- Kayla Maisonet - Teen Girl
- Dean Cain - Dean Cain
- Keisuke Hoashi - Dr. Cho
- Leon Simmons - Ernie
- David Theune - Stage Manager
- Julie Klausner - Donna
- Maria Christina Thayer - Amanda
- Fortune Feimster - Mary Jo
- Jack Axelrod - Elderly Veteran
- Ayumi Iizuka - Mother
- Lyle Kanouse - Teamster
- Tess Paras - Female Contestant
- Laura Bailey - Narrator (voice)
- Dan Levy - Dad (voice)
- Lordan Napoli - Stacy (voice)
- Bruce M. Stockert - Man at Bris
- Dan Mintz - Mintz
- Carole Goldman - Mrs. Tuchman
- Bunny Levine - Old Woman
- Penny Marshall - Tutti
- Lorraine Bracco - Vaughn
- Megan Heyn - Kristen
- Tessa Goss - News Anchor
- Duane R. Shepard Sr. - Percy
- Nora Dunn - Patty Mulaney
- Pete Holmes - Father Trey
- James Handy - Father Ed
- Art Napiontek - Ripped Andre
- Greta Sesheta - Cantor
- Ben Lawson - Greg
- Jerry Minor - Murphy
- Robert Baker - Chad
- Rocky McMurray - Recruiter
- Nico Santos - Contestant
- Adria Tennor - Flight Attendant
- Corey Martin Craig - Young Man
- Brennan Feonix - Audience Member
- Karey Dornetto - Mom (voice)
- Karey Dornetto - Brenda
- Kareem J. Grimes - Audience Member
- Scott Broderick - Audience Member
- Jamie Denbo - Sharisse
- Joy Osmanski - Alexa
- Eddie Pepitone - Arnie
- Brooke Lyons - Cassidy
- Sonya Eddy - Gerta
- Irene Roseen - Mrs. Regenbogen
- Nick Kroll - Jesse Tyler Munoz
- Ron Funches - Rodney
- Tanner Flood - Young Mulaney
- Edward Enriquez-Cohen - Stage Hand O.C.
- Danielle Kaplowitz - Woman
- Jen Reiter - Casting Director O.C.
- Liz Porter - Dancer
- Molly Shannon - Markie
- Bechir Sylvain - Bobby
- Ron G. - Darren
- J.M. Longoria - Photographer
- Thomas Crawford - French Waiter
- Kamala Jones - Hot Blonde
- Leena Huff - Girl
- Danielle Moné Truitt - Girl
- Kristi Clainos - Girl
- Bailee Madison - Ruby
- Frankie Shaw - Julia
- Barak Hardley - Paul
- Victoria Grace - Teen
- Natasha Leggero - Rodeo
John Mulaney interpreta a John en la serie.
Elliott Gould hace el papel de Oscar.
Zack Pearlman interpreta a Andre en la serie.
Nasim Pedrad interpreta a Jane en la serie.
Seaton Smith interpreta a Motif en la serie.
Martin Short hace el papel de Lou.
Tessa Goss interpreta a News Anchor en la serie.
Capítulo disponible en las siguientes plataformas:
