- Regina King - Marah
- Brandy Norwood - Herself
- Jesse L. Martin - Mustafa Hawkins
- Jon Secada - Self
- Howard Rollins - Reverend Hundley
- The Notorious B.I.G. - Self
- Brendan Kelly - Harry Donovan
- Titus Welliver - Frankie
- Michael Michele - Sandra
- Ben Vereen - Louie
- Christopher Williams - Self
- Ice-T - Danny Up
- Al Jarreau - Self
- Giancarlo Esposito - Adolfo Guzman
- D'Angelo - Self
- Naomi Campbell - Simone
- Aaliyah - Aaliyah
- Kirk Acevedo - Joey Claudio
- Mekhi Phifer - Sekou
- Ruben Santiago-Hudson - Johnny
- George O. Gore II - Gregory 'G' Williams
- Enrico Colantoni - David Kinsoling
- Eugene Byrd - Tiandre
- Jay O. Sanders - Howard
- Yolanda Whitaker - Nikki
- Saundra Santiago - Juanita Telles
- Eartha Kitt - Mrs. Stubbs
- Sam Groom - Walter DeWitt
- Gladys Knight - Natalie
- Salli Richardson-Whitfield - Tammy Barrett
- Adewale Akinnuoye-Agbaje - Cliff Ramsey
- Erica Gimpel - Melinda
- Treach - Sheik
- Jon Seda - Bobby Lunas
- Kimberly Russell - Leslie
- Eddie Levert - Self (The O'Jays)
- Eden Riegel - Megan Cooper
- Sean Nelson - Al
- Yancey Arias - Armando
- Victor Slezak - Dennis Fairchild
- Michelle Hurd - A.D.A. Reynolds
- Lisa Vidal - Carmen
- Judy Reyes - Helena
- Steve Ryan - Dave Cooper
- Brian Tarantina - Eddie Dodge
- Allison Janney - Vivian
- Conn Horgan - Bartender
- Jaime Perry - Roland
- Harold Hunter - Leroy
- John Speredakos - Dr. Wizen
- Amy Povich - Jane Simmons
- Ingrid Rogers - Vivian
- John Costelloe - John Santucci
- Stu 'Large' Riley - Hollis
- Sharrieff Pugh - Scooter
- Clarence Williams III - Donald Brooks
- Ed Wheeler - Reverend Braxton
- Geoff Pierson - Matthew Long
- Jack Gilpin - Headmaster Scowcroft
- Kaipo Schwab - Norton Lee
- Christopher Knowings - Tyndell
- Blake Bashoff - Simon
- Nancy Wilson - Self
- Jeffrey Wright - Andre Foreman
- Tony Darrow - Vinnie
- Angela Featherstone - Angela Mancini
- Bobby Womack - Self
- Lawrence Gilliard Jr. - Quentin
- Hillary Hawkins - Keesha
- Lawrence B. Adisa - Ray
- Nancy Ticotin - Teresa Torres
- Raymond Anthony Thomas - Dr. Ross
- Margo Martindale - Nurse Warner
- Jamie Tirelli - Mr. Claudio
- Jack Gwaltney - Dr. Parker
- Wanya Morris - Self [Boyz II Men]
- Shawn Stockman - Self [Boyz II Men]
- Nathan Morris - Self [Boyz II Men]
- Michael McCary - Self [Boyz II Men]
- Keith Sweat - Self
- José Zúñiga - Jimmy Torres
- Andre B. Blake - Xavier
- Kevin Carroll - Pastor Julian
- Cheryl Freeman - May Hundley
- Al Sharpton - Self
- Gerald Levert - Self
- Shannon Briggs - Ralphie
- Marcella Lowery - Postal Worker
- Denise Burse - Mrs. Reyes
- Sticky Fingaz - Khalil
- Ed Lover - Self
- Doctor Dré - Self
- Rolonda Watts - Self
- MC Lyte - Female Rapper
- Paul Calderon - Emilio Vasquez
- Ntare Guma Mbaho Mwine - Mitnick
- Darien Sills-Evans - Lawrence
- James Saito - Detective Chang
- Brian McKnight - Self
- Jerry Adler - Mr. Ross
- Jude Ciccolella - ATF Agent Weston
- James Brown - Self
- Jonathan Sagall - Rutger
- Gary Basaraba - Tirelli
- Phyllis Yvonne Stickney - Baptise
- Phyllis Yvonne Stickney - Esther Rashad
- Teena Marie - Self
- Ving Rhames - Max Villareal
- John Ortiz - Pago
- Novella Nelson - Prof. Cortez
- Jose Soto - Agee
- Elvis Nolasco - Oscar
- Raymond Rodriguez - Roberto
- Paulette Braxton - Naomi
- Chanté Moore - Self
- David Thornton - Alan Warwick
- Avery Kidd Waddell - Wayne
- Hassan Johnson - Red
- T. Ryder Smith - Lewis
- Shiek Mahmud-Bey - Crackhead
- Elizabeth Rodriguez - Gina
- George Coe - Mr. Braddock
- Willi One Blood - Dread Scott
- Frank Pellegrino - Det. Ricciarelli
- Montell Jordan - Self
- José Pérez - Mike Torres
- Deji LaRay - Antonie
- Edwin Hodge - Memo
- Johnny Williams - Leo Galloway
- Chuck Cooper - Sawyer
- Gary Perez - Nacio
- Teddy Riley - Self (Guy)
- Aaron Hall - Self (Guy)
- Damion Hall - Self (Guy)
- Fredro Starr - Alphonse
- Agustin Rodriguez - Oscar
- Jon B. - Self
- Isidra Vega - Monica Ledesma
- Cheryl 'Coko' Gamble - Self [SWV]
- Tamara 'Taj' Johnson-George - Self [SWV]
- LeAnne 'Lelee' Lyons - Self [SWV]
- Tevin Campbell - Himself
- Kim McGuire - Wilkes
- Dean Winters - Paul Delaney
- J.C. MacKenzie - Holmquist
- Ron Ryan - McBride
- Tony Hoty - Epstein
- James Hanlon - Wedge
- John Ring - Chief
- Dennis Christopher - Dr. Royce
- Steven Randazzo - Birelli
- Justin Theroux - Frankie Stone
- Larry Pine - Leonard
- Alice Playten - Homeless Woman
- Jennifer Esposito - Gina Stone
- Coco McPherson - Customizer
- Leo V. Finnie III - Car Washer
- William Mercado - Handball Player (uncredited)
- Derrick Simmons - Gary Renau (uncredited)
- Jared Harris - Seth Baines
- Mark Blum - Dr. Vincent
- Michael Dolan - Mark
- Stephanie Roth Haberle - Abby DeWitt
- Amelia Campbell - Debbie Rochon
- Tina Benko - Sarah Chapman
- Bruce Katzman - Vincent's Lawyer
- John Tormey - Mark's Boss
- Reggie Rock Bythewood
- Don Kurt
- Dick Wolf
- Brad Kern
Allison Janney hace el papel de Vivian.
Brian Tarantina hace el papel de Eddie Dodge.
Chuck Cooper interpreta a Sawyer en la serie.
Jon Seda interpreta a Bobby Lunas en la serie.
Paul Calderon hace el papel de Emilio Vasquez.
Mekhi Phifer hace el papel de Sekou.
Eugene Byrd interpreta a Tiandre en la serie.
Jeffrey Wright interpreta a Andre Foreman en la serie.
Margo Martindale interpreta a Nurse Warner en la serie.
Giancarlo Esposito interpreta a Adolfo Guzman en la serie.
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