- Richard Huw - Dr. John Cornell
- Will Mellor - DC Jed Griffiths
- Michael McKell - DS Trevor Hands / DI Trevor Hands
- Su Elliot - Maureen Hopgood
- René Zagger - PC Nick Klein
- Vincent Regan - Paul Harris
- Valerie Minifie - Mrs. Merrick
- Benedict Taylor - Neil Wake
- Gary Kemp - Dennis McKay
- Jeillo Edwards - Agnes Welsh
- John Duttine - John Pembrey
- Harry Lloyd - Matt Pattinson
- Pui Fan Lee - Solicitor
- Lee Warburton - Lee Kemp
- Anthony Flanagan - Dexter Barnes
- Tracie Bennett - Celia Seagrove
- Carl Wright - Darren
- Lee Ross - Andy Nash
- Daniel Schutzmann - Jonathan
- Raza Jaffrey - Kareem Dobar
- Danny Dyer - Marc Sharaff
- Paul Bown - Gary Sutcliffe
- Ramon Tikaram - DI Vince Ruddy
- Cyril Nri - Supt Adam Okaro
- Bradley Walsh - Phil Seagrove
- Shirley Cheriton - Barbara Dunn
- Andrew Tiernan - Gary Shale
- Lisa Maxwell - DI Samantha Nixon
- Debbie Arnold - Alison London
- Henry Goodman - Cameron Pattison
- Trevor McDonald - Self
- Oliver Cotton - Artyom Biartoulis
- Kenneth Cranham - Ray Morgan
- Ciarán Griffiths - PC Gary Best (uncredited)
- Jaime Winstone - Hannah
- Angel Coulby - Lee Allanson
- Paul Child - Michael Whittington
- Tony O'Callaghan - Sgt Matthew Boyden
- Clare Higgins - Lesley Pattison
- Hugh Sachs - Dr. Charles Renfield
- Anthony Stewart Head - Stewart Masters
- Ricky Grover - Dave Day
- Rebecca Lacey - Ruth Baxter
- Chiké Okonkwo - Marlon Raines
- Stephen Graham - Jason Phelps
- Robbie Earle - Interviewer
- Scott Bates
Stephen Graham interpreta a Jason Phelps en la serie.
Richard Hope interpreta a DS Barry Purvis en la serie.
Lindsey Coulson interpreta a DC Rosie MacManus en la serie.
Abhin Galeya interpreta a DC Simon Tait en la serie.
Diane Parish interpreta a DC Eva Sharpe en la serie.
Meera Syal interpreta a DCI Anita Wishart en la serie.
Will Mellor interpreta a DC Jed Griffiths en la serie.
Michael McKell hace el papel de DS Trevor Hands / DI Trevor Hands.
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