- Storme Toolis - Holly Griffin
- Jeremy Gittins - Vic (Speed Dater)
- Jenny Agutter - Yvonne Barrie
- Kieran O'Brien - Michael Jacobs
- Diana Weston - Jane Morley
- René Zagger - Andy Merrill
- Nicholas Jones - Michaela Pendle
- Gillian Taylforth - Emma Winters
- George Cole - Sir Edward Chambers
- Richard Briers - James Farlow
- Gavin Millar - Theatre Director
- Susan Jameson - Esther Lane
- Anita Dobson - Elaine Wanless
- Philip Whitchurch - Peter Jacobs
- Stephen Moore - Fred Donaldson
- Dexter Fletcher - Tommy Jackson
- Isla Blair - Alice Pimley
- John Fortune - Mel Simons
- Jamie Glover - Stewart Pimley
- Will Kemp - James Strickland
- Keith Barron - Ronnie Ross
- Cherie Lunghi - Diane Loveless
- Claire Bloom - Helen Brownlow
- David Savile - Ian Gordon
- Dermot Crowley - Derek Bennet
- Heather James - Alison
- Hannah Waterman - Emily Driscoll
- Bruce Alexander - Piers Wheeler
- Carol Starks - Sarah Griffin
- Liz White - Julia Kane
- Hermione Gulliford - Dr Lee
- Gary Oliver - Tony Otway
- Alix Wilton Regan - Tessa Dugdale
- Sophie Thompson - Fiona Kennedy
- Sophie Thompson - Ruth Shiree
- Louis Emerick - Neil Murphy
- Barnaby Kay - DAC Ned Hancock
- Nicola Stephenson - Emily Fraser
- Benjamin Whitrow - Edward Fraser
- Jarred Christmas - Keith
- Robin Berry - Fleet Sewer Guide
- Emily Taaffe - Emma
- Louis Mahoney - Harry Page
- Julie Graham - Tricia McAndrew
- Georgine Anderson - Peggy
- Jasper Jacob - Terry Hargreaves
- Keith Ramsay - Stewie McAndrew
- Katherine Jakeways - Hannah
- Lucy Ellinson - Police Officer
- Emma Ballantine - Young Nancy
- Ruby Thompson - Young Peggy
- Charlotte Cornwell - Alison Willis
- Clare Higgins - Francis Kane
- Oliver Cotton - Hugh Dryden
- Richard Dillane - Lawrence Delvin
- Susie Blake - Sarah Paxton
- David Hayman - Himself
- Amy Nuttall - Caitlin Standing
- Niamh Cusack - Joanne Gibson
- Tom Georgeson - Jason Harvey
- Jack Ellis - David Halburton
- Anthony Calf - D.A.C. Strickland
- Anthony Calf - Deputy Assistant Commissioner Robert Strickland
- Anthony Calf - Robert Strickland
- Anthony Calf - D.A.C. Robert Strickland
- Finlay Robertson - Jeremy Powell
- Leanne Best - Zoe Baines
- Nicholas Woodeson - Viktor Proust
- Emma Fielding - Caroline Tate
- Ian Bartholomew - Tallis
- Dominic Mafham - Stokes
- Margot Leicester - Barbara Haynes
- Struan Rodger - Jim Tanner
- Alun Raglan - Ethan
- Claire Cathcart - Harriet
- Claire Goose - DCI Mackie
- Ann Firbank - Nancy Evans
- Phil Davis - Gavin Gibson
- Gary Lewis - Alex Close
- Phil Daniels - D.C.S. Frank Paterson
- Jana Carpenter - Ruth Bisley
- Joe Absolom - Luke Hanson
- Bill Thomas - Michael Evans
- Tanmay Dhanania - Bobby Johal
- Jessica Turner - Diane Fletcher
- Geraldine Somerville - Asst. Commissioner Cynthia Kline
- Leon Ockenden - Kevin Humphreys
- Lorraine Burroughs - Gail Shaw
- Haydn Gwynne - Sara Hamlyn
- Simon MacCorkindale - Sir David Bryant
- Pooky Quesnel - Catherine Bryant
- David Troughton - Ricky Hanson
- Simon Gregor - Intense Man
- Tom McKay - Jason Bishop
- Theo Barklem-Biggs - Shane Evens
- Jot Davies - Warehouse Guard
- Tim Downie - Dave Pimley
