- Jake Johnson - Doc Michael
- Cristin Milioti - Bean
- Geoffrey Owens - Tom
- Regan Burns - Publisher
- Athena Perample - Tiffany Winters
- Emily Berry - Realtor
- McColm Kona Cephas Jr. - Roscoe Kid
- Reyn Doi - Nerdy Kid
- Colby Lemmo - Creature
- Kate Cochran - Claire (Sorority Victim)
- Caleb Thomas - Boyfriend
- Morgan Melton - Girlfriend
- LeShay N. Tomlinson - Teacher
- Ava Davila - Girl Coder #2
- Joy Regullano - Female Streamer
- Stephenson Crossley - Byron
- Tyrrell Cummings - Stephen
- Elisha Henig - Pootie Shoe
- Aparna Nancherla - Michelle
- John DiMaggio - Dan Williams
- Anthony Hopkins - Everlight Narrator (voice)
- Jonathan Wiggs - Jonathan
- Cooper J. Friedman - SnickrSnack
- Humphrey Ker - Paul
- Jason Fuchs - Strauss
- Maaz Ali - Receptionist
- Craig Mazin - Lou
- Craig Mazin - Sol Green
- Snoop Dogg - Snoop Dogg
- Isabella Abiera - 12-Year-Old Streamer
- Robert Timothy Smith - 9-Year-Old Streamer
- Caitlin McGee - Sue
- Josh Brener - Carl Longbottom
- Michael Cassidy - Peter Cromwell
- Susan James Berger - Rose
- Chet Grissom - Isaac Asimov
- Shelley Hennig - Ginny
- Shelley Hennig - A.E. Goldsmith
- Kendall Foote - Delivery Man
- Nicole Ghastin - Ursula K. Le Guin
- William Hurt - Peter Cromwell
- Alice Amter - Magda
- Christopher Naoki Lee - Kevin
- Genevieve Jones - Doctor
- Derek Waters - Phil
- Mort Burke - Anthony
- Parvesh Cheena - Zack Bakshi
- Mark W. Gray - Kenny
- Joe Manganiello - Joe Manganiello
- Austin Zajur - Travor
- Alanna Ubach - Shannon
- Lindsey Kraft - Sarah
- Isla Rose Hall - Young Poppy
- Judah Prehn - Young Ian
- Casey Sander - Grandpop
- Dionysio Basco - Benito
- Sam Witwer - Ian's Dad
- Robert Picardo - Principal Taggart
- Michael Naughton - Mikey
- Andrew Friedman - Andy
- Nandini Bapat - Dev
- Antoine Perry - Young Phil
- Amy Kim Waschke - Woman
- Zhandra Reyes - Maria
- James Coker - VC
- James Coker - Chase
- Jean-Paul DiFranco - Employee #2
- Thadeus Welch - Employee #3
- Mark Engelhardt - Police Officer Harris
- Justin Dray - Man
- Preston Galli - Library Student
- Alex Adler
- Jenny Siff
- Humphrey Ker
- Katie McElhenney
- Rob McElhenney
- Bryan Swarberg
- Ashley Borlik
- Kyle Mack
- Stephenson Crossley
- Jeanne McCarthy
- Diego Gat
- Jamie Hardt
- Joe Deveau
- Matthew E. Taylor
- Takeshi Furukawa
- James Cartwright
Rob McElhenney interpreta a Ian Grimm en la serie.
Anthony Hopkins interpreta a Everlight Narrator (voice) en la serie.
Ashly Burch interpreta a Rachel en la serie.
F. Murray Abraham interpreta a C.W. Longbottom en la serie.
Naomi Ekperigin interpreta a Carol en la serie.
David Hornsby hace el papel de David Brittlesbee.
William Hurt interpreta a Peter Cromwell en la serie.
Charlotte Nicdao interpreta a Poppy Li en la serie.
Jessie Ennis interpreta a Jo en la serie.
Imani Hakim hace el papel de Dana.
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