- Storme Toolis - Holly Griffin
- Jeremy Gittins - Vic (Speed Dater)
- Jenny Agutter - Yvonne Barrie
- Kieran O'Brien - Michael Jacobs
- Diana Weston - Jane Morley
- René Zagger - Andy Merrill
- Nicholas Jones - Michaela Pendle
- Gillian Taylforth - Emma Winters
- George Cole - Sir Edward Chambers
- Richard Briers - James Farlow
- Gavin Millar - Theatre Director
- Susan Jameson - Esther Lane
- Anita Dobson - Elaine Wanless
- Philip Whitchurch - Peter Jacobs
- Stephen Moore - Fred Donaldson
- Dexter Fletcher - Tommy Jackson
- Isla Blair - Alice Pimley
- John Fortune - Mel Simons
- Jamie Glover - Stewart Pimley
- Will Kemp - James Strickland
- Keith Barron - Ronnie Ross
- Cherie Lunghi - Diane Loveless
- Claire Bloom - Helen Brownlow
- David Savile - Ian Gordon
- Dermot Crowley - Derek Bennet
- Heather James - Alison
- Hannah Waterman - Emily Driscoll
- Bruce Alexander - Piers Wheeler
- Carol Starks - Sarah Griffin
- Liz White - Julia Kane
- Hermione Gulliford - Dr Lee
- Gary Oliver - Tony Otway
- Alix Wilton Regan - Tessa Dugdale
- Sophie Thompson - Fiona Kennedy
- Sophie Thompson - Ruth Shiree
- Louis Emerick - Neil Murphy
- Barnaby Kay - DAC Ned Hancock
- Nicola Stephenson - Emily Fraser
- Benjamin Whitrow - Edward Fraser
- Jarred Christmas - Keith
- Robin Berry - Fleet Sewer Guide
- Emily Taaffe - Emma
- Louis Mahoney - Harry Page
- Julie Graham - Tricia McAndrew
- Georgine Anderson - Peggy
- Jasper Jacob - Terry Hargreaves
- Keith Ramsay - Stewie McAndrew
- Katherine Jakeways - Hannah
- Lucy Ellinson - Police Officer
- Emma Ballantine - Young Nancy
- Ruby Thompson - Young Peggy
- Charlotte Cornwell - Alison Willis
- Clare Higgins - Francis Kane
- Oliver Cotton - Hugh Dryden
- Richard Dillane - Lawrence Delvin
- Susie Blake - Sarah Paxton
- David Hayman - Himself
- Amy Nuttall - Caitlin Standing
- Niamh Cusack - Joanne Gibson
- Tom Georgeson - Jason Harvey
- Jack Ellis - David Halburton
- Anthony Calf - D.A.C. Strickland
- Anthony Calf - Deputy Assistant Commissioner Robert Strickland
- Anthony Calf - Robert Strickland
- Anthony Calf - D.A.C. Robert Strickland
- Finlay Robertson - Jeremy Powell
- Leanne Best - Zoe Baines
- Nicholas Woodeson - Viktor Proust
- Emma Fielding - Caroline Tate
- Ian Bartholomew - Tallis
- Dominic Mafham - Stokes
- Margot Leicester - Barbara Haynes
- Struan Rodger - Jim Tanner
- Alun Raglan - Ethan
- Claire Cathcart - Harriet
- Claire Goose - DCI Mackie
- Ann Firbank - Nancy Evans
- Phil Davis - Gavin Gibson
- Gary Lewis - Alex Close
- Phil Daniels - D.C.S. Frank Paterson
- Jana Carpenter - Ruth Bisley
- Joe Absolom - Luke Hanson
- Bill Thomas - Michael Evans
- Tanmay Dhanania - Bobby Johal
- Jessica Turner - Diane Fletcher
- Geraldine Somerville - Asst. Commissioner Cynthia Kline
- Leon Ockenden - Kevin Humphreys
- Lorraine Burroughs - Gail Shaw
- Haydn Gwynne - Sara Hamlyn
- Simon MacCorkindale - Sir David Bryant
- Pooky Quesnel - Catherine Bryant
- David Troughton - Ricky Hanson
- Simon Gregor - Intense Man
- Tom McKay - Jason Bishop
- Theo Barklem-Biggs - Shane Evens
- Jot Davies - Warehouse Guard
- Tim Downie - Dave Pimley
- Diana Kent - Therapist
- Glyn Grimstead - Det. Insp. John Cassidy
- Jim Barclay - Ivor (Speed Dater)
- Gordon Milne - Brindsley (Speed Dater)
- Nicholas Day - Donald Bevan
- Natalie Forbes - Jane
- Paula Jennings - Paula
- Nadim Sawalha - Mr. Mazood
- Jeremy Beckman - Dealer
- Gary Cross - Poker Player 1
- Harry Miller - Poker Player 3
- Imogen Bain - Sylvia Ackerman
- Melanie Jessop - Doctor
- Kenny Ireland - George Morton
- Melanie Ramsay - Kathy
- Ian Bonar - Dog Fan
- Kim Thomson - Tiffany Barker
- Kate Magowan - Catherine Austin
- Sam Hazeldine - Mark Lane
- Ralph Ineson - D I Hamilton
- Nicole Charles - Alicia Trimble
- Michael Simkins - Colonel Kilmartin
- Andrew Tiernan - Sgt Major Sharratt
- Will Keen - Ronnie Glazebrook
- Phyllis Logan - Dr. Mathieson
- Paul Bown - Rod Erskine
- Glynis Barber - Cheryl Brooker
- Raquel Cassidy - Susannah Morton
- Mark Williams - David Beaumont
- Mark Rice-Oxley - Terry Thaxted
- Michael Landes - Leonard Kuziak
- Michael Brandon - Col. Charles Norton
- David Calder - Sid Lestade
- Christopher Fulford - Barry Lestade
- Kenneth Farrington - David Snow
- Jo Stone-Fewings - Tom Eldridge
- Diana Quick - Julia Eldridge
- Michael Melia - Vernon Murnaghan
- Tony Selby - Danny Paye
- Tom Turner - Care Worker
- Jan Harvey - Miranda Carson
- Ellie Haddington - Jean Bennett
- Sam Cox - Paul Rees
- Alice Patten - Vicky Anderson
- Paul Rhys - Sebastian Carter
- Elizabeth Tan - Penny Anderson
- Tom Wu - Daniel Cheung
- Nicholas Goh - Chinese Interpreter
- Mark Bazeley - Brandon Skye
- Sam Kelly - Guy Carse
- Sara Stewart - Lulu Questor
- Kirsty Mitchell - Katie Briers
- Justin Salinger - Clive Burgess
- Kevin Eldon - Dr Neville Moroni
- Joshua Osei - Oaf in Library
- Goran Kostić - Pavel Illich
- Sasha Behar - Emma Woodford
- David Ryall - Jasper Urquhart
- Anne Reid - Sophie Urquhart
- Jonathan Cullen - Jeremy Ventham
- Beth Goddard - Paula Symes
- Tom Mison - Tim Mortimer
- Rick Bacon - Auctioneer
- Scott Hazell - Student
- Francesca Wilson - Ventham's P.A.
- Adrian Schiller - John Davies
- Elijah Baker - Hoodie
- Samantha Bond - Anne Gorton
- Kevin McNally - Fred Blackledge
- Doon Mackichan - Gillian Withall
- Claire Cage - Older Woman
- Simon Ludders - Richard - MI5
- Neil Roberts - Anthony Vernon
- Connie Hyde - Karen Vernon
- Caroline Carver - Helen Vestry
- Neil Stuke - Duncan Miller
- Lizzie Roper - Tilly Shaw
- Sian Brooke - Eileen Harrison
- Alan McKenna - Mick Shaw
- Rudi Dharmalingam - Arun Kumar
- Rory MacGregor - Liam Braine
- Belinda Stewart-Wilson - Sarah Levene
- Rupert Graves - Adrian Levene
- Tuppence Middleton - Melanie Higgs
- Anna-Louise Plowman - Alison Levene
- Peter Wight - Colin Beck
- Johnny Harris - Nick Kellogg
- James Grogan - Eddie Mayfair
- Del Synnott - Danny Branston
- Michael Wildman - Milton Joseph
- John Benfield - Doug Palmer
- Maggie O'Neill - Ronni Mayfair
- Matthew Marsh - Harry Gallo
- Chloe Howman - Eve Aspinall
- Mark Springer - Ainsley O'Connor
- Genevieve O'Reilly - Miranda Armstrong
- Brian Croucher - Tony Mills
- John Shrapnel - DAC John Felsham
- Jimmy Yuill - George Milligan
- Heather Wright - Christine Johnson
- Rosalind March - Elaine Murray
- Roy Boyd - Michael Denby
- Georgie Glen - Anne Hargreaves
- Abigail Davies - Andrea Naylor
- Vicki Pepperdine - Madeleine Simmonds
- Trevor Bannister - Bob Ruxton
- Lucy Brown - Marie Braden
- Jamie Sives - Mark Slater
- Adrian McLoughlin - Barry Drake
- Natasha Little - Sarah Winslow
- Nicholas Farrell - James Winslow
- William Armstrong - Michael Ratcliffe
- Graham Bohea - Max
- Dan Mersh - Uniform PC
- Eleanor Matsuura - Tiffany Hayes
- Sally Phillips - Samantha Gerson
- Tim Plester - Darren Gerson
- Alexandra Roach - Nina Ward
- Susan Lynch - Claudia Scott
- Cavan Clerkin - Alan Rendall
- Laurence Spellman - Kator
- Stephen Wight - Psycho Chris
- Kazia Pelka - D.C.I. Melissa Temple
- Karen Seacombe - Cleaner
- Paul McGann - D.C.I. James Larson
- Jesse Birdsall - Tony Morgan
- Pandora Clifford - Vivienne Baxter
- Anna Calder-Marshall - Helen Baxter
- Anthony O'Donnell - Roger Bowman
- Colin Farrell - Wally Brooks
- Pavel Douglas - Greg Hazlett
- Caroline Harker - Tabitha Hall-Chalmers
- Vince Leigh - Murray Dwyer
- Anthony Flanagan - Anthony Bassett
- Flaminia Cinque - Yolanda Halsey
- Michael Colgan - Buzz McCaffery
- John Harding - Barry Metcalfe
- Joanna McCallum - Sheila Metcalfe
- Tony Haygarth - Peter Cooper
- Kate Ashfield - Hilary Newell
- Bill Buckhurst - Noel Kempinski
- Nicola Walker - Helen Hadley
- Brian Pettifer - Archie Milgrow
- Susannah Harker - Elizabeth Clayton
- Phoebe Fox - Eleanor Higgins
- Sam Crane - Oliver Lebbon
- Lucy Phelps - Melissa Parks
- Billy Matthews - Jacob Longley
- Tom Knight - Geoffrey Parks
- Tom Fisher - Colin Henry
- Alex Jennings - Professor Blake
- Lorraine Ashbourne - Moira Wright
- Sarah Smart - Catherine Green
- Andy Rush - Xander Levine
- Chris Ashby - Jake Bentley
- Beverly Hills - Liz Jackson
- Jack Hawkins - Ben Ransley
- John McArdle - Jim Marshall
- Kika Mirylees - Orla Ransley
- Jason Durr - Eddie Trenton
- Stephen Greif - Peter Russell
- Serge Soric - Lukas Klasnic
- Anna Jaskolka - Marta Lewis
- Katarina Čas - Hana Keranovic
- Serge Hazanavicius - Max Clement
- Ruby Bentall - Heidi
- Sylvia Syms - Beatrice
- Jan Francis - June Parker
- Maurice Lee - Young Milton Joseph
- Andrew Hilton - Alec Spencer
- John Warnaby - James Blake
- Kenneth Glenaan
- Dermot Boyd
- Scott Bates
- Metin Hüseyin
- Juliet May
- Keith Boak
- Simon Allen
- Sarah Pinborough
- J.C. Wilsher
- Dan Muirden
- Michael Crompton
- Matt Evans
- Gina Cronk
- Tom Sherry
- Keith Thompson
- Tom Mullens
- Alex Graham
Jamie Sives interpreta a Mark Slater en la serie.
Sara Stewart hace el papel de Lulu Questor.
Alun Armstrong hace el papel de Brian Lane.
Kevin McNally hace el papel de Fred Blackledge.
Nadim Sawalha interpreta a Mr. Mazood en la serie.
John Shrapnel interpreta a DAC John Felsham en la serie.
Kieran O'Brien interpreta a Michael Jacobs en la serie.
Dexter Fletcher interpreta a Tommy Jackson en la serie.
Gary Lewis hace el papel de Alex Close.
Isla Blair interpreta a Alice Pimley en la serie.
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