- Diana Kent - Therapist
- Glyn Grimstead - Det. Insp. John Cassidy
- Jim Barclay - Ivor (Speed Dater)
- Gordon Milne - Brindsley (Speed Dater)
- Nicholas Day - Donald Bevan
- Natalie Forbes - Jane
- Paula Jennings - Paula
- Nadim Sawalha - Mr. Mazood
- Jeremy Beckman - Dealer
- Gary Cross - Poker Player 1
- Harry Miller - Poker Player 3
- Imogen Bain - Sylvia Ackerman
- Melanie Jessop - Doctor
- Kenny Ireland - George Morton
- Melanie Ramsay - Kathy
- Ian Bonar - Dog Fan
- Kim Thomson - Tiffany Barker
- Kate Magowan - Catherine Austin
- Sam Hazeldine - Mark Lane
- Ralph Ineson - D I Hamilton
- Nicole Charles - Alicia Trimble
- Michael Simkins - Colonel Kilmartin
- Andrew Tiernan - Sgt Major Sharratt
- Will Keen - Ronnie Glazebrook
- Phyllis Logan - Dr. Mathieson
- Paul Bown - Rod Erskine
- Glynis Barber - Cheryl Brooker
- Raquel Cassidy - Susannah Morton
- Mark Williams - David Beaumont
- Mark Rice-Oxley - Terry Thaxted
- Michael Landes - Leonard Kuziak
- Michael Brandon - Col. Charles Norton
- David Calder - Sid Lestade
- Christopher Fulford - Barry Lestade
- Kenneth Farrington - David Snow
- Jo Stone-Fewings - Tom Eldridge
- Diana Quick - Julia Eldridge
- Michael Melia - Vernon Murnaghan
- Tony Selby - Danny Paye
- Tom Turner - Care Worker
- Jan Harvey - Miranda Carson
- Ellie Haddington - Jean Bennett
- Sam Cox - Paul Rees
- Alice Patten - Vicky Anderson
- Paul Rhys - Sebastian Carter
- Elizabeth Tan - Penny Anderson
- Tom Wu - Daniel Cheung
- Nicholas Goh - Chinese Interpreter
- Mark Bazeley - Brandon Skye
- Sam Kelly - Guy Carse
- Sara Stewart - Lulu Questor
- Kirsty Mitchell - Katie Briers
- Justin Salinger - Clive Burgess
- Kevin Eldon - Dr Neville Moroni
- Joshua Osei - Oaf in Library
- Goran Kostić - Pavel Illich
- Sasha Behar - Emma Woodford
- David Ryall - Jasper Urquhart
- Anne Reid - Sophie Urquhart
- Jonathan Cullen - Jeremy Ventham
- Beth Goddard - Paula Symes
- Tom Mison - Tim Mortimer
- Rick Bacon - Auctioneer
- Scott Hazell - Student
- Francesca Wilson - Ventham's P.A.
- Adrian Schiller - John Davies
- Elijah Baker - Hoodie
- Samantha Bond - Anne Gorton
- Kevin McNally - Fred Blackledge
- Doon Mackichan - Gillian Withall
- Claire Cage - Older Woman
- Simon Ludders - Richard - MI5
- Neil Roberts - Anthony Vernon
- Connie Hyde - Karen Vernon
- Caroline Carver - Helen Vestry
- Neil Stuke - Duncan Miller
- Lizzie Roper - Tilly Shaw
- Sian Brooke - Eileen Harrison
- Alan McKenna - Mick Shaw
- Rudi Dharmalingam - Arun Kumar
- Rory MacGregor - Liam Braine
- Belinda Stewart-Wilson - Sarah Levene
- Rupert Graves - Adrian Levene
- Tuppence Middleton - Melanie Higgs
- Anna-Louise Plowman - Alison Levene
- Peter Wight - Colin Beck
- Johnny Harris - Nick Kellogg
- James Grogan - Eddie Mayfair
- Del Synnott - Danny Branston
- Michael Wildman - Milton Joseph
- John Benfield - Doug Palmer
- Maggie O'Neill - Ronni Mayfair
- Matthew Marsh - Harry Gallo
- Chloe Howman - Eve Aspinall
- Mark Springer - Ainsley O'Connor
- Genevieve O'Reilly - Miranda Armstrong
- Brian Croucher - Tony Mills
- John Shrapnel - DAC John Felsham
- Jimmy Yuill - George Milligan
- Heather Wright - Christine Johnson
- Rosalind March - Elaine Murray
- Roy Boyd - Michael Denby
- Georgie Glen - Anne Hargreaves
- Abigail Davies - Andrea Naylor
- Vicki Pepperdine - Madeleine Simmonds
- Trevor Bannister - Bob Ruxton
- Lucy Brown - Marie Braden
- Jamie Sives - Mark Slater
- Adrian McLoughlin - Barry Drake
- Natasha Little - Sarah Winslow
- Nicholas Farrell - James Winslow
- William Armstrong - Michael Ratcliffe
- Graham Bohea - Max
- Dan Mersh - Uniform PC
- Eleanor Matsuura - Tiffany Hayes
- Sally Phillips - Samantha Gerson
- Tim Plester - Darren Gerson
- Alexandra Roach - Nina Ward
- Susan Lynch - Claudia Scott
- Cavan Clerkin - Alan Rendall
- Laurence Spellman - Kator
- Stephen Wight - Psycho Chris
- Kazia Pelka - D.C.I. Melissa Temple
- Karen Seacombe - Cleaner
- Paul McGann - D.C.I. James Larson
- Jesse Birdsall - Tony Morgan
- Pandora Clifford - Vivienne Baxter
- Anna Calder-Marshall - Helen Baxter
- Anthony O'Donnell - Roger Bowman
- Colin Farrell - Wally Brooks
- Pavel Douglas - Greg Hazlett
- Caroline Harker - Tabitha Hall-Chalmers
- Vince Leigh - Murray Dwyer
- Anthony Flanagan - Anthony Bassett
- Flaminia Cinque - Yolanda Halsey
- Michael Colgan - Buzz McCaffery
- John Harding - Barry Metcalfe
- Joanna McCallum - Sheila Metcalfe
- Tony Haygarth - Peter Cooper
- Kate Ashfield - Hilary Newell
- Bill Buckhurst - Noel Kempinski
- Nicola Walker - Helen Hadley
- Brian Pettifer - Archie Milgrow
- Susannah Harker - Elizabeth Clayton
- Phoebe Fox - Eleanor Higgins
- Sam Crane - Oliver Lebbon
- Lucy Phelps - Melissa Parks
- Billy Matthews - Jacob Longley
- Tom Knight - Geoffrey Parks
- Tom Fisher - Colin Henry
- Alex Jennings - Professor Blake
- Lorraine Ashbourne - Moira Wright
- Sarah Smart - Catherine Green
- Andy Rush - Xander Levine
- Chris Ashby - Jake Bentley
- Beverly Hills - Liz Jackson
- Jack Hawkins - Ben Ransley
- John McArdle - Jim Marshall
- Kika Mirylees - Orla Ransley
- Jason Durr - Eddie Trenton
- Stephen Greif - Peter Russell
- Serge Soric - Lukas Klasnic
- Anna Jaskolka - Marta Lewis
- Katarina Čas - Hana Keranovic
- Serge Hazanavicius - Max Clement
- Ruby Bentall - Heidi
- Sylvia Syms - Beatrice
- Jan Francis - June Parker
- Maurice Lee - Young Milton Joseph
- Andrew Hilton - Alec Spencer
- John Warnaby - James Blake
- Kenneth Glenaan
- Dermot Boyd
- Scott Bates
- Metin Hüseyin
- Juliet May
- Keith Boak
- Simon Allen
- Sarah Pinborough
- J.C. Wilsher
- Dan Muirden
- Michael Crompton
- Matt Evans
- Gina Cronk
- Tom Sherry
- Keith Thompson
- Tom Mullens
- Alex Graham
Jamie Sives interpreta a Mark Slater en la serie.
Sara Stewart interpreta a Lulu Questor en la serie.
Alun Armstrong interpreta a Brian Lane en la serie.
Kevin McNally interpreta a Fred Blackledge en la serie.
Nadim Sawalha interpreta a Mr. Mazood en la serie.
John Shrapnel hace el papel de DAC John Felsham.
Kieran O'Brien interpreta a Michael Jacobs en la serie.
Dexter Fletcher hace el papel de Tommy Jackson.
Gary Lewis interpreta a Alex Close en la serie.
Isla Blair interpreta a Alice Pimley en la serie.
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