- CCH Pounder - Loretta Wade
- Chelsea Field - Rita Deveraux
- Chelsea Field - Rita Devereaux
- Lance Tafelski - Dealer
- Andre De'Sean Shanks - Linus Warren
- Martin Bats Bradford - Ross P.
- Henry Frost - Dale
- Rocky Carroll - Leon Vance
- Joe Spano - T.C. Fornell
- Gabriel Olds - Oliver Huntington
- David Burke - Bernard Lanier
- Dorian Brown Pham - Helaine Morgan
- Chelsey Crisp - Marilyn Reed
- Gabe Begneaud - Albert Fontenot
- Hakim Callender - Sergeant Adams
- Brandon Stacy - Rance
- Steven Weber - Douglas Hamilton
- Eyal Podell - Douglas Wilkins
- Rodney Rowland - John Neville
- Adam Rose - Jesse Neville
- Aubrey Deeker Hernandez - Jake Dern
- Cyd Strittmatter - VKimberly Murdock
- Laura Allen - Katherine Wilson
- Melinda Page Hamilton - Alexandra Schwartz
- Adam J. Harrington - Jason Axelrod
- Andrew Borba - Roger Marcus
- Christopher Matthew Cook - Oscar Randolph
- Carrie Lazar - Lieutenant Clementine Hill
- James Yeargain - Mr. Silver
- Ron Flagge - Mr. Voodoo
- Carl Palmer - Bill Ravens
- Dean Stockwell - Tom Hamilton
- Cristine Rose - Hannah Tarlow
- Jeff Kober - Brick Myers
- Diane Neal - Abigail Borin
- Clayne Crawford - Cade Lambert
- Corbin Bernsen - Adam Huntley
- Eddie Matos - Julio
- Kerry Cahill - Sandra Jones
- Ian Casselberry - Steve Merris
- Rocco Brocato - Jeremy
- Jason Kirkpatrick - Tim Simms
- Tim DeZarn - Paul Hare
- Chris McGarry - Adam Calloway
- Cooper Thornton - Captain Stark
- Abbie Cobb - Alison Hewitt
- Kathleen Munroe - Anita Karr
- Ashton Leigh - Pam
- Cedric Sanders - John Brossette
- Lyle Brocato - Bronson Pomeroy
- Kanesha Washington - Heather Cobb
- Dendrie Taylor - Martha Roberts
- Mark Gessner - Oliver Crane
- Aidan Langford - Remy
- Maxwell Jenkins - Ryan Griggs
- Pasha Pellosie - Alexander Petrov
- Coley Campany - Tessa Edgar Prescott
- Rowan Smyth - Charlie Bell
- Jonathan Medina - Michael Martin
- Tim Russ - Felix Hill
- Riann Steele - Sydney Halliday
- Lou Diamond Phillips - Cedric Gossett
- Carlos Gómez - Dan Sanchez
- Izzie Steele - Carmen
- Victoria Gabrielle Platt - Michelle Silvera
- Melinda McGraw - Gina Powell
- Geoffrey Owens - Calvin Atkins
- Amy Rutberg - Angel
- Amy Rutberg - Megan Sutter
- Danny Burstein - Vincent Welles
- Christina Elizabeth Smith - Ginny Young
- Medalion Rahimi - Jazmine
- Rebecca Wisocky - Bernadine Caldwell
- Reggie Lee - Steven Thompson
- Samantha Soule - Amanda Landry
- Ellen Hollman - Amelia Parsons
- Stacy Keach - Cassius Pride
- Jeff Fahey - Charlie Conroy
- Tom Arnold - Elvis Bertrand
- Tim Griffin - Avery Walker
- Derek Webster - Raymond Isler
- Rebecca Luker - Rose LaSalle
- Eddie Cahill - Eddie Barrett
- Carlin James - Tan Benjawan
- Madison Thompson - Leah
- Faron Salisbury - Russian Handler
- Chelsea Gilligan - Selena Garret
- Clara Wong - Heather Daniels
- DeAriesha Mack - Rhonda
- Connie Shi - Quynh
- William DeMeritt - Gus
- Gavin Warren - Little Dwayne Pride
- David Selby - Red
- Linden Ashby - Tony Hicks
- Sherman Augustus - Jack Hardin
- West Liang - Tim Breaux
- Liz Elkins Newcomer - Security Tech
- Frederick Koehler - Elliot Whitman
- Lenny Platt - David Cabrera
- Matthew James Thomas - Ted Bradley
- Shelley Robertson - Nessa Mitchell
- Venus Ariel - Naomi Porter
- Mackenzie Mauzy - Sarah Murphy
- Katie Rose Clarke - Veronica
- Kelly Hu - Anna Yoon
- Keith David - Gene Holloway
- Mandy Levin - Christina Cooper
- Jasmine Batchelor - Audrey Spencer
- Turner Crumbley - Travis Hayes
- Michael Sun Lee - Feng Wei
- Shai Debroux - Norah Moncado
- America Olivo - Emily Landau
- Tom Lenk - Kevin McCable
- Paige Turco - Linda Pride
- Angel Desai - Dr. Tanaka
- Angel Desai - Beth Tanaka
- Shannon Marie Sullivan - Kyra Russell
- Cory Hart - Agent Winchester
- Lindsay Pulsipher - Kelly
- Alex Beh - Scott Sanders
- Kristin Carey - Sheri Pruitt
- Richard Thomas - Ezra Van Cleef
- Jamie Jackson - Vince Boucher
- Lee Osorio - Daniel Sloane
- Liza Lapira - Aminta Jax
- Brian Brightman - Captain Rogers
- Dan Southworth - Kasem
- Pisay Pao - Anada Benjawan
- Amor Owens - Lawan Nitaya
- Adam Chanler-Berat - Steven Marx
- Michelle Veintimilla - Elena Martinez
- Nneka Okafor - Rina Rollins
- Mandy González - Dr. Hernandez
- Cooper Jack Rubin - Tom
- Lucy Faust - Sue-Ann Hughes
- Chaz Lamar Shepherd - Joe Carson
- Brian Letscher - Jim Keene
- Neal Bledsoe - Man in the Red Suit
- Ellen Adair - Karla Monroe
- Charlotte Schweiger - Neila Diseris
- Cecilia Leal - Lana Breaux
- Darrius Phillip Thomas - Derrick Hillman
- Jessica Frances Dukes - Tour Guide
- Elizabeth Faith Ludlow - Frost
- Jasmine B. Johnson - Jasmine Bennet
- Escalante Lundy - Roger Colton
- Liza J. Bennett - Nancy McLane
- Daoud Heidami - Jason Mullins
- Max Gordon Moore - Grant
- Dustin Seavey - Gustin
- Brandon Morales - Eric Granger
- Emani White - Donna
- David Lind - Max Cahill
- Lilli Cooper - Officer Laughton
- Nedra Marie Taylor - Jessica Scarborough
- C.J. LeBlanc - Nathan Cox
- Ray Gaspard - Simon Gore
- Leander Suleiman - Basira Idrissi
- Joe Pistone - Mark Palmer
- Amanda Warren - Zahra Taylor
- Hunter Burke - Mike Banton
- Hunter Burke - Bart Roberts
- Larry Mitchell - Donovan Blakely
- Kimberli Flores - Maya Hidalgo
- Mike R. Moreau - Jefferson Parish Officer
- Mike R. Moreau - JPSO Officer (uncredited)
- Tyler Weaks - Lenny Yates
- Randall Newsome - Pat Campbell
- Damita Jane Howard - Stunt Double
- Caroline Hebert - Kelsey Weaver
- Tim J. Smith - Anthony Cousins
- Hannah Hodson - Allie Bowers
- Gareth Williams - Michael Hollard
- Diego Wallraff - Perez
- Justin David - Arjun Choudhury
- Schelle Purcell - Monica Brooks
- Kenneth Israel - Dr. Harris
- Konstantin Lavysh - Nico
- Dan Sheynin - Uber Driver
- Alicia Simmons-Miracle - Maggie
- Darryl Booker - Damon Donahue
- Brad Blanchard - Morelli
- Melissa Oulton Haas - Laura Archambeau
- Jake Wynne-Wilson - Bruce Archambeau
- Erica Gimpel - Lynette
- Sasha Diamond - Fiona Devlin
- Maximiliano Hernández - Ted
- Melissa Saint-Amand - Emily Tascioni
- Chet Hanks - Liam McCall
- Christin Rankins - Strip Club Owner
- Alie Urquhart - Beth Hogan
- Dena Tyler - Claire Hogan
- Taylor Rose - Simone Hogan
- Ron Menzel - Frank Hogan
- Cristian Gonzalez - Alex Dixon
- Jonathan Horne - Matt Dixon
- Matt Skollar - Arno Theron
- Darryl W. Handy - Sheriff Mott
- Matthew Humphreys - Bishop Landers
- Alkoya Brunson - CJ Mallory
- Angelena Swords - Suzanne Boynton
- Maria-Christina Oliveras - Reyes
- Brannon Cross - Tanner Chambers
- Justin Mortelliti - Sam Wilkes
- Christine Toy Johnson - Presley DeWitt
- Catherine Combs - Ariel
- Christopher Meyer - Danny Malloy
- Anne Dudek - Dawn Lin
- Russell Wong - Cam Lin
- BD Wong - Gabriel Lin
- Christian Menace - Kurt
- Sara Osi Scott - Sara
- Scott Deckert - Abel Brooks
- Thomas Philip O'Neill - Eddie Oberman
- Ben Bladon - Older Prisoner
- Darius Devontaye Green - Bus Driver
- Austin Naulty - Prison Guard
- Dani Deetté - Lucy Jameson
- Mac Brandt - Roland
- Maceo Oliver - Drummond
- Carlos Arce Jr. - Jack
- Susan McPhail - Joanie Matterson
- Johnny McPhail - Don Matterson
- Jamie Bernadette - Callie Tillford
- Petey Gibson - Ollie King
- Al Vicente - Bart Roberts
- Al Vicente - Ned Jacobs
- Chris Tardio - Elias Watkins
- Laura Shoop - Molly Lefrère
- Devyn A. Tyler - Amelia Boyd
- Gary Basaraba - Steven Bellamy
- Darri Ingolfsson - Karl Baptiste
- Kate Adair - Josie
- Silas Cooper - Jim Caron
- Nicholas Logan - Red
- Meg Gibson - Beverly Watkins
- Kwajalyn Brown - Sofia Lattimer
- Bill Martin Williams - Adam Caroftes
- Cody Bruno - Seth McLaughlin
- Phuong Kubacki - Ms. Wong
- Cara Mitsuko - Agent Lee
- Shanley Caswell - Laurel Pride
- Jason Alan Carvell - Jimmy Boyd
- Joanna Cassidy - Mena Pride
- Callie Thorne - Sasha Broussard
- Drew Scheid - Connor Davenport
- Mark Harmon - Leroy Jethro Gibbs
- Anna Enger Ritch - Kara Valentino
- James Ricker II - Joe Barns
- Pauley Perrette - Abby Sciuto
- Brian Dietzen - Jimmy Palmer
- Emily Wickersham - Ellie Bishop
- David McCallum - Donald Mallard
- Tyler Ritter - Luca Sciuto
- Cassidy Freeman - Eva Azarova
- Hal Ozsan - Ryan Porter
- Steven Waldren - Roy
- Steven Waldren - Roy (uncredited)
- Joseph Gatt - Victor Zelko
- Hoon Lee - Norman Wong
- Meghan Ory - Hannah Lee
- Laura Seay - Dana Wells
- Brianna Brown - Melody James
- Donald Watkins - Carl Hollister
- Jesse Malinowski - Wesley Mott
- Tim Dougherty - Mike
- Emily Kimball - Emily Birch
- Brett Lapeyrouse - John
- Christina Cox - Dinah Clark
- Drew Moerlein - Caleb Prescott
- Rocky Marquette - Cyd Lawson
- Antonio Evan Romero - Dylan Norris
- Lily Holleman - Emily Jansen
- Stephanie Erb - Molly Layne
- Ilan Muallem - Len Bowers
- Ajarae Coleman - Marlene Bell
- Clare Carey - Anna Boudreau
- James McDaniel - Papa Parks
- Matt Bushell - Hunter Franz
- Robert Diago DoQui - Navy C.O. Captain Peter Lee
- Frank Duffy - Tattoo Guy
- Isaiah LaBorde - Mace
- Tyler Kunkle - Jesse
- Ariadne Joseph - Naomi
- Benjamin Papac - Max 'PinZ0' Pinzon
- Annie Potts - Olivia Brody
- Vanessa Marano - Natalie
- Dora Madison - Tilda
- Gino Anthony Pesi - Max Wolf
- Alexander DiPersia - Vlad Stahl
- Tina Benko - Paulina Kurteva
- Bryan Batt - Dalton Greenbrick
- Samrat Chakrabarti - Jenner Blye
- Alex Quijano - Blake Huxley
- Ilia Volok - Burly Man
- Alexander Babara - Yanov
- Charles Barber - NOPD Officer (uncredited)
- Lev Gorn - Anton Pavlenko (uncredited)
- James Logan - Russian Driver (uncredited)
- Joshua Probus - Museum Kid (uncredited)
- Brad Spiers - Russian (uncredited)
- Michael Weatherly - Anthony DiNozzo
- Meredith Eaton - Carol Wilson
- Erika Alexander - Navy Commander Louanne Bates
- Jaynee-Lynne Kinchen - Brianne
- Sharon Conley - Karen Izzo
- Michael Nouri - Jason Campbell
- Boise Holmes - Brad Collins
- Grainger Hines - Sid Beachard
- Vivian Fleming-Alvarez - Judge
- K. Steele - Guard
- Alyma Dorsey - Inmate (uncredited)
- Tony Wharmby
- Oz Scott
- Gordon Lonsdale
- Geary McLeod
- Deborah Reinisch
- LeVar Burton
- Zach Strauss
- Lynne E. Litt
- Jonathan Kidd
- Sonya Winton
- Christopher Ambrose
- Sydney Mitchel
- Mark Harmon
- Greta Heinemann
- Joseph Zolfo
- Joshua Rexon
- Paul Guyot
- Nathan Lee
- John Lee Hooker
- Tree Adams
- Brian Kirk
Stacy Keach interpreta a Cassius Pride en la serie.
Joanna Cassidy interpreta a Mena Pride en la serie.
Scott Bakula interpreta a Dwayne Pride en la serie.
Lucas Black interpreta a Christopher LaSalle en la serie.
Dean Stockwell interpreta a Tom Hamilton en la serie.
Rob Kerkovich interpreta a Sebastian Lund en la serie.
Vanessa Ferlito hace el papel de Tammy Gregorio.
Necar Zadegan hace el papel de Hannah Khoury.
Charles Michael Davis interpreta a Quentin Carter en la serie.
Daryl Mitchell interpreta a Patton 'Triple P' Plame en la serie.
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