albertson - The Woman
- Donnelly Rhodes - Leonard
- Diane Racine - Mother
- Billy Gallo - Delivery Man
- Lee Wilkof - The Electrician
- Barbara Babcock - Paula Conroy
- Edan Gross - Jeffrey Millstein
- Dierk Torsek - Mr. Millstein
- Jarrett Lennon - Little Boy
- Brad Hall - Chuck
- Susan Anspach - Dr. Diane Hardy
- Charles Levin - Stan
- Jana Marie Hupp - Tracy
- Nike Doukas - Liz
- Whit Hertford - Alec (as Whitby Hertford)
- Rand Stone - Jeff
- Franc Luz - Eric
- Tom Nibley - The Waiter
- Paul Sand - Poko
- Eva Charney - Michelle
- Eva Charney - Miss Clark
- Diana Webster - Mrs. Lundquist
- Nicky Rose - Little Girl
- Ray Buktenica - Alan
- Raye Birk - Albert
- Raye Birk - Judge Talmadge
- Greg Kean - Brad (as Greg Kean Williams)
- Michael Garfield - Doug
- John Scott Clough - Jim
- Cynthia Steele - Mother #1
- Mary Garripoli - Mother #2
- Christopher Robin - Coughing Child (as Christopher Chas Robin)
- Linda Thorson - Janice Brattle
- James Staley - Ted
- Jane Galloway - Lucy
- Tony Longo - Stan
- Gregory Itzin - Frank
- Peter Hobbs - Dr. Garrison
- Kat Sawyer-Young - Woman Doctor
- William Bogert - Doctor #1
- Milt Oberman - Doctor #2
- Christine Belford - Fran
- Ed Hooks - Mailman
- Francis Guinan - Dr. Mitchell
- Jake Jundef - The Boy
- Richard Kind - Elton Sexton
- Debra Engle - Mrs. Sexton
- Billy O'Sullivan - Billy at 5
- Aeryk Egan - Billy at 11
- Zachary Benjamin - Little Kid
- James Duane Polk - Delivery Man
- David Rasche - Jack Trenton
- Holly Fields - Little Carol
- Candi Milo - Mrs. Ortiz
- Teresa Ganzel - Sharon
- Jon Patrick Walker - Acid
- Gil Junger
- Paul Junger Witt
- Tony Thomas
Nancy Cartwright interpreta a Ann en la serie.
Angie Dickinson interpreta a Jackie Sheridan en la serie.
Richard Mulligan hace el papel de Dr. Harry Weston.
Dinah Manoff interpreta a Carol Weston en la serie.
David Leisure interpreta a Charley Dietz en la serie.
Park Overall hace el papel de LaVerne Todd.
Marsha Warfield interpreta a Dr. Maxine Douglas en la serie.
Estelle Getty interpreta a Sophia Petrillo en la serie.
Capítulo disponible en las siguientes plataformas:
