- John Henson - Sweetums
- Martin Short - Self
- Micky Dolenz - Self
- Tony Bennett - Self
- John Goodman - Self
- Garth Brooks - Self
- Jason Alexander - Self
- Michelle Pfeiffer - Self
- Heather Locklear - Self
- Coolio - Self
- Daryl Hannah - Self
- Andie MacDowell - Self
- Prince - Self
- Sandra Bullock - Self
- Pierce Brosnan - Self
- Gilbert Gottfried - Self
- Rick Moranis - Self
- Paula Abdul - Self
- Cindy Crawford - Self
- Ed McMahon - Self
- Whoopi Goldberg - Self
- Dennis Quaid - Self
- George Takei - Self
- William Shatner - Self
- Don Rickles - Self
- Johnny Mathis - Self
- Billy Crystal - Self
- Larry King - Self
- Vendela Kirsebom - Self
- Bernard Shaw - Self
- Fred Willard - Self
- Christopher Darden - Self
- Kevin Eubanks - Self
- Arsenio Hall - Self
- Kathy Ireland - Self
- Jay Leno - Self
- Little Richard - Self
- Teller - Self
- Penn Jillette - Self
- Lori Fetrick - Self
- Raye Hollitt - Self
- Evander Holyfield - Self
- Kathy Najimy - Self
- Bob Keeshan - Self
- Ben Stein - Self
- Page Hannah - Self
- Leonard Nimoy - Self
- Jim Lewis
- Paul Flaherty
- Brian Henson
- Kirk R. Thatcher
- Jim Lewis
- Chris Plourde
Pierce Brosnan interpreta a Himself en la serie.
Martin Short hace el papel de Himself.
Brian Henson interpreta a Sal Minella / Seymour en la serie.
Daryl Hannah interpreta a Herself en la serie.
Whoopi Goldberg interpreta a Herself en la serie.
Michelle Pfeiffer interpreta a Herself en la serie.
Jason Alexander hace el papel de Himself.
John Goodman interpreta a Himself en la serie.
William Shatner interpreta a Himself en la serie.
George Takei interpreta a Himself en la serie.
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