- Cedric Smith - Dr. Paul Breedlove
- Ross Hull - Daniel Benedict
- Jennifer Dale - Wendy Stone
- Ralf Moeller - Lieutenant Bo Longstreet
- Gordon Currie - Frank Cross
- Joanne Vannicola - Maddie Conlan
- Jim Thorburn - Barry Sterling
- Reagan Pasternak - Toni Quintana
- Art Hindle - Noah Kilmartin
- Guylaine St-Onge - Danielle Hartman
- Kevin Jubinville - Todd
- Yannick Bisson - Richard Saunders
- Callum Keith Rennie - Zack Lockhart
- Emily Hampshire - Charlotte Cooke
- Tracy Shreve - Attractive Woman
- Paul Popowich - Mark Griffin
- Joanne Kelly - Kim
- Louis Ferreira - Henry Voight
- James Gallanders - Jay Minhouse
- Krista Allen - Lorna Templeton
- Danielle Hampton - Michelle Bigelow
- Scott Hylands - Clay Preston
- Graham Harley - Dr. Robert Harrow
- Michael Easton - Gabriel Ashlocke
- Bree Williamson - Miranda Davis
- Lindy Booth - Diana Moller
- Conrad Pla - Valdex
- Philip Akin - General Sutton
- Megan Fahlenbock - Claudia Manfred
- Andrew Tarbet - Kyle Strong
- Nick Mancuso - Judge
- Gary Hudson - Warden Wallington
- Jack Langedijk - Daniel Foster
- Steve Bacic - Nick Maddox
- Katia Corriveau - Kelly
- Alan van Sprang - Rae Larkin
- Karl Pruner - Simon Fletcher
- Eugene Robert Glazer - Nicholas Fox
- Romano Orzari - Domenic Rydell
- Sten Eirik - Anthony Gervais
- Sasha Roiz - Nathaniel
- Rachael Crawford - Samantha Bennett
- Gary Farmer - Dr. Marcus
- David Orth - William Dennett
- Anthony Christian Potenza - Hotel Clerk
- John Ralston - Carl
- Leon Pownall - Dr. Victor Palance
- Stuart Stone - Einstein
- Monika Schnarre - Riley Morgan
- Jeff Roop - Deklin Charvet
- Laura Vandervoort - Tina
- Marc Donato - Joshua Valentine
- Anne Openshaw - Angel Dorn
- Joy Tanner - Kendra MacEvoy
- Sarah Gadon - Catherine Hartman
- Rob Stefaniuk - Skeet Vossberg
- Karen LeBlanc - Morgan Fortier
- Chris Owens - Mr. Delay
- Sandrine Holt - Patricia
- Deborah Grover - Virginia Beals
- Max Morrow - Young Gabriel Ashlocke
- Stephen McHattie - Aaron Gaumont
- Lawrence Bayne - Sam Raymond
- Nigel Bennett - John Warren
- Christina Cox - Becky Dolan
- Joris Jarsky - McTeague
- Anna Silk - Asia
- David Sutcliffe - Mark Kearney
- Jenny Cooper - Lisa Larkin
- Janet-Laine Green - Senator Morrison
- Eddie McGee - Mal
- Ron Kennell - Levak Ivanov
- Krista Bridges - Alisha
- Paul Wu - Molecular Mutant
- Jessica Steen - Dr. Sara Stanton
- Lynne Cormack - Helen
- Steve Byers - Leo Pierce
- Peter Stebbings - Kristoff
- Dax Ravina - Bank Manager
- Melyssa Ade - Kara Whitely
- Janaya Stephens - Diane Taylor
- Rod Wilson - Corbin Valentine
- Greg Bryk - Ledeker
- Jeff Wincott - Grady Colt
- Daniel Kash - Christian
- David Hewlett - Hector Freimark
- Tom Barnett - Carter
- James Bulliard - Burke
- Angela Besharah - Stacey
- Lauren Collins - Megan Morrison
- Salvatore Antonio - Milo (as Salvatore Migliore)
- Shane Daly - Cody
- Ted Whittall - Sebastian Conway
- Ted Whittall - Carl Ames
- Sebastian Spence - Noel
- Ryan Scott Greene - Tyler Ryan
- Lisa Marcos - Avaris
- Sean Bell - Michael Azzarello
- Kevin Hicks - Carter
- Douglas O'Keeffe - Frank Thorne
- Chuck Byrn - Ruby
- Ingrid Hart - Alison
- Peter Van Wart - Steven Benedict
- Dylan Bierk - Sonya
- Alexander Pervakov - Yuri
- Alison MacLeod - Caroline
- Claudia Besso - Karen Bell
- Monique Ganderton - Donna Morse
- Jake Simons - Jack
- Laura Jordan - Bartender
- Desmond Campbell - Bouncer
- Tony Curtis Blondell - Drunken Guy
- Adam MacDonald - Renfield
- Sandi Stahlbrand - Colleen
- John Friesen - Harve
- Simon Northwood - GSA Agent
- Anthony Lemke - Charles Marlowe
- Gina Sorell - Jerri
- Sherry Hilliard - Alice
- Moya O'Connell - Ashley Elliott
- Mark Lutz - Eric Tanner
- Reuben Thompson - Henshaw
- Paulino Nunes - Burke
- Anthony Tullo - Corporal Clark Randall
- Christopher Bolton - Aldus Burke
- Xuan Fraser - Neil
- Kedar Brown - Axel
- Domenic Cina - Pablo
- Derwin Jordan - Calvin Porter
- Chick Reid - Nicole Carter
- Andrew Kenneth Martin - Caleb Mathias
- Larissa Laskin - Pamela Fries
- Raven Dauda - Maria
- Jason Jones - Cashier
- Tiara Sorensen - Lena Isley
- Jocelyn Snowdon - Megan Alexander
- Michael Anthony Rawlins - Artie Hill
- Matthew MacFadzean - Tony Reese
- Jim Codrington - Halloran
- Clyde Whitham - Dr. Tork
- Roman Podhora - Harvey Lanchester
- Kim Schraner - Kelly Rice
- Soo Garay - Aziza
- Melanie Marden - Valerie
- Lee Rumohr - Young Corporal
- Lee Rumohr - Lucian
- Markus Parilo - Veradi
- Noah Dalton Danby - The Beast / Michael Ward
- Noah Dalton Danby - Carter
- Andrew Massingham - Lout
- Karen Holness - Sophia Taylor
- Troy P. Liddell - Lieutenant
- Christopher Jacot - Young Adam Kane
- Drew Coombs - Matt
- Jonas Chernick - Josh
- Sean Orr - Military Guard
- Sean Orr - Pavel
- Elle Downs - Vendor
- Sasha Ormond - Link
- Leland Tilden - Link
- Vincent Walsh - Morrison
- Lina Giornofelice - Irina
- Joseph Scoren - Lynch
- Joseph Scoren - Lee Marker
- Natalie Brown - Secretary
- Gabriel Hogan - Josh Marcus
- Thomas Hauff - Zander Delassandro
- David Fox - Gerald Gilbert
- Anna Louise Richardson - Glenda Demerest
- Damir Andrei - Thom Reilly
- Chris Britton - J.K. Bergman
- Jeannette Sousa - Amanda Terry
- Colette Stevenson - Dr. Sarah Woolf
- Melinda Deines - Carla Reed
- David Lipper - Vic Morelli
- Frank Moore - McAllister
- Brandon Thomas - Cyrus Payton (voice)
- Noah Plener - Manager
- Kelvin Wheeler - Limo Driver
- Jenya Lano - Nikki Rodgers
- Deborah Odell - Lisa Valentine
- Deborah Odell - Kristen Greg
- Michael Copeman - Holcomb
- Sava Drayton - Dylan Carter
- Amanda Martínez - Lucinda Alvarez
- Patrick Salvagna - Connor Dolan
- A.C. Peterson - Carson Bailey
- Sheila Brand - Waitress
- Tig Fong - QJ-14 A
- Dean Copkov - QJ-14 B
- Steve Boyle - Skye
- Wesley French - Deacon
- Juan Carlos Velis - Gomes
- Rachel Hayward - Christina
- Allan Royal - Dr. Nigel Rigas
- Christopher Lee Clements - Kearns
- Layton Morrison - Dennis
- Philip Shepherd - Brako
- Laura Catalano - Serena
- Allan Hawco - Scientist
- Angelo Tsarouchas - Bartender
- Jonathan Goad - Thug
- Christopher Bondy - Silverman
- Stephen Bogaert - Harry Davis
- Matthew G. Taylor - Jack Martin
- Jennifer Hill - Jenna
- James Binkley - Guard
- James Binkley - Thug
- Karl Campbell - Prison Guard
- Thomas Patrice - FBI Driver
- Amy Price-Francis - Janet Nicholls
- Gary Reineke - Marsden
- James Downing - Frank 'Speedy' Sanders
- Jonathan Watton - Billy Larkin
- John Robinson - Jerzy Novotny
- Jane Moffat - Dr. Polly McWilliams
- Edgar George - Policeman
- Michèle Duquet - Dr. Louise Koby
- Martin Roach - Owen Taylor
- Hardee T. Lineham - Martin Freeman
- Joel Harris - Protocanth
- Neil Davison - Protocanth
- Jason Knight - Menotti
- Don Dickinson - Jock McAllister
- Katie Bergin - Elizabeth Bergen
- James McGowan - Dr. Richard Haines
- Richard Stroh - Silva
- Flossie McKnight - Psychic Interrogator
- Jeffrey R. Smith - Scientist
- Lyriq Bent - Harris
- Lyriq Bent - Randall Blake
- Sean Sullivan - Bartender
- Michael A. Miranda - Carlos Lavista
- Francisco Trujillo - Eduardo Cruz
- Diego Fuentes - Gary Allen
- Pragna Desai - Andrea Marshall
- Jennifer Vey - Candace Rockwell
- Jennifer Vey - Young Woman
- Laryssa Yanchak - Murder Victim
- Rob Archer - Rucker
- Rob Archer - Sniper
- Tony Craig - Major Klein
- Ron Lea - Dr. Vincent Arrigo
- Aaron Poole - Peter Morton
- Alexandra Castillo - Gina
- Carl Barlow - Prison Guard
- Suzanne Coy - Ruth
- Nancy Palk - Dr. Willett
- Kevin Rushton - Thug
- Kevin Rushton - McMullen
- Marie Ward - Nurse Campbell
- Mark Terene - Janitor
- Diego Klattenhoff - Johnny
- Tim Hamaguchi - Freaked Out Orderly
- Jessica Greco - Sandy Fetko
- Jeanette Roxborough - Terra
- Johnny Goltz - Wayne
- Shannon Lawson - Dr. Bellows
- James Collins - Swat Team Member
- Alex Karzis - Bain
- Pedro Miguel Arce - Troy
- Nobby Suzuki - Asian Man
- Paul Tedeschini - Man
- Jeff Teravainen - Jason Arnold
- George Tchortov - Elemental Mutant
- Jamaal Grant - Security Guard
- Jason Schombing - Eddie Boyle
- Philip Craig - Senator Daniel Richards
- Matt Cooke - Benedict
- Jack Duffy - Silver
- Darryl Flatman - Security Guard
- Eric Weinthal - Art Critic
- Vladimir Radian - Guard with dog
- Shaun Smyth - Keith Burstyn
- James Taku Leung - Member
- Bob Desrosiers - Member
- Jung-Yul Kim - Guard
- Robert Seeliger - Ethan Poe
- Marcia Bennett - Mrs. Hayes
- Aleks Paunovic - Nick
- Dan Petronijevic - Cole
- Randy Butcher - Truck Guard
- Wayne Lam - Delivery man
- Tim MacMenamin - Bank guard
- Heidi von Palleske - Dr. Denise Saunders
- Joan Gregson - Patty Paxton
- Patrick Garrow - Dr. Francis Gallant
- Desmond Scott - Old W. Killmartin
- Sean Clement - Young W. Killmartin
- David Gardner - Old Henry Burns
- Howard Hoover - Young Henry Burns
- Peter Cockett - Dr. John Gonsalves
- John Blackwood - Dr. Arnot
- John Stoneham Sr. - Dr. Howell
- Darren Marsman - Guard
- Ian Leung - Board Member
- George Buza - Dominion Contact
- George Buza - The Man
- Andrew Gillies - Dr. Kenneth Harrison
- David J. MacNeil - Board Member
- David Frisch - Board Member
- Ellen Dubin - Dr. Robinson
- Ronn Sarosiak - Williams
- Matt Gordon - Nolan Blackledge
- Craig Warnock - Kevin Gitre
- Amy Lalonde - Britney Zadora
- Ramona Pringle - Tiffany
- Kelly Fiddick - Cabdriver
- Lorry Ayers - Nurse
- Tim Eddis - Businessman
- Wayne Best - John Bishop
- Patrick Chilvers - Dooley
- Philip DeWilde - Nathan Reynolds
- Timothy Burd - The Guardian
- Kis Yurij - Molecular Link
- Jason Jazrawy - Tony LaPorta
- Nicolas Van Burek - Mike Robson
- Jinny Jacinto - Contortionist
- Arlene Mazerolle - Dominique
- Jeff Seymour - Dominion Council Head
- Don Ritchie - Council Member
- Chad Camilleri - Scientist
- Kevin Hare - Adam's double
- Craig Blair - QJ Soldier
- Stefen Hayes - Assassin
- Andrew Chalmers - Young Johnny
- Derwin Philips - Policeman
- Avi Arad
- Jay Firestone
Callum Keith Rennie interpreta a Zack Lockhart en la serie.
Timothy Burd hace el papel de The Guardian.
Lyriq Bent interpreta a Randall Blake en la serie.
Leon Pownall hace el papel de Dr. Victor Palance.
Sean Sullivan interpreta a Bartender en la serie.
Ralf Moeller interpreta a Lieutenant Bo Longstreet en la serie.
David Fox interpreta a Gerald Gilbert en la serie.
Emily Hampshire hace el papel de Charlotte Cooke.
Stephen McHattie interpreta a Aaron Gaumont en la serie.
Greg Bryk interpreta a Ledeker en la serie.
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